The role of electrostatic interactions in the antitumor activity of dimeric RNases

FEBS Journal

Volumn 273, Issue 16, 2006, Pages 3687-3697

  Notomista, Eugenio ^a   Mancheño, José Miguel ^b   Crescenzi, Orlando ^a   Di Donato, Alberto ^a   Gavilanes, José ^c   D'Alessio, Giuseppe ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Antitumor RNases; Electrostatic interaction energy; Electrostatic interactions; RNases; Transport through membranes

Indexed keywords

ENZYME INHIBITOR; RIBONUCLEASE; RIBONUCLEASE INHIBITOR; RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ARTIFICIAL MEMBRANE; COMPUTER MODEL; CORRELATION ANALYSIS; CYTOSOL; CYTOTOXICITY; ELECTRICITY; ENERGY; ENZYME ACTIVITY; INTRACELLULAR MEMBRANE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; COMPUTER SIMULATION; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSTATICS; HUMANS; INHIBITORY CONCENTRATION 50; INTRACELLULAR MEMBRANES; MEMBRANE FLUIDITY; RIBONUCLEASES;

BOS TAURUS;

EID: 33746704961     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2006.05373.x     Document Type: Article

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