A Nuclear Localization Sequence Endows Human Pancreatic Ribonuclease with Cytotoxic Activity

Biochemistry

Volumn 43, Issue 8, 2004, Pages 2167-2177

  Bosch, Montserrat ^a   Benito, Antoni ^a   Ribó, Marc ^a   Puig, Teresa ^a   Beaumelle, Bruno ^b   Vilanova, Maria ^a  

^a UNIVERSITY OF GIRONA   (Spain)

^b UNIVERSITÉ DE MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; CELLS; ENZYME INHIBITION; ENZYMES; RNA;

CYTOXICITY; NUCLEAR LOCALIZATION SIGNAL;

BIOCHEMISTRY;

ARGININE; CYTOSOLIC RIBONUCLEASE INHIBITOR; ENZYME VARIANT; PANCREATIC RIBONUCLEASE; PANCREATIC RIBONUCLEASE 5; RANPIRNASE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL NUCLEUS; COMPARTMENT MODEL; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; ENDOCYTOSIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; NUCLEAR LOCALIZATION SIGNAL; NUCLEOLUS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN PURIFICATION; RIBOSOME; RNA INTERFERENCE; RNA PROCESSING;

ACTIVE TRANSPORT, CELL NUCLEUS; CATALYSIS; CELL NUCLEUS; DRUG DESIGN; ENDOCYTOSIS; ENZYME INHIBITORS; ENZYME STABILITY; GROWTH INHIBITORS; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; INTRACELLULAR FLUID; ISOENZYMES; K562 CELLS; MUTAGENESIS, SITE-DIRECTED; NUCLEAR LOCALIZATION SIGNALS; RIBONUCLEASE, PANCREATIC; VARIATION (GENETICS);

EID: 1442300945     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035729+     Document Type: Article

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