Decreased stability and translation of T cell receptor ζ mRNA with an alternatively spliced 3′-untranslated region contribute to ζ chain down-regulation in patients with systemic lupus erythematosus

Journal of Biological Chemistry

Volumn 280, Issue 19, 2005, Pages 18959-18966

  Chowdhury, Bhabadeb ^a   Tsokos, Christos G ^a   Krishnan, Sandeep ^a   Robertson, James ^a   Fisher, Carolyn U ^a   Warke, Rahul G ^a   Warke, Vishal G ^a   Nambiar, Madhusoodana P ^a   Tsokos, George C ^a,b,c  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^c WRAIR   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; BIOSENSORS; CELLS; CONCENTRATION (PROCESS); GENETIC ENGINEERING; MUTAGENESIS; RNA;

MOLECULAR MECHANISMS; SYSTEMIC LUPUS ERYTHEMATOSUS; T CELL RECPTOR (TCR);

ENZYMES;

LUCIFERASE; MESSENGER RNA; NUCLEOTIDE; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ZETA CHAIN; UNCLASSIFIED DRUG; ANTIGEN T CELL RECEPTOR, ZETA CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; PRIMER DNA;

3' UNTRANSLATED REGION; ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; CELL LYSATE; CELL STRAIN COS7; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RECEPTOR DOWN REGULATION; RNA STABILITY; RNA TRANSCRIPTION; RNA TRANSLATION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; TRANSLATION REGULATION; ANIMAL; CELL STRAIN COS1; CHEMISTRY; DENSITOMETRY; DOWN REGULATION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; LEUKEMIA CELL LINE; METABOLISM; MOLECULAR CLONING; PROTEIN TERTIARY STRUCTURE; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME;

ANIMALIA;

3' UNTRANSLATED REGIONS; ALTERNATIVE SPLICING; ANIMALS; CLONING, MOLECULAR; COS CELLS; DENSITOMETRY; DNA PRIMERS; DOWN-REGULATION; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; IMMUNOBLOTTING; JURKAT CELLS; LUCIFERASES; LUPUS ERYTHEMATOSUS, SYSTEMIC; MEMBRANE PROTEINS; PROTEIN BIOSYNTHESIS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ANTIGEN, T-CELL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 21344456900     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501048200     Document Type: Article

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