A ribonuclease a variant low catalytic activity but high cytotoxicity

Journal of Biological Chemistry

Volumn 275, Issue 14, 2000, Pages 9893-9896

  Bretscher, Lynn E ^a,b   Abel, Richele L ^a   Raines, Ronald T ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RANPIRNASE; RECOMBINANT RIBONUCLEASE A; RIBONUCLEASE A; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG CYTOTOXICITY; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME STABILITY; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; ANTINEOPLASTIC AGENTS; CELL DIVISION; DNA, NEOPLASM; EGG PROTEINS; ENZYME STABILITY; HUMANS; K562 CELLS; KINETICS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; RIBONUCLEASE, PANCREATIC; RIBONUCLEASES; THYMIDINE; VARIATION (GENETICS);

ESCHERICHIA COLI;

EID: 0034615926     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.14.9893     Document Type: Article

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