Cutting edge: Emergence of CD127high functionally competent memory T cells is compromised by high viral loads and inadequate T cell help

Journal of Immunology

Volumn 174, Issue 10, 2005, Pages 5926-5930

  Fuller, Michael J ^a   Hildeman, David A ^c   Sabbaj, Steffanie ^b   Gaddis, Dalia E ^a   Tebo, Anne E ^a   Shang, Liang ^a   Goepfert, Paul A ^a,b   Zajac, Allan J ^a  

^a University of Alabama at Birmingham   (United States)

^b University of Alabama at Birmingham   (United States)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; INTERLEUKIN 2; INTERLEUKIN 7 RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TETRAMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; FEMALE; FLOW CYTOMETRY; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MEMORY CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS INFECTION; VIRUS LOAD;

EID: 18644370174     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.10.5926     Document Type: Article

References (24)

1. Fuller, M. J., and A. J. Zajac. 2003. Ablation of CD8 and CD4 T cell responses by high viral loads. J. Immunol. 170: 477-486.
2. Wherry, E. J., J. N. Blattman, K. Murali-Krishna, R. van der Most, and R. Ahmed. 2003. Viral persistence alters CD8 T-cell Immunodominance and tissue distribution and results in distinct stages of functional impairment. J. Virol. 77: 4911-4927.
3. Fuller, M. J., A. Khanolkar, A. E. Tebo, and A. J. Zajac. 2004. Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections. J. Immunol. 172: 4204-4214.
4. Wherry, E. J., and R. Ahmed. 2004. Memory CD8 T-cell differentiation during viral infection. J. Virol. 78: 5535-5545.
5. + T cells after acute infection. Nat. Immunol. 5: 927-933.
6. + T-cell response. Nat. Rev. Immunol. 4: 595-602.
7. Schluns, K. S., W. C. Kieper, S. C. Jameson, and L. Lefrancois. 2000. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat. Immunol. 1: 426-432.
8. Prlic, M., L. Lefrancois, and S. C. Jameson, 2002. Multiple choices: regulation of memory CD8 T cell generation and homeostasis by interleukin (IL)-7 and IL-15. J. Exp. Med. 195:F49-F52.
9. Kaech, S. M., J. T. Tan, E. J. Wherry, B. T. Konieczny, C. D. Suth, and R. Ahmed. 2003. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 4: 1191-1198.
10. Huster, K. M.,V. Busch, M. Schiemann, K. Linkemann, K. M. Kerksiek, H. Wagner, and D. H. Busch. 2004. Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8 memory T cell subsets. Proc. Natl. Acad. Sci. USA 101: 5610-5615.
11. Madakamutil, L. T., U. Christen, C. J. Lena, Y. Wang-Zhu, A. Attinger, M. Sundarrajan, W. Ellmeier, M. G. von Herrath, P. Jensen, D. R. Littman, and H. Cheroutre. 2004. CD8αα-mediated survival and differentiation of CD8 memory T cell precursors. Science 304: 590-593.
12. + T cell memory. Proc. Natl. Acad. Sci. USA 101: 9357-9362.
13. Kondrack, R. M., J. Harbertson, J. T. Tan, M. E. McBreen, C. D. Suth, and L. M. Bradley. 2003, Interleukin 7 regulates the survival and generation of memory CD4 cells. J. Exp. Med. 198: 1797-1806.
14. Li, J., G. Huston, and S. L. Swain, 2003. IL-7 promotes the transition of CD4 effectors to persistent memory cells. J. Exp. Med. 198: 1807-1815.
15. Crawford, F., H. Kozono, J. White, P. Marrack, and J. Kappler. 1998. Detection of antigen-specific T cells with mulrivalent soluble class II MHC covalent peptide complexes. Immunity 8: 675-682.
16. + T cell responses in vivo and in vitro. Proc. Natl. Acad. Sci. USA 96: 9781-9786.
17. Khanolkar, A., M. J. Fuller, and A. J. Zajac. 2004. CD4 T cell-dependent CD8 T cell maturation. J. Immunol. 172: 2834-2844.
18. Lechner, F., D. K. Wong, P. R. Dunbar, R. Chapman, R. T. Chung, P. Dohrenwend, G. Robbins, R. Phillips, P. Klenerman, and B. D. Walker. 2000. Analysis of successful immune responses in persons infected with hepatitis C virus. J. Exp. Med. 191: 1499-1512.
19. Wherry, E. J., D. L. Barber, S. M. Kaech, J. N. Blattman, and R. Ahmed. 2004. Antigen-independent memory CD8 T cells do not develop during chronic viral infection. Proc. Natl. Acad. Sci. USA 101: 16004-16009.
20. Carini, C., M. F. McLane, K. H. Mayer, and M. Essex. 1994. Deregulation of interleukin-7 receptor may genetate loss of cytotoxic T cell response in human immunodeficiency virus type 1 infection. Eur. J. Immunol. 24: 2927-2934.
21. + T cells is reduced in HIV infection and partially restored with effective antitetroviral therapy. J. Acquired Immune Defic. Syndr. 28: 454-457.
22. Mussini, C., M. Pinti, V. Borghi, M. Nasi, G. Amorico, E. Monterastelli, L. Moretti, L. Troiano, R. Esposito, and A. Cossarizza. 2002. Features of 'CD4-exploders', HIV-positive patients with an optimal immune reconstitution after potent antiretroviral therapy. AIDS 16: 1609-1616.
23. + T cells in HIV-infected individuals. J. Immunol. 174: 2900-2909.
24. + T-cell immune responses during chronic viral infection. J. Virol. 78: 3578-3600.