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Volumn 66, Issue SUPPL. 3, 2007, Pages

Systemic lupus erythematosus: New molecular targets

Author keywords

[No Author keywords available]

Indexed keywords

CALMODULIN DEPENDENT KINASE IV; CASPASE 3; CD3 ANTIGEN; HERMES ANTIGEN; INTERLEUKIN 2; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOTRANSFERASE; PROTEIN KINASE SYK; RHO KINASE; TRANSCRIPTION FACTOR ELF 1; UNCLASSIFIED DRUG;

EID: 35648998047     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.2007.078493     Document Type: Conference Paper
Times cited : (30)

References (51)
  • 1
    • 0032502801 scopus 로고    scopus 로고
    • Homeostasis and self-tolerance in the immune system: Turning lymphocytes off
    • Parijs LV, Abbas AK. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science 1998;280:243-8.
    • (1998) Science , vol.280 , pp. 243-248
    • Parijs, L.V.1    Abbas, A.K.2
  • 2
    • 27344438941 scopus 로고    scopus 로고
    • Immune cells and cytokines in systemic lupus erythematosus: An update
    • Kyttaris VC, Juang YT, Tsokos GC. Immune cells and cytokines in systemic lupus erythematosus: an update. Curr Opin Rheumatol 2005;17:518-22.
    • (2005) Curr Opin Rheumatol , vol.17 , pp. 518-522
    • Kyttaris, V.C.1    Juang, Y.T.2    Tsokos, G.C.3
  • 3
    • 0038062836 scopus 로고    scopus 로고
    • Rewiring the T-cell: Signaling defects and novel prospects for the treatment of SLE
    • Tsokos GC, Nambiar MP, Tenbrock K, Juang YT. Rewiring the T-cell: signaling defects and novel prospects for the treatment of SLE. Trends Immunol 2003;24:259-63.
    • (2003) Trends Immunol , vol.24 , pp. 259-263
    • Tsokos, G.C.1    Nambiar, M.P.2    Tenbrock, K.3    Juang, Y.T.4
  • 4
    • 0029164734 scopus 로고
    • TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus
    • Vassilopoulos D, Kovacs B, Tsokos GC. TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus. J Immunol 1995;155:2269-81.
    • (1995) J Immunol , vol.155 , pp. 2269-2281
    • Vassilopoulos, D.1    Kovacs, B.2    Tsokos, G.C.3
  • 5
    • 0032036481 scopus 로고    scopus 로고
    • Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain
    • Liossis SN, Ding XZ, Dennis GJ, Tsokos GC. Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain. J Clin Invest 1998;101:1448-57.
    • (1998) J Clin Invest , vol.101 , pp. 1448-1457
    • Liossis, S.N.1    Ding, X.Z.2    Dennis, G.J.3    Tsokos, G.C.4
  • 6
    • 0033065837 scopus 로고    scopus 로고
    • Immune cell signaling defects in lupus: Activation, anergy and death
    • Tsokos GC, Liossis SN. Immune cell signaling defects in lupus: activation, anergy and death. Immunol Today 1999;20:119-24.
    • (1999) Immunol Today , vol.20 , pp. 119-124
    • Tsokos, G.C.1    Liossis, S.N.2
  • 7
    • 0347928787 scopus 로고    scopus 로고
    • Prevalence of T cell receptor zeta chain deficiency in systemic lupus erythematosus
    • Nambiar MP, Mitchell JP, Ceruti RP, Malloy MA, Tsokos GC. Prevalence of T cell receptor zeta chain deficiency in systemic lupus erythematosus. Lupus 2003;12:46-51.
    • (2003) Lupus , vol.12 , pp. 46-51
    • Nambiar, M.P.1    Mitchell, J.P.2    Ceruti, R.P.3    Malloy, M.A.4    Tsokos, G.C.5
  • 8
    • 0034966463 scopus 로고    scopus 로고
    • T cell signaling abnormalities in systemic lupus erythematosus are associated with increased mutations/polymorphisms and splice variants of T cell receptor zeta chain messenger RNA
    • Nambiar MP, Enyedy EJ, Warke VG, Krishnan S, Dennis G, Wong HK, et al. T cell signaling abnormalities in systemic lupus erythematosus are associated with increased mutations/polymorphisms and splice variants of T cell receptor zeta chain messenger RNA. Anhritis Rheum 2001;44:1336- 50.
    • (2001) Anhritis Rheum , vol.44 , pp. 1336-1350
    • Nambiar, M.P.1    Enyedy, E.J.2    Warke, V.G.3    Krishnan, S.4    Dennis, G.5    Wong, H.K.6
  • 9
    • 0034744286 scopus 로고    scopus 로고
    • Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus
    • Enyedy EJ, Nambiar MP, Liossis SN, Dennis G, Kammer GM, Tsokos GC. Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus. Arthritis Rheum 2001;44:1114-21.
    • (2001) Arthritis Rheum , vol.44 , pp. 1114-1121
    • Enyedy, E.J.1    Nambiar, M.P.2    Liossis, S.N.3    Dennis, G.4    Kammer, G.M.5    Tsokos, G.C.6
  • 11
    • 0033753014 scopus 로고    scopus 로고
    • Signal transduction by the high-affinity immunoglobulin E receptor FcRI: Coupling form to function
    • Nadler MJS, Mathews SA, Turner T, Kinet JP. Signal transduction by the high-affinity immunoglobulin E receptor FcRI: coupling form to function. Adv Immunol 2000;76:325-55.
    • (2000) Adv Immunol , vol.76 , pp. 325-355
    • Nadler, M.J.S.1    Mathews, S.A.2    Turner, T.3    Kinet, J.P.4
  • 12
    • 0037443553 scopus 로고    scopus 로고
    • Forced expression of the Fc receptor gamma-chain renders human T cells hyperresponsive to TCR/CD3 stimulation
    • Nambiar MP, Fisher CU, Kumar A, Tsokos CG, Warke VG, Tsokos GC. Forced expression of the Fc receptor gamma-chain renders human T cells hyperresponsive to TCR/CD3 stimulation. J Immunol 2003;170:2871-6.
    • (2003) J Immunol , vol.170 , pp. 2871-2876
    • Nambiar, M.P.1    Fisher, C.U.2    Kumar, A.3    Tsokos, C.G.4    Warke, V.G.5    Tsokos, G.C.6
  • 13
    • 0034978660 scopus 로고    scopus 로고
    • Polymorphisms/mutations of TCR-zeta-chain promoter and 3′ untranslated region and selective expression of TCR zeta-chain with an alternatively spliced 3′ untranslated region in patients with systemic lupus erythematosus
    • Nambiar MP, Enyedy EJ, Warke VG, Krishnan S, Dennis G, Kammer GM, et al. Polymorphisms/mutations of TCR-zeta-chain promoter and 3′ untranslated region and selective expression of TCR zeta-chain with an alternatively spliced 3′ untranslated region in patients with systemic lupus erythematosus. J Autoimmun 2001;16:133-42.
    • (2001) J Autoimmun , vol.16 , pp. 133-142
    • Nambiar, M.P.1    Enyedy, E.J.2    Warke, V.G.3    Krishnan, S.4    Dennis, G.5    Kammer, G.M.6
  • 14
    • 0037111374 scopus 로고    scopus 로고
    • Defective production of functional 98-kDa form of Elf-1 is responsible for the decreased expression of TCR zeta-chain in patients with systemic lupus erythematosus
    • Juang YT, Tenbrock K, Nambiar MP, Gourley MF, Tsokos GC. Defective production of functional 98-kDa form of Elf-1 is responsible for the decreased expression of TCR zeta-chain in patients with systemic lupus erythematosus. J Immunol 2002;169:6048-55.
    • (2002) J Immunol , vol.169 , pp. 6048-6055
    • Juang, Y.T.1    Tenbrock, K.2    Nambiar, M.P.3    Gourley, M.F.4    Tsokos, G.C.5
  • 15
    • 21344456900 scopus 로고    scopus 로고
    • Decreased stability and translation of T cell receptor zeta mRNA with an alternatively spliced 3′-untranslated region contribute to zeta chain down-regulation in patients with systemic lupus erythematosus
    • Chowdhury B, Tsokos CG, Krishnan S, Robertson J, Fisher CU, Warke RG, et al. Decreased stability and translation of T cell receptor zeta mRNA with an alternatively spliced 3′-untranslated region contribute to zeta chain down-regulation in patients with systemic lupus erythematosus. J Biol Chem 2005;280:18959-66.
    • (2005) J Biol Chem , vol.280 , pp. 18959-18966
    • Chowdhury, B.1    Tsokos, C.G.2    Krishnan, S.3    Robertson, J.4    Fisher, C.U.5    Warke, R.G.6
  • 16
    • 23844449332 scopus 로고    scopus 로고
    • Increased caspase-3 expression and activity contribute to reduced CD3zeta expression in systemic lupus erythematosus T cells
    • Krishnan S, Kiang JG, Fisher CU, Nambiar MP, Nguyen HT, Kyttaris VC, et al. Increased caspase-3 expression and activity contribute to reduced CD3zeta expression in systemic lupus erythematosus T cells. J Immunol 2005;175:3417-23.
    • (2005) J Immunol , vol.175 , pp. 3417-3423
    • Krishnan, S.1    Kiang, J.G.2    Fisher, C.U.3    Nambiar, M.P.4    Nguyen, H.T.5    Kyttaris, V.C.6
  • 17
    • 27144541457 scopus 로고    scopus 로고
    • The cyclic AMP response element modulator regulates transcription of the TCR zeta-chain
    • Tenbrock K, Kyttaris VC, Ahlmann M, Ehrchen JM, Tolnay M, Melkonyan H, et al. The cyclic AMP response element modulator regulates transcription of the TCR zeta-chain. J Immunol 2005;175:5975-80.
    • (2005) J Immunol , vol.175 , pp. 5975-5980
    • Tenbrock, K.1    Kyttaris, V.C.2    Ahlmann, M.3    Ehrchen, J.M.4    Tolnay, M.5    Melkonyan, H.6
  • 18
    • 33751566519 scopus 로고    scopus 로고
    • Stability and translation of TCR zeta mRNA are regulated by the adenosine-uridine-rich elements in splice-deleted 3′ untranslated region of zeta-chain
    • Chowdhury B, Krishnan S, Tsokos CG, Robertson JW, Fisher CU, Nambiar MP, et al. Stability and translation of TCR zeta mRNA are regulated by the adenosine-uridine-rich elements in splice-deleted 3′ untranslated region of zeta-chain. J Immunol 2006;177:8248-57.
    • (2006) J Immunol , vol.177 , pp. 8248-8257
    • Chowdhury, B.1    Krishnan, S.2    Tsokos, C.G.3    Robertson, J.W.4    Fisher, C.U.5    Nambiar, M.P.6
  • 19
    • 34247374347 scopus 로고    scopus 로고
    • TCRzeta mRNA splice variant forms observed in the peripheral blood T cells from systemic lupus erythematosus patients
    • Tsuzaka K, Nozaki K, Kumazawa C, Shiraishi K, Setoyama Y, Yoshimoto K, et al. TCRzeta mRNA splice variant forms observed in the peripheral blood T cells from systemic lupus erythematosus patients. Springer Semin Immunopathol 2006;28:185-93.
    • (2006) Springer Semin Immunopathol , vol.28 , pp. 185-193
    • Tsuzaka, K.1    Nozaki, K.2    Kumazawa, C.3    Shiraishi, K.4    Setoyama, Y.5    Yoshimoto, K.6
  • 20
    • 33745839779 scopus 로고    scopus 로고
    • Abnormal Fas/FasL and caspase-3-mediated apoptotic signaling pathways of T lymphocyte subset in patients with systemic lupus erythematosus
    • Xue C, Lan-Lan W, Bei C, Jie C, Wei-Hua F. Abnormal Fas/FasL and caspase-3-mediated apoptotic signaling pathways of T lymphocyte subset in patients with systemic lupus erythematosus. Cell Immunol 2006;239:121-8.
    • (2006) Cell Immunol , vol.239 , pp. 121-128
    • Xue, C.1    Lan-Lan, W.2    Bei, C.3    Jie, C.4    Wei-Hua, F.5
  • 22
    • 14844347540 scopus 로고    scopus 로고
    • A splice variant of the TCR zeta mRNA lacking exon 7 leads to the down-regulation of TCR zeta, the TCR/CD3 complex, and IL-2 production in systemic lupus erythematosus T cells
    • Tsuzaka K, Setoyama Y, Yoshimoto K, Shiraishi K, Suzuki K, Abe T, et al. A splice variant of the TCR zeta mRNA lacking exon 7 leads to the down-regulation of TCR zeta, the TCR/CD3 complex, and IL-2 production in systemic lupus erythematosus T cells. J Immunol 2005;174:3518-25.
    • (2005) J Immunol , vol.174 , pp. 3518-3525
    • Tsuzaka, K.1    Setoyama, Y.2    Yoshimoto, K.3    Shiraishi, K.4    Suzuki, K.5    Abe, T.6
  • 23
    • 0038342830 scopus 로고    scopus 로고
    • Reconstitution of deficient T cell receptor zeta chain restores T cell signaling and augments T cell receptor/CD3-induced interleukin-2 production in patients with systemic lupus erythematosus
    • Nambiar MP, Fisher CU, Warke VG, Krishnan S, Mitchell JP, Delaney N, et al. Reconstitution of deficient T cell receptor zeta chain restores T cell signaling and augments T cell receptor/CD3-induced interleukin-2 production in patients with systemic lupus erythematosus. Arthritis Rheum 2003;48:1948-55.
    • (2003) Arthritis Rheum , vol.48 , pp. 1948-1955
    • Nambiar, M.P.1    Fisher, C.U.2    Warke, V.G.3    Krishnan, S.4    Mitchell, J.P.5    Delaney, N.6
  • 24
    • 0030949124 scopus 로고    scopus 로고
    • Functional rafts in cell membranes
    • Simons K, Ikonen E. Functional rafts in cell membranes. Nature 1997;387:569-72.
    • (1997) Nature , vol.387 , pp. 569-572
    • Simons, K.1    Ikonen, E.2
  • 25
    • 0034625373 scopus 로고    scopus 로고
    • Structure and function of sphingolipid- and cholesterol-rich membrane rafts
    • Brown DA, London E. Structure and function of sphingolipid- and cholesterol-rich membrane rafts. J Biol Chem 2000;275:17221-4.
    • (2000) J Biol Chem , vol.275 , pp. 17221-17224
    • Brown, D.A.1    London, E.2
  • 26
    • 2942586874 scopus 로고    scopus 로고
    • Alterations in lipid raft composition and dynamics contribute to abnormal T cell responses in systemic lupus erythematosus
    • Krishnan S, Nambiar MP, Warke VG, Fisher CU, Mitchell J, Delaney N, et al. Alterations in lipid raft composition and dynamics contribute to abnormal T cell responses in systemic lupus erythematosus. J Immunol 2004;172:7821-31.
    • (2004) J Immunol , vol.172 , pp. 7821-7831
    • Krishnan, S.1    Nambiar, M.P.2    Warke, V.G.3    Fisher, C.U.4    Mitchell, J.5    Delaney, N.6
  • 27
    • 0036164354 scopus 로고    scopus 로고
    • Abnormal expression of various molecular forms and distribution of T cell receptor zeta chain in patients with systemic lupus erythematosus
    • Nambiar MP, Enyedy EJ, Fisher CU, Krishnan S, Warke VG, Gilliland WR, et al. Abnormal expression of various molecular forms and distribution of T cell receptor zeta chain in patients with systemic lupus erythematosus. Arthritis Rheum 2002;46:163-74.
    • (2002) Arthritis Rheum , vol.46 , pp. 163-174
    • Nambiar, M.P.1    Enyedy, E.J.2    Fisher, C.U.3    Krishnan, S.4    Warke, V.G.5    Gilliland, W.R.6
  • 28
    • 2142710163 scopus 로고    scopus 로고
    • Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus
    • Jury EC, Kabouridis PS, Flores-Borja F, Mageed RA, lsenberg DA. Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus. J Clin Invest 2004;113:1176-87.
    • (2004) J Clin Invest , vol.113 , pp. 1176-1187
    • Jury, E.C.1    Kabouridis, P.S.2    Flores-Borja, F.3    Mageed, R.A.4    lsenberg, D.A.5
  • 29
    • 0033998793 scopus 로고    scopus 로고
    • The role of lipid rafts in T cell antigen receptor (TCR) signalling
    • Janes PW, Ley SC, Magee AI, Kabouridis PS. The role of lipid rafts in T cell antigen receptor (TCR) signalling. Semin Immunol 2000;12:23-34.
    • (2000) Semin Immunol , vol.12 , pp. 23-34
    • Janes, P.W.1    Ley, S.C.2    Magee, A.I.3    Kabouridis, P.S.4
  • 30
    • 0032101348 scopus 로고    scopus 로고
    • Membrane compartmentation is required for efficient T cell activation
    • Xavier R, Brennan T, Li Q, McCormack C, Seed B. Membrane compartmentation is required for efficient T cell activation. Immunity 1998;8:723-32.
    • (1998) Immunity , vol.8 , pp. 723-732
    • Xavier, R.1    Brennan, T.2    Li, Q.3    McCormack, C.4    Seed, B.5
  • 31
    • 33846536952 scopus 로고    scopus 로고
    • Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus
    • Li Y, Harada T, Juang YT, Kyttaris VC, Wang Y, Zidanic M, et al. Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus. J Immunol 2007;178:1938-47.
    • (2007) J Immunol , vol.178 , pp. 1938-1947
    • Li, Y.1    Harada, T.2    Juang, Y.T.3    Kyttaris, V.C.4    Wang, Y.5    Zidanic, M.6
  • 33
    • 33646186619 scopus 로고    scopus 로고
    • Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis
    • Ma A, Koka R, Burkett P. Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. Annu Rev Immunol 2006;24:657-79.
    • (2006) Annu Rev Immunol , vol.24 , pp. 657-679
    • Ma, A.1    Koka, R.2    Burkett, P.3
  • 34
    • 0019948507 scopus 로고
    • Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus
    • Alcocer-Varela J, Alarcon-Segovia D. Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus. J Clin Invest 1982;69:1388-92.
    • (1982) J Clin Invest , vol.69 , pp. 1388-1392
    • Alcocer-Varela, J.1    Alarcon-Segovia, D.2
  • 35
    • 0030560974 scopus 로고    scopus 로고
    • Defective CD3-mediated cell death in activated T cells from patients with systemic lupus erythematosus: Role of decreased intracellular TNF-alpha
    • Kovacs B, Vassilopoulos D, Vogelgesang SA, Tsokos GC. Defective CD3-mediated cell death in activated T cells from patients with systemic lupus erythematosus: role of decreased intracellular TNF-alpha. Clin Immunol Immunopathol 1996;81:293-302.
    • (1996) Clin Immunol Immunopathol , vol.81 , pp. 293-302
    • Kovacs, B.1    Vassilopoulos, D.2    Vogelgesang, S.A.3    Tsokos, G.C.4
  • 36
    • 0242403301 scopus 로고    scopus 로고
    • Quantification of regulatory T cells in patients with systemic lupus erythematosus
    • Crispin JC, Martinez A, Alcocer-Varela J. Quantification of regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun 2003;21:273-6.
    • (2003) J Autoimmun , vol.21 , pp. 273-276
    • Crispin, J.C.1    Martinez, A.2    Alcocer-Varela, J.3
  • 37
    • 33846900430 scopus 로고    scopus 로고
    • Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus
    • Valencia X, Yarboro C, Illei G, Lipsky PE. Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol 2007;178:2579-88.
    • (2007) J Immunol , vol.178 , pp. 2579-2588
    • Valencia, X.1    Yarboro, C.2    Illei, G.3    Lipsky, P.E.4
  • 38
    • 0029815848 scopus 로고    scopus 로고
    • A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation
    • Rothenberg EV, Ward SB. A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation. PNAS 1996;93:9358-65.
    • (1996) PNAS , vol.93 , pp. 9358-9365
    • Rothenberg, E.V.1    Ward, S.B.2
  • 39
    • 33750219508 scopus 로고    scopus 로고
    • Both integrated and differential regulation of components of the IL-2/IL-2 receptor system
    • Kim HP, Imbert J, Leonard WJ. Both integrated and differential regulation of components of the IL-2/IL-2 receptor system. Cytokine Growth Factor Rev 2006;17:349-66.
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 349-366
    • Kim, H.P.1    Imbert, J.2    Leonard, W.J.3
  • 40
    • 0033179001 scopus 로고    scopus 로고
    • Abnormal NF-kappa B activity in T lymphocytes from patients with systemic lupus erythematosus is associated with decreased p65-RelA protein expression
    • Wong HK, Kammer GM, Dennis G, Tsokos GC. Abnormal NF-kappa B activity in T lymphocytes from patients with systemic lupus erythematosus is associated with decreased p65-RelA protein expression. J Immunol 1999;163:1682-9.
    • (1999) J Immunol , vol.163 , pp. 1682-1689
    • Wong, H.K.1    Kammer, G.M.2    Dennis, G.3    Tsokos, G.C.4
  • 41
    • 0036264363 scopus 로고    scopus 로고
    • Direct transfer of p65 into T lymphocytes from systemic lupus erythematosus patients leads to increased levels of interleukin-2 promoter activity
    • Herndon TM, Juang YT, Solomou EE, Rothwell SW, Gourley MF, Tsokos GC. Direct transfer of p65 into T lymphocytes from systemic lupus erythematosus patients leads to increased levels of interleukin-2 promoter activity. Clin Immunol 2002;103:145-53.
    • (2002) Clin Immunol , vol.103 , pp. 145-153
    • Herndon, T.M.1    Juang, Y.T.2    Solomou, E.E.3    Rothwell, S.W.4    Gourley, M.F.5    Tsokos, G.C.6
  • 42
    • 3042534462 scopus 로고    scopus 로고
    • Transcriptional regulation of interleukin 2 in SLE T cells
    • Tenbrock K, Tsokos GC. Transcriptional regulation of interleukin 2 in SLE T cells. Int Rev Immunol 2004;23:333-45.
    • (2004) Int Rev Immunol , vol.23 , pp. 333-345
    • Tenbrock, K.1    Tsokos, G.C.2
  • 43
    • 0037443547 scopus 로고    scopus 로고
    • The cyclic adenosine 5′-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism
    • Tenbrock K, Juang YT, Tolnay M, Tsokos GC. The cyclic adenosine 5′-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism. J Immunol 2003;170:2971-6.
    • (2003) J Immunol , vol.170 , pp. 2971-2976
    • Tenbrock, K.1    Juang, Y.T.2    Tolnay, M.3    Tsokos, G.C.4
  • 44
    • 0037108487 scopus 로고    scopus 로고
    • Antisense cyclic adenosine 5′-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic lupus erythematosus
    • Tenbrock K, Juang YT, Gourley MF, Nambiar MP, Tsokos GC. Antisense cyclic adenosine 5′-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic lupus erythematosus. J Immunol 2002;169:4147-52.
    • (2002) J Immunol , vol.169 , pp. 4147-4152
    • Tenbrock, K.1    Juang, Y.T.2    Gourley, M.F.3    Nambiar, M.P.4    Tsokos, G.C.5
  • 45
    • 4344718846 scopus 로고    scopus 로고
    • Cyclic adenosine 5′-monophosphate response element modulator is responsible for the decreased expression of c-fos and activator protein-1 binding in T cells from patients with systemic lupus erythematosus
    • Kyttaris VC, Juang YT, Tenbrock K, Weinstein A, Tsokos GC. Cyclic adenosine 5′-monophosphate response element modulator is responsible for the decreased expression of c-fos and activator protein-1 binding in T cells from patients with systemic lupus erythematosus. J Immunol 2004;173:3557-63.
    • (2004) J Immunol , vol.173 , pp. 3557-3563
    • Kyttaris, V.C.1    Juang, Y.T.2    Tenbrock, K.3    Weinstein, A.4    Tsokos, G.C.5
  • 46
    • 16844376445 scopus 로고    scopus 로고
    • Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV
    • Juang YT, Wang Y, Solomou EE, Li Y, Mawrin C, Tenbrock K, et al. Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV. J Clin Invest 2005;115:996-1005.
    • (2005) J Clin Invest , vol.115 , pp. 996-1005
    • Juang, Y.T.1    Wang, Y.2    Solomou, E.E.3    Li, Y.4    Mawrin, C.5    Tenbrock, K.6
  • 47
    • 0035252894 scopus 로고    scopus 로고
    • Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
    • Janssens V, Goris J. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J 2001;353:417-39.
    • (2001) Biochem J , vol.353 , pp. 417-439
    • Janssens, V.1    Goris, J.2
  • 48
    • 0027221605 scopus 로고
    • Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation
    • Wadzinski BE, Wheat WH, Jaspers S, Peruski LF, Lickteig RL, Johnson GL, et al. Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation. Mol Cell Biol 1993;13:2822-34.
    • (1993) Mol Cell Biol , vol.13 , pp. 2822-2834
    • Wadzinski, B.E.1    Wheat, W.H.2    Jaspers, S.3    Peruski, L.F.4    Lickteig, R.L.5    Johnson, G.L.6
  • 49
    • 0027441139 scopus 로고
    • Interleukin-1-induced signaling in T-cells. Evidence for the involvement of phosphatases PP1 and PP2A in regulating protein kinase C-mediated protein phosphorylation and interleukin-2 synthesis
    • Kracht M, Heiner A, Resch K, Szamel M. Interleukin-1-induced signaling in T-cells. Evidence for the involvement of phosphatases PP1 and PP2A in regulating protein kinase C-mediated protein phosphorylation and interleukin-2 synthesis. J Biol Chem 1993;268:21066-72.
    • (1993) J Biol Chem , vol.268 , pp. 21066-21072
    • Kracht, M.1    Heiner, A.2    Resch, K.3    Szamel, M.4
  • 50
    • 27644546349 scopus 로고    scopus 로고
    • Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus
    • Katsiari CG, Kyttaris VC, Juang YT, Tsokos GC. Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus. J Clin Invest 2005;115:3193-204.
    • (2005) J Clin Invest , vol.115 , pp. 3193-3204
    • Katsiari, C.G.1    Kyttaris, V.C.2    Juang, Y.T.3    Tsokos, G.C.4
  • 51
    • 31144451804 scopus 로고    scopus 로고
    • Transcriptional repression of interleukin-2 in human systemic lupus erythematosus
    • Katsiari CG, Tsokos GC. Transcriptional repression of interleukin-2 in human systemic lupus erythematosus. Autoimmun Rev 2006;5:118-21.
    • (2006) Autoimmun Rev , vol.5 , pp. 118-121
    • Katsiari, C.G.1    Tsokos, G.C.2


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