The glucuronidation of Δ4-3-keto C19- and C21-hydroxysteroids by human liver microsomal and recombinant UDP-glucuronosyltransferases (UGTs): 6α- and 21-hydroxyprogesterone are selective substrates for UGT2B7

Drug Metabolism and Disposition

Volumn 35, Issue 3, 2007, Pages 363-370

  Bowalgaha, K ^a   Elliot, D J ^a   Mackenzie, P I ^a   Knights, K M ^a   Miners, J O ^a,b  

^a FLINDERS UNIVERSITY   (Australia)

^b FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

11ALPHA HYDROXYPROGESTERONE; 11BETA HYDROXYPROGESTERONE; 16ALPHA HYDROXYPROGESTERONE; 4 ANDROSTEN 7ALPHA OL 3,17 DIONE; 6ALPHA HYDROXYPROGESTERONE; 6BETA HYDROXYANDROSTENEDIONE; 6BETA HYDROXYPROGESTERONE; ANDROSTENEDIONE DERIVATIVE; DEOXYCORTICOSTERONE; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A10; GLUCURONOSYLTRANSFERASE 1A4; GLUCURONOSYLTRANSFERASE 1A9; GLUCURONOSYLTRANSFERASE 2B15; GLUCURONOSYLTRANSFERASE 2B17; GLUCURONOSYLTRANSFERASE 2B7; HYDROXYPROGESTERONE; PROGESTERONE DERIVATIVE; RECOMBINANT ENZYME; TESTOSTERONE; UNCLASSIFIED DRUG; GLUCURONIDE; RECOMBINANT PROTEIN; ZIDOVUDINE;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG GLUCURONIDATION; DRUG STRUCTURE; ENZYME ACTIVITY; GASTROINTESTINAL TRACT; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER MICROSOME; MICHAELIS MENTEN KINETICS; PRIORITY JOURNAL; STEREOCHEMISTRY; BIOSYNTHESIS; CELL LINE; DRUG ANTAGONISM; GENETICS; METABOLISM;

CELL LINE; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; HYDROXYPROGESTERONES; MICROSOMES, LIVER; RECOMBINANT PROTEINS; TESTOSTERONE; ZIDOVUDINE;

EID: 33847383675     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.013052     Document Type: Article

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