Combinatorial RNAi on intestinal cathepsin B-like proteinases in Caenorhabditis elegans questions the perception of their role in nematode biology

Molecular and Biochemical Parasitology

Volumn 145, Issue 1, 2006, Pages 128-132

  Geldhof, P ^a   Molloy, C ^a   Knox, D P ^a  

^a MOREDUN RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Caenorhabditis elegans; Cathepsin B like cysteine proteinase; Combinatiorial RNAi; Nematode; Parasite

Indexed keywords

CATHEPSIN B; DOUBLE STRANDED RNA; PROTEINASE;

ARTICLE; CAENORHABDITIS ELEGANS; COMBINATORIAL CHEMISTRY; ENZYME ACTIVATION; ENZYME DEGRADATION; GENE EXPRESSION; KNOCKOUT GENE; LARVAL DEVELOPMENT; MOLECULAR BIOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE DEVELOPMENT; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE;

ANIMALS; BASE SEQUENCE; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CATHEPSIN B; COMBINATORIAL CHEMISTRY TECHNIQUES; CYSTEINE ENDOPEPTIDASES; INTESTINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, DOUBLE-STRANDED; RNA, MESSENGER;

CAENORHABDITIS ELEGANS;

EID: 28044458583     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2005.09.016     Document Type: Article

References (24)

1. D.L. Redmond, and D.P. Knox Protection studies in sheep using affinity-purified and recombinant cysteine proteinases of adult Haemonchus contortus Vaccine 22 2004 4252 4261
2. A. Loukas, J.M. Bethony, and A.L. Williamson Vaccination of dogs with a recombinant cysteine protease from the intestine of canine hookworms diminishes the fecundity and growth of worms J Infect Dis 2004 1952 1961
3. A.L. Williamson, P.J. Brindley, D.P. Knox, P.J. Hotez, and A. Loukas Digestive proteases of blood-feeding nematodes Trends Parasitol 19 2003 417 423
4. C.G. Larminie, and I.L. Johnstone Isolation and characterization of four developmentally regulated cathepsin B-like cysteine protease genes from the nematode Caenorhabditis elegans DNA Cell Biol 15 1996 75 82
5. C. Ray, and J.H. McKerrow Gut-specific and developmental expression of a Caenorhabditis elegans cysteine protease gene Mol Biochem Parasitol 51 1992 239 249
6. C. Britton, J.H. McKerrow, and I.L. Johnstone Regulation of the Caenorhabditis elegans gut cysteine protease gene cpr-1: requirement for GATA motifs J Mol Biol 283 1998 15 27
7. R.S. Kamath, A.G. Fraser, and Y. Dong Systematic functional analysis of the Caenorhabditis elegans genome using RNAi Nature 421 2003 220 221
8. A.G. Fraser, R.S. Kamath, P. Zipperlin, M. Martinez-Campos, M. Sohrmann, and J. Ahringer Functional genomic analysis of C. elegans chromosome I by systematic RNA interference Nature 408 2000 325 330
9. P. Zipperlen, A.G. Fraser, R.S. Kamath, M. Martinez-Campos, and J. Ahringer Roles for 147 embryonic lethal genes on C. elegans chromosome I identified by RNA interference and video microscopy EMBO J 20 2001 3984 3992
10. R.S. Kamath, M. Martinez-Campos, P. Zipperlin, A.G. Fraser, and J. Ahringer Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans Genome Biol 2001 2
11. I. Maeda, Y. Kohara, M. Yamamoto, and A. Sugimoto Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi Curr Biol 11 2001 171 176
12. P. Geldhof, C. Whitton, W.F. Gregory, M. Blaxter, and D.P. Knox Characterisation of the two most abundant genes in the Haemonchus contortus expressed sequence tag dataset Int J Parasitol 35 2005 513 522
13. P. Geldhof, E. Claerebout, D.P. Knox, J. Jagneessens, and J. Vercruysse Proteinases released in vitro by the parasitic stages of the bovine abomasal nematode Ostertagia ostertagi Parasitology 121 2000 639 647
14. B. Wiederanders Structure-function relationships in class CA1 cysteine peptidase propeptides Acta Biochim Pol 50 2003 691 713
15. M. Sajid, J.H. McKerrow, and E. Hansell Functional expression and characterisation of Schisosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase Mol Biochem Parasitol 131 2003 65 75
16. D.P. Jasmer, M.D. Mitreva, and J.P. McCarter mRNA sequences for Haemonchus contortus intestinal cathepsin B-like cysteine proteases display an extreme in abundance and diversity compared with other adult mammalian parasitic nematodes Mol Biochem Parasitol 137 2004 297 305
17. A. Rehman, and D.P. Jasmer Defined characteristics of cathepsin B-like proteins from nematodes: inferred functional diversity and phylogenetic relationships Mol Biochem Parasitol 102 1999 297 310
18. K.A. Kuznicki, P.A. Smith, W.M. Leung-Chiu, A.O. Estevez, H.C. Scott, and K.L. Bennett Combinatorial RNA interference indicates GLH-4 can compensate for GLH-1; these two P granule components are critical for fertility in C. elegans Development 127 2000 2907 2916
19. C.M. Schubert, R. Lin, C.J. de Vries, R.H. Plasterk, and J.R. Priess MEX-5 and MEX-6 function to establish soma/germline asymmetry in early C. elegans embryos Mol Cell 5 2000 671 682
20. F.J. Thompson, C. Britton, and I. Wheatley Biochemical and molecular characterization of two cytidine deaminases in the nematode Caenorhabditis elegans Biochem J 365 2002 99 107
21. D. Combes, Y. Fedon, J.P. Toutant, and M. Arpagaus Multiple ace genes encoding acetylcholinesterases of Caenorhabditis elegans have distinct tissue expression Eur J Neurosci 18 2003 497 512
22. F.I. Pellerone, S.K. Archer, C.A. Behm, W.N. Grant, M.J. Lacey, and A.C. Somerville Trehalose metabolism in Caenorhabditis elegans and filarial nematodes Int J Parasitol 33 2003 1195 1206
23. P. Gonczy, C. Echeverri, and K. Oegema Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III Nature 408 2000 331 336
24. C.A. Behm, M.M. Bendig, J.P. McCarter, and A.E. Sluder RNAi-based discovery and validation of new drug targets in filarial nematodes Trends Parasitol 21 2005 97 100