Conformational stability is a determinant of ribonuclease A cytotoxicity

Journal of Biological Chemistry

Volumn 275, Issue 23, 2000, Pages 17463-17467

  Klink, Tony A ^a   Raines, Ronald T ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INHIBITOR PROTEIN; PANCREATIC RIBONUCLEASE; RANPIRNASE; RIBONUCLEASE A; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL TRIAL; DISULFIDE BOND; DRUG CYTOTOXICITY; ENZYME CONFORMATION; ENZYME STABILITY; ENZYME STRUCTURE; ERYTHROLEUKEMIA CELL; HUMAN; HUMAN CELL; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; ANIMALS; CATTLE; CELL SURVIVAL; EGG PROTEINS; ENZYME STABILITY; HUMANS; KINETICS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; RIBONUCLEASE, PANCREATIC; RIBONUCLEASES; TUMOR CELLS, CULTURED; VARIATION (GENETICS);

EID: 0034625439     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M001132200     Document Type: Article

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