RNA interference targeting cathepsin L and Z-like cysteine proteases of Onchocerca volvulus confirmed their essential function during L3 molting

Molecular and Biochemical Parasitology

Volumn 138, Issue 2, 2004, Pages 165-170

  Lustigman, Sara ^a   Zhang, Jun ^a   Liu, Jing ^a   Oksov, Yelena ^a   Hashmi, Sarwar ^a  

^a NEW YORK BLOOD CENTER   (United States)

Author keywords

Cysteine protease; Gene function; Molting; O. volvulus; Parasitic nematodes; RNAi

Indexed keywords

CATHEPSIN; CATHEPSIN L; CATHEPSIN Z; CYSTEINE PROTEINASE; DOUBLE STRANDED RNA; ENZYME ANTIBODY; GENE PRODUCT; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CUTICLE; ENZYME ACTIVITY; FILARIA; FLUORESCENCE; GENE FUNCTION; HUMAN; HUMAN CELL; IMMUNOELECTRON MICROSCOPY; LARVA; MOLTING; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCHOCERCA VOLVULUS; PRIORITY JOURNAL; RNA INTERFERENCE; SEPARATION TECHNIQUE;

ANIMALS; BASE SEQUENCE; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; ENZYME REPRESSION; GENES, HELMINTH; LARVA; MICROSCOPY, ELECTRON; MICROSCOPY, IMMUNOELECTRON; MOLECULAR SEQUENCE DATA; MOLTING; ONCHOCERCA VOLVULUS; RNA INTERFERENCE; RNA, DOUBLE-STRANDED; SKIN;

NEMATODA; ONCHOCERCA; ONCHOCERCA VOLVULUS;

EID: 8844224148     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2004.08.003     Document Type: Article

References (24)

1. WHO. Onchocerciasis and its control. Report of a WHO Expert Committee on Onchocerciasis Control. World Health Organ Tech Rep Ser 1995;852:1-104.
2. Y. Dadzie, M. Neira, and D. Hopkins Final report of the conference on the eradicability of Onchocerciasis Filaria J 2 2003 2
3. K. Awadzi, D.A. Boakye, and G. Edwards An investigation of persistent microfilaridermias despite multiple treatments with ivermectin, in two onchocerciasis-endemic foci in Ghana Ann Trop Med Parasitol 98 2004 231 249
4. T.B. Nutman Future directions for vaccine-related onchocerciasis research Trends Parasitol 18 2002 237 239
5. M. Lizotte-Waniewski, W. Tawe, and D.B. Guiliano Identification of potential vaccine and drug target candidates by expressed sequence tag analysis and immunoscreening of Onchocerca volvulus larval cDNA libraries Infect Immun 68 2000 3491 3501
6. S.A. Williams, S.J. Laney, M. Lizotte-Waniewski, L. Ann Bierwert, and T.R. Unnasch The river blindness genome project Parasitol Today 18 2002 86 90
7. M. Blaxter, J. Daub, D. Guiliano, J. Parkinson, and C. Whitton The Brugia malayi genome project: expressed sequence tags and gene discovery Trans R Soc Trop Med Hyg 96 2002 7 17
8. P.A. Sharp RNA interference - 2001 Genes Dev 15 2001 485 490
9. A.A. Aboobaker, and M.L. Blaxter Use of RNA interference to investigate gene function in the human filarial nematode parasite Brugia malayi Mol Biochem Parasitol 129 2003 41 51
10. A.S. Hussein, K. Kichenin, and M.E. Selkirk Suppression of secreted acetylcholinesterase expression in Nippostrongylus brasiliensis by RNA interference Mol Biochem Parasitol 122 2002 91 94
11. P.E. Urwin, C.J. Lilley, and H.J. Atkinson Ingestion of double-stranded RNA by preparasitic juvenile cyst nematodes leads to RNA interference Mol Plant Microbe Interact 15 2002 747 752
12. S. Lustigman, J.H. McKerrow, and K. Shah Cloning of a cysteine protease required for the molting of Onchocerca volvulus third stage larvae J Biol Chem 271 1996 30181 30189
13. S. Hashmi, C. Britton, J. Liu, D.B. Guiliano, Y. Oksov, and S. Lustigman Cathepsin L is essential for embryogenesis and development of Caenorhabditis elegans J Biol Chem 277 2002 3477 3486
14. D.B. Guiliano, X. Hong, and J.H. McKerrow A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodeling Mol Biochem Parasitol 136 2004 227 242
15. J.K. Richer, W.G. Hunt, J.A. Sakanari, and R.B. Grieve Dirofilaria immitis: effect of fluoromethyl ketone cysteine protease inhibitors on the third- to fourth-stage molt Exp Parasitol 76 1993 221 231
16. S. Hashmi, J. Zhang, Y. Oksov, and S. Lustigman The Caenorhabditis elegans cathepsin Z-like cysteine protease, Ce-CPZ-1, has a multifunctional role during the worms' development J Biol Chem 279 2004 6035 6045
17. O. Bain, S. Wanji, and P. Enyong New features on the moults and morphogenesis of the human filaria Loa loa by using rodent hosts consequences Parasite 5 1998 37 46
18. J.E. Allen, J. Daub, and D. Guiliano Analysis of genes expressed at the infective larval stage validates utility of Litomosoides sigmodontis as a murine model for filarial vaccine development Infect Immun 68 2000 5454 5458
19. L. Timmons, and A. Fire Specific interference by ingested dsRNA Nature 395 1998 854
20. A. Fire, S. Xu, M.K. Montgomery, S.A. Kostas, S.E. Driver, and C.C. Mello Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature 391 1998 806 811
21. Z. Liu, J. Peng, R. Mo, C. Hui, and C.H. Huang Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals J Biol Chem 276 2001 1424 1433
22. J.H. McKerrow, T. Huima, and S. Lustigman Do filarid nematodes have a vascular system? Parasitol Today 15 1999 123
23. G. Strote, and I. Bonow Morphological demonstration of essential functional changes after in vitro and in vivo transition of infective Onchocerca volvulus to the post-infective stage Parasitol Res 77 1991 526 535
24. D.R. Brooks, P.J. Appleford, L. Murray, and R.E. Isaac An essential role in molting and morphogenesis of Caenorhabditis elegans for ACN-1, a novel member of the angiotensin-converting enzyme family that lacks a metallopeptidase active site J Biol Chem 278 2003 52340 52346