Increasing the potency of a cytotoxin with an arginine graft

Protein Engineering, Design and Selection

Volumn 20, Issue 10, 2007, Pages 505-509

  Fuchs, Stephen M ^a,b   Rutkoski, Thomas J ^a   Kung, Vanessa M ^a   Groeschl, Ryan T ^a   Raines, Ronald T ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Cancer; Coulombic interaction; Protein transduction domain; Ribonuclease; Ribonuclease inhibitor

Indexed keywords

AMINO ACIDS; CELLS; ENZYME ACTIVITY; ENZYME INHIBITION; PROTEINS;

ARGININE; CYTOSOL; CYTOTOXIC ACTIVITY; RIBONUCLEASE INHIBITOR; RIBONUCLEOLYTIC ACTIVITY;

CYTOTOXICITY;

ARGININE; CYTOTOXIN; RIBONUCLEASE A; RIBONUCLEASE INHIBITOR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CYTOTOXICITY; DRUG POTENCY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEOMICS;

AMINO ACID SEQUENCE; AMINO ACIDS, ACIDIC; ANIMALS; ARGININE; BINDING SITES; CATIONS; CATTLE; CELL LINE; CYTOTOXINS; DATABASES, PROTEIN; HUMANS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PERMEABILITY; PROTEIN STRUCTURE, QUATERNARY; PROTEINS; RECOMBINANT PROTEINS; RIBONUCLEASE, PANCREATIC;

BOVINAE;

EID: 36249031694     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzm051     Document Type: Article

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