-
1
-
-
26044468809
-
Opportunities and challenges in antiparasitic drug discovery
-
PINK R, HUDSON A, MOURIES MA, BENDIG M: Opportunities and challenges in antiparasitic drug discovery. Nat. Rev. Drug Discov. (2005) 4(9):727-740.
-
(2005)
Nat. Rev. Drug Discov
, vol.4
, Issue.9
, pp. 727-740
-
-
PINK, R.1
HUDSON, A.2
MOURIES, M.A.3
BENDIG, M.4
-
2
-
-
9444230640
-
The life and times of ivermectin - a success story
-
OMURA S, CRUMP A: The life and times of ivermectin - a success story. Nat. Rev. Microbiol. (2004) 2(12):984-989.
-
(2004)
Nat. Rev. Microbiol
, vol.2
, Issue.12
, pp. 984-989
-
-
OMURA, S.1
CRUMP, A.2
-
3
-
-
0028036881
-
Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans
-
CULLY DF, VASSILATIS DK, LIU KK et al.: Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. Nature (1994) 371(6499):707-711.
-
(1994)
Nature
, vol.371
, Issue.6499
, pp. 707-711
-
-
CULLY, D.F.1
VASSILATIS, D.K.2
LIU, K.K.3
-
4
-
-
4444328499
-
Drug resistance in veterinary helminths
-
WOLSTENHOLME AJ, FAIRWEATHER I, PRICHARD R, VON SAMSON-HIMMELSTJERNA G, SANGSTER NC: Drug resistance in veterinary helminths. Trends Parasitol. (2004) 20(10):469-476.
-
(2004)
Trends Parasitol
, vol.20
, Issue.10
, pp. 469-476
-
-
WOLSTENHOLME, A.J.1
FAIRWEATHER, I.2
PRICHARD, R.3
VON SAMSON-HIMMELSTJERNA, G.4
SANGSTER, N.C.5
-
5
-
-
26844472830
-
Field evaluation of the efficacy and safety of emodepside/praziquantel spot-on solution against naturally acquired nematode and cestode infections in domestic cats
-
ALTREUTHER G, BUCH J, CHARLES SD et al.: Field evaluation of the efficacy and safety of emodepside/praziquantel spot-on solution against naturally acquired nematode and cestode infections in domestic cats. Parasitol. Res. (2005) 97(Suppl. 1):S58-S64.
-
(2005)
Parasitol. Res
, vol.97
, Issue.SUPPL. 1
-
-
ALTREUTHER, G.1
BUCH, J.2
CHARLES, S.D.3
-
6
-
-
0034788818
-
Activity of the cyclic depsipeptide emodepside (BAY 44-4400) against larval and adult stages of nematodes in rodents and the influence on worm survival
-
HARDER A, VON SAMSON-HIMMELSTJERNA G: Activity of the cyclic depsipeptide emodepside (BAY 44-4400) against larval and adult stages of nematodes in rodents and the influence on worm survival. Parasitol. Res. (2001) 87(11):924-928.
-
(2001)
Parasitol. Res
, vol.87
, Issue.11
, pp. 924-928
-
-
HARDER, A.1
VON SAMSON-HIMMELSTJERNA, G.2
-
8
-
-
0037282198
-
The effect of the anthelmintic emodepside at the neuromuscular junction of the parasitic nematode Ascaris suum
-
WILLSON J, AMLIWALA K, HARDER A, HOLDEN-DYE L, WALKER RJ: The effect of the anthelmintic emodepside at the neuromuscular junction of the parasitic nematode Ascaris suum. Parasitology (2003) 126(Part 1):79-86.
-
(2003)
Parasitology
, vol.126
, Issue.PART 1
, pp. 79-86
-
-
WILLSON, J.1
AMLIWALA, K.2
HARDER, A.3
HOLDEN-DYE, L.4
WALKER, R.J.5
-
9
-
-
33645030241
-
Robust Salmonella metabolism limits possibilities for new antimicrobials
-
BECKER D, SELBACH M, ROLLENHAGEN C et al.: Robust Salmonella metabolism limits possibilities for new antimicrobials. Nature (2006) 440(7082):303-307.
-
(2006)
Nature
, vol.440
, Issue.7082
, pp. 303-307
-
-
BECKER, D.1
SELBACH, M.2
ROLLENHAGEN, C.3
-
10
-
-
4444382693
-
Genomic filtering: An approach to discovering novel antiparasitics
-
MCCARTER JP: Genomic filtering: an approach to discovering novel antiparasitics. Trends Parasitol. (2004) 20(10):462-468.
-
(2004)
Trends Parasitol
, vol.20
, Issue.10
, pp. 462-468
-
-
MCCARTER, J.P.1
-
11
-
-
13944278892
-
RNAi-based discovery and validation of new drug targets in filarial nematodes
-
BEHM CA, BENDIG MM, MCCARTER JP, SLUDER AE: RNAi-based discovery and validation of new drug targets in filarial nematodes. Trends Parasitol. (2005) 21(3):97-100.
-
(2005)
Trends Parasitol
, vol.21
, Issue.3
, pp. 97-100
-
-
BEHM, C.A.1
BENDIG, M.M.2
MCCARTER, J.P.3
SLUDER, A.E.4
-
13
-
-
33646933785
-
A small-molecule screen in C. elegans yields a new calcium channel antagonist
-
KWOK TC, RICKER N, FRASER R et al.: A small-molecule screen in C. elegans yields a new calcium channel antagonist. Nature (2006) 441(7089):91-95.
-
(2006)
Nature
, vol.441
, Issue.7089
, pp. 91-95
-
-
KWOK, T.C.1
RICKER, N.2
FRASER, R.3
-
14
-
-
28044458583
-
Combinatorial RNAi on intestinal cathepsin B-like proteinases in Caenorhabditis elegans questions the perception of their role in nematode biology
-
GELDHOF P, MOLLOY C, KNOX DP: Combinatorial RNAi on intestinal cathepsin B-like proteinases in Caenorhabditis elegans questions the perception of their role in nematode biology. Mol. Biochem. Parasitol. (2006) 145(1):128-132.
-
(2006)
Mol. Biochem. Parasitol
, vol.145
, Issue.1
, pp. 128-132
-
-
GELDHOF, P.1
MOLLOY, C.2
KNOX, D.P.3
-
15
-
-
33749044812
-
RNAi in Haemonchus contortus: A potential method for target validation
-
ZAWADZKI JL, PRESIDENTE PJ, MEEUSEN EN, DE VEER MJ: RNAi in Haemonchus contortus: a potential method for target validation. Trends Parasitol. (2006) 22(11):495-499.
-
(2006)
Trends Parasitol
, vol.22
, Issue.11
, pp. 495-499
-
-
ZAWADZKI, J.L.1
PRESIDENTE, P.J.2
MEEUSEN, E.N.3
DE VEER, M.J.4
-
16
-
-
33847310222
-
RNA interference in parasitic nematodes of animals: A reality check?
-
KNOX DP, GELDHOF P, VISSER A, BRITTON C: RNA interference in parasitic nematodes of animals: a reality check? Trends Parasitol. (2007) 23(3):105-107.
-
(2007)
Trends Parasitol
, vol.23
, Issue.3
, pp. 105-107
-
-
KNOX, D.P.1
GELDHOF, P.2
VISSER, A.3
BRITTON, C.4
-
17
-
-
34249708427
-
-
GELDHOF P, VISSER A, CLARK D et al.: RNA interference in parasitic helminths: current situation, potential pitfalls and future prospects. Parasitology (2007):1-11.
-
GELDHOF P, VISSER A, CLARK D et al.: RNA interference in parasitic helminths: current situation, potential pitfalls and future prospects. Parasitology (2007):1-11.
-
-
-
-
18
-
-
0038512548
-
Use of RNA interference to investigate gene function in the human filarial nematode parasite Brugia malayi
-
ABOOBAKER AA, BLAXTER ML: Use of RNA interference to investigate gene function in the human filarial nematode parasite Brugia malayi. Mol. Biochem. Parasitol. (2003) 129(1):41-51.
-
(2003)
Mol. Biochem. Parasitol
, vol.129
, Issue.1
, pp. 41-51
-
-
ABOOBAKER, A.A.1
BLAXTER, M.L.2
-
19
-
-
23044447546
-
Development of methods for RNA interference in the sheep gastrointestinal parasite, Trichostrongylus colubriformis
-
ISSA Z, GRANT WN, STASIUK S, SHOEMAKER CB: Development of methods for RNA interference in the sheep gastrointestinal parasite, Trichostrongylus colubriformis. Int. J. Parasitol. (2005) 35(9):935-940.
-
(2005)
Int. J. Parasitol
, vol.35
, Issue.9
, pp. 935-940
-
-
ISSA, Z.1
GRANT, W.N.2
STASIUK, S.3
SHOEMAKER, C.B.4
-
20
-
-
33745009743
-
Testing the efficacy of RNA interference in Haemonchus contortus
-
GELDHOF P, MURRAY L, COUTHIER A et al.: Testing the efficacy of RNA interference in Haemonchus contortus. Int. J. Parasitol. (2006) 36(7):801-810.
-
(2006)
Int. J. Parasitol
, vol.36
, Issue.7
, pp. 801-810
-
-
GELDHOF, P.1
MURRAY, L.2
COUTHIER, A.3
-
21
-
-
8844224148
-
RNA interference targeting cathepsin L and Z-like cysteine proteases of Onchocerca volvulus confirmed their essential function during L3 molting
-
LUSTIGMAN S, ZHANG J, LIU J, OKSOV Y, HASHMI S: RNA interference targeting cathepsin L and Z-like cysteine proteases of Onchocerca volvulus confirmed their essential function during L3 molting. Mol. Biochem. Parasitol. (2004) 138(2):165-170.
-
(2004)
Mol. Biochem. Parasitol
, vol.138
, Issue.2
, pp. 165-170
-
-
LUSTIGMAN, S.1
ZHANG, J.2
LIU, J.3
OKSOV, Y.4
HASHMI, S.5
-
22
-
-
0037448540
-
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
-
KAMATH RS, FRASER AG, DONG Y et al.: Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature (2003) 421(6920):231-237.
-
(2003)
Nature
, vol.421
, Issue.6920
, pp. 231-237
-
-
KAMATH, R.S.1
FRASER, A.G.2
DONG, Y.3
-
23
-
-
1542298437
-
Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions
-
SIMMER F, MOORMAN C, VAN DER LINDEN AM et al.: Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol. (2003) 1(1):77-84.
-
(2003)
PLoS Biol
, vol.1
, Issue.1
, pp. 77-84
-
-
SIMMER, F.1
MOORMAN, C.2
VAN DER LINDEN, A.M.3
-
24
-
-
0037386422
-
Suppression of cathepsin B expression in Schistosoma mansoni by RNA interference
-
SKELLY PJ, DA'DARA A, HARN DA: Suppression of cathepsin B expression in Schistosoma mansoni by RNA interference. Int. J. Parasitol. (2003) 33(4):363-369.
-
(2003)
Int. J. Parasitol
, vol.33
, Issue.4
, pp. 363-369
-
-
SKELLY, P.J.1
DA'DARA, A.2
HARN, D.A.3
-
25
-
-
0038222465
-
Using RNA interference to manipulate endogenous gene expression in Schistosoma mansoni sporocysts
-
BOYLE JP, WU XJ, SHOEMAKER CB, YOSHINO TP: Using RNA interference to manipulate endogenous gene expression in Schistosoma mansoni sporocysts. Mol. Biochem. Parasitol. (2003) 128(2):205-215.
-
(2003)
Mol. Biochem. Parasitol
, vol.128
, Issue.2
, pp. 205-215
-
-
BOYLE, J.P.1
WU, X.J.2
SHOEMAKER, C.B.3
YOSHINO, T.P.4
-
26
-
-
0033608994
-
Double-stranded RNA specifically disrupts gene expression during planarian regeneration
-
SANCHEZ ALVARADO A, NEWMARK PA: Double-stranded RNA specifically disrupts gene expression during planarian regeneration. Proc. Natl. Acad. Sci. USA (1999) 96(9):5049-5054.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, Issue.9
, pp. 5049-5054
-
-
SANCHEZ, A.A.1
NEWMARK, P.A.2
-
27
-
-
17844395204
-
Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria
-
REDDIEN PW, BERMANGE AL, MURFITT KJ, JENNINGS JR, SANCHEZ ALVARADO A: Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria. Dev. Cell (2005) 8(5):635-649.
-
(2005)
Dev. Cell
, vol.8
, Issue.5
, pp. 635-649
-
-
REDDIEN, P.W.1
BERMANGE, A.L.2
MURFITT, K.J.3
JENNINGS, J.R.4
SANCHEZ, A.A.5
-
29
-
-
3042692958
-
Metabolism
-
Lee DL Ed, Taylor & Francis, London
-
BEHM CA: Metabolism. In: The Biology of Nematodes. Lee DL (Ed.), Taylor & Francis, London (2002):261-290.
-
(2002)
The Biology of Nematodes
, pp. 261-290
-
-
BEHM, C.A.1
-
30
-
-
0032988608
-
The apicoplast as a potential therapeutic target in toxoplasma and other apicomplexan parasites: Some additional thoughts
-
ROOS DS: The apicoplast as a potential therapeutic target in toxoplasma and other apicomplexan parasites: some additional thoughts. Parasitol. Today (1999) 15(1):41.
-
(1999)
Parasitol. Today
, vol.15
, Issue.1
, pp. 41
-
-
ROOS, D.S.1
-
31
-
-
0038307857
-
400000 nematode ESTs on the Net
-
PARKINSON J, MITREVA M, HALL N, BLAXTER M, MCCARTER JP: 400000 nematode ESTs on the Net. Trends Parasitol. (2003) 19(7):283-286.
-
(2003)
Trends Parasitol
, vol.19
, Issue.7
, pp. 283-286
-
-
PARKINSON, J.1
MITREVA, M.2
HALL, N.3
BLAXTER, M.4
MCCARTER, J.P.5
-
32
-
-
9644260489
-
A transcriptomic analysis of the phylum nematoda
-
PARKINSON J, MITREVA M, WHITTON C et al.: A transcriptomic analysis of the phylum nematoda. Nat. Genet. (2004) 36(12):1259-1267.
-
(2004)
Nat. Genet
, vol.36
, Issue.12
, pp. 1259-1267
-
-
PARKINSON, J.1
MITREVA, M.2
WHITTON, C.3
-
34
-
-
0010325737
-
Biochemistry of filarial worms
-
BARRETT J: Biochemistry of filarial worms. Helminthological Abstracts (1983) A52:1-18.
-
(1983)
Helminthological Abstracts
, vol.A52
, pp. 1-18
-
-
BARRETT, J.1
-
35
-
-
0025834815
-
Amino acid metabolism in helminths
-
BARRETT J: Amino acid metabolism in helminths. Adv. Parasitol. (1991) 30:39-105.
-
(1991)
Adv. Parasitol
, vol.30
, pp. 39-105
-
-
BARRETT, J.1
-
36
-
-
0030991355
-
Helminth detoxification mechanisms
-
BARRETT J: Helminth detoxification mechanisms. J. Helminthol. (1997) 71(2):85-89.
-
(1997)
J. Helminthol
, vol.71
, Issue.2
, pp. 85-89
-
-
BARRETT, J.1
-
40
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
LIPINSKI CA, LOMBARDO F, DOMINY BW, FEENEY PJ: Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. (2001) 46(1-3):3-26.
-
(2001)
Adv. Drug Deliv. Rev
, vol.46
, Issue.1-3
, pp. 3-26
-
-
LIPINSKI, C.A.1
LOMBARDO, F.2
DOMINY, B.W.3
FEENEY, P.J.4
-
41
-
-
11144320699
-
Navigating chemical space for biology and medicine
-
LIPINSKI C, HOPKINS A: Navigating chemical space for biology and medicine. Nature (2004) 432(7019):855-861.
-
(2004)
Nature
, vol.432
, Issue.7019
, pp. 855-861
-
-
LIPINSKI, C.1
HOPKINS, A.2
-
43
-
-
0026611714
-
Binding of [3H]benzimidazole carbamates to mammalian brain tubulin and the mechanism of selective toxicity of the benzimidazole anthelmintics
-
RUSSELL GJ, GILL JH, LACEY E: Binding of [3H]benzimidazole carbamates to mammalian brain tubulin and the mechanism of selective toxicity of the benzimidazole anthelmintics. Biochem. Pharmacol. (1992) 43(5):1095-1100.
-
(1992)
Biochem. Pharmacol
, vol.43
, Issue.5
, pp. 1095-1100
-
-
RUSSELL, G.J.1
GILL, J.H.2
LACEY, E.3
-
44
-
-
0026474422
-
The kinetics of mebendazole binding to Haemonchus contortus tubulin
-
GILL JH, LACEY E: The kinetics of mebendazole binding to Haemonchus contortus tubulin. Int. J. Parasitol. (1992) 22(7):939-946.
-
(1992)
Int. J. Parasitol
, vol.22
, Issue.7
, pp. 939-946
-
-
GILL, J.H.1
LACEY, E.2
-
45
-
-
33645559431
-
Drug resistance and neurotransmitter receptors of nematodes: Recent studies on the mode of action of levamisole
-
MARTIN RJ, VERMA S, LEVANDOSKI M et al.: Drug resistance and neurotransmitter receptors of nematodes: recent studies on the mode of action of levamisole. Parasitology (2005) 131 (Suppl.):S71-S84.
-
(2005)
Parasitology
, vol.131
, Issue.SUPPL.
-
-
MARTIN, R.J.1
VERMA, S.2
LEVANDOSKI, M.3
-
46
-
-
0028229150
-
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
-
SCHINKEL AH, SMIT JJ, VAN TELLINGEN O et al.: Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell (1994) 77(4):491-502.
-
(1994)
Cell
, vol.77
, Issue.4
, pp. 491-502
-
-
SCHINKEL, A.H.1
SMIT, J.J.2
VAN TELLINGEN, O.3
-
47
-
-
33746630292
-
A microarray analysis of gene expression in the free-living stages of the parasitic nematode Strongyloides ratti
-
THOMPSON FJ, BARKER CL, HUGHES L et al.: A microarray analysis of gene expression in the free-living stages of the parasitic nematode Strongyloides ratti. BMC Genomics (2006) 7:157.
-
(2006)
BMC Genomics
, vol.7
, pp. 157
-
-
THOMPSON, F.J.1
BARKER, C.L.2
HUGHES, L.3
-
48
-
-
21344449339
-
Searching new targets for anthelminthic strategies: Interference with glycosphingolipid biosynthesis and phosphorylcholine metabolism affects development of Caenorhabditis elegans
-
LOCHNIT G, BONGAARTS R, GEYER R: Searching new targets for anthelminthic strategies: interference with glycosphingolipid biosynthesis and phosphorylcholine metabolism affects development of Caenorhabditis elegans. Int. J. Parasitol. (2005) 35:911-923.
-
(2005)
Int. J. Parasitol
, vol.35
, pp. 911-923
-
-
LOCHNIT, G.1
BONGAARTS, R.2
GEYER, R.3
-
49
-
-
33750124210
-
Techniques for analysis, sorting, and dispensing of C. elegans on the COPAS flow-sorting system
-
PULAK R: Techniques for analysis, sorting, and dispensing of C. elegans on the COPAS flow-sorting system. Methods Mol. Biol. (2006) 351:275-286.
-
(2006)
Methods Mol. Biol
, vol.351
, pp. 275-286
-
-
PULAK, R.1
-
50
-
-
33845903833
-
Drugs for bad bugs: Confronting the challenges of antibacterial discovery
-
PAYNE DJ, GWYNN MN, HOLMES DJ, POMPLIANO DL: Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat. Rev. Drug Discov. (2007) 6(1):29-40.
-
(2007)
Nat. Rev. Drug Discov
, vol.6
, Issue.1
, pp. 29-40
-
-
PAYNE, D.J.1
GWYNN, M.N.2
HOLMES, D.J.3
POMPLIANO, D.L.4
|