Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: Synthesis and structure-activity relationships for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N- (benzyloxycarbonyl)amino)piperidin-1-yl)butanes

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 18, 2001, Pages 2475-2479

  Finke, Paul E ^a   Oates, Bryan ^a   Mills, Sander G ^a   MacCoss, Malcolm ^a   Malkowitz, Lorraine ^a   Springer, Martin S ^a   Gould, Sandra L ^a   DeMartino, Julie A ^a   Carella, Anthony ^a   Carver, Gwen ^a   Holmes, Karen ^a   Danzeisen, Renee ^a   Hazuda, Daria ^a   Kessler, Joseph ^a   Lineberger, Janet ^a   Miller, Michael ^a   Schleif, William A ^a   Emini, Emilio A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 CHLOROPHENYL) 1 [N (METHYL) N (PHENYLSULFONYL)AMINO] 4 [SPIRO(2,3 DIHYDROBENZOTHIOPHENE 3,4' PIPERIDIN 1' YL)]BUTANE SULFUR OXIDE; 4 [N (BENZYLOXYCARBONYL)AMINO]PIPERIDINE DERIVATIVE; ANTIVIRUS AGENT; BENZAMIDE DERIVATIVE; CARBAMIC ACID DERIVATIVE; CHEMOKINE RECEPTOR CCR5; N BENZYLOXYCARBONYLAMINO DERIVATIVE; PIPERIDINE DERIVATIVE; PROTEIN INHIBITOR; SPIRO COMPOUND; SPIRO(INDAN 1 ONE 2,4' PIPERIDIN 1' YL)DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; CHO CELL; CONTROLLED STUDY; DRUG CONFORMATION; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; IC 50; NONHUMAN; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-HIV AGENTS; BUTANES; CELLS, CULTURED; CRICETINAE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HIV-1; HUMANS; INHIBITORY CONCENTRATION 50; NEUTROPHILS; PIPERIDINES; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 17944365465     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00492-9     Document Type: Article

References (16)