Synthesis and biological evaluation of vancomycin dimers with potent activity against vancomycin-resistant bacteria: Target-accelerated combinatorial synthesis

Chemistry - A European Journal

Volumn 7, Issue 17, 2001, Pages 3824-3843

  Nicolaou, K C ^a,b   Hughes, Robert ^a,b   Cho, Suk Young ^a,b   Winssinger, Nicolas ^a,b   Labischinski, Harald ^c   Endermann, Rainer ^c  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BAYER AG   (Germany)

Author keywords

Antibiotics; Biological evaluation; Combinatorial synthesis; Synthesis design; Vancomycin

Indexed keywords

AMINO ACIDS; BACTERIA; DIMERS; SYNTHESIS (CHEMICAL);

BIOLOGICAL EVALUATION;

ANTIBIOTICS;

2 ACETYLLYSYLALANYLALANINE; ALKENE; ANTI INFECTIVE AGENTS; ANTIINFECTIVE AGENT; CROSS LINKING REAGENT; CROSS LINKING REAGENTS; DIMER; DISULFIDE; PEPTIDE LIBRARY; TRIPEPTIDE; UNCLASSIFIED DRUG; VANCOMYCIN; VANCOMYCIN DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; CHEMISTRY; COMBINATORIAL CHEMISTRY; CONTROLLED STUDY; DIMERIZATION; DRUG EFFECT; DRUG RESISTANCE; DRUG STRUCTURE; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; GRAM POSITIVE COCCI; METHODOLOGY; MICROBIOLOGICAL EXAMINATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; COMBINATORIAL CHEMISTRY TECHNIQUES; CROSS-LINKING REAGENTS; DIMERIZATION; DRUG RESISTANCE; ENTEROCOCCUS FAECIUM; GRAM-POSITIVE COCCI; MICROBIAL SENSITIVITY TESTS; PEPTIDE LIBRARY; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP; VANCOMYCIN;

EID: 0035801386     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-3765(20010903)7:17<3824::AID-CHEM3824>3.0.CO;2-1     Document Type: Article

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