Disruption of shape-complementarity markers to create cytotoxic variants of ribonuclease A

Journal of Molecular Biology

Volumn 354, Issue 1, 2005, Pages 41-54

  Rutkoski, Thomas J ^a   Kurten, Erin L ^a   Mitchell, Julie C ^a   Raines, Ronald T ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Cancer; Cytotoxin; Onconase ; Protein protein interaction; Ribonuclease inhibitor

Indexed keywords

ARGININE; ASPARAGINE; ASPARTIC ACID; ENZYME INHIBITOR; ENZYME VARIANT; GLYCINE; RANPIRNASE; RIBONUCLEASE A; RIBONUCLEASE INHIBITOR; UNCLASSIFIED DRUG;

ALGORITHM; AMINO ACID SUBSTITUTION; ARTICLE; CANCER CELL; CATALYSIS; CHEMOTHERAPY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DRUG ACTIVITY; DRUG SELECTIVITY; ENZYME CONFORMATION; GEOMETRY; HUMAN; HUMAN CELL; MAMMAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

AMPHIBIA; BOVINAE; MAMMALIA;

EID: 27344441004     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2005.08.007     Document Type: Article

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