Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast

Journal of Cell Biology

Volumn 164, Issue 4, 2004, Pages 535-546

  Gillett, Emily S ^a   Espelin, Christopher W ^a   Sorger, Peter K ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Chromosome segregation; Kinetochores; Metaphase; Mitosis; Mitotic spindle apparatus

Indexed keywords

BENZIMIDAZOLE; BUB1 RELATED PROTEIN; BUB3 PROTEIN; GREEN FLUORESCENT PROTEIN; NOCODAZOLE; PROTEIN MAD1; PROTEIN MAD2;

ANAPHASE; ARTICLE; BUDDING; CELL CYCLE; CENTROMERE; CHROMOSOME SEGREGATION; EVOLUTION; METAPHASE; MICROTUBULE ASSEMBLY; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; YEAST CELL;

ANIMALS; CARRIER PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; CHROMOSOME SEGREGATION; CHROMOSOMES, FUNGAL; GENES, CDC; KINETOCHORES; MACROMOLECULAR SUBSTANCES; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; MITOTIC SPINDLE APPARATUS; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROTEIN KINASES; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION;

ANIMALIA; GOES; MAMMALIA; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 1242307468     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200308100     Document Type: Article

References (60)

1. Abruzzi, K.C., M. Magendantz, and F. Solomon. 2002. An alpha-tubulin mutant demonstrates distinguishable functions among the spindle assembly checkpoint genes in Saccharomyces cerevisiae. Genetics. 161:983-994.
2. Basu, J., H. Bousbaa, E. Logarinho, Z. Li, B.C. Williams, C. Lopes, C.E. Sunkel, and M.L. Goldberg. 1999. Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila. J. Cell Biol. 146:13-28.
3. Biggins, S., and A.W. Murray. 2001. The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint. Genes Dev. 15:3118-3129.
4. Biggins, S., F.F. Severin, N. Bhalla, I. Sassoon, A.A. Hyman, and A.W. Murray. 1999. The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast. Genes Dev. 13:532-544.
5. Cheeseman, I.M., M. Enquist-Newman, T. Muller-Reichert, D.G. Drubin, and G. Barnes. 2001. Mitotic spindle integrity and kinetochore function linked by the Duo1p-Dam1p complex. J. Cell Biol. 152:197-212.
6. Cleveland, D.W., Y. Mao, and K.F. Sullivan. 2003. Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell. 112:407-421.
7. Connelly, C., and P. Hieter. 1996. Budding yeast SKP1 encodes an evolutionarily conserved kinetochore protein required for cell cycle progression. Cell. 86:275-285.
8. De Wulf, P., A.D. McAinsh, and P.K. Sorger. 2003. Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev. 17:2902-2921.
9. Dobles, M., V. Liberal, M.L. Scott, R. Benezra, and P.K. Sorger. 2000. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell. 101:635-645.
10. Doheny, K.F., P.K. Sorger, A.A. Hyman, S. Tugendreich, F. Spencer, and P. Hieter. 1993. Identification of essential components of the S. cerevisiae kinetochore. Cell. 73:761-774.
11. Donaldson, M.M., A.A. Tavares, H. Ohkura, P. Deak, and D.M. Glover. 2001. Metaphase arrest with centromere separation in polo mutants of Drosophila. J. Cell Biol. 153:663-676.
12. Farr, K.A., and M.A. Hoyt. 1998. Bub1p kinase activates the Saccharomyces cerevisiae spindle assembly checkpoint. Mol. Cell. Biol. 18:2738-2747.
13. Gardner, R.D., A. Poddar, C. Yellman, P.A. Tavormina, M.C. Monteagudo, and D.J. Burke. 2001. The spindle checkpoint of the yeast Saccharomyces cerevisiae requires kinetochore function and maps to the CBF3 domain. Genetics. 157:1493-1502.
14. Goh, P.Y., and J.V. Kilmartin. 1993. NDC10: a gene involved in chromosome segregation in Saccharomyces cerevisiae. J. Cell Biol. 121:503-512.
15. Guacci, V., D. Koshland, and A. Strunnikov. 1997. A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae. Cell. 91:47-57.
16. He, X., S. Asthana, and P.K. Sorger. 2000. Transient sister chromatid separation and elastic deformation of chromosomes during mitosis in budding yeast. Cell. 101:763-775.
17. He, X., D.R. Rines, C.W. Espelin, and P.K. Sorger. 2001. Molecular analysis of kinetochore-microtubule attachment in budding yeast. Cell. 106:195-206.
18. Hoyt, M.A., L. Totis, and B.T. Roberts. 1991. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell. 66:507-517.
19. Iouk, T., O. Kerscher, R.J. Scott, M.A. Basrai, and R.W. Wozniak. 2002. The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint. J. Cell Biol. 159:807-819.
20. Jacobs, C.W., A.E. Adams, P.J. Szaniszlo, and J.R. Pringle. 1988. Functions of microtubules in the Saccharomyces cerevisiae cell cycle. J. Cell Biol. 107:1409-1426.
21. Janke, C., J. Ortiz, J. Lechner, A. Shevchenko, M.M. Magiera, C. Schramm, and E. Schiebel. 2001. The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control. EMBO J. 20:777-791.
22. Janke, C., J. Ortiz, T.U. Tanaka, J. Lechner, and E. Schiebel. 2002. Four new subunits of the Dam1-Duo1 complex reveal novel functions in sister kinetochore biorientation. EMBO J. 21:181-193.
23. Jin, Q.W., J. Fuchs, and J. Loidl. 2000. Centromere clustering is a major determinant of yeast interphase nuclear organization. J. Cell Sci. 113:1903-1912.
24. Jones, M.H., X. He, T.H. Giddings, and M. Winey. 2001. Yeast Dam1p has a role at the kinetochore in assembly of the mitotic spindle. Proc. Natl. Acad. Sci. USA. 98:13675-13680.
25. Kalitsis, P., E. Earle, K.J. Fowler, and K.H. Choo. 2000. Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis. Genes Dev. 14:2277-2282.
26. Kerscher, O., L.B. Crotti, and M.A. Basrai. 2003. Recognizing chromosomes in trouble: association of the spindle checkpoint protein Bub3p with altered kinetochores and a unique defective centromere. Mol. Cell. Biol. 23:6406-6418.
27. Kim, J.H., J.S. Kang, and C.S. Chan. 1999. Sli15 associates with the ipl1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae. J. Cell Biol. 145:1381-1394.
28. King, J.M., and R.B. Nicklas. 2000. Tension on chromosomes increases the number of kinetochore microtubules but only within limits. J. Cell Sci. 113:3815-3823.
29. Kitagawa, K., R. Abdulle, P.K. Bansal, G. Cagney, S. Fields, and P. Hieter. 2003. Requirement of skp1-bub1 interaction for kinetochore-mediated activation of the spindle checkpoint. Mol. Cell. 11:1201-1213.
30. Kitagawa, R., and A.M. Rose. 1999. Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans. Nat. Cell Biol. 1:514-521.
31. Kosco, K.A., C.G. Pearson, P.S. Maddox, P.J. Wang, I.R. Adams, E.D. Salmon, K. Bloom, and T.C. Huffaker. 2001. Control of microtubule dynamics by Stu2p is essential for spindle orientation and metaphase chromosome alignment in yeast. Mol. Biol. Cell. 12:2870-2880.
32. Li, R., and A.W. Murray. 1991. Feedback control of mitosis in budding yeast. Cell. 66:519-531. (published erratum in Cell. 1994. 79:following 388).
33. Li, R., and A.W. Murray. 1991. Feedback control of mitosis in budding yeast. Cell. 66:519-531. (published erratum in Cell. 1994. 79:following 388).
34. Li, X., and R.B. Nicklas. 1995. Mitotic forces control a cell-cycle checkpoint. Nature. 373:630-632.
35. Martin-Lluesma, S., V.M. Stucke, and E.A. Nigg. 2002. Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2. Science. 297:2267-2270.
36. McAinsh, A.D., J.D. Tytell, and P.K. Sorger. 2003. Structure, function, and regulation of budding yeast kinetochores. Annu. Rev. Cell Dev. Biol. 19:519-539.
37. McCleland, M.L., R.D. Gardner, M.J. Kallio, J.R. Daum, G.J. Gorbsky, D.J. Burke, and P.T. Stukenberg. 2003. The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity. Genes Dev. 17:101-114.
38. Megee, P.C., C. Mistrot, V. Guacci, and D. Koshland. 1999. The centromeric sister chromatid cohesion site directs Mcd1p binding to adjacent sequences. Mol. Cell. 4:445-450.
39. Merdes, A., and J. De Mey. 1990. The mechanism of kinetochore-spindle attachment and polewards movement analyzed in PtK2 cells at the prophase-prometaphase transition. Eur. J. Cell Biol. 53:313-325.
40. Morgan, D.O. 1999. Regulation of the APC and the exit from mitosis. Nat. Cell Biol. 1:E47-E53.
41. Nicklas, R.B., and S.C. Ward. 1994. Elements of error correction in mitosis: microtubule capture, release, and tension. J. Cell Biol. 126:1241-1253.
42. Rieder, C.L., A. Schultz, R. Cole, and G. Sluder. 1994. Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle. J. Cell Biol. 127:1301-1310.
43. Rieder, C.L., R.W. Cole, A. Khodjakov, and G. Sluder. 1995. The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores. J. Cell Biol. 130:941-948.
44. Rines, D.R., X. He, and P.K. Sorger. 2002. Quantitative microscopy of green fluorescent protein-labeled yeast. Methods Enzymol. 351:16-34.
45. Severin, F., B. Habermann, T. Huffaker, and T. Hyman. 2001a. Stu2 promotes mitotic spindle elongation in anaphase. J. Cell Biol. 153:435-442.
46. Severin, F., A.A. Hyman, and S. Piatti. 2001b. Correct spindle elongation at the metaphase/anaphase transition is an APC-dependent event in budding yeast. J. Cell Biol. 155:711-718.
47. Sharp-Baker, H., and R.H. Chen. 2001. Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity. J. Cell Biol. 153:1239-1250.
48. Shonn, M.A., R. McCarroll, and A.W. Murray. 2000. Requirement of the spindle checkpoint for proper chromosome segregation in budding yeast meiosis. Science. 289:300-303.
49. Shonn, M.A., A.L. Murray, and A.W. Murray. 2003. Spindle checkpoint component Mad2 contributes to biorientation of homologous chromosomes. Curr. Biol. 13:1979-1984.
50. Sorger, P.K., F.F. Severin, and A.A. Hyman. 1994. Factors required for the binding of reassembled yeast kinetochores to microtubules in vitro. J. Cell Biol. 127:995-1008.
51. Stern, B.M., and A.W. Murray. 2001. Lack of tension at kinetochores activates the spindle checkpoint in budding yeast. Curr. Biol. 11:1462-1467.
52. Strunnikov, A.V., J. Kingsbury, and D. Koshland. 1995. CEP3 encodes a centromere protein of Saccharomyces cerevisiae. J. Cell Biol. 128:749-760.
53. Tanaka, T.U., N. Rachidi, C. Janke, G. Pereira, M. Galova, E. Schiebel, M.J. Stark, and K. Nasmyth. 2002. Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Cell. 108:317-329.
54. Tavormina, P.A., and D.J. Burke. 1998. Cell cycle arrest in cdc20 mutants of Saccharomyces cerevisiae is independent of Ndc10p and kinetochore function but requires a subset of spindle checkpoint genes. Genetics. 148:1701-1713.
55. Trelles-Sticken, E., J. Loidl, and H. Scherthan. 1999. Bouquet formation in budding yeast: initiation of recombination is not required for meiotic telomere clustering. J. Cell Sci. 112:651-658.
56. Warren, C.D., D.M. Brady, R.C. Johnston, J.S. Hanna, K.G. Hardwick, and F.A. Spencer. 2002. Distinct chromosome segregation roles for spindle checkpoint proteins. Mol. Biol. Cell. 13:3029-3041.
57. Waters, J.C., R.H. Chen, A.W. Murray, and E.D. Salmon. 1998. Localization of Mad2 to kinetochores depends on microtubule attachment, not tension. J. Cell Biol. 141:1181-1191.
58. Wigge, P.A., and J.V. Kilmartin. 2001. The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation. J. Cell Biol. 152:349-360.
59. Yu, H. 2002. Regulation of APC-Cdc20 by the spindle checkpoint. Curr. Opin. Cell Biol. 14:706-714.
60. Zheng, L., Y. Chen, and W.H. Lee. 1999. Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins. Mol. Cell. Biol. 19:5417-5428.