Diversity and function of orphan nuclear receptors in nematodes

Critical Reviews in Eukaryotic Gene Expression

Volumn 12, Issue 1, 2002, Pages 65-88

  Van Gilst, Marc ^a   Gissendanner, Christopher R ^b,c   Sluder, Ann E ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Cambria Pharmaceuticals Inc   (United States)

^c NEW ENGLAND BIOLABS   (United States)

Author keywords

C. elegans; DNA binding domain; Gene superfamily; Ligand binding domain

Indexed keywords

CELL NUCLEUS RECEPTOR; CELL RECEPTOR; DNA; DNA BINDING PROTEIN; LIGAND;

BINDING SITE; CAENORHABDITIS ELEGANS; DNA BINDING; EVOLUTION; GENOME; LIGAND BINDING; METAZOON; NEMATODE; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; CLASSIFICATION; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; INVERTEBRATA; METAZOA; NEMATODA;

AMINO ACID SEQUENCE; ANIMALS; CAENORHABDITIS ELEGANS; DNA; DNA-BINDING PROTEINS; LIGANDS; MOLECULAR SEQUENCE DATA; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 0036592159     PISSN: 10454403     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevEukaryotGeneExpr.v12.i1.40     Document Type: Review

References (140)

1. Akerib CC, Meyer BJ (1994): Identification of X chromosome regions in Caenorhabditis elegans that contain sexdetermination signal elements. Genetics 138:1105-1125.
2. Antebi A, Culotti JG, Hedgecock EM (1998): daf-12 regulates developmental age and the dauer alternative in Caenorhabditis elegans. Development 125:1191-1205.
3. Antebi A, Yeh WH, Tait D, Hedgecock EM, Riddle DL (2000): daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans. Genes Dev 14:1512-1527.
4. Arabidopsis Genome Initiative T (2000): Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature 408:796-815.
5. Asahina M, Ishihara T, Jindra M, Kohara Y, Katsura I, Hirose S (2000): The conserved nuclear receptor Ftz-F1 is required for embryogenesis, moulting and reproduction in Caenorhabditis elegans. Genes to Cells 5:711-723.
6. Atkins GB, Hu X, Guenther MG, Rachez C, Freedman LP, Lazar MA (1999): Coactivators for the orphan nuclear receptor RORalpha. Mol Endocrinol 13:1550-1557.
7. Ayala FJ, Rzhetsky A, Ayala FJ (1998): Origin of the metazoan phyla: Molecular clocks confirm palentological estimates. Proc Natl Acad Sci USA 95:606-611.
8. Beato M, Herrlich P, Schütz G (1995): Steroid hormone receptors: Many actors in search of a plot. Cell 83:851-857.
9. Blackwell T (1995): Selection of protein binding sites from random nucleic acid sequences. Methods Enzymol 254:604-618.
10. Bogan AA, Dallas-Yang Q, Ruse MD Jr, Maeda Y, Jiang G, Nepomuceno L, Scanlan TS, Cohen FE, Sladek FM (2000): Analysis of protein dimerization and ligand binding of orphan receptor HNF4alpha. J Mol Biol 302:831-851.
11. Broadus J, McCabe JR, Endrizzi B, Thummel CS, Woodard CT (1999): The Drosophila beta FTZ-F1 orphan nuclear receptor provides competence for stage-specific responses to the steroid hormone ecdysone. Mol Cell 3:143-149.
12. Broeks A, Janssen HW, Calafat J, Plasterk RH (1995): A P-glycoprotein protects Caenorhabditis elegans against natural toxins. EMBO J 14:1858-1866.
13. C. elegans Sequencing Consortium T (1998): Genome sequence of the nematode C. elegans: A platform for investigating biology. Science 282:2012-2018.
14. Carmi I, Kopczynski JB, Meyer BJ (1998): The nuclear hormone receptor SEX-1 is an X-chromosome signal that determines nematode sex. Nature 396:168-173.
15. Carney GE, Wade AA, Sapra R, Goldstein ES, Bender M (1997): DHR3, an ecdysone-inducible early-late gene encoding a Drosophila nuclear receptor, is required for embryogenesis. Proc Natl Acad Sci USA 94:12024-12029.
16. Chen PJ, Cho S, Jin SW, Ellis RE (2001): Specification of germ cell fates by fog-3 has been conserved during nematode evolution. Genetics 158:1513-1525.
17. Chitwood DJ, Feldlaufer MF (1990): Ecdysteroids in axenically propagated Caenorhabditis elegans and culture medium. J Nematol 22:598-607.
18. de Bono M, Hodgkin J (1996): Evolution of sex determination in Caenorhabditis: Unusually high divergence of tra-1 and its functional consequences. Genetics 144:587-595.
19. Dhadialla TS, Carlson GR, Le DP (1998): New insecticides with ecdysteroidal and juvenile hormone activity. Annu Rev Entomol 43:545-569.
20. EmeryJG, Ohlstein EH, Jaye M (2001): Therapeutic modulation of transcription factor activity. Trends Pharmacol Sci 22:233-240.
21. Escriva H, Safi R, Hanni C, Langlois M-C, Saumitou-Laprade P, Stehelin D, Capron A, Pierce R, Laudet V (1997): Ligand binding was acquired during evolution of nuclear receptors. Proc Natl Acad Sci USA 94:6803-6808.
22. Evans RM (1988): The steroid and thyroid hormone receptor superfamily. Science 240:889-895.
23. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC (1998): Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391:806-811.
24. Fisk GJ, Thummel CS (1995): Isolation, regulation, and DNA-binding properties of three Drosophila nuclear hormone receptor superfamily members. Proc Natl Acad Sci USA 92:10604-10608.
25. Fisk GJ, Thummel CS (1998): The DHR78 nuclear receptor is required for ecdysteroid signaling during the onset of Drosophila metamorphosis. Cell 93:543-555.
26. Fitch DHA, Thomas WK (1997): Evolution. In Riddle DL, Blumenthal T, Meyer BJ, Priess JR (eds): C. Elegans II. Cold Spring Harbor Laboratory Press, Plainview, NY, 815-850.
27. Forman BM, Chen J, Blumberg B, Kliewer SA, Henshaw R, Ong ES, Evans RM (1994): Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors. Mol Endocrinol 8:1253-1261.
28. Francoijs CJJ, Klomp JPG, Knegtel RMA. Sequence annotation of nuclear receptor ligand-binding domains by automated homology modeling. Protein Eng 2000; 13:391-394.
29. Fraser AG, Kamath RS, Zipperlen P, Martinez-Campos M, Sohrmann M, Ahringer J (2000): Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408:325-330.
30. Freedman LP (1997): Molecular Biology of Steroid and Nuclear Hormone Receptors. Birkhauser, Boston.
31. Gampe RT Jr, Montana VG, Lambert MH, Miller AB, Bledsoe RK, Milburn MV, Kliewer SA, Willson TM, Xu HE (2000): Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors. Mol Cell 5:545-555.
32. Gerisch B, Weitzel C, Kober-Eisermann C, Rottiers V, Antebi A (2001): A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span. Dev Cell 1:841-851.
33. Giguere V (1999): Orphan nuclear receptors: From gene to function. Endocr Rev 20:689-725.
34. Giguere V, McBroom LD, Flock G (1995): Determinants of target gene specificity for ROR alpha 1: Monomeric DNA binding by an orphan nuclear receptor. Mol Cell Biol 15:2517-2526.
35. Gissendanner CR (2001): Functional Analysis of Nuclear Receptor Genes in the Nematode Caenorhabditis Elegans. Doctoral dissertation, University of Georgia, Athens.
36. Gissendanner CR, Sluder AE (2000): nhr-25, the C. elegans orthologue of ftz-f1, is required for epidermal and somatic gonad development. Develop Biol 221:259-272.
37. Glass CK (1994): Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers. Endocrinol Rev 15:391-407.
38. Glass CK, Rosenfeld MG (2000): The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev 14:121-141.
39. Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG (1996): Life with 6000 genes. Science 274:546-567.
40. Gonczy P, Echeverri G, Oegema K, Coulson A, Jones SJ, Copley RR, Duperon J, Oegema J, Brehm M, Cassin E, Hannak E, Kirkham M, Pichler S, Flohrs K, Goessen A, Leidel S, Alleaume AM, Martin C, Ozlu N, Bork P, Hyman AA (2000): Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III. Nature 408:331-336.
41. Grasso LC, Hayward DC, Trueman JW, Hardie KM, Janssens PA, Ball EE (2001): The evolution of nuclear receptors: Evidence from the coral Acropora. Mol Phylogenet Evol 21:93-102.
42. Guichet A, Copeland JWR, Erdelyi M, Hlousek D, Zavorszky P, Ho J, Brown S, Percival-Smith A, Krause HM, Ephrussi A (1997): The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors. Nature 385:548-552.
43. Handschin C, Podvinec M, Meyer UA (2000): CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR). Proc Natl Acad Sci USA 97:10769-10774.
44. Hansen D, Pilgrim D (1998): Molecular evolution of a sex determination protein: FEM-2 (pp2c) in Caenorhabditis. Genetics 149:1353-1362.
45. Harding HP, Lazar MA (1995): The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat. Mol Cell Biol 15:4791-4802.
46. Harrison PM, Echols N, Gerstein MB (2001): Digging for dead genes: An analysis of the characteristics of the pseudogene population in the Caenorhabditis elegans genome. Nucleic Acids Res 29:818-830.
47. Hodgkin J.(1997): Genetics. In Riddle DL, Blumenthal T, Meyer BJ, Priess JR (eds): C. Elegans II. Cold Spring Harbor Laboratory Press, Plainview, NY, 881-1047.
48. Ito M, Achermann JC, Jameson JL (2000): A naturally occurring steroidogenic factor-1 mutation exhibits differential binding and activation of target genes. J Biol Chem 275:31708-31714.
49. Jansen G, Hazendonk E, Thijssen KL, Plasterk RHA (1997): Reverse genetics by chemical mutagenesis in Caenorhabditis elegans. Nat Genet 17:119-121.
50. Jia K, Albert PS, Riddle DL (2002): DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity. Development 129:221-231.
51. Jiang G, Nepomuceno L, Hopkins K, Sladek FM (1995): Exclusive homodimerization of the orphan receptor hepatocyte nuclear factor 4 defines a new subclass of nuclear receptors. Mol Cell Biol 15:5131-5143.
52. Jones SA, Moore LB, Shenk JL, Wisely GB, Hamilton GA, McKee DD, Tomkinson NC, LeCluyse EL, Lambert MH, Willson TM, Kliewer SA, Moore JT (2000): The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution. Mol Endocrinol 14:27-39.
53. Kadowaki Y, Toyoshima K, Yamamoto T (1992): Ear3/COUP-TF binds most tightly to a response element with tandem repeat separated by one nucleotide. Biochem Biophys Res Commun 183:492-498.
54. Kageyama Y, Masuda S, Hirose S, Ueda H (1997): Temporal regulation of the mid-prepupal gene FTZ-F1: DHR3 early late gene product is one of the plural positive regulators. Genes Cells 2:559-569.
55. Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA (2002): Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem 277:2908-2915.
56. Kastner P, Mark M, Chambon P (1995): Nonsteroid nuclear receptors: What are genetic studies telling us about their role in real life? Cell 83:859-869.
57. Kliewer SA, Lehmann JM, Willson TM (1999): Orphan nuclear receptors: Shifting endocrinology into reverse. Science 284:757-760.
58. Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM (1992): Retinoid X receptorCOUP-TF interactions modulate retinoic acid signaling. Proc Natl Acad Sci USA 89:1448-1452.
59. Knoll AH, Carroll SB (1999): Early animal evolution: Emerging views from comparative biology and geology. Science 284:2129-2137.
60. Kobayashi M, Takezawa S, Hara K, Yu RT, Umesono Y, Agata K, Taniwaki M, Yasuda K, Umesono K (1999): Identification of a photoreceptor cell-specific nuclear receptor. Proc Natl Acad Sci USA 96:4814-4819.
61. Kostrouch Z, Kostrouchova M, Love W, Jannini E, Piatigorsky J, Rall JE (1998): Retinoic acid X receptor in the diploblast, Tripedalia cystophora. Proc Natl Acad Sci USA 95:13442-13447.
62. Kostrouchova M, Krause M, Kostrouch Z, Rall JE (1998): CHR3: A Caenorhabditis elegans orphan nuclear hormone receptor required for proper epidermal development and molting. Development 125:1617-1626.
63. Kostrouchova M, Krause M, Kostrouch Z, Rail JE (2001): Nuclear hormone receptor CHR3 is a critical regulator of all four larval molts of the nematode Caenorhabditis elegans. Proc Natl Acad Sci USA 98:7360-7365.
64. Kuwabara PE (1996): Interspecies comparison reveals evolution of control regions in the nematode sexdetermining gene tra-2. Genetics 144:597-607.
65. Lam G, Hall BL, Bender M, Thummel CS (1999): DHR3 is required for the prepupal-pupal transition and differentiation of adult structures during Drosophila metamorphosis. Dev Biol 212:204-216.
66. Lam GT, Jiang C, Thummel CS (1997): Coordination of larval and prepupal gene expression by the DHR3 orphan receptor during Drosophila metamorphosis. Development 124:1757-1769.
67. Laudet V (1997): Evolution of the nuclear receptor superfamily: Early diversification from an ancestral orphan receptor. J Mol Endocrinol 19:207-226.
68. Lin TM, Young WJ, Chang C (1995): Multiple functions of the TR2-11 orphan receptor in modulating activation of two key cis-acting elements involved in the retinoic acid signal transduction system. J Biol Chem 270:30121-30128.
69. Lindblom TH (2000): Functional Diversity Among the Caenorhabditis Elegans Members of the Nuclear Receptor Superfamily. Doctoral dissertation, University of Georgia, Athens.
70. Lindblom TH, Pierce GJ, Sluder AE (2001): A C. elegans orphan nuclear receptor contributes to xenobiotic resistance. Curr Biol 11:864-868.
71. Liu LX, Spoerke JM, Mulligan EL, Chen J, Reardon B, Westlund B, Sun L, Abel K, Armstrong B, Hardiman G, King J, McCague L, Basson M, Clover R, Johnson CD (1999): High-throughput isolation of Caenorhabditis elegans deletion mutants. Genome Res 9:859-867.
72. Luisi BF, Xu WX, Otwinowski Z, Freedman LP, Yamamoto KR, Sigler PB (1991): Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature 352:497-505.
73. Lutz B, Kuratani S, Cooney AJ, Wawersik S, Tsai SY, Eichele G, Tsai MJ (1994): Developmental regulation of the orphan receptor COUP-TF II gene in spinal motor neurons. Development 120:25-36.
74. Maeda I, Kohara Y, Yamamoto M, Sugimoto A (2001): Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi. Curr Biol 11:171-176.
75. Maglich JM, Sluder AE, Guan X, Shi Y, McKee DD, Carrick K, Kamdar K, Willson TM, Moore JT (2001): Comparison of complete nuclear receptor sets from the human, C. elegans, and Drosophila genomes. Gen Biol 2:0029.1-0029.7.
76. Maina C, Sluder A (2001): [Analysis of C. elegans nuclear receptor cDNA sequences]. Sequences deposited in GenBank, http://www.ncbi.nlm.nih.gov/. Unpublished data.
77. Mangelsdorf DJ (1994): Vitamin A receptors. Nutr Rev 52:S32-S44.
78. Mangelsdorf DJ, Evans RM (1995): The RXR heterodimers and orphan receptors. Cell 83:841-850.
79. Manglesdorf DJ, Thummel C, Beato M, Herrlich P, Schütz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM (1995): The nuclear receptor superfamily: The second decade. Cell 83:835-839.
80. Meinke G, Sigler PB (1999): DNA-binding mechanism of the monomeric orphan nuclear receptor NGFI-B. Nat Struct Biol 6:471-477.
81. Menzel R, Bogaert T, Achazi R (2001): A systematic gene expression screen of Caenorhabditis elegans cytochrome P450 genes reveals CYP35 as strongly xenobiotic inducible. Arch Biochem Biophys 395:158-168.
82. Meyer BJ (1997): Sex determination and X chromosome dosage compensation. In Riddle DL, Blumenthal T, Meyer BJ, Priess JR (eds): C. Elegans II. Cold Spring Harbor Laboratory Press, Plainview, NY, 209-240.
83. Miyabayashi T, Palfreyman MT, Sluder AE, Slack F, Sengupta P (1999): Expression and function of members of a divergent nuclear receptor family in C. elegans. Develop Biol 215:314-331.
84. Mlodzik M, Hiromi Y, Weber U, Goodman CS, Rubin GM (1990): The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates. Cell 60:211-224.
85. Monaghan AP, Bock D, Gass P, Schwager A, Wolfer DP, Lipp HP, Schutz G (1997): Defective limbic system in mice lacking the tailless gene. Nature 390:515-517.
86. Moore LB, Parks DJ, Jones SA, Bledsoe RK, Consler TG, Stimmel JB, Goodwin B, Liddle C, Blanchard SG, Willson TM, Collins JL, Kliewer SA (2000): Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J Biol Chem 275:15122-15127.
87. Much JW, Slade DJ, Klampert K, Garriga G, Wightman B (2000): The fax-1 nuclear hormone receptor regulates axon pathfinding and neurotransmitter expression. Development 127:703-712.
88. Murata T, Kageyama Y, Hirose S, Ueda H (1996): Regulation of the EDG84A gene by FTZ-F1 during metamorphosis in Drosophila melanogaster. Mol Cell Biol 16:6509-6515.
89. Naar AM, Lemon BD, Tjian R (2001): Transcriptional coactivator complexes. Annu Rev Biochem 70:475-501.
90. Nelson CC, Hendy SC, Romaniuk PJ (1995a): Relationship between P-box amino acid sequence and DNA binding specificity of the thyroid hormone receptor: The effects of half-site sequence in everted repeats. J Biol Chem 270:16981-16987.
91. Nelson CC, Hendy SC, Romaniuk PJ (1995b): Relationship between P-box amino acid sequence and DNA binding specificity of the thyroid hormone receptor: the effects of sequences flanking half-sites in thyroid hormone response elements. J Biol Chem 270:16988-16994.
92. Nicoll M, Akerib CC, Meyer BJ (1997): X-chromosomecounting mechanisms that determine nematode sex. Nature 388:200-204.
93. Nuclear Receptors Committee T (1999): A unified nomenclature system for the nuclear receptor superfamily. Cell 97:1-2.
94. Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY (1999): The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. Genes Dev 13:1037-1049.
95. Peterson KJ, Davidson EH (2000): Regulatory evolution and the origin of the bilaterians. Proc Natl Acad Sci U S A 97:4430-4433.
96. Rastinejad F (2001): Retinoid X receptor and its partners in the nuclear receptor family. Curr Opin Struct Biol 11:33-38.
97. Repa JJ, Manglesdorf DJ (1999): Nuclear receptor regulation of cholesterol and bile acid metabolism. Curr Opin Biotechnol 10:557-563.
98. Rhind NR, Miller LM, Kopczynski JB, Meyer BJ (1995): xol-1 acts as an early switch in the C. elegans male/herma phrodite decision. Cell 80:71-82.
99. Richards G (1997): The ecdysone regulatory cascades in Drosophila. Adv Develop Biol 5:81-135.
100. Riddle DL, Albert PS (1997): Genetic and environmental regulation of dauer larva development. In Riddle DL, Blumenthal T, Meyer BJ, Priess JR (eds): C. elegans II. Cold Spring Harbor Laboratory Press, Plainview, NY, 739-768.
101. Robinson-Rechavi M, Maina C, Gissendanner C, Laudet V, Sluder A. Evolution of Nuclear Receptors in Nematodes: Evidence for An Explosive Radiation of Orphan Receptor HNF4. Manuscript in preparation, 2002.
102. Segraves WA, Hogness DS (1990): The E75 ecdysoneinducible gene responsible for the 75B early puff in Drosophila encodes two new members of the steroid receptor superfamily. Genes Dev 4:204-219.
103. Sengupta P, Chou JH, Bargmann CI (1996): odr-10 encodes a seven transmembrane domain olfactory receptor required for responses to the odorant diacetyl. Cell 84:899-909.
104. Sengupta P, Colbert HA, Bargmann CI (1994): The C. elegans gene odr-7 encodes an olfactory-specific member of the nuclear receptor superfamily. Cell 79:971-980.
105. Shea C, Hough D, Xiao J, Tzertinis G, Maina C. An RXR Orthology from The Parasite Nematode, Dirofilaria Immitis. Manuscript in preparation, 2002.
106. Shostak Y, Van Gilst M, Yamamoto K. In Vitro Genomic Selection: From C. Elgans DAF-12 Binding Sites to Target Genes. Manuscript submitted. 2002
107. Sluder A (2002): [Preliminary Analysis of Nuclear Receptor Sequences in A Working Assembly of The Complete Caenorhabditis Briggsae Genome Sequence.] Unpublished data. Access to the C. briggsae genome sequence was generously provided by the Sanger Institute and the Washington University Genome Sequencing Center; http://genome.wusd.edu/projects/cbriggsae/
108. Sluder AE, Lindblom T, Ruvkun G (1997): The Caenorhabditis elegans orphan nuclear hormone receptor gene nhr-2 functions in early embryonic development. Dev Biol 184:303-319.
109. Sluder AE, Maina CV (2001): Nuclear receptors in nematodes: Themes and variations. Trends Genet 17:206-213.
110. Sluder AE, Mathews SW, Hough D, Yin VP, Maina CV (1999): The nuclear receptor superfamily has undergone extensive proliferation and diversification in nematodes. Gen Res 9:103-120.
111. Snow MI, Larsen PL (2000): Structure and expression of daf-12: A nuclear hormone receptor with three isoforms that are involved in development and aging in Caenorhabditis elegans. Biochim Biophys Acta 1494:104-116.
112. Strecker TR, Merriam JR, Lengyel JA (1988): Graded requirement for the zygotic terminal gene, tailless, in the brain and tail region of the Drosophila embryo. Development 102:721-34.
113. Streit A, Li W, Robertson B, Schein J, Kamal IH, Marra M, Wood WB (1999): Homologs of the Caenorhabditis elegans masculinizing gene her-1 in C. briggsae and the filarial parasite Brugia malayi. Genetics 152:1573-1584.
114. Tavemarakis N, Wang SL, Dorovkov M, Ryazanov A, Driscoll M (2000): Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes. Nat Genet 24:180-183.
115. Thummel C (1995): From embryogenesis to metamorphosis: The regulation and function of Drosophila nuclear receptor superfamily members. Cell 83:871-877.
116. Thummel CS (2001): Molecular mechanisms of developmental timing in C. elegans and Drosophila. Dev Cell 1:453-465.
117. Tsai SY, Tsai MJ (1997): Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): Coming of age. Endocr Rev 18:229-240.
118. Tuerk C (1997): Using the SELEX combinatorial chemistry process to find to find high affinity nucleic acid ligands to target molecules. Methods Mol Biol 67:219-230.
119. Umesono K, Evans RM (1989): Determinants of target gene specificity for steroid/thyroid hormone receptors. Cell 57:1139-1146.
120. Van Gilst M, Yamamoto K. C. Elegans Nuclear Hormone Receptors Utilize Highly Conserved DNA-binding Mechanisms. Manuscript in preparation, 2002.
121. Walthall WW (1990): Metamorphic-like changes in the nervous system of the nematode Caenorhabditis elegans. J Neurobiol 21:1085-1091.
122. Walthall WW, Plunkett JA (1995): Genetic transformation of the synaptic pattern of a motoneuron class in Caenorhabditis elegans. J Neurosci 15:1035-1043.
123. Waxman DJ (1999): P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR. Arch Biochem Biophys 369:11-23.
124. Wei P, Zhang J, Egan-Hafley M, Liang S, Moore DD (2000): The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature 407:920-923.
125. White KP, Hurban P, Watanabe T, Hogness DS (1997): Coordination of Drosophila metamorphosis by two ecdysone-induced nuclear receptors. Science 276:114-117.
126. Wightman B, Baran R, Garriga G (1997): Genes that guide growth cones along the C. elegans ventral nerve cord. Development 124:2571-2580.
127. Wilson TE, Fahrner TJ, Milbrandt J (1993): The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction. Mol Cell Biol 13:5794-5804.
128. Wilson TE, Paulsen RE, Padgett KA, Milbrandt J (1992): Participation of non-zinc finger residues in DNA binding by two nuclear orphan receptors. Science 256:107-110.
129. Xie W, Barwick JL, Downes M, Blumberg B, Simon CM, Nelson MC, Neuschwander-Tetri BA, Brunt EM, Guzelian PS, Evans RM (2000): Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature 406:435-439.
130. Xie W, Radominska-Pandya A, Shi Y, Simon CM, Nelson MC, Ong ES, Waxman DJ, Evans RM (2001): An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc Natl Acad Sci USA 98:3375-3380.
131. Yamada M, Murata T, Hirose S, Lavorgna G, Suzuki E, Ueda H (2000): Temporally restricted expression of transcription factor betaFTZ-F1: Significance for embryogenesis, molting and metamorphosis in Drosophila melanogaster. Development 127:5083-5092.
132. Yamamoto KR (1995): Multilayered control of intracellular receptor function. Harvey Lect 91:1-19.
133. Yan ZH, Medvedev A, Hirose T, Gotoh H, Jetten AM (1997): Characterization of the response element and DNA binding properties of the nuclear orphan receptor germ cell nuclear factor/retinoid receptorrelated testis-associated receptor. J Biol Chem 272:10565-10572.
134. Yu RT, McKeown M, Evans RM, Umesono K (1994): Relationship between Drosophila gap gene tailless and a vertebrate nuclear receptor TLX. Nature 370:375-379.
135. Yu Y, Li W, Su K, Yussa M, Han W, Perrimon N, Pick L (1997): The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain protein Ftz. Nature 385:552-555.
136. Zelhof AC, Yao TP, Chen JD, Evans RM, McKeown M (1995): Seven-up inhibits ultraspiracle-based signaling pathways in vitro and in vivo. Mol Cell Biol 15:6736-6745.
137. Zhao Q, Chasse SA, Devarakonda S, Sierk ML, Ahvazi B, Rastinejad F (2000): Structural basis of RXR-DNA interactions. J Mol Biol 296:509-520.
138. Zhao Q, Khorasanizadeh S, Miyoshi Y, Lazar MA, Rastinejad F (1998): Structural elements of an orphan nuclear receptor-DNA complex. Mol Cell 1:849-861.
139. Zhou C, Qiu Y, Pereira FA, Crair MC, Tsai SY, Tsai MJ (1999): The nuclear orphan receptor COUP-TFI is required for differentiation of subplate neurons and guidance of thalamocortical axons. Neuron 24:847-859.
140. Zhou HM, Walthall WW (1998): UNC-55, an orphan nuclear hormone receptor, orchestrates synaptic specificity among two classes of motor neurons inCaenorhabditis elegans. J Neurosci 18:10438-10444.