RNA interference in parasitic nematodes of animals: a reality check?

Trends in Parasitology

Volumn 23, Issue 3, 2007, Pages 105-107

  Knox, David P ^a   Geldhof, Peter ^b   Visser, Aline ^b   Britton, Collette ^c  

^a MOREDUN RESEARCH INSTITUTE   (United Kingdom)

^b GHENT UNIVERSITY   (Belgium)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA;

ANIMAL; ARTICLE; CAENORHABDITIS ELEGANS; GENE FUNCTION; HIGH THROUGHPUT SCREENING; NEMATODE; NONHUMAN; PARASITE DEVELOPMENT; PARASITE EXAMINATION; RNA INTERFERENCE;

ANIMALS; GENE EXPRESSION REGULATION; GENE SILENCING; GENES, HELMINTH; NEMATODA; RNA INTERFERENCE; RNA, HELMINTH;

ANIMALIA; CAENORHABDITIS ELEGANS; NEMATODA;

EID: 33847310222     PISSN: 14714922     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pt.2007.01.007     Document Type: Article

References (28)

1. Maeda I., et al. Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi. Curr. Biol. 11 (2001) 171-176
2. Kamath R.S., et al. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421 (2003) 231-237
3. Hansen M., et al. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet. 1 (2005) 119-128
4. Kennerdell J.R., and Carthew R.W. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway. Cell 95 (1998) 1017-1026
5. Ngo H., et al. Double-stranded RNA induces mRNA degradation in Trypanosoma brucei. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 14687-14692
6. Elbashir S.M., et al. Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J. 20 (2001) 6877-6888
7. Britton C., and Murray L. Using Caenorhabditis elegans for functional analysis of genes of parasitic nematodes. Int. J. Parasitol. 36 (2006) 651-659
8. Geldhof, P. et al. RNA interference in helminths: current situation, potential pitfalls and future prospects. Parasitology (in press)
9. Issa Z., et al. Development of methods for RNA interference in the sheep gastrointestinal parasite, Trichostrongylus colubriformis. Int. J. Parasitol. 35 (2005) 935-940
10. Geldhof P., et al. Testing the efficacy of RNA interference in Haemonchus contortus. Int. J. Parasitol. 36 (2006) 801-810
11. Visser A., et al. Efficacy and specificity of RNA interference in larval life stages of Ostertagia ostertagi. Parasitology 133 (2006) 777-783
12. Kamath R.S., and Ahringer J. Genome-wide RNAi screening in Caenorhabditis elegans. Methods 30 (2003) 313-321
13. Zawadzki J., et al. RNAi in Haemonchus contortus: a potential method for target evaluation. Trends Parasitol. 22 (2006) 495-499
14. Tabara H., et al. RNAi in C. elegans: soaking in the genome sequence. Science 282 (1998) 430-431
15. Stringfellow F. Cultivation of Haemonchus contortus (Nematoda: Trichostrongylidae) from infective larvae to the adult male and the egg-laying female. J. Parasitol. 72 (1986) 339-345
16. Felix, M.A., ed. (2006) Oscheius tipulae. In WormBook, The C. elegans Research Community doi:10.1895/wormbook.1.7.1 (http://www.wormbook.org)
17. Fire A., et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391 (1998) 806-811
18. Tijsterman M., et al. PPW-1, a PAZ/PIWI protein required for efficient germline RNAi, is defective in a natural isolate of C. elegans. Curr. Biol. 12 (2002) 1535-1540
19. Kotze A.C., and Bagnall N.H. RNA interference in Haemonchus contortus: suppression of β-tubulin gene expression in L3, L4 and adult worms in vitro. Mol. Biochem. Parasitol. 145 (2006) 101-110
20. Weaver J.C. Electroporation theory. Concepts and mechanisms. Methods Mol. Biol. 55 (1995) 3-28
21. Correnti J.M., et al. Long-term suppression of cathepsin B levels by RNA interference retards schistosome growth. Mol. Biochem. Parasitol. 143 (2005) 209-215
22. Hussein A.S., et al. Suppression of secreted acetylcholinesterase expression in Nippostrongylus brasiliensis by RNA interference. Mol. Biochem. Parasitol. 122 (2002) 91-94
23. Grishok A. RNAi mechanisms in Caenorhabditis elegans. FEBS Lett. 579 (2005) 5932-5939
24. Liu Q., et al. R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. Science 301 (2003) 1921-1925
25. Tabara H., et al. The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans. Cell 109 (2002) 861-871
26. Caplen N.J., et al. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 9742-9747
27. Persengiev S.P., et al. Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs). RNA 10 (2004) 12-18
28. Valiunas V., et al. Connexin-specific cell-to-cell transfer of short interfering RNA by gap junctions. J. Physiol. 568 (2005) 459-468