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Volumn 144, Issue 3, 2007, Pages 254-266

Recent progress in tolerance induction through mixed chimerism

Author keywords

Chimerism; Costimulation blockade; Tolerance; Transplantation

Indexed keywords

ABATACEPT; BUSULFAN; IMMUNOSUPPRESSIVE AGENT; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN;

EID: 35348833592     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000104740     Document Type: Review
Times cited : (20)

References (121)
  • 5
    • 0000658958 scopus 로고
    • Immunogenetic consequences of vascular anastomoses between bovine twins
    • Owen RD: Immunogenetic consequences of vascular anastomoses between bovine twins. Science 1945;102:400-401.
    • (1945) Science , vol.102 , pp. 400-401
    • Owen, R.D.1
  • 6
    • 0035754206 scopus 로고    scopus 로고
    • Transplantation tolerance from a historical perspective
    • Starzl TE, Zinkernagel RM: Transplantation tolerance from a historical perspective. Nat Rev Immunol 2001;1:233-239.
    • (2001) Nat Rev Immunol , vol.1 , pp. 233-239
    • Starzl, T.E.1    Zinkernagel, R.M.2
  • 7
    • 0005984244 scopus 로고
    • Actively acquired tolerance' of foreign cells
    • Billingham RE, Brent L, Medawar PB: 'Actively acquired tolerance' of foreign cells. Nature 1953;172:603-606.
    • (1953) Nature , vol.172 , pp. 603-606
    • Billingham, R.E.1    Brent, L.2    Medawar, P.B.3
  • 8
    • 84959796172 scopus 로고
    • Successful skin homografts after the administration of high dosage X radiation and homologous bone marrow
    • Main JM, Prehn RT: Successful skin homografts after the administration of high dosage X radiation and homologous bone marrow. J Natl Cancer Inst 1955;1023-1028.
    • (1955) J Natl Cancer Inst , pp. 1023-1028
    • Main, J.M.1    Prehn, R.T.2
  • 9
    • 0024209925 scopus 로고
    • Graft-versus-host-related immunosuppression is induced in mixed chimeras by alloresponses against either host or donor lymphohematopoietic cells
    • Sykes M, Sheard MA, Sachs DH: Graft-versus-host-related immunosuppression is induced in mixed chimeras by alloresponses against either host or donor lymphohematopoietic cells. J Exp Med 1988;168:2391-2396.
    • (1988) J Exp Med , vol.168 , pp. 2391-2396
    • Sykes, M.1    Sheard, M.A.2    Sachs, D.H.3
  • 10
    • 0019424659 scopus 로고
    • Self recognition in allogeneic radiation chimeras: A radiation-resistant host element dictates the self specificity and immune response gene phenotype of T-helper cells
    • Singer A, Hathcock KS, Hodes RJ: Self recognition in allogeneic radiation chimeras: a radiation-resistant host element dictates the self specificity and immune response gene phenotype of T-helper cells. J Exp Med 1981;153:1286-1301.
    • (1981) J Exp Med , vol.153 , pp. 1286-1301
    • Singer, A.1    Hathcock, K.S.2    Hodes, R.J.3
  • 11
    • 0021251825 scopus 로고
    • Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts
    • Ildstad ST, Sachs DH: Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts. Nature 1984;307:168-170.
    • (1984) Nature , vol.307 , pp. 168-170
    • Ildstad, S.T.1    Sachs, D.H.2
  • 12
    • 0021845739 scopus 로고
    • Characterization of mixed allogeneic chimeras: Immunocompetence, in vitro reactivity, and genetic specificity of tolerance
    • Ildstad ST, Wren SM, Bluestone JA, Barbieri SA, Sachs DH: Characterization of mixed allogeneic chimeras: immunocompetence, in vitro reactivity, and genetic specificity of tolerance. J Exp Med 1985;162:231-244.
    • (1985) J Exp Med , vol.162 , pp. 231-244
    • Ildstad, S.T.1    Wren, S.M.2    Bluestone, J.A.3    Barbieri, S.A.4    Sachs, D.H.5
  • 14
    • 0028341472 scopus 로고
    • Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantion in mice conditioned with a non-myeloablative regimen
    • Tomita Y, Khan A, Sykes M: Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantion in mice conditioned with a non-myeloablative regimen. J Immunol 1994;153:1087-1098.
    • (1994) J Immunol , vol.153 , pp. 1087-1098
    • Tomita, Y.1    Khan, A.2    Sykes, M.3
  • 15
    • 0032528258 scopus 로고    scopus 로고
    • Intrathymic deletion of alloreactive T cells in mixed bone marrow chimeras prepared with a non-myeloablative conditioning regimen
    • Manilay JO, Pearson DA, Sergio JJ, Swenson KG, Sykes M: Intrathymic deletion of alloreactive T cells in mixed bone marrow chimeras prepared with a non-myeloablative conditioning regimen. Transplantation 1998;66:96-102.
    • (1998) Transplantation , vol.66 , pp. 96-102
    • Manilay, J.O.1    Pearson, D.A.2    Sergio, J.J.3    Swenson, K.G.4    Sykes, M.5
  • 16
    • 0018085532 scopus 로고
    • On the thymus in the differentiation of 'H-2 self-recognition' by T cells: Evidence for dual recognition?
    • Zinkernagel RM, Callahan GN, Althage A, Cooper S, Klein PA, Klein J: On the thymus in the differentiation of 'H-2 self-recognition' by T cells: evidence for dual recognition? J Exp Med 1978;147:882-896.
    • (1978) J Exp Med , vol.147 , pp. 882-896
    • Zinkernagel, R.M.1    Callahan, G.N.2    Althage, A.3    Cooper, S.4    Klein, P.A.5    Klein, J.6
  • 17
    • 23944526117 scopus 로고    scopus 로고
    • Requirement of a higher degree of chimerism for skin allograft tolerance in cyclophosphamide-induced tolerance
    • Iwai T, Tomita Y, Zhang QW, Shimizu I, Nomoto K, Yasui H: Requirement of a higher degree of chimerism for skin allograft tolerance in cyclophosphamide-induced tolerance. Transpl Int 2005;17:795-803.
    • (2005) Transpl Int , vol.17 , pp. 795-803
    • Iwai, T.1    Tomita, Y.2    Zhang, Q.W.3    Shimizu, I.4    Nomoto, K.5    Yasui, H.6
  • 18
    • 33745064578 scopus 로고    scopus 로고
    • Is clinical tolerance realistic in the next decade?
    • Ashton-Chess J, Brouard S, Soulillou J-P: Is clinical tolerance realistic in the next decade? Transpl Int 2006;19:539-548.
    • (2006) Transpl Int , vol.19 , pp. 539-548
    • Ashton-Chess, J.1    Brouard, S.2    Soulillou, J.-P.3
  • 19
    • 0028013320 scopus 로고
    • Myelosuppressive conditioning is required to achieve engraftment of pluripotent stem cells contained in moderate doses of syngeneic bone marrow
    • Tomita Y, Sachs DH, Sykes M: Myelosuppressive conditioning is required to achieve engraftment of pluripotent stem cells contained in moderate doses of syngeneic bone marrow. Blood 1994;83:939-948.
    • (1994) Blood , vol.83 , pp. 939-948
    • Tomita, Y.1    Sachs, D.H.2    Sykes, M.3
  • 20
    • 0023046991 scopus 로고
    • Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance
    • Cobbold SP, Martin G, Qin S, Waldmann H: Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance. Nature 1986;323:164-165.
    • (1986) Nature , vol.323 , pp. 164-165
    • Cobbold, S.P.1    Martin, G.2    Qin, S.3    Waldmann, H.4
  • 21
    • 0024561069 scopus 로고
    • Mixed chimerism and permanent specific transplantation tolerance induced by a non-lethal preparative regimen
    • Sharabi Y, Sachs DH: Mixed chimerism and permanent specific transplantation tolerance induced by a non-lethal preparative regimen. J Exp Med 1989;169:493-502.
    • (1989) J Exp Med , vol.169 , pp. 493-502
    • Sharabi, Y.1    Sachs, D.H.2
  • 22
    • 0036933578 scopus 로고    scopus 로고
    • Minimal conditioning required in a murine model of T cell depletion, thymic irradiation and high-dose bone marrow transplantation for the induction of mixed chimerism and tolerance
    • Wekerle T, Nikolic B, Pearson DA, Swenson KG, Sykes M: Minimal conditioning required in a murine model of T cell depletion, thymic irradiation and high-dose bone marrow transplantation for the induction of mixed chimerism and tolerance. Transpl Int 2002;15:248-253.
    • (2002) Transpl Int , vol.15 , pp. 248-253
    • Wekerle, T.1    Nikolic, B.2    Pearson, D.A.3    Swenson, K.G.4    Sykes, M.5
  • 23
    • 0030024697 scopus 로고    scopus 로고
    • Additional mAb injections can replace thymic irradiation to allow induction of mixed chimerism and tolerance in mice receiving bone marrow transplantation after conditioning with anti-T cell mAbs and 3 Gy whole body irradiation
    • Tomita Y, Sachs DH, Khan A, Sykes M: Additional mAb injections can replace thymic irradiation to allow induction of mixed chimerism and tolerance in mice receiving bone marrow transplantation after conditioning with anti-T cell mAbs and 3 Gy whole body irradiation. Transplantation 1996;61:469-477.
    • (1996) Transplantation , vol.61 , pp. 469-477
    • Tomita, Y.1    Sachs, D.H.2    Khan, A.3    Sykes, M.4
  • 25
    • 0030752411 scopus 로고    scopus 로고
    • Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning
    • Sykes M, Szot GL, Swenson K, Pearson DA: Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning. Nat Med 1997;3:783-787.
    • (1997) Nat Med , vol.3 , pp. 783-787
    • Sykes, M.1    Szot, G.L.2    Swenson, K.3    Pearson, D.A.4
  • 26
    • 0025339511 scopus 로고
    • A cell culture model for T lymphocyte clonal anergy
    • Schwartz RH: A cell culture model for T lymphocyte clonal anergy. Science 1990;248:1349-1356.
    • (1990) Science , vol.248 , pp. 1349-1356
    • Schwartz, R.H.1
  • 27
    • 0033571542 scopus 로고    scopus 로고
    • Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance
    • Wekerle T, Sayegh MH, Ito H, Hill J, Chandraker A, Pearson DA, Swenson KG, Zhao G, Sykes M: Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance. Transplantation 1999;68:1348-1355.
    • (1999) Transplantation , vol.68 , pp. 1348-1355
    • Wekerle, T.1    Sayegh, M.H.2    Ito, H.3    Hill, J.4    Chandraker, A.5    Pearson, D.A.6    Swenson, K.G.7    Zhao, G.8    Sykes, M.9
  • 28
    • 0032526283 scopus 로고    scopus 로고
    • Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance
    • Wekerle T, Sayegh MH, Hill J, Zhao Y, Chandraker A, Swenson KG, Zhao G, Sykes M: Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance. J Exp Med 1998;187:2037-2044.
    • (1998) J Exp Med , vol.187 , pp. 2037-2044
    • Wekerle, T.1    Sayegh, M.H.2    Hill, J.3    Zhao, Y.4    Chandraker, A.5    Swenson, K.G.6    Zhao, G.7    Sykes, M.8
  • 29
    • 0035879193 scopus 로고    scopus 로고
    • Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression
    • Adams AB, Durham MM, Kean L, Shirasugi N, Ha J, Williams MA, Rees PA, Cheung MC, Mittelstaedt S, Bingaman AW, et al: Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression. J Immunol 2001;167:1103-1111.
    • (2001) J Immunol , vol.167 , pp. 1103-1111
    • Adams, A.B.1    Durham, M.M.2    Kean, L.3    Shirasugi, N.4    Ha, J.5    Williams, M.A.6    Rees, P.A.7    Cheung, M.C.8    Mittelstaedt, S.9    Bingaman, A.W.10
  • 30
    • 0035880243 scopus 로고    scopus 로고
    • Requirements for the promotion of allogeneic engraftment by anti-CD154 (anti-CD40L) monoclonal antibody under nonmyeloablative conditions
    • Taylor PA, Lees CJ, Waldmann H, Noelle RJ, Blazar BR: Requirements for the promotion of allogeneic engraftment by anti-CD154 (anti-CD40L) monoclonal antibody under nonmyeloablative conditions. Blood 2001;98:467-474.
    • (2001) Blood , vol.98 , pp. 467-474
    • Taylor, P.A.1    Lees, C.J.2    Waldmann, H.3    Noelle, R.J.4    Blazar, B.R.5
  • 33
    • 0032429341 scopus 로고    scopus 로고
    • Hematopoietic chimerism and tolerance of T cells, B cells, and NK cells
    • Sykes M, Ohdan H, Manilay JO, Wekerle T, Yang YG: Hematopoietic chimerism and tolerance of T cells, B cells, and NK cells. Transpl Proc 1998;30:420.
    • (1998) Transpl Proc , vol.30 , pp. 420
    • Sykes, M.1    Ohdan, H.2    Manilay, J.O.3    Wekerle, T.4    Yang, Y.G.5
  • 34
    • 0032549859 scopus 로고    scopus 로고
    • Tolerization of anti-Galα 1-3Gal natural antibody-forming B cells by induction of mixed chimerism
    • Yang Y-G, deGoma E, Ohdan H, Bracy JL, Xu Y, Iacomini J, Thall AD, Sykes M: Tolerization of anti-Galα 1-3Gal natural antibody-forming B cells by induction of mixed chimerism. J Exp Med 1998;187:1335-1342.
    • (1998) J Exp Med , vol.187 , pp. 1335-1342
    • Yang, Y.-G.1    deGoma, E.2    Ohdan, H.3    Bracy, J.L.4    Xu, Y.5    Iacomini, J.6    Thall, A.D.7    Sykes, M.8
  • 35
    • 0038528572 scopus 로고    scopus 로고
    • NK cell tolerance in mixed allogeneic chimeras
    • Zhao Y, Ohdan H, Manilay JO, Sykes M: NK cell tolerance in mixed allogeneic chimeras. J Immunol 2003;170:5398-5405.
    • (2003) J Immunol , vol.170 , pp. 5398-5405
    • Zhao, Y.1    Ohdan, H.2    Manilay, J.O.3    Sykes, M.4
  • 36
    • 0035284740 scopus 로고    scopus 로고
    • CD4 T cellmediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is dependent on CD40-CD40 ligand interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this pathway
    • Ito H, Kurtz J, Shaffer J, Sykes M: CD4 T cellmediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is dependent on CD40-CD40 ligand interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this pathway. J Immunol 2001;166:2970-2981.
    • (2001) J Immunol , vol.166 , pp. 2970-2981
    • Ito, H.1    Kurtz, J.2    Shaffer, J.3    Sykes, M.4
  • 37
    • 0035863758 scopus 로고    scopus 로고
    • Allogeneic chimerism with low-dose irradiation, antigen presensitization, and costimulator blockade in H-2 mismatched mice
    • Quesenberry PJ, Zhong S, Wang H, Stewart M: Allogeneic chimerism with low-dose irradiation, antigen presensitization, and costimulator blockade in H-2 mismatched mice. Blood 2001;97:557-564.
    • (2001) Blood , vol.97 , pp. 557-564
    • Quesenberry, P.J.1    Zhong, S.2    Wang, H.3    Stewart, M.4
  • 38
    • 0034654374 scopus 로고    scopus 로고
    • Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: Absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice
    • Seung E, Iwakoshi N, Woda BA, Markees TG, Mordes JP, Rossini AA, Greiner DL: Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice. Blood 2000;95:2175-2182.
    • (2000) Blood , vol.95 , pp. 2175-2182
    • Seung, E.1    Iwakoshi, N.2    Woda, B.A.3    Markees, T.G.4    Mordes, J.P.5    Rossini, A.A.6    Greiner, D.L.7
  • 39
    • 85047692674 scopus 로고    scopus 로고
    • Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning
    • Seung E, Mordes JP, Rossini AA, Greiner DL: Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning. J Clin Invest 2003;112:795-808.
    • (2003) J Clin Invest , vol.112 , pp. 795-808
    • Seung, E.1    Mordes, J.P.2    Rossini, A.A.3    Greiner, D.L.4
  • 40
    • 0038576227 scopus 로고    scopus 로고
    • The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade
    • Blaha P, Bigenzahn S, Koporc Z, Schmid M, Langer F, Selzer E, Bergmeister H, Wrba F, Kurtz J, Kiss C, et al: The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade. Blood 2003;101:2886-2893.
    • (2003) Blood , vol.101 , pp. 2886-2893
    • Blaha, P.1    Bigenzahn, S.2    Koporc, Z.3    Schmid, M.4    Langer, F.5    Selzer, E.6    Bergmeister, H.7    Wrba, F.8    Kurtz, J.9    Kiss, C.10
  • 41
    • 0034235458 scopus 로고    scopus 로고
    • Administration of anti-CD40 ligand and donor bone marrow leads to hematopoietic chimerism and donor-specific tolerance without cytoreductive conditioning
    • Durham MM, Bingaman AW, Adams AB, Ha J, Waitze S-Y, Pearson TC, Larsen CP: Administration of anti-CD40 ligand and donor bone marrow leads to hematopoietic chimerism and donor-specific tolerance without cytoreductive conditioning. J Immunol 2000;165:1-4.
    • (2000) J Immunol , vol.165 , pp. 1-4
    • Durham, M.M.1    Bingaman, A.W.2    Adams, A.B.3    Ha, J.4    Waitze, S.-Y.5    Pearson, T.C.6    Larsen, C.P.7
  • 44
    • 1442331657 scopus 로고    scopus 로고
    • Local irradiation enhances congenic donor pluripotent hematopoietic stem cell engraftment similarly in irradiated and nonirradiated sites
    • Ito H, Takeuchi Y, Shaffer J, Sykes M: Local irradiation enhances congenic donor pluripotent hematopoietic stem cell engraftment similarly in irradiated and nonirradiated sites. Blood 2004;103:1949-1954.
    • (2004) Blood , vol.103 , pp. 1949-1954
    • Ito, H.1    Takeuchi, Y.2    Shaffer, J.3    Sykes, M.4
  • 45
    • 0036493491 scopus 로고    scopus 로고
    • A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation
    • Kean LS, Durham MM, Adams AB, Hsu LL, Perry JR, Dillehay D, Pearson TC, Waller EK, Larsen CP, Archer DR: A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation. Blood 2002;99:1840-1849.
    • (2002) Blood , vol.99 , pp. 1840-1849
    • Kean, L.S.1    Durham, M.M.2    Adams, A.B.3    Hsu, L.L.4    Perry, J.R.5    Dillehay, D.6    Pearson, T.C.7    Waller, E.K.8    Larsen, C.P.9    Archer, D.R.10
  • 46
    • 0034071426 scopus 로고    scopus 로고
    • Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment
    • Wekerle T, Kurtz J, Ito H, Ronquillo JV, Dong V, Zhao G, Shaffer J, Sayegh MH, Sykes M: Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment. Nat Med 2000;6:464-469.
    • (2000) Nat Med , vol.6 , pp. 464-469
    • Wekerle, T.1    Kurtz, J.2    Ito, H.3    Ronquillo, J.V.4    Dong, V.5    Zhao, G.6    Shaffer, J.7    Sayegh, M.H.8    Sykes, M.9
  • 48
    • 23044482250 scopus 로고    scopus 로고
    • Short-term immunosuppression facilitates induction of mixed chimerism and tolerance after bone marrow transplantation without cytoreductive conditioning
    • Blaha P, Bigenzahn S, Koporc Z, Sykes M, Muehlbacher F, Wekerle T: Short-term immunosuppression facilitates induction of mixed chimerism and tolerance after bone marrow transplantation without cytoreductive conditioning. Transplantation 2005;80:237-243.
    • (2005) Transplantation , vol.80 , pp. 237-243
    • Blaha, P.1    Bigenzahn, S.2    Koporc, Z.3    Sykes, M.4    Muehlbacher, F.5    Wekerle, T.6
  • 49
    • 33244488261 scopus 로고    scopus 로고
    • Induction of mixed chimerism through transplantation of CD45-congenic mobilized peripheral blood stem cells after nonmyeloablative irradiation
    • Koporc Z, Bigenzahn S, Blaha P, Fariborz E, Selzer E, Sykes M, Muehlbacher F, Wekerle T: Induction of mixed chimerism through transplantation of CD45-congenic mobilized peripheral blood stem cells after nonmyeloablative irradiation. Biol Blood Marrow Transplant 2006;12:284-292.
    • (2006) Biol Blood Marrow Transplant , vol.12 , pp. 284-292
    • Koporc, Z.1    Bigenzahn, S.2    Blaha, P.3    Fariborz, E.4    Selzer, E.5    Sykes, M.6    Muehlbacher, F.7    Wekerle, T.8
  • 50
    • 33646671989 scopus 로고    scopus 로고
    • Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myelosuppressive conditioning
    • Graca L, Daley S, Fairchild P, Cobbold S, Waldmann H: Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myelosuppressive conditioning. BMC Immunol 2006;7:9.
    • (2006) BMC Immunol , vol.7 , pp. 9
    • Graca, L.1    Daley, S.2    Fairchild, P.3    Cobbold, S.4    Waldmann, H.5
  • 51
    • 24744462330 scopus 로고    scopus 로고
    • Long-term mixed chimerism after immunologic conditioning and MHC-mismatched stem-cell transplantation is dependent on NK-cell tolerance
    • Westerhuis G, Maas WGE, Willemze R, Toes REM, Fibbe WE: Long-term mixed chimerism after immunologic conditioning and MHC-mismatched stem-cell transplantation is dependent on NK-cell tolerance. Blood 2005;106:2215-2220.
    • (2005) Blood , vol.106 , pp. 2215-2220
    • Westerhuis, G.1    Maas, W.G.E.2    Willemze, R.3    Toes, R.E.M.4    Fibbe, W.E.5
  • 52
    • 0036839605 scopus 로고    scopus 로고
    • Combined effects of calcineurin inhibitors or sirolimus with anti-CD40L mAb on alloengraftment under nonmyeloablative conditions
    • Taylor PA, Lees CJ, Wilson JM, Ehrhardt MJ, Campbell MT, Noelle RJ, Blazar BR: Combined effects of calcineurin inhibitors or sirolimus with anti-CD40L mAb on alloengraftment under nonmyeloablative conditions. Blood 2002;100:3400-3407.
    • (2002) Blood , vol.100 , pp. 3400-3407
    • Taylor, P.A.1    Lees, C.J.2    Wilson, J.M.3    Ehrhardt, M.J.4    Campbell, M.T.5    Noelle, R.J.6    Blazar, B.R.7
  • 55
    • 0037097593 scopus 로고    scopus 로고
    • Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell
    • Taylor PA, Friedman TM, Korngold R, Noelle RJ, Blazar BR: Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell. Blood 2002;99:4601-4609.
    • (2002) Blood , vol.99 , pp. 4601-4609
    • Taylor, P.A.1    Friedman, T.M.2    Korngold, R.3    Noelle, R.J.4    Blazar, B.R.5
  • 60
    • 14644392163 scopus 로고    scopus 로고
    • CTLA-4Ig is finally making it: A personal perspective
    • Bluestone JA: CTLA-4Ig is finally making it: a personal perspective. Am J Transplant 2005;5:423-424.
    • (2005) Am J Transplant , vol.5 , pp. 423-424
    • Bluestone, J.A.1
  • 62
    • 0036852242 scopus 로고    scopus 로고
    • When ligand becomes receptor - tolerance via B7 signaling on DCs
    • Finger EB, Bluestone JA: When ligand becomes receptor - tolerance via B7 signaling on DCs. Nat Immunol 2002;3:1056-1057.
    • (2002) Nat Immunol , vol.3 , pp. 1056-1057
    • Finger, E.B.1    Bluestone, J.A.2
  • 66
    • 0344613988 scopus 로고    scopus 로고
    • Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance
    • Li Y, Li XC, Zheng XX, Wells AD, Turka LA, Strom TB: Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nature Med 1999;5:1298-1302.
    • (1999) Nature Med , vol.5 , pp. 1298-1302
    • Li, Y.1    Li, X.C.2    Zheng, X.X.3    Wells, A.D.4    Turka, L.A.5    Strom, T.B.6
  • 68
    • 2542450949 scopus 로고    scopus 로고
    • Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: Evidence for anergy and deletion but not regulatory cells
    • Kurtz J, Shaffer J, Lie A, Anosova N, Benichou G, Sykes M: Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: evidence for anergy and deletion but not regulatory cells. Blood 2004;103:4336-4343.
    • (2004) Blood , vol.103 , pp. 4336-4343
    • Kurtz, J.1    Shaffer, J.2    Lie, A.3    Anosova, N.4    Benichou, G.5    Sykes, M.6
  • 69
    • 0035865066 scopus 로고    scopus 로고
    • Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death
    • Wekerle T, Kurtz J, Sayegh MH, Ito H, Wells AD, Bensinger S, Shaffer J, Turka LA, Sykes M: Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death. J Immunol 2001;166:2311-2316.
    • (2001) J Immunol , vol.166 , pp. 2311-2316
    • Wekerle, T.1    Kurtz, J.2    Sayegh, M.H.3    Ito, H.4    Wells, A.D.5    Bensinger, S.6    Shaffer, J.7    Turka, L.A.8    Sykes, M.9
  • 70
    • 21244483043 scopus 로고    scopus 로고
    • Roles of deletion and regulation in creating mixed chimerism and allograft tolerance using a nonlymphoablative irradiation-free protocol
    • Domenig C, Sanchez-Fueyo A, Kurtz J, Alexopoulos SP, Mariat C, Sykes M, Strom TB, Zheng XX: Roles of deletion and regulation in creating mixed chimerism and allograft tolerance using a nonlymphoablative irradiation-free protocol. J Immunol 2005;175:51-60.
    • (2005) J Immunol , vol.175 , pp. 51-60
    • Domenig, C.1    Sanchez-Fueyo, A.2    Kurtz, J.3    Alexopoulos, S.P.4    Mariat, C.5    Sykes, M.6    Strom, T.B.7    Zheng, X.X.8
  • 71
    • 0032521267 scopus 로고    scopus 로고
    • Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose
    • Bemelman F, Honey K, Adams E, Cobbold S, Waldmann H: Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose. J Immunol 1998;160:2645-2648.
    • (1998) J Immunol , vol.160 , pp. 2645-2648
    • Bemelman, F.1    Honey, K.2    Adams, E.3    Cobbold, S.4    Waldmann, H.5
  • 72
    • 19344373375 scopus 로고    scopus 로고
    • Tolerance in mixed chimerism - a role for regulatory cells?
    • Kurtz J, Wekerle T, Sykes M: Tolerance in mixed chimerism - a role for regulatory cells? Trends Immunol 2004;25:518-523.
    • (2004) Trends Immunol , vol.25 , pp. 518-523
    • Kurtz, J.1    Wekerle, T.2    Sykes, M.3
  • 75
    • 33646703806 scopus 로고    scopus 로고
    • Overcoming T cell-mediated rejection of bone marrow allografts by T-regulatory cells: Synergism with veto cells and rapamycin
    • Steiner D, Brunicki N, Bachar-Lustig E, Taylor PA, Blazar BR, Reisner Y: Overcoming T cell-mediated rejection of bone marrow allografts by T-regulatory cells: synergism with veto cells and rapamycin. Exp Hematol 2006;34:802-808.
    • (2006) Exp Hematol , vol.34 , pp. 802-808
    • Steiner, D.1    Brunicki, N.2    Bachar-Lustig, E.3    Taylor, P.A.4    Blazar, B.R.5    Reisner, Y.6
  • 76
    • 13544258633 scopus 로고    scopus 로고
    • Donor CD4+CD25+ T cells promote engraftment and tolerance following MHC-mismatched hematopoietic cell transplantation
    • Hanash AM, Levy RB: Donor CD4+CD25+ T cells promote engraftment and tolerance following MHC-mismatched hematopoietic cell transplantation. Blood 2005;105:1828-1836.
    • (2005) Blood , vol.105 , pp. 1828-1836
    • Hanash, A.M.1    Levy, R.B.2
  • 78
    • 0344553377 scopus 로고    scopus 로고
    • Heterologous immunity: An overlooked barrier to tolerance
    • Adams AB, Pearson TC, Larsen CP: Heterologous immunity: an overlooked barrier to tolerance. Immunol Rev 2003;196:147-160.
    • (2003) Immunol Rev , vol.196 , pp. 147-160
    • Adams, A.B.1    Pearson, T.C.2    Larsen, C.P.3
  • 79
    • 0037111238 scopus 로고    scopus 로고
    • Cutting edge: Persistent viral infection prevents tolerance induction and escapes immune control following CD28/CD40 blockade-based regimen
    • Williams MA, Onami TM, Adams AB, Durham MM, Pearson TC, Ahmed R, Larsen CP: Cutting edge: persistent viral infection prevents tolerance induction and escapes immune control following CD28/CD40 blockade-based regimen. J Immunol 2002;169:5387-5391.
    • (2002) J Immunol , vol.169 , pp. 5387-5391
    • Williams, M.A.1    Onami, T.M.2    Adams, A.B.3    Durham, M.M.4    Pearson, T.C.5    Ahmed, R.6    Larsen, C.P.7
  • 81
    • 0033214355 scopus 로고    scopus 로고
    • Stable mixed chimerism in dogs given donor antigen, CTLA4Ig, and 100 cGy total body irradiation before and pharmacologic immunosuppression after marrow transplant
    • Storb R, Yu C, Zaucha JM, Deeg HJ, Georges G, Kiem HP, Nash RA, McSweeney PA, Wagner JL: Stable mixed chimerism in dogs given donor antigen, CTLA4Ig, and 100 cGy total body irradiation before and pharmacologic immunosuppression after marrow transplant. Blood 1999;94:2523-2529.
    • (1999) Blood , vol.94 , pp. 2523-2529
    • Storb, R.1    Yu, C.2    Zaucha, J.M.3    Deeg, H.J.4    Georges, G.5    Kiem, H.P.6    Nash, R.A.7    McSweeney, P.A.8    Wagner, J.L.9
  • 84
    • 0034897889 scopus 로고    scopus 로고
    • Kawai T, Sogawa H, Koulmanda M, Smith RN, O'Neil JJ, Wee SL, Boskovic S, Sykes M, Colvin RB, Sachs DH, et al: Long-term islet allograft function in the absence of chronic immunosuppression: a case report of a nonhuman primate previously made tolerant to a renal allograft from the same donor. Transplantation 2001;72:351-354.
    • Kawai T, Sogawa H, Koulmanda M, Smith RN, O'Neil JJ, Wee SL, Boskovic S, Sykes M, Colvin RB, Sachs DH, et al: Long-term islet allograft function in the absence of chronic immunosuppression: a case report of a nonhuman primate previously made tolerant to a renal allograft from the same donor. Transplantation 2001;72:351-354.
  • 88
    • 33745235090 scopus 로고    scopus 로고
    • Transplant tolerance in non-human primates: Progress, current challenges and unmet needs
    • Kean LS, Gangappa S, Pearson TC, Larsen CP: Transplant tolerance in non-human primates: Progress, current challenges and unmet needs. Am J Transplant 2006;6:884-893.
    • (2006) Am J Transplant , vol.6 , pp. 884-893
    • Kean, L.S.1    Gangappa, S.2    Pearson, T.C.3    Larsen, C.P.4
  • 91
    • 0032852141 scopus 로고    scopus 로고
    • Combined histocompatible leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: The induction of allograft tolerance through mixed lymphohematopoietic chimerism
    • Spitzer TR, Delmonico F, Tolkoff-Rubin N, McAffee S, Sackstein R, Saidman S, Colby C, Sykes M, Sachs DH, Cosimi AB: Combined histocompatible leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism. Transplantation 1999;68:480-484.
    • (1999) Transplantation , vol.68 , pp. 480-484
    • Spitzer, T.R.1    Delmonico, F.2    Tolkoff-Rubin, N.3    McAffee, S.4    Sackstein, R.5    Saidman, S.6    Colby, C.7    Sykes, M.8    Sachs, D.H.9    Cosimi, A.B.10
  • 92
    • 2942711587 scopus 로고    scopus 로고
    • Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patients
    • Sidiropoulos PI, Boumpas DT: Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patients. Lupus 2004;13:391-397.
    • (2004) Lupus , vol.13 , pp. 391-397
    • Sidiropoulos, P.I.1    Boumpas, D.T.2
  • 93
    • 0036871663 scopus 로고    scopus 로고
    • What's in the pipeline? New immunosuppressive drugs in transplantation
    • Vincenti F: What's in the pipeline? New immunosuppressive drugs in transplantation. Am J Transplant 2002;2:898-903.
    • (2002) Am J Transplant , vol.2 , pp. 898-903
    • Vincenti, F.1
  • 94
    • 0037333857 scopus 로고    scopus 로고
    • A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis
    • Boumpas DT, Furie R, Manzi S, Illei GG, Wallace DJ, Balow JE, Vaishnaw A: A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis. Arthritis Rheum 2003;48:719-727.
    • (2003) Arthritis Rheum , vol.48 , pp. 719-727
    • Boumpas, D.T.1    Furie, R.2    Manzi, S.3    Illei, G.G.4    Wallace, D.J.5    Balow, J.E.6    Vaishnaw, A.7
  • 95
    • 33645890847 scopus 로고    scopus 로고
    • New approaches to prevent transplant rejection: Co-stimulation blockers anti-CD40L and CTLA4Ig
    • Pree I, Wekerle T: New approaches to prevent transplant rejection: co-stimulation blockers anti-CD40L and CTLA4Ig. Drug Discov Today Ther Strateg 2006;3:41-47.
    • (2006) Drug Discov Today Ther Strateg , vol.3 , pp. 41-47
    • Pree, I.1    Wekerle, T.2
  • 98
    • 0037100379 scopus 로고    scopus 로고
    • Superhumanized' antibodies: Reduction of immunogenic potential by complementarity-determining region grafting with human germline sequences: application to an anti-CD28
    • Tan P, Mitchell DA, Buss TN, Holmes MA, Anasetti C, Foote J: 'Superhumanized' antibodies: reduction of immunogenic potential by complementarity-determining region grafting with human germline sequences: application to an anti-CD28. J Immunol 2002;169:1119-1125.
    • (2002) J Immunol , vol.169 , pp. 1119-1125
    • Tan, P.1    Mitchell, D.A.2    Buss, T.N.3    Holmes, M.A.4    Anasetti, C.5    Foote, J.6
  • 104
    • 17544386950 scopus 로고    scopus 로고
    • Establishing immunological tolerance through the induction of molecular chimerism
    • Bagley J, Bracy J, Tian C, Kang E-S, Iacomini J: Establishing immunological tolerance through the induction of molecular chimerism. Front Biosci 2002;7:1333-1337.
    • (2002) Front Biosci , vol.7 , pp. 1333-1337
    • Bagley, J.1    Bracy, J.2    Tian, C.3    Kang, E.-S.4    Iacomini, J.5
  • 105
    • 33646708077 scopus 로고    scopus 로고
    • Avenues for immunomodulation and graft protection by gene therapy in transplantation
    • Moore DJ, Markmann JF, Deng S: Avenues for immunomodulation and graft protection by gene therapy in transplantation. Transpl Int 2006;19:435-445.
    • (2006) Transpl Int , vol.19 , pp. 435-445
    • Moore, D.J.1    Markmann, J.F.2    Deng, S.3
  • 106
    • 0032544673 scopus 로고    scopus 로고
    • Inhibition of xenoreactive natural antibody production by retroviral gene therapy
    • Bracy JL, Sachs DH, Iacomini J: Inhibition of xenoreactive natural antibody production by retroviral gene therapy. Science 1998;281:1845-1847.
    • (1998) Science , vol.281 , pp. 1845-1847
    • Bracy, J.L.1    Sachs, D.H.2    Iacomini, J.3
  • 107
    • 0023865253 scopus 로고
    • Immunological unresponsiveness induced by recipient cells transfected with donor MHC genes
    • Madsen JC, Superina RA, Wood KJ, Morris PJ: Immunological unresponsiveness induced by recipient cells transfected with donor MHC genes. Nature 1988;332:161-164.
    • (1988) Nature , vol.332 , pp. 161-164
    • Madsen, J.C.1    Superina, R.A.2    Wood, K.J.3    Morris, P.J.4
  • 108
    • 0037097841 scopus 로고    scopus 로고
    • Induction of T-cell tolerance to an MHC class I alloantigen by gene therapy
    • Bagley J, Tian C, Sachs DH, Iacomini J: Induction of T-cell tolerance to an MHC class I alloantigen by gene therapy. Blood 2002;99:4394-4399.
    • (2002) Blood , vol.99 , pp. 4394-4399
    • Bagley, J.1    Tian, C.2    Sachs, D.H.3    Iacomini, J.4
  • 109
    • 0037103238 scopus 로고    scopus 로고
    • Induction of central deletional T cell tolerance by gene therapy
    • Kang E-S, Iacomini J: Induction of central deletional T cell tolerance by gene therapy. J Immunol 2002;169:1930-1935.
    • (2002) J Immunol , vol.169 , pp. 1930-1935
    • Kang, E.-S.1    Iacomini, J.2
  • 110
    • 33644847664 scopus 로고    scopus 로고
    • Induction of alloreactive CD4 T cell tolerance in molecular chimeras: A possible role for regulatory T cells
    • Forman D, Kang E-S, Tian C, Paez-Cortez J, Iacomini J: Induction of alloreactive CD4 T cell tolerance in molecular chimeras: a possible role for regulatory T cells. J Immunol 2006;176:3410-3416.
    • (2006) J Immunol , vol.176 , pp. 3410-3416
    • Forman, D.1    Kang, E.-S.2    Tian, C.3    Paez-Cortez, J.4    Iacomini, J.5
  • 111
    • 0043027756 scopus 로고    scopus 로고
    • B cell tolerance to xenoantigens
    • Ohdan H, Sykes M: B cell tolerance to xenoantigens. Xenotransplantation 2003;10:98-106.
    • (2003) Xenotransplantation , vol.10 , pp. 98-106
    • Ohdan, H.1    Sykes, M.2
  • 112
    • 0032549859 scopus 로고    scopus 로고
    • Tolerization of anti-Galalpha1-3Gal natural antibody-forming B cells by induction of mixed chimerism
    • Yang YG, deGoma E, Ohdan H, Bracy JL, Xu Y, Iacomini J, Thall AD, Sykes M: Tolerization of anti-Galalpha1-3Gal natural antibody-forming B cells by induction of mixed chimerism. J Exp Med 1998;187:1335-1342.
    • (1998) J Exp Med , vol.187 , pp. 1335-1342
    • Yang, Y.G.1    deGoma, E.2    Ohdan, H.3    Bracy, J.L.4    Xu, Y.5    Iacomini, J.6    Thall, A.D.7    Sykes, M.8
  • 113
    • 0032728567 scopus 로고    scopus 로고
    • Mixed chimerism induced without lethal conditioning prevents T cell-and anti-Galα1,3Gal- mediated graft rejection
    • Ohdan H, Yang Y-G, Shimizu A, Swenson KG, Sykes M: Mixed chimerism induced without lethal conditioning prevents T cell-and anti-Galα1,3Gal- mediated graft rejection. J Clin Invest 1999;104:281-290.
    • (1999) J Clin Invest , vol.104 , pp. 281-290
    • Ohdan, H.1    Yang, Y.-G.2    Shimizu, A.3    Swenson, K.G.4    Sykes, M.5
  • 114
    • 0035876364 scopus 로고    scopus 로고
    • T cell and B cell tolerance to Gal α1,3Gal-expressing heart xenografts is achieved in α1,3-galactosyltransferase-deficient mice by non-myeloablative induction of mixed chimerism
    • Ohdan H, Yong-Guang Y, Swenson KG, Kitamura H, Sykes M: T cell and B cell tolerance to Gal α1,3Gal-expressing heart xenografts is achieved in α1,3-galactosyltransferase-deficient mice by non-myeloablative induction of mixed chimerism. Transplantation 2001;71:1532-1542.
    • (2001) Transplantation , vol.71 , pp. 1532-1542
    • Ohdan, H.1    Yong-Guang, Y.2    Swenson, K.G.3    Kitamura, H.4    Sykes, M.5
  • 115
    • 32844454591 scopus 로고    scopus 로고
    • Differing Mechanisms of Early and Late B Cell Hyporesponsiveness Induced by Mixed Chimerism
    • Kawahara T, Shimizu I, Ohdan H, Zhao G, Sykes M: Differing Mechanisms of Early and Late B Cell Hyporesponsiveness Induced by Mixed Chimerism. Am J Transplant 2005;5:2821-2829.
    • (2005) Am J Transplant , vol.5 , pp. 2821-2829
    • Kawahara, T.1    Shimizu, I.2    Ohdan, H.3    Zhao, G.4    Sykes, M.5
  • 116
    • 14344264156 scopus 로고    scopus 로고
    • Mixed hematopoietic chimerism for the simultaneous induction of T and B cell tolerance
    • Sykes M, Shimizu I, Kawahara T: Mixed hematopoietic chimerism for the simultaneous induction of T and B cell tolerance. Transplantation 2005;79:28-29.
    • (2005) Transplantation , vol.79 , pp. 28-29
    • Sykes, M.1    Shimizu, I.2    Kawahara, T.3
  • 117
    • 0034330694 scopus 로고    scopus 로고
    • Induction of B-cell tolerance by retroviral gene therapy
    • Bracy JL, Iacomini J: Induction of B-cell tolerance by retroviral gene therapy. Blood 2000;96:3008-3015.
    • (2000) Blood , vol.96 , pp. 3008-3015
    • Bracy, J.L.1    Iacomini, J.2
  • 120
    • 20444486632 scopus 로고    scopus 로고
    • Suppression extends to major histocompatibility antigens linked to tolerizing minor histocompatibility antigens, but not the other way round
    • Bemelman F, Yong S-L, Tissingh R, Schellekens P, ten Berge I: Suppression extends to major histocompatibility antigens linked to tolerizing minor histocompatibility antigens, but not the other way round. Transpl Int 2005;18:423-428.
    • (2005) Transpl Int , vol.18 , pp. 423-428
    • Bemelman, F.1    Yong, S.-L.2    Tissingh, R.3    Schellekens, P.4    ten Berge, I.5


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