Low-level CD4+ T cell activation is associated with low susceptibility to HIV-1 infection

Journal of Immunology

Volumn 175, Issue 9, 2005, Pages 6117-6122

  Koning, Fransje A ^a,d   Otto, Sigrid A ^a   Hazenberg, Mette D ^b   Dekker, Linda ^a   Prins, Maria ^c   Miedema, Frank ^a   Schuitemaker, Hanneke ^a,e  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b GLADSTONE INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (United States)

^c MUNICIPAL HEALTH SERVICE   (Netherlands)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e SANQUIN RESEARCH   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD27 ANTIGEN; CD38 ANTIGEN; CD4 ANTIGEN; CD45RO ANTIGEN; CD70 ANTIGEN; CD8 ANTIGEN; HLA DR ANTIGEN; KI 67 ANTIGEN;

ADULT; ALLELE; ARTICLE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; HEREDITY; HIGH RISK POPULATION; HOMOZYGOSITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MALE; PRIORITY JOURNAL; SEXUALLY TRANSMITTED DISEASE; T LYMPHOCYTE;

EID: 27144528202     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.9.6117     Document Type: Article

References (45)

1. Scarlatti, G., T. Leitner, V. Hodara, E. Halapi, P. Rossi, J. Albert, and E. M. Fenyo. 1993. Neutralizing antibodies and viral characteristics in mother-to-child transmission of HIV-1. AIDS 7(Suppl. 2): S45-S48.
2. Kliks, S. C., D. W. Wara, D. V. Landers, and J. A. Levy. 1994. Features of HIV-1 that could influence maternal-child transmission. J. Am. Med. Assoc. 272: 467-474.
3. Fang, G., H. Burger, R. Crimson, P. Tropper, S. Nachman, D. Mayers, O. Weislow, R. Moore, C. Reyelt, N. Hutcheon, D. Baker, and B. Weiser. 1995. Maternal plasma human immunodeficiency virus type 1 RNA level: a determinant and projected threshold for mother-to-child transmission. Proc. Natl. Acad. Sci. USA 92: 12100-12104.
4. Ometto, L., C. Zanotto, A. Maccabruni, D. Caselli, D. Truscia, C. Giaquinto, E. Ruga, L. Chieco-Bianchi, and A. De Rossi. 1995. Viral phenotype and host-cell susceptibility to HIV-1 infection as risk factors for mother-to-child HIV-1 transmission. AIDS 9: 427-434.
5. Rowland-Jones, S., J. Sutton, K. Ariyoshi, T. Dong, F. Gotch, S. McAdam, D. Whitby, S. Sabally, A. Gallimore, T. Corrah, et al. 1995. HIV-specific cytotoxic T cells in HIV-exposed but uninfected Gambian women. Nat. Med. 1: 59-64.
6. Sriwanthana, B., T. Hodge, T. D. Mastro, C. S. Dezzutti, K. Bond, H. A. Stephens, L. G. Kostrikis, K. Limpakarnjanarat, N. L. Young, S. H. Qari, et al. 2001. HIV-specific cytotoxic T lymphocytes, HLA-A11, and chemokine-related factors may act synergistically to determine HIV resistance in CCR5 δ32-negative female sex workers in Chiang Rai, northern Thailand. AIDS Res. Hum. Retroviruses 17: 719-734.
7. Jennes, W., S. Sawadogo, S. Koblavi-Deme, B. Vuylsteke, C. Maurice, T. H. Roels, T. Chorba, J. N. Nkengasong, and L. Kestens. 2003. Cellular human immunodeficiency virus (HIV)-protective factors: a comparison of HIV-exposed seronegative female sex workers and female blood donors in Abidjan, Cote d'Ivoire. J. Infect. Dis. 187: 206-214.
8. Messele, T., T. F. Rinke de Wit, M. Brouwer, M. Aklilu, T. Birru, A. L. Fontanet, H. Schuitemaker, and D. Hamann. 2001. No difference in in vitro susceptibility to HIV type 1 between high-risk HIV-negative Ethiopian commercial sex workers and low-risk control subjects. AIDS Res. Hum. Retroviruses 17: 433-441.
9. Butera, S. T., T. L. Pisell, K. Limpakarnjanarat, N. L. Young, T. W. Hodge, T. D. Mastro, and T. M. Folks. 2001. Production of a novel viral suppressive activity associated with resistance to infection among female sex workers exposed to HIV type 1. AIDS Res. Hum. Retroviruses 17: 735-744.
10. Zagury, D., A. Lachgar, V. Chams, L. S. Fall, J. Bernard, J. F. Zagury, B. Bizzini, A. Gringeri, E. Santagostino, J. Rappaport, et al. 1998. C-C chemokines, pivotal in protection against HIV type 1 infection. Proc. Natl. Acad. Sci. USA 95: 3857-3861.
11. Salkowitz, J. R., S. F. Purvis, H. Meyerson, P. Zimmerman, T. R. O'Brien, L. Aledort, M. E. Eyster, M. Hilgartner, C. Kessler, B. A. Konkle, et al. 2001. Characterization of high-risk HIV-1 seronegative hemophiliacs. Clin. Immunol. 98: 200-211.
12. + T cells from exposed uninfected individuals expressing the wild-type CCR-5 allele. J. Exp. Med. 186: 455-460.
13. Blaak, H., A. B. Van't Wout, M. Brouwer, M. Cornelissen, N. A. Kootstra, N. Albrecht-van Lent, R. P. M. Keet, J. Goudsmit, R. A. Coutinho, and H. Schuitemaker. 1998. Infectious cellular load in HIV-1-infected individuals and susceptibility of PBMC from their exposed partners to NSI HIV-1 as major determinants for HIV-1 transmission in homosexual couples. J. Virol. 72: 218-224.
14. + lymphocytes from exposed-uninfected individuals: association with low expression of CCR5 and high production of β-chemokines. Virology 244: 66-73.
15. Promadej, N., C. Costello, M. M. Wernett, P. S. Kulkarni, V. A. Robison, K. E. Nelson, T. W. Hodge, V. Suriyanon, A. Duerr, and J. M. McNicholl. 2003. Broad human immunodeficiency virus (HIV)-specific T cell responses to conserved HIV proteins in HIV-seronegative women highly exposed to a single HIV-infected partner. J. Infect. Dis. 187: 1053-1063.
16. Shieh, B., Y. P. Yan, N. Y. Ko, Y. E. Liau, Y. C. Liu, H. H. Lin, P. P. Chen, and C. Li. 2001. Detection of elevated serum β-chemokine levels in seronegative Chinese individuals exposed to human immunodeficiency virus type 1. Clin. Infect. Dis. 33: 273-279.
17. Yang, O. O., W. J. Boscardin, J. Matud, M. A. Hausner, L. E. Hultin, P. M. Hultin, R. Shih, J. Ferbas, F. P. Siegal, M. Shodell, et al. 2002. Immunologic profile of highly exposed yet HIV type 1-seronegative men. AIDS Res. Hum. Retroviruses 18: 1051-1065.
18. Liu, R., W. A. Paxton, S. Choe, D. Ceradini, S. R. Martin, R. Horuk, M. E. MacDonald, H. Stuhlmann, R. A. Koup, and N. R. Landau. 1996. Homozygous defect in HIV-1 corecepfor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 86: 367-377.
19. Samson, M., F. Libert, B. J. Doranz, J. Rucker, C. Liesnard, C.-M. Farber, S. Saragosti, C. Lapouméroulie, J. Cognaux, C. Forceille, et al. 1996. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382: 722-725.
20. Dean, M., M. Camngton, C. Winkler, G. A. Huttley, M. W. Smith, R. Allikmets, J. J. Goedert, S. P. Buchbinder, E. Vittinghoff, E. Gomperts, et al. 1996. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 273: 1856-1862.
21. Huang, Y., W. A. Paxton, S. M. Wolinsky, A. U. Neumann, L. Zhang, T. He, S. Kang, D. Ceradini, Z. Jin, K. Yazdanbakhsh, et al. 1996. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat. Med. 2: 1240-1243.
22. Philpott, S., B. Weiser, P. Tarwater, S. H. Vermund, C. A. Kleeberger, S. J. Gange, K. Anastos, M. Cohen, R. M. Greenblatt, A. Kovacs, et al. 2003. CC chemokine receptor 5 genotype and susceptibility to transmission of human immunodeficiency virus type 1 in women. J. Infect. Dis. 187: 569-575.
23. Tang, J., B. Shelton, N. J. Makhatadze, Y. Zhang, M. Schaen, L. G. Louie, J. J. Goedert, E. C. Seaberg, J. B. Margolick, J. Mellors, and R. A. Kaslow. 2002. Distribution of chemokine receptor CCR2 and CCR5 genotypes and their relative contribution to human immunodeficiency virus type 1 (HIV-1) seroconversion, early HIV-1 RNA concentration in plasma, and later disease progression. J. Virol. 76: 662-672.
24. Mangano, A., E. Gonzalez, R. Dhanda, G. Catano, M. Bamshad, A. Bock, R. Duggirala, K. Williams, S. Mummidi, R. A. Clark, et al. 2001. Concordance between the CC chemokine receptor 5 genetic determinants that alter risks of transmission and disease progression in children exposed perinatally to human immunodeficiency virus. J. Infect. Dis. 183: 1574-1585.
25. Rowland-Jones, S. L., T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, et al. 1999. Broadly cross-reactive HIV-specific cytotoxic T lymphocytes in highly exposed persistently seronegative donors. Immunol. Lett. 66: 9-14.
26. Goh, W. C., J. Markee, R. E. Akridge, M. Meldorf, L. Musey, T. Karchmer, M. Krone, A. Collier, L. Corey, M. Emerman, and M. J. McElrath. 1999. Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects. J. Infect. Dis. 179: 548-557.
27. Bernard, N. F., C. M. Yannakis, J. S. Lee, and C. M. Tsoukas. 1999. Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocyte activity in HIV-exposed seronegative persons. J. Infect. Dis. 179: 538-547.
28. De Maria, A., C. Cirillo, and L. Moretta. 1994. Occurrence of human immunodeficiency virus type 1 (HIV-1)-specific cytolytic T cell activity in apparently uninfected children born to HIV-1 infected mothers. J. Infect. Dis. 170: 1296-1299.
29. Bienzle, D., K. S. MacDonald, F. M. Smaill, C. Kovacs, M. Baqi, B. Courssaris, M. A. Luscher, S. L. Walmsley, and K. L. Rosenthal. 2000. Factors contributing to the lack of human immunodeficiency virus type 1 (HIV-1) transmission in HIV-1-discordant partners. J. Infect. Dis. 182: 123-132.
30. Makedonas, G., J. Bruneau, H. Lin, R. P. Sekaly, F. Lamothe, and N. F. Bernard. 2002. HIV-specific CD8 T cell activity in uninfected injection drug users is associated with maintenance of seronegativity. AIDS 16: 1595-1602.
31. Koning, F. A., C. A. Jansen, J. Dekker, R. A. Kaslow, N. Dukers, D. van Baarle, M. Prins, and H. Schuitemaker. 2004. Correlates of resistance to HIV-1 infection in homosexual men with high-risk sexual behaviour. AIDS 18: 1117-1126.
32. Pinto, L. A., J. Sullivan, J. A. Berzofsky, M. Clerici, H. A. Kessler, A. L. Landay, and G. M. Shearer. 1995. Env-specific cytotoxic T lymphocyte responses in HIV seronegative health care workers occupationally exposed to HIV-contaminated body fluids. J. Clin. Invest. 96: 867-876.
33. + T cells. Science 286: 1353-1357.
34. + T cells in transmission and acute simian immunodeficiency virus infection. Proc. Natl. Acad Sci. USA 101: 5640-5645.
35. Sewankambo, N., R. H. Gray, M. J. Wawer, L. Paxton, D. McNaim, F. Wabwire-Mangen, D. Serwadda, C. Li, N. Kiwanuka, S. L. Hillier, et al. 1997. HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis. Lancet 350: 546-550.
36. Cohn, M. A., S. S. Frankel, S. Rugpao, M. A. Young, G. Willett, S. Tovanabutra, C. Khamboonruang, T. Vancott, L. Bhoopat, S. Barrick, et al. 2001. Chronic inflammation with increased human immunodeficiency virus (HIV) RNA expression in the vaginal epithelium of HIV-infected Thai women. J Infect. Dis. 184: 410-417.
37. Van Damme, L., G. Ramjee, M. Alary, B. Vuylsteke, V. Chandeying, H. Rees, P. Sirivongrangson, L. Mukenge-Tshibaka, V. Ettiegne-Traore, C. Uaheowitchai, et al. 2002. Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial. Lancet 360: 971-977.
38. Dukers, N. H., N. Renwick, M. Prins, R. B. Geskus, T. F. Schulz, G. J. Weverling, R. A. Coutinho, and J. Goudsmit. 2000. Risk factors for human herpesvirus 8 seropositivity and HHV8 seroconversion in a cohort of homosexual men. Am. J. Epidemiol. 151: 213-224.
39. Dukers, N. H., S. M. Bruisten, J. A. van den Hoek, J. B. de Wit, G. J. van Doornum, and R. A. Coutinho. 2000. Strong decline in herpes simplex virus antibodies over time among young homosexual men is associated with changing sexual behavior. Am. J. Epidemiol. 152: 666-673.
40. + T cell responses fail to protect against infection in 3 highly exposed initially seronegative subjects. AIDS Vaccine 04, 30 August-1 September. Lausanne, Switzerland. Poster 132.
41. Messele, T., M. Brouwer, M. Girma, A. L. Fontanet, F. Miedema, D. Hamann, and T. F. Rinke de Wit. 2001. Plasma levels of viro-immunological markers in HIV-infected and non-infected Ethiopians: correlation with cell surface activation markers. Clin. Immunol. 98: 212-219.
42. Paxton, W. A., S. R. Martin, D. Tse, T. R. O'Brien, J. Skurnick, N. L. Vandevanter, N. Padian, J. F. Braun, D. P. Kotler, S. M. Wolinsky, and R. A. Koup. 1996. Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures. Nat. Med. 2: 412-417.
43. Fowke, K. R., T. Dong, S. L. Rowland-Jones, J. Oyugi, W. J. Rutherford, J. Kimani, P. Krausa, J. Bwayo, J. N. Simonsen, G. M. Shearer, and F. A. Plummer. 1998. HIV type 1 resistance in Kenyan sex workers is not associated with altered cellular susceptibility to HIV type 1 infection or enhanced β-chemokine production. AIDS Res. Hum. Retroviruses 14: 1521-1530.
44. Zhu, T., L. Corey, Y. Hwangbo, J. M. Lee, G. H. Learn, J. I. Mullins, and M. J. McElrath. 2003. Persistence of extraordinarily low levels of genetically homogeneous human immunodeficiency virus type 1 in exposed seronegative individuals. J. Virol. 77: 6108-6116.
45. Koning, F. A., T. J. K. van der Vorst, and H. Schuitemaker. 2005. Low levels of human immunodeficiency virus type 1 DNA in high-risk seronegative men. J. Virol. 79: 6551-6553.