Comparative homology modeling of human cytochrome P4501A1 (CYP1A1) and confirmation of residues involved in 7-ethoxyresorufin O-deethylation by site-directed mutagenesis and enzyme kinetic analysis

Archives of Biochemistry and Biophysics

Volumn 468, Issue 1, 2007, Pages 58-69

  Lewis, B C ^a   Mackenzie, P I ^a   Miners, J O ^a  

^a FLINDERS UNIVERSITY   (Australia)

Author keywords

CYP1A1; Cytochrome P450; EROD; Homology model; Mutagenesis; Substrate inhibition

Indexed keywords

CYTOCHROME P450 1A1; CYTOCHROME P450 2C5; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; ETHOXYRESORUFIN; ETHOXYRESORUFIN DEETHYLASE; MUTANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; MOLECULAR MODEL; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STEREOCHEMISTRY;

AMINO ACID SEQUENCE; AMINO ACIDS; BINDING SITES; COMPUTER SIMULATION; CYTOCHROME P-450 CYP1A1; ENZYME ACTIVATION; HUMANS; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OXAZINES; PROTEIN BINDING; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 36049033829     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2007.09.014     Document Type: Article

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