Distinct molecular program imposed on CD4+ T cell targets by CD4+CD25+ regulatory T cells

Journal of Immunology

Volumn 177, Issue 10, 2006, Pages 6952-6961

  Sukiennicki, Teresa L ^a   Fowell, Deborah J ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; COMPLEMENTARY DNA; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CLONAL ANERGY; COMPUTER PROGRAM; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC ASSOCIATION; GROWTH INHIBITION; IMMUNOMODULATION; MALE; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; TRANSCRIPTION REGULATION;

EID: 33750799561     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.10.6952     Document Type: Article

References (52)

1. + regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6: 345-352.
2. von Boehmer, H. 2005. Mechanisms of suppression by suppressor T cells. Nat. Immunol. 6: 338-344.
3. + regulatory T cells. Nat. Immunol. 4: 330-336.
4. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188: 287-296.
5. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10: 1969-1980.
6. + cells controlling a pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression, and tissue invasion. J. Immunol. 173: 2942-2951.
7. + T cells prevent the development of organ-specific autoimmune disease by inhibiting the differentiation of autoreactive effector T cells. J. Immunol. 175: 7135-7142.
8. + cells in vivo. J. Immunol. 172: 3391-3398.
9. + T cells for IL-2 and exploit it for the induction of IL-10 production. Int. Immunol. 17: 279-288.
10. Malek, T. R., A. Yu, V. Vincek, P. Scibelli, and L. Kong. 2002. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rβ-deficient mice: implications for the nonredundant function of IL-2. Immunity 17: 167-178.
11. + T cell suppressor function. J. Immunol. 172: 6519-6523.
12. + regulatory T cell activity. J. Immunol. 175: 7274-7280.
13. Asseman, C., S. Mauze, M. W. Leach, R. L. Coffman, and F. Powrie. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190: 995-1004.
14. + T cells. J. Autoimmun. 16: 115-123.
15. + regulatory T cells. J. Exp. Med. 201: 737-746.
16. + regulatory T cell activity in both humans and mice. J. Immunol. 172: 834-842.
17. + regulatory T cells control autoimmunity? Curr. Opin. Immunol. 17: 638-642.
18. Tang, Q., J. Y. Adams, A. J. Tooley, M. Bi, B. T. Fife, P. Serra, P. Santamaria, R. M. Locksley, M. F. Krummel, and J. A. Bluestone. 2006. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat. Immunol. 7: 83-92.
19. + T cells and dendritic cells in vivo. J. Exp. Med. 203: 505-511.
20. + T cells facilitate the induction of T cell anergy. J. Immunol. 167: 4271-4275.
21. + regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. J. Immunol. 174: 1783-1786.
22. Grossman, W. J., J. W. Verbsky, W. Barchet, M. Colonna, J. P. Atkinson, and T. J. Ley. 2004. Human T regulatory cells can use the perform pathway to cause autologous target cell death. Immunity 21: 589-601.
23. + T cells. J. Immunol. 173: 5008-5020.
24. George, T. C., J. Bilsborough, J. L. Viney, and A. M. Norment. 2003. High antigen dose and activated dendritic cells enable Th cells to escape regulatory T cell-mediated suppression in vitro. Eur. J. Immunol. 33: 502-511.
25. + regulatory T cells. J. Exp. Med. 201: 181-187.
26. -/- mice. J. Immunol. 173: 1059-1065.
27. Heissmeyer, V., F. Macian, S. H. Im, R. Varma, S. Feske, K. Venuprasad, H. Gu, Y. C. Liu, M. L. Dustin, and A. Rao. 2004. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat. Immunol. 5: 255-265.
28. Buckley, A. F., C. T. Kuo, and J. M. Leiden. 2001. Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway. Nat. Immunol. 2: 698-704.
29. Tarrant, J. M., J. Groom, D. Metcalf, R. Li, B. Borobokas, M. D. Wright, D. Tarlinton, and L. Robb. 2002. The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses. Mol. Cell Biol. 22: 5006-5018.
30. + regulatory T cells is mediated by cell surface-bound transforming growth factor β. J. Exp. Med. 194: 629-644.
31. Lechner, O., J. Lauber, A. Franzke, A. Sarukhan, H. von Boehmer, and J. Buer. 2001. Fingerprints of anergic T cells. Curr. Biol. 11: 587-595.
32. Macian, F., F. Garcia-Cozar, S. H. Im, H. F. Horton, M. C. Byrne, and A. Rao. 2002. Transcriptional mechanisms underlying lymphocyte tolerance. Cell 109: 719-731.
33. Devireddy, L. R., and M. R. Green. 2003. Transcriptional program of apoptosis induction following interleukin 2 deprivation: identification of RC3, a calcium/calmodulin binding protein, as a novel proapoptotic factor. Mol. Cell Biol. 23: 4532-4541.
34. + lymphocytes. J. Immunol. 171: 5328-5336.
35. Gorelik, L., and R. A. Flavell. 2002. Transforming growth factor-β in T-cell biology. Nat. Rev. Immunol. 2: 46-53.
36. + T cells. Immunity 18: 535-547.
37. Nakao, A., M. Afrakhte, A. Moren, T. Nakayama, J. L. Christian, R. Heuchel, S. Itoh, M. Kawabata, N. E. Heldin, C. H. Heldin, and P. ten Dijke. 1997. Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling. Nature 389: 631-635.
38. - T cells through Foxp3 induction and down-regulation of Smad7. J. Immunol. 172: 5149-5153.
39. Huppa, J. B., M. Gleimer, C. Sumen, and M. M. Davis. 2003. Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Nat. Immunol. 4: 749-755.
40. + T cell response. J. Exp. Med. 201: 1555-1565.
41. Kobayashi, I., L. Jin, K. H. Ruebel, J. M. Bayliss, O. Hidehiro, and R. V. Lloyd. 2003. Regulation of cell growth and expression of 7B2, PC2, and PC 1/3 by TGFβ1 and sodium butyrate in a human pituitary cell line (HP75). Endocrine 22: 285-292.
42. Kee, B. L., R. R. Rivera, and C. Murre. 2001. Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF-β. Nat. Immunol. 2: 242-247.
43. Li, H., M. Dai, and Y. Zhuang. 2004. A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome. Immunity 21: 551-560.
44. Wang, F., I. Millet, K. Bottomly, and A. Vignery. 1992. Calcitonin gene-related peptide inhibits interleukin 2 production by murine T lymphocytes. J. Biol. Chem. 267: 21052-21057.
45. Tedder, T. F., A. Forsgren, A. W. Boyd, L. M. Nadler, and S. F. Schlossman. 1986. Antibodies reactive with the B1 molecule inhibit cell cycle progression but not activation of human B lymphocytes. Eur. J. Immunol. 16: 881-887.
46. Lambrecht, B. N. 2001. Immunologists getting nervous: neuropeptides, dendritic cells and T cell activation. Respir. Res. 2: 133-138.
47. Millet, I., R. J. Phillips, R. S. Sherwin, S. Ghosh, R. E. Voll, R. A. Flavell, A. Vignery, and M. Rincon. 2000. Inhibition of NF-κB activity and enhancement of apoptosis by the neuropeptide calcitonin gene-related peptide. J. Biol. Chem. 275: 15114-15121.
48. Korthauer, U., W. Nagel, E. M. Davis, M. M. Le Beau, R. S. Menon, E. O. Mitchell, C. A. Kozak, W. Kolanus, and J. A. Bluestone. 2000. Anergic T lymphocytes selectively express an integrin regulatory protein of the cytohesin family. J. Immunol. 164: 308-318.
49. Carlson, M. 1997. Genetics of transcriptional regulation in yeast: connections to the RNA polymerase II CTD. Annu. Rev. Cell. Dev. Biol. 13: 1-23.
50. Sun, X., Y. Zhang, H. Cho, P. Rickert, E. Lees, W. Lane, and D. Reinberg. 1998. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. Mol. Cell 2: 213-222.
51. Ram, P. A., and D. J. Waxman. 1999. SOCS/CIS protein inhibition of growth hormone-stimulated STATS signaling by multiple mechanisms. J. Biol. Chem. 274: 35553-35561.
52. Kovanen, P. E., L. Young, A. Al-Shami, V. Rovella, C. A. Pise-Masison, M. F. Radonovich, J. Powell, J. Fu, J. N. Brady, P. J. Munson, and W. J. Leonard. 2005. Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes. Int. Immunol. 17: 1009-1021.