Changing the net charge from negative to positive makes ribonuclease Sa cytotoxic

Protein Science

Volumn 11, Issue 10, 2002, Pages 2522-2525

  Ilinskaya, Olga N ^a   Dreyer, Florian ^a,b   Mitkevich, Vladimir A ^c   Shaw, Kevin L ^d   Nick Pace, C ^a,b,c   Makarov, Alexander A ^a,b,e  

^a KAZAN FEDERAL UNIVERSITY   (Russian Federation)

^b JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^c ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^d GROVE CITY COLLEGE   (United States)

^e TEXAS A M COLLEGE OF MEDICINE   (United States)

Author keywords

Charge reversal mutants; Cytotoxicity; Net charge; Ribonuclease Sa; v ras transformed fibroblasts

Indexed keywords

ANTINEOPLASTIC AGENT; MUTANT PROTEIN; RIBONUCLEASE 3K; RIBONUCLEASE 5K; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CELL TRANSFORMATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG TARGETING; ELECTRICITY; ENZYME ACTIVITY; ENZYME STABILITY; ENZYME STRUCTURE; MAMMAL CELL; MOUSE; NONHUMAN; ONCOGENE RAS; PH; PRIORITY JOURNAL; RIBONUCLEASE SA; STREPTOMYCES AUREOFACIENS; VIRUS ONCOGENE;

3T3 CELLS; ANIMALS; FIBROBLASTS; ISOENZYMES; MICE; MUTATION; RIBONUCLEASES; STREPTOMYCES AUREOFACIENS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; MAMMALIA; STREPTOMYCES; STREPTOMYCES AUREOFACIENS;

EID: 0036784623     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.0216702     Document Type: Article

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