Abnormal NF-κB activity in T lymphocytes from patients with systemic lupus erythematosus is associated with decreased p65-RelA protein expression

Journal of Immunology

Volumn 163, Issue 3, 1999, Pages 1682-1689

  Wong, Henry K ^a   Kammer, Gary M ^b   Dennis, Greg ^c   Tsokos, George C ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b Uniformed Services University of the Health Sciences   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CYTOKINE; HYDROXYCHLOROQUINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; METHOTREXATE; STEROID; T LYMPHOCYTE RECEPTOR;

ANTIBODY SPECIFICITY; ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE;

AUTORADIOGRAPHY; CALCIMYCIN; DNA-BINDING PROTEINS; DOWN-REGULATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; KINETICS; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE ACTIVATION; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; NORMAL DISTRIBUTION; RECEPTORS, ANTIGEN, T-CELL; SEVERITY OF ILLNESS INDEX; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE; TIME FACTORS; TRANSCRIPTION FACTOR RELA;

EID: 0033179001     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Tsokos, G. C., B. Kovacs, and S. N. Liossis. 1997. Lymphocytes, cytokines, inflammation, and immune trafficking. Curr. Opin. Rheum. 9:380.
2. Liossis, S. N., P. P. Sfikakis, and G. C. Tsokos. 1998. Immune cell signaling aberrations in human lupus. Immunol. Res. 18:27.
3. Vassilopoulos, D., B. Kovacs, and G. C. Tsokos. 1995. TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus. J. Immunol. 155:2269.
4. Liossis, S. N., X. Z. Ding, G. J. Dennis, and G. C. Tsokos. 1998. Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus: deficient expression of the T cell receptor ζ-chain. J. Clin. Invest. 101:1448.
5. Dayal, A. K., and G. M. Kammer. 1996. The T cell enigma in lupus. Arthritis Rheum. 39:23.
6. Kammer, G. M., I. U. Khan, J. A. Kammer, I. Olorenshaw, and D. Mathis. 1996. Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes: II. Abnormal isozyme kinetics. J. Immunol. 157:2690.
7. Kammer, G. M., I. U. Khan, and C. J. Malemud. 1994. Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes. J. Clin. Invest. 94:422.
8. Koshy, M., D. Berger, and M. K. Crow. 1996. Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes. J. Clin. Invest 98:826.
9. Desai-Mehta, A., L. Lu, R. Ramsey-Goldman, and S. K. Datta. 1996. Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production. J. Clin. Invest. 97:2063.
10. Kovacs, B., S. N. Liossis, G. J. Dennis, and G. C. Tsokos. 1997. Increased expression of functional Fas-ligand in activated T cells from patients with systemic lupus erythematosus. Autoimmunity 25:213.
11. Stohl, W. 1995. Impaired polyclonal T cell cytolytic activity: a possible risk factor for systemic lupus erythematosus. Arthritis Rheum. 38:506.
12. Ohtsuka, K., J. D. Gray, M. M. Stimmler, B. Toro, and D. A. Horwitz. 1998. Decreased production of TGF-β by lymphocytes from patients with systemic lupus erythematosus. J. Immunol. 160:2539.
13. Kovacs, B., D. Vassilopoulos, S. A. Vogelgesang, and G. C. Tsokos. 1996. Defective CD3-mediated cell death in activated T cells from patients with systemic lupus erythematosus: role of decreased intracellular TNF-α. Clin. Immunol. Immunopathol. 81:293.
14. Alcocer-Varela, J., and D. Alarcon-Segovia. 1982. Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus. J. Clin. Invest. 69:1388.
15. de Faucal, P., A. Godard, M. A. Peyrat, J. F. Moreau, and J. P. Soulillou. 1984. Impaired IL-2 production by lymphocytes of patients with systemic lupus erythematosus. Ann. Immunol. 135:161.
16. Linker-Israeli, M., A. C. Bakke, R. C. Kitridou, S. Gendler, S. Gillis, and D. A. Horwitz. 1983. Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE). J. Immunol. 130:2651.
17. Murakawa, Y., S. Takada, Y. Ueda, N. Suzuki, T. Hoshino, and T. Sakane. 1985. Characterization of T lymphocyte subpopulations responsible for deficient interleukin 2 activity in patients with systemic lupus erythematosus. J. Immunol. 134: 187.
18. Fraser, J. D., D. Straus, and A. Weiss. 1993. Signal transduction events leading to T-cell lymphokine gene expression. Immunol. Today 14:357.
19. Jain, J., C. Loh, and A. Rao. 1995. Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol. 7:333.
20. Rothenberg, E. V., and S. B. Ward. 1996. A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation. Proc. Natl. Acad. Sci. USA 93:9358.
21. Berridge, M. J. 1997. Lymphocyte activation in health and disease. Crit. Rev. Immunol. 17:155.
22. Kalli, K., C. Huntoon, M. Bell, and D. J. McKean. 1998. Mechanism responsible for T-cell antigen receptor-and CD28-or interleukin 1 (IL-1) receptor-initiated regulation of IL-2 gene expression by NF-κB. Mol. Cell. Biol. 18:3140.
23. Granelli-Piperno, A., and P. Nolan. 1991. Nuclear transcription factors that bind to elements of the IL-2 promoter: induction requirements in primary human T cells. J. Immunol. 147:2734.
24. McGuire, K. L., and M. Iacobelli. 1997. Involvement of Rel, Fos, and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells. J. Immunol. 159:1319.
25. Hughes, C. C., and J. S. Pober. 1996. Transcriptional regulation of the interleukin-2 gene in normal human peripheral blood T cells: convergence of costimulatory signals and differences from transformed T cells. J. Biol. Chem. 271:5369.
26. Maggirwar, S. B., E. W. Harhaj, and S. C. Sun. 1997. Regulation of the interleukin-2 CD28-responsive element by NF-ATp and various NF-κB/Rel transcription factors. Mol. Cell. Biol. 17:2605.
27. Lai, J. H., G. Horvath, J. Subleski, J. Bruder, P. Ghosh, and T. H. Tan. 1995. RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 promoter. Mol. Cell. Biol. 15:4260.
28. Musso, M., P. Ghiorzo, P. Fiorentini, R. Giuffrida, P. Ciotti, C. Garre, R. Ravazzolo, and G. Bianchi-Scarra. 1996. An upstream positive regulatory element in human GM-CSF promoter is recognized by NF-κB/Rel family members. Biochem. Biophys. Res. Commun. 223:64.
29. Shannon, M. F., S. R. Himes, and L. S. Coles. 1995. GM-CSF and IL-2 share common control mechanisms in response to costimulatory signals in T cells. J. Leukocyte Biol. 57:767.
30. Delphin, S., and J. Stavnezer. 1995. Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-κB/p50. J. Exp. Med. 181:181.
31. Kasibhatla, S., L. Genestier, and D. R. Green. 1999. Regulation of Fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor κB. J. Biol. Chem. 274:987.
32. Attar, R. M., J. Caamano, D. Carrasco, V. Iotsova, H. Ishikawa, R. P. Ryseck, F. Weih, and R. Bravo. 1997. Genetic approaches to study Rel/NF-κB/I κB function in mice. Semin. Cancer Biol. 8:93.
33. Harlow, E., and D. Lane. 1988. Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Plainview.
34. Andrews, N. C., and D. V. Faller. 1991. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19:2499.
35. May, M. J., and S. Ghosh. 1997. Rel/NF-κB and I κB proteins: an overview. Semin. Cancer Biol. 8:63.
36. Scheinman, R. I., P. C. Cogswell, A. K. Lofquist, and A. S. Baldwin, Jr. 1995. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids [see comments]. Science 270:283.
37. Auphan, N., J. A. DiDonato, C. Rosette, A. Helmberg, and M. Karin. 1995. Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB synthesis [see comments]. Science 270:286.
38. Sussman, J. J., J. S. Bonifacino, J. Lippincott-Schwartz, A. M. Weissman, T. Saito, R. D. Klausner, and J. D. Ashwell. 1988. Failure to synthesize the T cell CD3-ζ chain: structure and function of a partial T cell receptor complex. Cell 52:85.
39. Ballard, D. W., E. P. Dixon, N. J. Peffer, H. Bogerd, S. Doerre, B. Stein, and W. C. Greene. 1992. The 65-kDa subunit of human NF-κB functions as a potent transcriptional activator and a target for v-Rel-mediated repression. Proc. Natl. Acad. Sci. USA 89:1875.
40. Baer, M., A. Dillner, R. C. Schwartz, C. Sedon, S. Nedospasov, and P. F. Johnson. 1998. Tumor necrosis factor α transcription in macrophages is attenuated by an autocrine factor that preferentially induces NF-κB p50. Mol. Cell. Biol. 18:5678.
41. + T cells express perturbed AP-1 and NF-κB transcription factors. Proc. Natl. Acad. Sci. USA 93:979.
42. Baldwin, A. S., Jr. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649.
43. Beg, A. A., W. C. Sha, R. T. Bronson, S. Ghosh, and D. Baltimore. 1995. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature 376:167.
44. Sha, W. C., H. C. Liou, E. I. Tuomanen, and D. Baltimore. 1995. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell 80:321.
45. Horak, I. 1995. Immunodeficiency in IL-2-knockout mice. Clin. Immunol. Immunopathol. 76:S172.
46. Contractor, N. V., H. Bassiri, T. Reya, A. Y. Park, D. C. Baumgart, M. A. Wasik, S. G. Emerson, and S. R. Carding. 1998. Lymphoid hyperplasia, autoimmunity, and compromised intestinal intraepithelial lymphocyte development in colitis-free gnotobiotic IL-2-deficient mice. J. Immunol. 160:385.