The cyclic adenosine 5′-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism

Journal of Immunology

Volumn 170, Issue 6, 2003, Pages 2971-2976

  Tenbrock, Klaus ^a   Juang, Yuang Taung ^a   Tolnay, Mate ^a   Tsokos, George C ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; CD28 ANTIGEN; CD3 ANTIGEN; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ENDONUCLEASE; HISTONE; HISTONE ACETYLTRANSFERASE; IMMUNOMODULATING AGENT; INTERLEUKIN 2;

ACETYLATION; ARTICLE; CHROMATIN; CHROMATIN CONDENSATION; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; CYTOKINE PRODUCTION; ENZYME ACTIVITY; GENE INDUCTION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NORMAL HUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0037443547     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.6.2971     Document Type: Article

References (40)

1. Jain, J., C. Loh, and A. Rao. 1995. Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol. 7:333.
2. Rothenberg, E. V., and S. B. Ward. 1996. A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation. Proc. Natl. Acad. Sci. USA 93:9358.
3. Powell, J. D., J. A. Ragheb, S. Kitagawa-Sakakida, and R. H. Schwartz. 1998. Molecular regulation of interleukin-2 expression by CD28 costimulation and anergy. Immunol. Rev. 165:287.
4. Umlauf, S. W., B. Beverly, O. Lantz, and R. H. Schwartz. 1995. Regulation of interleukin 2 gene expression by CD28 costimulation in mouse T-cell clones: both nuclear and cytoplasmic RNAs are regulated with complex kinetics. Mol. Cell Biol. 15:3197.
5. Ragheb, J. A., M. Deen, and R. H. Schwartz. 1999. CD28-Mediated regulation of mRNA stability requires sequences within the coding region of the IL-2 mRNA. J. Immunol. 163:120.
6. Solomou, E. E., Y. T. Juang, M. F. Gourley, G. M. Kammer, and G. C. Tsokos. 2001. Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus. J. Immunol. 166:4216.
7. Powell, J. D., C. G. Lerner, G. R. Ewoldt, and R. H. Schwartz. 1999. The -180 site of the IL-2 promoter is the target of CREB/CREM binding in T cell anergy. J. Immunol. 163:6631.
8. Tenbrock, K., Y. T. Juang, M. F. Gourley, M. P. Nambiar, and G. C. Tsokos. 2002. Antisense cyclic adenosine 5′-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic lupus erythematosus. J. Immunol. 169:4147.
9. Solomou, E. E., Y. T. Juang, and G. C. Tsokos. 2001. Protein kinase C-θ participates in the activation of cyclic AMP-responsive element-binding protein and its subsequent binding to the -180 site of the IL-2 promoter in normal human T lymphocytes. J. Immunol. 166:5665.
10. Barton, K., N. Muthusamy, M. Chanyangam, C. Fischer, C. Clendenin, and J. M. Leiden. 1996. Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB. Nature 379:81.
11. Hussain, M. A., P. B. Daniel, and J. F. Habener. 2000. Glucagon stimulates expression of the inducible cAMP early repressor and suppresses insulin gene expression in pancreatic β-cells. Diabetes 49:1681.
12. Foulkes, N. S., G. Duval, and P. Sassone-Corsi. 1996. Adaptive inducibility of CREM as transcriptional memory of circadian rhythms. Nature 381:83.
13. Sassone-Corsi, P. 1995. Transcription factors responsive to cAMP. Annu. Rev. Cell. Dev. Biol. 11:355.
14. Daniel, P. B., L. Rohrbach, and J. F. Habener. 2000. Novel cyclic adenosine 3′,5′monophosphate (cAMP) response element modulator θ isoforms expressed by two newly identified cAMP-responsive promoters active in the testis. Endocrinology 141:3923.
15. Foulkes, N. S., E. Borrelli, and P. Sassone-Corsi. 1991. CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell 64:739.
16. De Cesare, D., and P. Sassone-Corsi. 2000. Transcriptional regulation by cyclic AMP-responsive factors. Prog. Nucleic Acid Res. Mol. Biol. 64:343.
17. Monaco, L., and P. Sassone-Corsi. 1997. Cross-talk in signal transduction: Ras-dependent induction of cAMP-responsive transcriptional repressor ICER by nerve growth factor. Oncogene 15:2493.
18. Bodor, J., L. Feigenbaum, J. Bodorova, C. Bare, M. S. Reitz, Jr., and R. E. Gress. 2001. Suppression of T-cell responsiveness by inducible cAMP early repressor (ICER). J. Leukocyte Biol. 69:1053.
19. Bodor, J., J. Bodorova, and R. E. Gress. 2000. Suppression of T cell function: a potential role for transcriptional repressor ICER. J. Leukocyte Biol. 67:774.
20. Chrivia, J. C., R. P. Kwok, N. Lamb, M. Hagiwara, M. R. Montminy, and R. H. Goodman. 1993. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365:855.
21. Asahara, H., S. Tartare-Deckert, T. Nakagawa, T. Ikehara, F. Hirose, T. Hunter, T. Ito, and M. Montminy. 2002. Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. Mol. Cell Biol. 22:2974.
22. Asahara, H., B. Santoso, E. Guzman, K. Du, P. A. Cole, I. Davidson, and M. Montminy. 2001. Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB. Mol. Cell Biol. 21:7892.
23. Ferreri, K., G. Gill, and M. Montminy. 1994. The cAMP-regulated transcription factor CREB interacts with a component of the TFIID complex. Proc. Natl. Acad. Sci. U.S.A 91:1210.
24. Rao, S., E. Procko, and M. F. Shannon. 2001. Chromatin remodeling, measured by a novel real-time polymerase chain reaction assay, across the proximal promoter region of the IL-2 gene. J. Immunol. 167:4494.
25. Hughes, C. C., and J. S. Pober. 1996. Transcriptional regulation of the interleukin-2 gene in normal human peripheral blood T cells: convergence of costimulatory signals and differences from transformed T cells. J. Biol. Chem. 271:5369.
26. Garcia-Cozar, F. J., I. J. Molina, M. J. Cuadrado, M. Marubayashi, J. Pena, and M. Santamaria. 1996. Defective B7 expression on antigen-presenting cells underlying T cell activation abnormalities in systemic lupus erythematosus (SLE) patients. Clin. Exp. Immunol. 104:72.
27. Via, C. S., G. C. Tsokos, B. Bermas, M. Clerici, and G. M. Shearer. 1993. T cell-antigen-presenting cell interactions in human systemic lupus erythematosus: evidence for heterogeneous expression of multiple defects. J. Immunol. 151:3914.
28. Kammer, G. M., T. M. Haqqi, P. Hasler, and C. J. Malemud. 1993. The effect of circulating serum factors from patients with systemic lupus erythematosus on protein kinase A (PKA) activity and PKA-dependent protein phosphorylation in T lymphocytes. Clin. Immunol. Immunopathol. 67:8.
29. Tsokos, G. C., H. K. Wong, E. J. Enyedy, and M. P. Nambiar. 2000. Immune cell signaling in lupus. Curr. Opin. Rheumatol. 12:355.
30. Foulkes, N. S., B. M. Laoide, F. Schlotter, and P. Sassone-Corsi. 1991. Transcriptional antagonist cAMP-responsive element modulator (CREM) down-regulates c-fos cAMP-induced expression. Proc. Natl. Acad. Sci. USA 88:5448.
31. Masquilier, D., and P. Sassone-Corsi. 1992. Transcriptional cross-talk: nuclear factors CREM and CREB bind to AP-1 sites and inhibit activation by Jun. J. Biol. Chem. 267:22460.
32. Montminy, M. 1997. Transcriptional regulation by cyclic AMP. Annu. Rev. Biochem. 66:807.
33. Butscher, W. G., C. M. Haggerty, S. Chaudhry, and K. Gardner. 2001. Targeting of p300 to the interleukin-2 promoter via CREB-Rel cross-talk during mitogen and oncogenic molecular signaling in activated T-cells. J. Biol. Chem. 276:27647.
34. Merika, M., A. J. Williams, G. Chen, T. Collins, and D. Thanos. 1998. Recruitment of CBP/p300 by the IFN β enhanceosome is required for synergistic activation of transcription. Mol. Cell 1:277.
35. Mayr, B., and M. Montminy. 2001. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat. Rev. Mol. Cell Biol. 2:599.
36. Snowden, A. W., L. A. Anderson, G. A. Webster, and N. D. Perkins. 2000. A novel transcriptional repression domain mediates p21(WAF1/CIP1) induction of p300 transactivation. Mol. Cell. Biol. 20:2676.
37. Yang, S. H., D. C. Bumpass, N. D. Perkins, and A. D. Sharrocks. 2002. The ETS domain transcription factor Elk-1 contains a novel class of repression domain. Mol. Cell. Biol. 22:5036.
38. Yang, X., F. Zhang, and J. E. Kudlow. 2002. Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression. Cell 110:69.
39. Xu, W., H. Chen. K. Du, H. Asahara, M. Tini, B. M. Emerson, M. Montminy, and R. M. Evans. 2001. A transcriptional switch mediated by cofactor methylation. Science 294:2507.
40. Seo, S. B., P. McNamara, S. Heo, A. Turner, W. S. Lane, and D. Chakravarti. 2001. Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein. Cell 104:119.