T cell immune responses to HIV-1

Frontiers in Bioscience

Volumn 12, Issue 6, 2007, Pages 2330-2343

  Vasan, Sandhya ^a   Schlesinger, Sarah J ^a,b   Arrode, Geraldine ^b,c  

^a AARON DIAMOND AIDS RESEARCH CENTER   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

HIV 1; Immune response; Immune system; Immunity; Infection; Review; T cell; Vaccine

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

HUMAN IMMUNODEFICIENCY VIRUS VACCINE;

ANIMAL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; REVIEW; T LYMPHOCYTE;

AIDS VACCINES; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; HIV INFECTIONS; HIV-1; HUMANS; T-LYMPHOCYTES;

EID: 36049043155     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/2235     Document Type: Article

References (140)

1. Perfetto, S. P., P. K. Chattopadhyay & M. Roederer: Seventeen-colour flow cytometry: unravelling the immune system. Nat Rev Immunol, 4, 648-55 (2004) (Pubitemid 39025050)
2. Kaech, S. M. & R. Ahmed: Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat Immunol, 2, 415-22 (2001) (Pubitemid 33706139)
3. Badovinac, V. P., B. B. Porter & J. T. Harty: Programmed contraction of CD8 (+) T cells after infection. Nat Immunol, 3, 619-26 (2002) (Pubitemid 34752470)
4. Combadiere, B., A. Boissonnas, G. Carcelain, E. Lefranc, A. Samri, F. Bricaire, P. Debre & B. Autran: Distinct time effects of vaccination on long-term proliferative and IFN-gamma-producing T cell memory to smallpox in humans. J Exp Med, 199, 1585-93 (2004) (Pubitemid 38780413)
5. Seder, R. A. & R. Ahmed: Similarities and differences in CD4+ and CD8+ effector and memory T cell generation. Nat Immunol, 4, 835-42 (2003) (Pubitemid 37098653)
6. Khanolkar, A., M. J. Fuller & A. J. Zajac: CD4 T celldependent CD8 T cell maturation. J Immunol, 172, 2834-44 (2004) (Pubitemid 38263668)
7. Janssen, E. M., E. E. Lemmens, T. Wolfe, U. Christen, M. G. von Herrath & S. P. Schoenberger: CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes. Nature, 421, 852-6 (2003) (Pubitemid 36254145)
8. Fuller, M. J., D. A. Hildeman, S. Sabbaj, D. E. Gaddis, A. E. Tebo, L. Shang, P. A. Goepfert & A. J. Zajac: Cutting edge: emergence of CD127high functionally competent memory T cells is compromised by high viral loads and inadequate T cell help. J Immunol, 174, 5926-30 (2005) (Pubitemid 40663777)
9. Grakoui, A., N. H. Shoukry, D. J. Woollard, J. H. Han, H. L. Hanson, J. Ghrayeb, K. K. Murthy, C. M. Rice & C. M. Walker: HCV persistence and immune evasion in the absence of memory T cell help. Science, 302, 659-62 (2003) (Pubitemid 37310924)
10. Huster, K. M., V. Busch, M. Schiemann, K. Linkemann, K. M. Kerksiek, H. Wagner & D. H. Busch: Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets. Proc Natl Acad Sci U S A, 101, 5610-5 (2004) (Pubitemid 38481204)
11. Sallusto, F., D. Lenig, R. Forster, M. Lipp & A. Lanzavecchia: Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature, 401, 708-12 (1999)
12. Wherry, E. J. & R. Ahmed: Memory CD8 T-cell differentiation during viral infection. J Virol, 78, 5535-45 (2004) (Pubitemid 38661640)
13. Klenerman, P. & A. Hill: T cells and viral persistence: lessons from diverse infections. Nat Immunol, 6, 873-9 (2005) (Pubitemid 43090441)
14. van Lier, R. A., I. J. ten Berge & L. E. Gamadia: Human CD8 (+) T-cell differentiation in response to viruses. Nat Rev Immunol, 3, 931-9 (2003)
15. Lanzavecchia, A. & F. Sallusto: Understanding the generation and function of memory T cell subsets. Curr Opin Immunol, 17, 326-32 (2005) (Pubitemid 40692670)
16. Fontenot, A. P., B. E. Palmer, A. K. Sullivan, F. G. Joslin, C. C. Wilson, L. A. Maier, L. S. Newman & B. L. Kotzin: Frequency of beryllium-specific, central memory CD4 T cells in blood determines proliferative response. J Clin Invest (2005)
17. Harari, A., F. Vallelian, P. R. Meylan & G. Pantaleo: Functional heterogeneity of memory CD4 T cell responses in different conditions of antigen exposure and persistence. J Immunol, 174, 1037-45 (2005) (Pubitemid 40094300)
18. Geginat, J., F. Sallusto & A. Lanzavecchia: Cytokine-driven proliferation and differentiation of human naive, central memory and effector memory CD4+ T cells. Pathol Biol (Paris), 51, 64-6 (2003) (Pubitemid 36427572)
19. Klebanoff, C. A., L. Gattinoni, P. Torabi-Parizi, K. Kerstann, A. R. Cardones, S. E. Finkelstein, D. C. Palmer, P. A. Antony, S. T. Hwang, S. A. Rosenberg, T. A. Waldmann & N. P. Restifo: Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells. Proc Natl Acad Sci U S A, 102, 9571-6 (2005) (Pubitemid 40981722)
20. Sun, Y., J. E. Schmitz, P. M. Acierno, S. Santra, R. A. Subbramanian, D. H. Barouch, D. A. Gorgone, M. A. Lifton, K. R. Beaudry, K. Manson, V. Philippon, L. Xu, H. T. Maecker, J. R. Mascola, D. Panicali, G. J. Nabel & N. L. Letvin: Dysfunction of simian immunodeficiency virus/simian human immunodeficiency virus-induced IL-2 expression by central memory CD4+ T lymphocytes. J Immunol, 174, 4753-60 (2005)
21. Wherry, E. J., V. Teichgraber, T. C. Becker, D. Masopust, S. M. Kaech, R. Antia, U. H. von Andrian & R. Ahmed: Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol, 4, 225-34 (2003) (Pubitemid 36322131)
22. Sadagopal, S., R. R. Amara, D. C. Montefiori, L. S. Wyatt, S. I. Staprans, N. L. Kozyr, H. M. McClure, B. Moss & H. L. Robinson: Signature for long-term vaccine-mediated control of a Simian and human immunodeficiency virus 89.6P challenge: stable lowbreadth and low-frequency T-cell response capable of coproducing gamma interferon and interleukin-2. J Virol, 79, 3243-53 (2005) (Pubitemid 40327914)
23. Vaccari, M., C. J. Trindade, D. Venzon, M. Zanetti & G. Franchini: Vaccine-Induced CD8+ Central Memory T Cells in Protection from Simian AIDS. J Immunol, 175, 3502-7 (2005) (Pubitemid 41292007)
24. Baron, V., C. Bouneaud, A. Cumano, A. Lim, T. P. Arstila, P. Kourilsky, L. Ferradini & C. Pannetier: The repertoires of circulating human CD8 (+) central and effector memory T cell subsets are largely distinct. Immunity, 18, 193-204 (2003) (Pubitemid 36262995)
25. Schwendemann, J., C. Choi, V. Schirrmacher & P. Beckhove: Dynamic differentiation of activated human peripheral blood CD8+ and CD4+ effector memory T cells. J Immunol, 175, 1433-9 (2005) (Pubitemid 41023042)
26. Willinger, T., T. Freeman, H. Hasegawa, A. J. Mc Michael & M. F. Callan: Molecular signatures distinguish human central memory from effector memory CD8 T cell subsets. J Immunol, 175, 5895-903 (2005) (Pubitemid 41508074)
27. Altfeld, M., M. M. Addo, E. S. Rosenberg, F. M. Hecht, P. K. Lee, M. Vogel, X. G. Yu, R. Draenert, M. N. Johnston, D. Strick, T. M. Allen, M. E. Feeney, J. O. Kahn, R. P. Sekaly, J. A. Levy, J. K. Rockstroh, P. J. Goulder & B. D. Walker: Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection. Aids, 17, 2581-91 (2003) (Pubitemid 38402336)
28. Scriba, T. J., H. T. Zhang, H. L. Brown, A. Oxenius, N. Tamm, S. Fidler, J. Fox, J. N. Weber, P. Klenerman, C. L. Day, M. Lucas & R. E. Phillips: HIV-1-specific CD4+ T lymphocyte turnover and activation increase upon viral rebound. J Clin Invest, 115, 443-50 (2005) (Pubitemid 40385486)
29. Ramduth, D., P. Chetty, N. C. Mngquandaniso, N. Nene, J. D. Harlow, I. Honeyborne, N. Ntumba, S. Gappoo, C. Henry, P. Jeena, M. M. Addo, M. Altfeld, C. Brander, C. Day, H. Coovadia, P. Kiepiela, P. Goulder & B. Walker: Differential Immunogenicity of HIV-1 Clade C Proteins in Eliciting CD8+ and CD4+ Cell Responses. J Infect Dis, 192, 1588-96 (2005) (Pubitemid 41504694)
30. Iyasere, C., J. C. Tilton, A. J. Johnson, S. Younes, B. Yassine-Diab, R. P. Sekaly, W. W. Kwok, S. A. Migueles, A. C. Laborico, W. L. Shupert, C. W. Hallahan, R. T. Davey, Jr., M. Dybul, S. Vogel, J. Metcalf & M. Connors: Diminished proliferation of human immunodeficiency virus-specific CD4+ T cells is associated with diminished interleukin-2 (IL-2) production and is recovered by exogenous IL-2. J Virol, 77, 10900-9 (2003) (Pubitemid 37204283)
31. Younes, S. A., B. Yassine-Diab, A. R. Dumont, M. R. Boulassel, Z. Grossman, J. P. Routy & R. P. Sekaly: HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity. J Exp Med, 198, 1909-22 (2003) (Pubitemid 38032123)
32. Harari, A., S. Petitpierre, F. Vallelian & G. Pantaleo: Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapy. Blood, 103, 966-72 (2004) (Pubitemid 38129558)
33. Palmer, B. E., E. Boritz & C. C. Wilson: Effects of sustained HIV-1 plasma viremia on HIV-1 Gag-specific CD4+ T cell maturation and function. J Immunol, 172, 3337-47 (2004) (Pubitemid 38263726)
34. Palmer, B. E., N. Blyveis, A. P. Fontenot & C. C. Wilson: Functional and Phenotypic Characterization of CD57+CD4+ T Cells and Their Association with HIV-1-Induced T Cell Dysfunction. J Immunol, 175, 8415-23 (2005) (Pubitemid 41798409)
35. Rosenberg, E. S., J. M. Billingsley, A. M. Caliendo, S. L. Boswell, P. E. Sax, S. A. Kalams & B. D. Walker: Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia. Science, 278, 1447-50 (1997) (Pubitemid 27509814)
36. Imami, N., A. Pires, G. Hardy, J. Wilson, B. Gazzard & F. Gotch: A balanced type 1/type 2 response is associated with long-term nonprogressive human immunodeficiency virus type 1 infection. J Virol, 76, 9011-23 (2002) (Pubitemid 34919860)
37. Alatrakchi, N., C. S. Graham, Q. He, K. E. Sherman & M. J. Koziel: CD8+ cell responses to hepatitis C virus (HCV) in the liver of persons with HCV-HIV coinfection versus HCV monoinfection. J Infect Dis, 191, 702-9 (2005) (Pubitemid 40271057)
38. Sousa, A. E., A. F. Chaves, A. Loureiro & R. M. Victorino: Comparison of the frequency of interleukin (IL)-2-, interferon-gamma-, and IL-4-producing T cells in 2 diseases, human immunodeficiency virus types 1 and 2, with distinct clinical outcomes. J Infect Dis, 184, 552-9 (2001) (Pubitemid 32783545)
39. Emu, B., E. Sinclair, D. Favre, W. J. Moretto, P. Hsue, R. Hoh, J. N. Martin, D. F. Nixon, J. M. McCune & S. G. Deeks: Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment. J Virol, 79, 14169-78 (2005) (Pubitemid 41552715)
40. Koning, F. A., S. A. Otto, M. D. Hazenberg, L. Dekker, M. Prins, F. Miedema & H. Schuitemaker: Low-level CD4+ T cell activation is associated with low susceptibility to HIV-1 infection. J Immunol, 175, 6117-22 (2005) (Pubitemid 41508099)
41. Pantaleo, G., J. F. Demarest, H. Soudeyns, C. Graziosi, F. Denis, J. W. Adelsberger, P. Borrow, M. S. Saag, G. M. Shaw, R. P. Sekaly & et al.: Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV. Nature, 370, 463-7 (1994) (Pubitemid 24263551)
42. Koup, R. A., J. T. Safrit, Y. Cao, C. A. Andrews, G. McLeod, W. Borkowsky, C. Farthing & D. D. Ho: Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol, 68, 4650-5 (1994) (Pubitemid 24183063)
43. Borrow, P., H. Lewicki, B. H. Hahn, G. M. Shaw & M. B. Oldstone: Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J Virol, 68, 6103-10 (1994) (Pubitemid 24258634)
44. Altfeld, M., E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins & B. D. Walker: Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J Exp Med, 193, 169-80 (2001) (Pubitemid 32524449)
45. Cao, J., J. McNevin, S. Holte, L. Fink, L. Corey & M. J. McElrath: Comprehensive analysis of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon-secreting CD8+ T cells in primary HIV-1 infection. J Virol, 77, 6867-78 (2003) (Pubitemid 36666880)
46. Dalod, M., M. Dupuis, J. C. Deschemin, C. Goujard, C. Deveau, L. Meyer, N. Ngo, C. Rouzioux, J. G. Guillet, J. F. Delfraissy, M. Sinet & A. Venet: Weak anti-HIV CD8 (+)T-cell effector activity in HIV primary infection. J Clin Invest, 104, 1431-9 (1999)
47. Betts, M. R., D. R. Ambrozak, D. C. Douek, S. Bonhoeffer, J. M. Brenchley, J. P. Casazza, R. A. Koup & L. J. Picker: Analysis of total human immunodeficiency virus (HIV)-specific CD4 (+) and CD8 (+) T-cell responses: relationship to viral load in untreated HIV infection. J Virol, 75, 11983-91 (2001) (Pubitemid 33115870)
48. Addo, M. M., X. G. Yu, A. Rathod, D. Cohen, R. L. Edridge, D. Strick, M. N. Johnston, C. Corcoran, A. G. Wurcel, C. A. Fitzpatrick, M. E. Feeney, W. R. Rodriguez, N. Basgoz, R. Draenert, D. R. Stone, C. Brander, P. J. Goulder, E. S. Rosenberg, M. Altfeld & B. D. Walker: Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J Virol, 77, 2081-92 (2003) (Pubitemid 36110021)
49. Frahm, N., B. T. Korber, C. M. Adams, J. J. Szinger, R. Draenert, M. M. Addo, M. E. Feeney, K. Yusim, K. Sango, N. V. Brown, D. SenGupta, A. Piechocka-Trocha, T. Simonis, F. M. Marincola, A. G. Wurcel, D. R. Stone, C. J. Russell, P. Adolf, D. Cohen, T. Roach, A. StJohn, A. Khatri, K. Davis, J. Mullins, P. J. Goulder, B. D. Walker & C. Brander: Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities. J Virol, 78, 2187-200 (2004) (Pubitemid 38228912)
50. Gea-Banacloche, J. C., S. A. Migueles, L. Martino, W. L. Shupert, A. C. McNeil, M. S. Sabbaghian, L. Ehler, C. Prussin, R. Stevens, L. Lambert, J. Altman, C. W. Hallahan, J. C. de Quiros & M. Connors: Maintenance of large numbers of virus-specific CD8+ T cells in HIVinfected progressors and long-term nonprogressors. J Immunol, 165, 1082-92 (2000) (Pubitemid 30484780)
51. Draenert, R., C. L. Verrill, Y. Tang, T. M. Allen, A. G. Wurcel, M. Boczanowski, A. Lechner, A. Y. Kim, T. Suscovich, N. V. Brown, M. M. Addo & B. D. Walker: Persistent recognition of autologous virus by high-avidity CD8 T cells in chronic, progressive human immunodeficiency virus type 1 infection. J Virol, 78, 630-41 (2004) (Pubitemid 38067584)
52. Tussey, L. G., U. S. Nair, M. Bachinsky, B. H. Edwards, J. Bakari, K. Grimm, J. Joyce, R. Vessey, R. Steigbigel, M. N. Robertson, J. W. Shiver & P. A. Goepfert: Antigen burden is major determinant of human immunodeficiency virus-specific CD8+ T cell maturation state: potential implications for therapeutic immunization. J Infect Dis, 187, 364-74 (2003) (Pubitemid 36184577)
53. Ellefsen, K., A. Harari, P. Champagne, P. A. Bart, R. P. Sekaly & G. Pantaleo: Distribution and functional analysis of memory antiviral CD8 T cell responses in HIV-1 and cytomegalovirus infections. Eur J Immunol, 32, 3756-64 (2002) (Pubitemid 36024411)
54. Champagne, P., G. S. Ogg, A. S. King, C. Knabenhans, K. Ellefsen, M. Nobile, V. Appay, G. P. Rizzardi, S. Fleury, M. Lipp, R. Forster, S. Rowland-Jones, R. P. Sekaly, A. J. McMichael & G. Pantaleo: Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature, 410, 106-11 (2001) (Pubitemid 32225845)
55. Papagno, L., C. A. Spina, A. Marchant, M. Salio, N. Rufer, S. Little, T. Dong, G. Chesney, A. Waters, P. Easterbrook, P. R. Du nbar, D. Shepherd, V. Cerundolo, V.Emery, P. Griffiths, C. Conlon, A. J. McMichael, D. D. Richman, S. L. Rowland-Jones & V. Appay: Immune Activation and CD8 (+) T-Cell Differentiation towards Senescence in HIV-1 Infection. PLoS Biol, 2, E20 (2004)
56. Brenchley, J. M., N. J. Karandikar, M. R. Betts, D. R. Ambrozak, B. J. Hill, L. E. Crotty, J. P. Casazza, J. Kuruppu, S. A. Migueles, M. Connors, M. Roederer, D. C. Douek & R. A. Koup: Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood, 101, 2711-20 (2003) (Pubitemid 36857634)
57. Gray, C. M., J. Lawrence, J. M. Schapiro, J. D. Altman, M. A. Winters, M. Crompton, M. Loi, S. K. Kundu, M. M. Davis & T. C. Merigan: Frequency of class I HLArestricted anti-HIV CD8+ T cells in individuals receiving highly active antiretroviral therapy (HAART). J Immunol, 162, 1780-8 (1999)
58. Benito, J. M., M. Lopez, S. Lozano, P. Martinez, M. Kuroda, J. Gonzalez-Lahoz & V. Soriano: Phenotype and functional characteristics of HIV-specific cytotoxic CD8+ T cells in chronically infected patients: dual effects of highly active antiretroviral therapy. J Acquir Immune Defic Syndr, 34, 255-66 (2003) (Pubitemid 37377358)
59. Migueles, S. A., A. C. Laborico, W. L. Shupert, M. S. Sabbaghian, R. Rabin, C. W. Hallahan, D. Van Baarle, S. Kostense, F. Miedema, M. McLaughlin, L. Ehler, J. Metcalf, S. Liu & M. Connors: HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nat Immunol, 3, 1061-8 (2002) (Pubitemid 35363659)
60. Arrode, G., J. S. Finke, H. Zebroski, F. P. Siegal & R. M. Steinman: CD8+ T cells from most HIV-1-infected patients, even when challenged with mature dendritic cells, lack functional recall memory to HIV gag but not other viruses. Eur J Immunol, 35, 159-70 (2005) (Pubitemid 40123862)
61. Lichterfeld, M., D. E. Kaufmann, X. G. Yu, S. K. Mui, M M. Addo, M. N. Johnston, D. Cohen, G. K. Robbins, E. Pae, G. Alter, A. Wurcel, D. Stone, E. S. Rosenberg, B. D. Walker & M. Altfeld: Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells. J Exp Med, 200, 701-12 (2004) (Pubitemid 39299457)
62. Zimmerli, S. C., A. Harari, C. Cellerai, F. Vallelian, P. A. Bart & G. Pantaleo: HIV-1-specific IFN-gamma/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells. Proc Natl Acad Sci U S A, 102, 7239-44 (2005) (Pubitemid 40696363)
63. Hess, C., M. Altfeld, S. Y. Thomas, M. M. Addo, E. S. Rosenberg, T. M. Allen, R. Draenert, R. L. Eldrige, J. van Lunzen, H. J. Stellbrink, B. D. Walker & A. D. Luster: HIV-1 specific CD8+ T cells with an effector phenotype and control of viral replication. Lancet, 363, 863-6 (2004) (Pubitemid 38368837)
64. Pantaleo, G. & R. A. Koup: Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know. Nat Med, 10, 806-10 (2004) (Pubitemid 39070851)
65. Jansen, C. A., D. van Baarle & F. Miedema: HIVspecific CD4 (+) T cells and viremia: who's in control? Trends Immunol (2006)
66. Betts, M. R., M. C. Nason, S. M. West, S. C. De Rosa, S. A. Migueles, J. Abraham, M. M. Lederman, J. M. Benito, P. A. Goepfert, M. Connors, M. Roederer & R. A. Koup: HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T-cells. Blood (2006)
67. Sheppard, H. W.: Inactivated- or killed-virus HIV/AIDS vaccines. Curr Drug Targets Infect Disord, 5, 131-41 (2005) (Pubitemid 40974793)
68. Arthur, L. O., S. W. Pyle, P. L. Nara, J. W. Bess, Jr., M. A. Gonda, J. C. Kelliher, R. V. Gilden, W. G. Robey, D. P. Bolognesi, R. C. Gallo & et al.: Serological responses in chimpanzees inoculated with human immunodeficiency virus glycoprotein (gp120) subunit vaccine. Proc Natl Acad Sci U S A, 84, 8583-7 (1987) (Pubitemid 18033459)
69. Orentas, R. J., J. E. Hildreth, E. Obah, M. Polydefkis, G. E. Smith, M. L. Clements & R. F. Siliciano: Induction of CD4+ human cytolytic T cells specific for HIV-infected cells by a gp160 subunit vaccine. Science, 248, 1234-7 (1990)
70. Miskovsky, E. P., A. Y. Liu, W. Pavlat, R. Viveen, P. E. Stanhope, D. Finzi, W. M. Fox, 3rd, R. H. Hruban, E. R. Podack & R. F. Siliciano: Studies of the mechanism of cytolysis by HIV-1-specific CD4+ human CTL clones induced by candidate AIDS vaccines. J Immunol, 153, 2787-99 (1994) (Pubitemid 24278148)
71. VaxGen vaccine trial fails the test but may offer insights. AIDS Alert, 18, 41, 43-5 (2003)
72. Santra, S., D. H. Barouch, M. J. Kuroda, J. E. Schmitz, G. R. Krivulka, K. Beaudry, C. I. Lord, M. A. Lifton, L. S. Wyatt, B. Moss, V. M. Hirsch & N. L. Letvin: Prior vaccination increases the epitopic breadth of the cytotoxic T-lymphocyte response that evolves in rhesus monkeys following a simian-human immunodeficiency virus infection. J Virol, 76, 6376-81 (2002) (Pubitemid 34556333)
73. Wang, B., J. Boyer, V. Srikantan, K. Ugen, L. Gilbert, C. Phan, K. Dang, M. Merva, M. G. Agadjanyan, M. Newman & et al.: Induction of humoral and cellular immune responses to the human immunodeficiency type 1 virus in nonhuman primates by in vivo DNA inoculation. Virology, 211, 102-12 (1995)
74. MacGregor, R. R., J. D. Boyer, K. E. Ugen, K. E. Lacy, S. J. Gluckman, M. L. Bagarazzi, M. A. Chattergoon, Y. Baine, T. J. Higgins, R. B. Ciccarelli, L. R. Coney, R. S. Ginsberg & D. B. Weiner: First human trial of a DNAbased vaccine for treatment of human immunodeficiency virus type 1 infection: safety and host response. J Infect Dis, 178, 92-100 (1998) (Pubitemid 28328080)
75. Barouch, D. H., A. Craiu, S. Santra, M. A. Egan, J. E. Schmitz, M. J. Kuroda, T. M. Fu, J. H. Nam, L. S. Wyatt, M. A. Lifton, G. R. Krivulka, C. E. Nickerson, C. I. Lord, B. Moss, M. G. Lewis, V. M. Hirsch, J. W. Shiver & N. L. Letvin: Elicitation of high-frequency cytotoxic Tlymphocyte responses against both dominant and subdominant simian-human immunodeficiency virus epitopes by DNA vaccination of rhesus monkeys. J Virol, 75, 2462-7 (2001) (Pubitemid 32147585)
76. Boyer, J. D., B. Wang, K. E. Ugen, M. Agadjanyan, A. Javadian, P. Frost, K. Dang, R. A. Carrano, R. Ciccarelli, L. Coney, W. V. Williams & D. B. Weiner: In vivo protective anti-HIV immune responses in non-human primates through DNA immunization. J Med Primatol, 25, 242-50 (1996) (Pubitemid 126463686)
77. Caulfield, M. J., S. Wang, J. G. Smith, T. W. Tobery, X. Liu, M. E. Davies, D. R. Casimiro, T. M. Fu, A. Simon, R. K. Evans, E. A. Emini & J. Shiver: Sustained peptidespecific gamma interferon T-cell response in rhesus macaques immunized with human immunodeficiency virus gag DNA vaccines. J Virol, 76, 10038-43 (2002) (Pubitemid 35006544)
78. Boyer, J. D., K. E. Ugen, B. Wang, M. Agadjanyan, L. Gilbert, M. L. Bagarazzi, M. Chattergoon, P. Frost, A. Javadian, W. V. Williams, Y. Refaeli, R. B. Ciccarelli, D. McCallus, L. Coney & D. B. Weiner: Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination. Nat Med, 3, 526-32 (1997) (Pubitemid 27198650)
79. Calarota, S. A. & D. B. Weiner: Enhancement of human immunodeficiency virus type 1-DNA vaccine potency through incorporation of T-helper 1 molecular adjuvants. Immunol Rev, 199, 84-99 (2004) (Pubitemid 38736766)
80. Musey, L., Y. Ding, M. Elizaga, R. Ha, C. Celum & M. J. McElrath: HIV-1 vaccination administered intramuscularly can induce both systemic and mucosal T cell immunity in HIV-1-uninfected individuals. J Immunol, 171, 1094-101 (2003) (Pubitemid 36871427)
81. Egan, M. A., W. A. Pavlat, J. Tartaglia, E. Paoletti, K. J. Weinhold, M. L. Clements & R. F. Siliciano: Induction of human immunodeficiency virus type 1 (HIV-1)-specific cytolytic T lymphocyte responses in seronegative adults by a nonreplicating, host-range-restricted canarypox vector (ALVAC) carrying the HIV-1MN env gene. J Infect Dis, 171, 1623-7 (1995)
82. Evans, T. G., E. G. Kallas, M. Campbell, J. Andrews, D. Schwartz, M. Keefer & P. Caudrelier: Evaluation of canarypox-induced CD8 (+) responses following immunization by measuring the effector population IFNgamma production. Immunol Lett, 77, 7-15 (2001) (Pubitemid 32434410)
83. Worku, S., G. J. Gorse, R. B. Belshe & D. F. Hoft: Canarypox vaccines induce antigen-specific human gammadelta T cells capable of interferon-gamma production. J Infect Dis, 184, 525-32 (2001) (Pubitemid 32783541)
84. Girard, M., E. van der Ryst, F. Barre-Sinoussi, P. Nara, J. Tartaglia, E. Paoletti, C. Blondeau, M. Jennings, F. Verrier, B. Meignier & P. N. Fultz: Challenge of chimpanzees immunized with a recombinant canarypox-HIV-1 virus. Virology, 232, 98-104 (1997) (Pubitemid 27244467)
85. Hanke, T., T. J. Blanchard, J. Schneider, G. S. Ogg, R. Tan, M. Becker, S. C. Gilbert, A. V. Hill, G. L. Smith & A. McMichael: Immunogenicities of intravenous and intramuscular administrations of modified vaccinia virus Ankara-based multi-CTL epitope vaccine for human immunodeficiency virus type 1 in mice. J Gen Virol, 79 (Pt 1), 83-90 (1998) (Pubitemid 28039304)
86. Barouch, D. H. & G. J. Nabel: Adenovirus vector-based vaccines for human immunodeficiency virus type 1. Hum Gene Ther, 16, 149-56 (2005) (Pubitemid 40344207)
87. Shiver, J. W., T. M. Fu, L. Chen, D. R. Casimiro, M. E. Davies, R. K. Evans, Z. Q. Zhang, A. J. Simon, W. L. Trigona, S. A. Dubey, L. Huang, V. A. Harris, R. S. Long, X. Liang, L. Handt, W. A. Schleif, L. Zhu, D. C. Freed, N. V. Persaud, L. Guan, K. S. Punt, A. Tang, M. Chen, K. A. Wilson, K. B. Collins, G. J. Heidecker, V. R. Fernandez, H. C. Perry, J. G. Joyce, K. M. Grimm, J. C. Cook, P. M. Keller, D. S. Kresock, H. Mach, R. D. Troutman, L. A. Isopi, D. M. Williams, Z. Xu, K. E. Bohannon, D. B. Volkin, D. C. Montefiori, A. Miura, G. R. Krivulka, M. A. Lifton, M. J. Kuroda, J. E. Schmitz, N. L. Letvin, M. J. Caulfield, A. J. Bett, R. Youil, D. C. Kaslow & E. A. Emini: Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity. Nature, 415, 331-5 (2002) (Pubitemid 34087555)
88. Lorin, C., F. Delebecque, V. Labrousse, L. Da Silva, F. Lemonnier, M. Brahic & F. Tangy: A recombinant live attenuated measles vaccine vector primes effective HLAA0201-restricted cytotoxic T lymphocytes and broadly neutralizing antibodies against HIV-1 conserved epitopes. Vaccine, 23, 4463-72 (2005) (Pubitemid 40967974)
89. Fultz, P. N., J. Stallworth, D. Porter, M. Novak, M. J. Anderson & C. D. Morrow: Immunogenicity in pig-tailed macaques of poliovirus replicons expressing HIV-1 and SIV antigens and protection against SHIV-89.6P disease. Virology, 315, 425-37 (2003) (Pubitemid 37324633)
90. Davis, N. L., I. J. Caley, K. W. Brown, M. R. Betts, D. M. Irlbeck, K. M. McGrath, M. J. Connell, D. C. Montefiori, J. A. Frelinger, R. Swanstrom, P. R. Johnson & R. E. Johnston: Vaccination of macaques against pathogenic simian immunodeficiency virus with Vnezuelan equine encephalitis virus replicon particles. J Virol, 74, 371-8 (2000) (Pubitemid 30002918)
91. Rose, N. F., P. A. Marx, A. Luckay, D. F. Nixon, W. J. Moretto, S. M. Donahoe, D. Montefiori, A. Roberts, L. Buonocore & J. K. Rose: An effective AIDS vaccine based on live attenuated vesicular stomatitis virus recombinants. Cell, 106, 539-49 (2001) (Pubitemid 32879316)
92. Sundback, M., I. Douagi, C. Dayaraj, M. N. Forsell, E. K. Nordstrom, G. M. McInerney, K. Spangberg, L. Tjader, E. Bonin, M. Sundstrom, P. Liljestrom & G. B. Karlsson Hedestam: Efficient expansion of HIV-1-specific T cell responses by homologous immunization with recombinant Semliki Forest virus particles. Virology, 341, 190-202 (2005) (Pubitemid 41416729)
93. Cayabyab, M. J., A. H. Hovav, T. Hsu, G. R. Krivulka, M. A. Lifton, D. A. Gorgone, G. J. Fennelly, B. F. Haynes, W. R. Jacobs, Jr. & N. L. Letvin: Generation of CD8+ T-cell responses by a recombinant nonpathogenic Mycobacterium smegmatis vaccine vector expressing human immunodeficiency virus type 1 Env. J Virol, 80, 1645-52 (2006) (Pubitemid 43228706)
94. Shata, M. T., M. S. Reitz, Jr., A. L. DeVico, G. K. Lewis & D. M. Hone: Mucosal and systemic HIV-1 Env-specific CD8 (+) T-cells develop after intragastric vaccination with a Salmonella Env DNA vaccine vector. Vaccine, 20, 623-9 (2001) (Pubitemid 32973809)
95. Vecino, W. H., P. M. Morin, R. Agha, W. R. Jacobs, Jr. & G. J. Fennelly: Mucosal DNA vaccination with highly attenuated Shigella is superior to attenuated Salmonella and comparable to intramuscular DNA vaccination for T cells against HIV. Immunol Lett, 82, 197-204 (2002) (Pubitemid 34556965)
96. Amara, R. R., F. Villinger, S. I. Staprans, J. D. Altman, D. C. Montefiori, N. L. Kozyr, Y. Xu, L. S. Wyatt, P. L. Earl, J. G. Herndon, H. M. McClure, B. Moss & H. L. Robinson: Different patterns of immune responses but similar control of a simian-human immunodeficiency virus 89.6P mucosal challenge by modified vaccinia virus Ankara (MVA) and DNA/MVA vaccines. J Virol, 76, 7625-31 (2002) (Pubitemid 34760986)
97. Yang, Z. Y., L. S. Wyatt, W. P. Kong, Z. Moodie, B. Moss & G. J. Nabel: Overcoming immunity to a viral vaccine by DNA priming before vector boosting. J Virol, 77, 799-803 (2003) (Pubitemid 36005022)
98. Vuola, J. M., S. Keating, D. P. Webster, T. Berthoud, S. Dunachie, S. C. Gilbert & A. V. Hill: Differential immunogenicity of various heterologous prime-boost vaccine regimens using DNA and viral vectors in healthy volunteers. J Immunol, 174, 449-55 (2005) (Pubitemid 40007434)
99. Mwau, M., I. Cebere, J. Sutton, P. Chikoti, N. Winstone, E. G. Wee, T. Beattie, Y. H. Chen, L. Dorrell, H. McShane, C. Schmidt, M. Brooks, S. Patel, J. Roberts, C. Conlon, S. L. Rowland-Jones, J. J. Bwayo, A. J. McMichael & T. Hanke: A human immunodeficiency virus 1 (HIV-1) clade A vaccine in clinical trials: stimulation of HIV-specific T-cell responses by DNA and recombinant modified vaccinia virus Ankara (MVA) vaccines in humans. J Gen Virol, 85, 911-9 (2004) (Pubitemid 38489556)
100. Amara, R. R., F. Villinger, J. D. Altman, S. L. Lydy, S. P. O'Neil, S. I. Staprans, D. C. Montefiori, Y. Xu, J. G. Herndon, L. S. Wyatt, M. A. Candido, N. L. Kozyr, P. L. Earl, J. M. Smith, H. L. Ma, B. D. Grimm, M. L. Hulsey, J. Miller, H. M. McClure, J. M. McNicholl, B. Moss & H. L. Robinson: Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science, 292, 69-74 (2001) (Pubitemid 32289126)
101. Bertley, F. M., P. A. Kozlowski, S. W. Wang, J. Chappelle, J. Patel, O. Sonuyi, G. Mazzara, D. Montefiori, A. Carville, K. G. Mansfield & A. Aldovini: Control of simian/human immunodeficiency virus viremia and disease progression after IL-2-augmented DNA-modified vaccinia virus Ankara nasal vaccination in nonhuman primates. J Immunol, 172, 3745-57 (2004) (Pubitemid 38337959)
102. Hanke, T., R. V. Samuel, T. J. Blanchard, V. C. Neumann, T. M. Allen, J. E. Boyson, S. A. Sharpe, N. Cook, G. L. Smith, D. I. Watkins, M. P. Cranage & A. J. McMichael: Effective induction of simian immunodeficiency virus-specific cytotoxic T lymphocytes in macaques by using a multiepitope gene and DNA primemodified vaccinia virus Ankara boost vaccination regimen. J Virol, 73, 7524-32 (1999) (Pubitemid 29383236)
103. Makitalo, B., P. Lundholm, J. Hinkula, C. Nilsson, K. Karlen, A. Morner, G. Sutter, V. Erfle, J. L. Heeney, B. Wahren, G. Biberfeld & R. Thorstensson: Enhanced cellular immunity and systemic control of SHIV infection by combined parenteral and mucosal administration of a DNA prime MVA boost vaccine regimen. J Gen Virol, 85, 2407-19 (2004) (Pubitemid 39162614)
104. McConkey, S. J., W. H. Reece, V. S. Moorthy, D. Webster, S. Dunachie, G. Butcher, J. M. Vuola, T. J. Blanchard, P. Gothard, K. Watkins, C. M. Hannan, S. Everaere, K. Brown, K. E. Kester, J. Cummings, J. Williams, D. G. Heppner, A. Pathan, K. Flanagan, N. Arulanantham, M. T. Roberts, M. Roy, G. L. Smith, J. Schneider, T. Peto, R. E. Sinden, S. C. Gilbert & A. V. Hill: Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans. Nat Med, 9, 729-35 (2003) (Pubitemid 36749222)
105. Allen, T. M., T. U. Vogel, D. H. Fuller, B. R. Mothe, S. Steffen, J. E. Boyson, T. Shipley, J. Fuller, T. Hanke, A. Sette, J. D. Altman, B. Moss, A. J. McMichael & D. I. Watkins: Induction of AIDS virus-specific CTL activity in fresh, unstimulated peripheral blood lymphocytes from rhesus macaques vaccinated with a DNA prime/modified vaccinia virus Ankara boost regimen. J Immunol, 164, 4968-78 (2000) (Pubitemid 30238103)
106. Doria-Rose, N. A., C. Ohlen, P. Polacino, C. C. Pierce, M. T. Hensel, L. Kuller, T. Mulvania, D. Anderson, P. D. Greenberg, S. L. Hu & N. L.
107. Amara, R. R., C. Ibegbu, F. Villinger, D. C. Montefiori, S. Sharma, P. Nigam, Y. Xu, H. M. McClure & H. L. Robinson: Studies using a viral challenge and CD8 T cell depletions on the roles of cellular and humoral immunity in the control of an SHIV-89.6P challenge in DNA/MVA-vaccinated macaques. Virology, 343, 246-55 (2005) (Pubitemid 41598364)
108. Abdool Karim, S. S.: Top stories of 2004. DNA-MVA prime boost: another vaccine candidate bites the dust. AIDS Clin Care, 17, 5 (2005)
109. Casimiro, D. R., A. Tang, L. Chen, T. M. Fu, R. K. Evans, M. E. Davies, D. C. Freed, W. Hurni, J. M. Aste-Amezaga, L. Guan, R. Long, L. Huang, V. Harris, D. K. Nawrocki, H. Mach, R. D. Troutman, L. A. Isopi, K. K. Murthy, K. Rice, K. A. Wilson, D. B. Volkin, E. A. Emini & J. W. Shiver: Vaccine-induced immunity in baboons by using DNA and replication-incompetent adenovirus type 5 vectors expressing a human immunodeficiency virus type 1 gag gene. J Virol, 77, 7663-8 (2003) (Pubitemid 36734536)
110. Kent, S. J., A. Zhao, S. J. Best, J. D. Chandler, D. B. Boyle & I. A. Ramshaw: Enhanced T-cell immunogenicity and protective efficacy of a human immunodeficiency virus type 1 vaccine regimen consisting of consecutive priming with DNA and boosting with recombinant fowlpox virus. J Virol, 72, 10180-8 (1998) (Pubitemid 28520889)
111. Matano, T., M. Kobayashi, H. Igarashi, A. Takeda, H. Nakamura, M. Kano, C. Sugimoto, K. Mori, A. Iida, T. Hirata, M. Hasegawa, T. Yuasa, M. Miyazawa, Y. Takahashi, M. Yasunami, A. Kimura, D. H. O'Connor, D. I. Watkins & Y. Nagai: Cytotoxic T lymphocyte-based control of simian immunodeficiency virus replication in a preclinical AIDS vaccine trial. J Exp Med, 199, 1709-18 (2004) (Pubitemid 38822004)
112. Casimiro, D. R., A. J. Bett, T. M. Fu, M. E. Davies, A. Tang, K. A. Wilson, M. Chen, R. Long, T. McKelvey, M. Chastain, S. Gurunathan, J. Tartaglia, E. A. Emini & J. Shiver: Heterologous human immunodeficiency virus type 1 priming-boosting immunization strategies involving replication-defective adenovirus and poxvirus vaccine vectors. J Virol, 78, 11434-8 (2004) (Pubitemid 39299689)
113. Hanke, T., C. Barnfield, E. G. Wee, L. Agren, R. V. Samuel, N. Larke & P. Liljestrom: Construction and immunogenicity in a prime-boost regimen of a Semliki Forest virus-vectored experimental HIV clade A vaccine. J Gen Virol, 84, 361-8 (2003) (Pubitemid 36175710)
114. Nilsson, C., B. Makitalo, P. Berglund, F. Bex, P. Liljestrom, G. Sutter, V. Erfle, P. ten Haaft, J. Heeney, G.Biberfeld & R. Thorstensson: Enhanced simian immunodeficiency virus-specific immune responses in macaques induced by priming with recombinant Semliki Forest virus and boosting with modified vaccinia virus Ankara. Vaccine, 19, 3526-36 (2001) (Pubitemid 32710305)
115. Haglund, K., I. Leiner, K. Kerksiek, L. Buonocore, E. Pamer & J. K. Rose: High-level primary CD8 (+) T-cell response to human immunodeficiency virus type 1 gag and env generated by vaccination with recombinant vesicular stomatitis viruses. J Virol, 76, 2730-8 (2002) (Pubitemid 34184859)
116. Ramsburg, E., N. F. Rose, P. A. Marx, M. Mefford, D. F. Nixon, W. J. Moretto, D. Montefiori, P. Earl, B. Moss & J. K. Rose: Highly effective control of an AIDS virus challenge in macaques by using vesicular stomatitis virus and modified vaccinia virus Ankara vaccine vectors in a single-boost protocol. J Virol, 78, 3930-40 (2004) (Pubitemid 38437199)
117. Mwau, M., A. J. McMichael & T. Hanke: Design and validation of an enzyme-linked immunospot assay for use in clinical trials of candidate HIV vaccines. AIDS Res Hum Retroviruses, 18, 611-8 (2002) (Pubitemid 35356580)
118. Russell, N. D., M. G. Hudgens, R. Ha, C. Havenar-Daughton & M. J. McElrath: Moving to human immunodeficiency virus type 1 vaccine efficacy trials: defining T cell responses as potential correlates of immunity. J Infect Dis, 187, 226-42 (2003) (Pubitemid 36132636)
119. Sun, Y., E. Iglesias, A. Samri, G. Kamkamidze, T. Decoville, G. Carcelain & B. Autran: A systematic comparison of methods to measure HIV-1 specific CD8 T cells. J Immunol Methods, 272, 23-34 (2003) (Pubitemid 36050742)
120. De Rosa, S. C., F. X. Lu, J. Yu, S. P. Perfetto, J. Falloon, S. Moser, T. G. Evans, R. Koup, C. J. Miller & M. Roederer: Vaccination in humans generates broad T cell cytokine responses. J Immunol, 173, 5372-80 (2004) (Pubitemid 39392120)
121. Yang, O. O.: Will we be able to 'spot' an effective HIV-1 vaccine? Trends Immunol, 24, 67-72 (2003) (Pubitemid 36120641)
122. Locher, C. P., R. M. Grant, E. A. Collisson, G. Reyes-Teran, T. Elbeik, J. O. Kahn & J. A. Levy: Antibody and cellular immune responses in breakthrough infection subjects after HIV type 1 glycoprotein 120 vaccination. AIDS Res Hum Retroviruses, 15, 1685-9 (1999)
123. Kahn, J. O., K. S. Steimer, J. Baenziger, A. M. Duliege, M. Feinberg, T. Elbeik, M. Chesney, N. Murcar, D. Chernoff & F. Sinangil: Clinical, immunologic, and virologic observations related to human immunodeficiency virus (HIV) type 1 infection in a volunteer in an HIV-1 vaccine clinical trial. J Infect Dis, 171, 1343-7 (1995)
124. McElrath, M. J., L. Corey, P. D. Greenberg, T. J. Matthews, D. C. Montefiori, L. Rowen, L. Hood & J. I. Mullins: Human immunodeficiency virus type 1 infection despite prior immunization with a recombinant envelope vaccine regimen. Proc Natl Acad Sci U S A, 93, 3972-7 (1996) (Pubitemid 26144232)
125. Lee, D., B. S. Graham, Y. L. Chiu, P. B. Gilbert, M. J. McElrath, R. B. Belshe, S. P. Buchbinder, H. W. Sheppard, B. A. Koblin, K. H. Mayer, M. C. Keefer, M. J. Mulligan & C. L. Celum: Breakthrough infections during phase 1 and 2 prime-boost HIV-1 vaccine trials with canarypox vectors (ALVAC) and booster dose of recombinant gp120 or gp160. J Infect Dis, 190, 903-7 (2004) (Pubitemid 39120966)
126. Betts, M. R., B. Exley, D. A. Price, A. Bansal, Z. T. Camacho, V. Teaberry, S. M. West, D. R. Ambrozak, G. Tomaras, M. Roederer, J. M. Kilby, J. Tartaglia, R. Belshe, F. Gao, D. C. Douek, K. J. Weinhold, R. A. Koup, P. Goepfert & G. Ferrari: Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection. Proc Natl Acad Sci U S A, 102, 4512-7 (2005) (Pubitemid 40397143)
127. Banchereau, J. & R. M. Steinman: Dendritic cells and the control of immunity. Nature, 392, 245-52 (1998) (Pubitemid 28155090)
128. Maranon, C., J. F. Desoutter, G. Hoeffel, W. Cohen, D. Hanau & A. Hosmalin: Dendritic cells cross-present HIV antigens from live as well as apoptotic infected CD4+ T lymphocytes. Proc Natl Acad Sci U S A, 101, 6092-7 (2004) (Pubitemid 38520533)
129. Van Gulck, E. R., P. Ponsaerts, L. Heyndrickx, K. Vereecken, F. Moerman, A. De Roo, R. Colebunders, G. Van den Bosch, D. R. Van Bockstaele, V. F. Van Tendeloo, S. Allard, B. Verrier, C. Maranon, G. Hoeffel, A. Hosmalin, Z. N. Berneman & G. Vanham: Efficient stimulation of HIV-1-specific T-cells using dendritic cells electroporated with mRNA encoding autologous HIV-1 Gag and Env protein. Blood (2005)
130. Wilson, C. C., W. C. Olson, T. Tuting, C. R. Rinaldo, M. T. Lotze & W. J. Storkus: HIV-1-specific CTL responses primed in vitro by blood-derived dendritic cells and Th1-biasing cytokines. J Immunol, 162, 3070-8 (1999) (Pubitemid 29309338)
131. Zhao, X. Q., X. L. Huang, P. Gupta, L. Borowski, Z. Fan, S. C. Watkins, E. K. Thomas & C. R. Rinaldo, Jr.: Induction of anti-human immunodeficiency virus type 1 (HIV-1) CD8 (+) and CD4 (+) T-cell reactivity by dendritic cells loaded with HIV-1 X4-infected apoptotic cells. J Virol, 76, 3007-14 (2002) (Pubitemid 34184885)
132. Engelmayer, J., M. Larsson, A. Lee, M. Lee, W. I. Cox, R. M. Steinman & N. Bhardwaj: Mature dendritic cells infected with canarypox virus elicit strong anti-human immunodeficiency virus CD8+ and CD4+ T-cell responses from chronically infected individuals. J Virol, 75, 2142-53 (2001) (Pubitemid 32147553)
133. Tsunetsugu-Yokota, Y., Y. Morikawa, M. Isogai, A. Kawana-Tachikawa, T. Odawara, T. Nakamura, F. Grassi, B. Autran & A. Iwamoto: Yeast-derived human immunodeficiency virus type 1 p55 (gag) virus-like particles activate dendritic cells (DCs) and induce perforin expression in Gag-specific CD8 (+) T cells by crosspresentation of DCs. J Virol, 77, 10250-9 (2003) (Pubitemid 37129668)
134. Badovinac, V. P., K. A. Messingham, A. Jabbari, J. S. Haring & J. T. Harty: Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination. Nat Med, 11, 748-56 (2005) (Pubitemid 41021207)
135. Lu, W., L. C. Arraes, W. T. Ferreira & J. M. Andrieu: Therapeutic dendritic-cell vaccine for chronic HIV-1 infection. Nat Med, 10, 1359-65 (2004) (Pubitemid 40022718)
136. Trumpfheller C., J. F., C. B. Lopez, T. M. Moran, B. Moltedo, H. Soares, Y. Huang, S. J. Schlesinger, C. G. Park, M. C. Nussenzweig, A. Granelli-Piperno, R. M. Steinman.: Intensified and protective CD4+ T cell immunity in mice with anti-dendritic cell HIV gag fusion antibody vaccine. Journal of Experimental Medecine, (in press) (2006)
137. Bukczynski, J., T. Wen, C. Wang, N. Christie, J. P. Routy, M. R. Boulassel, C. M. Kovacs, K. S. Macdonald, M. Ostrowski, R. P. Sekaly, N. F. Bernard & T. H. Watts: Enhancement of HIV-specific CD8 T cell responses by dual costimulation with CD80 and CD137L. J Immunol, 175, 6378-89 (2005) (Pubitemid 41598878)
138. Song, X. T., K. Evel-Kabler, L. Rollins, M. Aldrich, F. Gao, X. F. Huang & S. Y. Chen: An Alternative and Effective HIV Vaccination Approach Based on Inhibition of Antigen Presentation Attenuators in Dendritic Cells. PLoS Med, 3, e11 (2006)
139. Gruters, R. A., C. A. van Baalen & A. D. Osterhaus: The advantage of early recognition of HIV-infected cells by cytotoxic T-lymphocytes. Vaccine, 20, 2011-5 (2002) (Pubitemid 34450804)
140. Estcourt, M. J., S. Letourneau, A. J. McMichael & T. Hanke: Vaccine route, dose and type of delivery vector determine patterns of primary CD8+ T cell responses. Eur J Immunol, 35, 2532-40 (2005) (Pubitemid 41404036)