Bacterial resistance to vancomycin: Five genes and one missing hydrogen bond tell the story

Chemistry and Biology

Volumn 3, Issue 1, 1996, Pages 21-28

  Walsh, C T ^a   Fisher, S L ^a   Park, I S ^a   Prahalad, M ^a   Wu, Z ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; BACTERIAL GENE; BACTERIUM; DRUG EFFECT; GENETICS; HYDROGEN BOND; R FACTOR; REVIEW; SIGNAL TRANSDUCTION;

ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL PROTEINS; DRUG RESISTANCE, MICROBIAL; GENES, BACTERIAL; HYDROGEN BONDING; R FACTORS; SIGNAL TRANSDUCTION; VANCOMYCIN;

EID: 0029678259     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(96)90079-4     Document Type: Review

References (11)

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7. Bugg, T.D.H., Dutka-Malen, S., Arthur, M., Courvalin, P. & Walsh, C.T. (1991). Identification of vancomycin resistance protein VanA as a D-alanine:o-alanine ligase of altered substrate specificity. Biochemistry 30, 2017-2021.
8. Bugg, T.D.H., Wright, G.D., Dutka-Malen, S., Arthur, M., Courvalin, P. & Walsh, C.T. (1991). Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. Biochemistry 30, 10408-10415.
9. Wright, G.D. & Walsh, C.T. (1992). D-Alanyl-D-alanine ligases and the molecular mechanism of vancomycin resistance. Accounts Chem. Res. 25, 468-473.
10. Walsh, C.T. (1993). Vancomycin resistance - decoding the molecular logic. Science 261, 308-309.
11. Wu, Z., Wright, G.D. & Walsh, C.T. (1995). Overexpression, purification, and characterization of VanX, a D-,D-dipeptidase which is essential for vancomycin resistance in Enterococcus faecium BM4147. Biochemistry 34, 2455-2463.