HIV-1 specific CD8+ T cells with an effector phenotype and control of viral replication

Lancet

Volumn 363, Issue 9412, 2004, Pages 863-866

  Hess, Christoph ^a   Altfeld, Marcus ^b   Thomas, Seddon Y ^a   Addo, Marylyn M ^b   Rosenberg, Eric S ^b   Allen, Todd M ^b   Draenert, Rika ^b   Eldrige, Robert L ^b   Van Lunzen, Jan ^c   Stellbrink, Hans J ^c   Walker, Bruce D ^b   Luster, Andrew D ^a,d  

^a Div Rheumatology Allerg Immunol   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; PERFORIN;

ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL SUBPOPULATION; CELLULAR IMMUNITY; CONTROLLED STUDY; DATA ANALYSIS; EFFECTOR CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; VIRUS REPLICATION;

EID: 12144285675     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(04)15735-8     Document Type: Article

References (5)

1. Appay V., Nixon D.F., Donahoe S.M., et al. HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J Exp Med. 192:2000;63-75.
2. Champagne P., Ogg G.S., King A.S., et al. Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature. 410:2001;106-111.
3. Sallusto F., Lenig D., Forster R., Lipp M., Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 401:1999;708-712.
4. Rosenberg E.S., Altfeld M., Poon S.H., et al. Immune control of HIV-1 after early treatment of acute infection. Nature. 407:2000;523-526.
5. Migueles S.A., Laborico A.C., Shupert W.L., et al. HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nat Immunol. 3:2002;1061-1068.