Suppression of T-cell responsiveness by inducible cAMP early repressor (ICER)

Journal of Leukocyte Biology

Volumn 69, Issue 6, 2001, Pages 1053-1059

  Bodor, J ^a   Feigenbaum, L ^a   Bodorova, J ^a   Bare, C ^a   Reitz M S , Jr ^a   Gress, R E ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Chemokines; Cytokines; Transcription factors

Indexed keywords

CHEMOKINE; CYCLIC AMP; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ARTICLE; FLOW CYTOMETRY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE; TH1 CELL; TH2 CELL; TRANSGENIC MOUSE;

ANIMALS; CELL DIVISION; CHEMOKINES; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT MODULATOR; CYTOKINES; DINOPROSTONE; DNA-BINDING PROTEINS; FORSKOLIN; GENE EXPRESSION REGULATION; HUMANS; INTERFERON TYPE II; INTERLEUKIN-2; IONOMYCIN; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; SECOND MESSENGER SYSTEMS; SPLEEN; TETRADECANOYLPHORBOL ACETATE; TH1 CELLS; TH2 CELLS; TRANSCRIPTION, GENETIC;

EID: 0034978987     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Cyclic AMP-responsive DNA-binding protein: Structure based on cloned placental cDNA
2. CREM gene: Use of alternative DNA binding domains generate multiple antagonists of cAMP-induced transcription
3. Role of transcription factors CREB and CREM in cAMP-regulated transcription during spermatogenesis
4. Inducibility and negative autoregulation of CREM: An alternative promoter directs the expression of ICER, an early response repressor
5. Rhythmic transcription and autoregulatory loops: Winding up the biological clock
6. Rhythmic transcription and autoregulatory loops: Nuclear pacemaker CREM
7. cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes
8. Thyroid-stimulating hormone (TSH)-directed induction of the CREM gene in the thyroid gland participates in the long-term desensitization of the TSH receptor
9. The transcriptional coactivators p300 and CBP are histone acetyltransferases
10. Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300 CREB-binding protein (CBP)
11. CREB-binding protein/p300 are transcriptional coactivators of p65
12. Coordinate transactivation of the interleukin-2 CD28 response element by c-Rel and ATF-1/CREB2
13. Lymphocyte responses and cytokines
14. Lymphokine production by human T cells in disease states
15. Chemokines and leukocyte traffic
16. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes
17. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
18. + T cells
19. Calcium ionophore-treated peripheral blood monocytes and dendritic cells rapidly display characteristics of activated dendritic cells
20. Stable polarization of peripheral blood T cells towards type 1 or type 2 phenotype after polyclonal activation
21. Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs
22. Role of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytes
23. Differential regulation and transcriptional control of immediate early gene expression in forskolin-treated WEHI7.2 thymoma cells
24. An isoform of transcription factor CREM expressed during spermatogenesis lacks the phosphorylation domain and represses cAMP-induced transcription
25. Specificity of expression and effects of eicosanoid mediators in normal physiology and human diseases
26. Molecular regulation of cytokine gene expression: Interferon-gamma as a model system
27. Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists
28. Differential modulation of T helper type 1 (Th1) and T helper type 2 (Th2) cytokine secretion by prostaglandin E2 critically depends on interleukin-2
29. Molecular regulation of interleukin-2 expression by CD28 costimulation anergy
30. Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene
31. Interferon-gamma expression by Th1 effector T cells mediated bv the p38 MAP kinase signaling pathway
32. Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB
33. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300
34. Suppression of T cell function: A potential role for transcriptional repressor ICER