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Volumn 2, Issue 10, 2002, Pages 898-903

What's in the pipeline? New immunosuppressive drugs in transplantation

Author keywords

Immunosuppression; Monoclonal antibodies; Transplantation

Indexed keywords

2 CYANO 3 HYDROXY N [4 (TRIFLUOROMETHYL)PHENYL] 6 HEPTYNAMIDE; BASILIXIMAB; CALCINEURIN INHIBITOR; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR1; CYCLOSPORIN; EFALIZUMAB; FINGOLIMOD; GEMCITABINE; HUMAN OKT3; IMMUNOSUPPRESSIVE AGENT; JANUS KINASE; LEFLUNOMIDE; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1 ANTIBOBY; MERIMEPODIB; MONOCLONAL ANTIBODY B7.1; MONOCLONAL ANTIBODY B7.2; MONOCLONAL ANTIBODY CAMPATH 3; MONOCLONAL ANTIBODY CD3; MONOCLONAL ANTIBODY CD45RB; MONOCLONAL ANTIBODY IDEC 131; MONOCLONAL ANTIBODY LEA29Y; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RAPAMYCIN; SPHINGOSINE 1 PHOSPHATE; UNCLASSIFIED DRUG; VISILIZUMAB; ZAP 70 INHIBITOR;

EID: 0036871663     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-6143.2002.21005.x     Document Type: Article
Times cited : (91)

References (46)
  • 1
    • 1542422139 scopus 로고    scopus 로고
    • A randomized, prospective multicenter pharmacoepidemiologic study of cyclosporine microemulsion in stable renal graft recipients. Report of the Canadian Neoral® Renal Transplantation Study Group
    • Keown P, Landsberg D, Halloran P et al. A randomized, prospective multicenter pharmacoepidemiologic study of cyclosporine microemulsion in stable renal graft recipients. Report of the Canadian Neoral® Renal Transplantation Study Group. Transplantation 1996; 62: 1744-1752.
    • (1996) Transplantation , vol.62 , pp. 1744-1752
    • Keown, P.1    Landsberg, D.2    Halloran, P.3
  • 2
    • 0036460895 scopus 로고    scopus 로고
    • Cyclosporine microemulsion and tacrolimus are associated with decreased chronic allograft failure and improved long-term graft survival as compared with Sandimmune
    • Meier-Kriesche H-U, Kaplan B. Cyclosporine microemulsion and tacrolimus are associated with decreased chronic allograft failure and improved long-term graft survival as compared with Sandimmune. Am J Transplant 2002; 2: 100-104.
    • (2002) Am J Transplant , vol.2 , pp. 100-104
    • Meier-Kriesche, H.-U.1    Kaplan, B.2
  • 3
    • 0031001622 scopus 로고    scopus 로고
    • A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation
    • Pirsch JD, Miller J, Deierhoi MH, Vincenti F, Filo RS, the FK506 Kidney Transplant Study Group. A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. Transplantation 1997; 63: 977-983.
    • (1997) Transplantation , vol.63 , pp. 977-983
    • Pirsch, J.D.1    Miller, J.2    Deierhoi, M.H.3    Vincenti, F.4    Filo, R.S.5
  • 4
    • 0027994850 scopus 로고
    • A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression in liver transplantation
    • The US Multicenter FK506 Liver Study Group. A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression in liver transplantation. N Engl J Med 1994; 331: 1110-1115.
    • (1994) N Engl J Med , vol.331 , pp. 1110-1115
  • 5
    • 0032774414 scopus 로고    scopus 로고
    • Mycophenolate mofetil in cadaveric renal transplantation
    • US Renal Transplant Mycophenolate Mofetil Study Group. Mycophenolate mofetil in cadaveric renal transplantation. Am J Kidney Dis 1999; 34: 296-303.
    • (1999) Am J Kidney Dis , vol.34 , pp. 296-303
  • 6
    • 33746530366 scopus 로고    scopus 로고
    • Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: A randomized multicenter study
    • Kahan BD, for the Rapamune US Study Group. Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomized multicenter study. Lancet 2000; 356: 194-202.
    • (2000) Lancet , vol.356 , pp. 194-202
    • Kahan, B.D.1
  • 7
    • 6844236357 scopus 로고    scopus 로고
    • Interleukin 2 receptor blockade with daclizumab to prevent acute rejection in renal transplantation
    • Vincenti F, Kirkman R, Light S et al. Interleukin 2 receptor blockade with daclizumab to prevent acute rejection in renal transplantation. N Engl J Med 1998; 338: 161-165.
    • (1998) N Engl J Med , vol.338 , pp. 161-165
    • Vincenti, F.1    Kirkman, R.2    Light, S.3
  • 8
    • 0033608073 scopus 로고    scopus 로고
    • Reduction of the occurrence of acute cellular rejection among renal allograft recipients treated with basiliximab, a chimeric anti-interleukin-2-receptor monoclonal antibody
    • Kahan BD, Rajagopalan PR, Hall M, for the United States Simulect Renal Study Group. Reduction of the occurrence of acute cellular rejection among renal allograft recipients treated with basiliximab, a chimeric anti-interleukin-2-receptor monoclonal antibody. Transplantation 1999; 67: 276-284.
    • (1999) Transplantation , vol.67 , pp. 276-284
    • Kahan, B.D.1    Rajagopalan, P.R.2    Hall, M.3
  • 9
    • 0345676502 scopus 로고    scopus 로고
    • Results of the double-blind, randomized, multicenter, phase III clinical trial of Thymoglobulin versus ATGAM in the treatment of acute graft rejection episodes after renal transplantation
    • Gaber AO, First MR, Tesi RJ et al. Results of the double-blind, randomized, multicenter, phase III clinical trial of Thymoglobulin versus ATGAM in the treatment of acute graft rejection episodes after renal transplantation. Transplantation 1998; 66: 29-37.
    • (1998) Transplantation , vol.66 , pp. 29-37
    • Gaber, A.O.1    First, M.R.2    Tesi, R.J.3
  • 11
    • 0001696208 scopus 로고    scopus 로고
    • Results from a human tolerance trial using campath-1H with and without infliximab
    • Kirk AD, Hale DA, Hoffmann SC et al. Results from a human tolerance trial using campath-1H with and without infliximab (abstract #958). Am J Transplant 2002; 2 (Suppl. 3): 378.
    • (2002) Am J Transplant , vol.2 , Issue.SUPPL. 3 , pp. 378
    • Kirk, A.D.1    Hale, D.A.2    Hoffmann, S.C.3
  • 12
    • 0001696206 scopus 로고    scopus 로고
    • Campath-1H induction plus rapamycin monotherapy in renal transplantation
    • Knechtle SJ, Pirsch JD, Becker BN et al. Campath-1H induction plus rapamycin monotherapy in renal transplantation (abstract #1276). Am J Transplant 2002; 2 (Suppl. 3): 459.
    • (2002) Am J Transplant , vol.2 , Issue.SUPPL. 3 , pp. 459
    • Knechtle, S.J.1    Pirsch, J.D.2    Becker, B.N.3
  • 13
    • 0001399085 scopus 로고    scopus 로고
    • Rituxan for reduction of anti-HLA antibodies in patients awaiting renal transplantation
    • Vieira CA, Agarwal A, Book BK et al. Rituxan for reduction of anti-HLA antibodies in patients awaiting renal transplantation (abstract #870). Am J Transplant 2002; 2 (Suppl. 3): 356.
    • (2002) Am J Transplant , vol.2 , Issue.SUPPL. 3 , pp. 356
    • Vieira, C.A.1    Agarwal, A.2    Book, B.K.3
  • 14
    • 0034722921 scopus 로고    scopus 로고
    • Phase I trial of HuM291, a humanized anti-CD3 antibody, in patients receiving renal allografts from living donors
    • Norman DJ, Vincenti F, DeMattos AM et al. Phase I trial of HuM291, a humanized anti-CD3 antibody, in patients receiving renal allografts from living donors. Transplantation 2000; 70: 1707-1712.
    • (2000) Transplantation , vol.70 , pp. 1707-1712
    • Norman, D.J.1    Vincenti, F.2    DeMattos, A.M.3
  • 15
    • 0033572786 scopus 로고    scopus 로고
    • Phase I study of an engineered aglycosylated humanized CD3 antibody in renal transplant rejection
    • Friend PJ, Hale G, Chatenoud L et al. Phase I study of an engineered aglycosylated humanized CD3 antibody in renal transplant rejection. Transplantation 1999; 68: 1632-1637.
    • (1999) Transplantation , vol.68 , pp. 1632-1637
    • Friend, P.J.1    Hale, G.2    Chatenoud, L.3
  • 16
    • 0033568236 scopus 로고    scopus 로고
    • Phase I trial of a humanized, Fc receptor nonbonding OKT3 antibody, huOKT3gamma1 (ala-Ala) in the treatment of acute renal allograft rejection
    • Woodle ES, Xu D, Zivlin RA et al. Phase I trial of a humanized, Fc receptor nonbonding OKT3 antibody, huOKT3gamma1 (ala-Ala) in the treatment of acute renal allograft rejection. Transplantation 1999; 68: 608-616.
    • (1999) Transplantation , vol.68 , pp. 608-616
    • Woodle, E.S.1    Xu, D.2    Zivlin, R.A.3
  • 17
    • 0000203537 scopus 로고    scopus 로고
    • Preliminary results of the use of humanized anti-CD154 in human renal allotransplantation
    • Kirk AD, Knechtle SJ, Sollinger HW, Vincenti FG, Stecher S, Nadeau K. Preliminary results of the use of humanized anti-CD154 in human renal allotransplantation (abstract #223). Am J Transplant 2001; 1 (Suppl. 1): 190.
    • (2001) Am J Transplant , vol.1 , Issue.SUPPL. 1 , pp. 190
    • Kirk, A.D.1    Knechtle, S.J.2    Sollinger, H.W.3    Vincenti, F.G.4    Stecher, S.5    Nadeau, K.6
  • 18
    • 0024327898 scopus 로고
    • The leukocyte common antigen family
    • Thomas ML. The leukocyte common antigen family. Ann Rev Immunol 1989; 7: 339-369.
    • (1989) Ann Rev Immunol , vol.7 , pp. 339-369
    • Thomas, M.L.1
  • 19
    • 13144250128 scopus 로고    scopus 로고
    • Antibody mediated targeting of CD45 isoforms: A novel immunotherapeutic strategy
    • Basadonna G, Auersvald L, Khuong C et al. Antibody mediated targeting of CD45 isoforms: a novel immunotherapeutic strategy. Proc Natl Acad Sci USA 1998; 95: 3821-3826.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 3821-3826
    • Basadonna, G.1    Auersvald, L.2    Khuong, C.3
  • 20
    • 15844415783 scopus 로고    scopus 로고
    • Prevention and reversal of renal allograft rejection by antibody against CD45RB
    • Lazarovits A, Poppema S, Zhang Z et al. Prevention and reversal of renal allograft rejection by antibody against CD45RB. Nature 1996: 380: 717-720.
    • (1996) Nature , vol.380 , pp. 717-720
    • Lazarovits, A.1    Poppema, S.2    Zhang, Z.3
  • 21
    • 0012376149 scopus 로고    scopus 로고
    • Anti-CD45: A new approach towards tolerance induction
    • Rothstein DM, Basadonna GP. Anti-CD45: a new approach towards tolerance induction. Graft 1999;2: 239-245.
    • (1999) Graft , vol.2 , pp. 239-245
    • Rothstein, D.M.1    Basadonna, G.P.2
  • 22
    • 0033559042 scopus 로고    scopus 로고
    • A randomized multicenter trial of the anti-ICAL-1 monoclonal antibody (enlimomab) for the prevention of acute rejection and delayed onset of graft function in cadaveric renal transplantation: A report of the European Anti-ICAM-1 Renal Transplant Study Group
    • Samela K, Wrammer L, Ekberg H et al. A randomized multicenter trial of the anti-ICAL-1 monoclonal antibody (enlimomab) for the prevention of acute rejection and delayed onset of graft function in cadaveric renal transplantation: a report of the European Anti-ICAM-1 Renal Transplant Study Group. Transplantation 1999; 67: 729-736.
    • (1999) Transplantation , vol.67 , pp. 729-736
    • Samela, K.1    Wrammer, L.2    Ekberg, H.3
  • 23
    • 0025255615 scopus 로고
    • Structure and function of the leukocyte adhesion molecules CD11/CD18
    • Arnaout MA. Structure and function of the leukocyte adhesion molecules CD11/CD18. Blood 1990; 75: 1037-1050.
    • (1990) Blood , vol.75 , pp. 1037-1050
    • Arnaout, M.A.1
  • 24
    • 0029813191 scopus 로고    scopus 로고
    • Long-term survival of solid organ allografts by brief anti-lymphocyte function-associated antigen-1 monoclonal antibody monotherapy
    • Nakakura EK, Shorthouse RA, Zheng B, McCabe SM, Jardieu PM, Morris RE. Long-term survival of solid organ allografts by brief anti-lymphocyte function-associated antigen-1 monoclonal antibody monotherapy. Transplantation 1996; 62: 547-552.
    • (1996) Transplantation , vol.62 , pp. 547-552
    • Nakakura, E.K.1    Shorthouse, R.A.2    Zheng, B.3    McCabe, S.M.4    Jardieu, P.M.5    Morris, R.E.6
  • 25
    • 0000907307 scopus 로고    scopus 로고
    • A phase I/II trial of anti-CD11a monoclonal antibody in renal transplantation
    • Vincenti F, Mendez R, Rajagopalan PR et al. A phase I/II trial of anti-CD11a monoclonal antibody in renal transplantation (abstract #562). Am J Transplant 2001; 1 (Suppl. 1): 276.
    • (2001) Am J Transplant , vol.1 , Issue.SUPPL. 1 , pp. 276
    • Vincenti, F.1    Mendez, R.2    Rajagopalan, P.R.3
  • 26
    • 0032543306 scopus 로고    scopus 로고
    • The role of T-cell costimulatory activation pathways in transplant rejection
    • Sayegh MH, Turka LA. The role of T-cell costimulatory activation pathways in transplant rejection. N Engl J Med 1998; 448: 1813-1821.
    • (1998) N Engl J Med , vol.448 , pp. 1813-1821
    • Sayegh, M.H.1    Turka, L.A.2
  • 27
    • 0035059417 scopus 로고    scopus 로고
    • Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
    • Salomon B, Bluestone JA. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu Rev Immunol 2001; 19: 225-252.
    • (2001) Annu Rev Immunol , vol.19 , pp. 225-252
    • Salomon, B.1    Bluestone, J.A.2
  • 28
    • 15844404353 scopus 로고    scopus 로고
    • Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
    • Larsen CP, Elwood ET, Alexander DZ et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996; 381: 434-438.
    • (1996) Nature , vol.381 , pp. 434-438
    • Larsen, C.P.1    Elwood, E.T.2    Alexander, D.Z.3
  • 29
    • 0034917195 scopus 로고    scopus 로고
    • Importance of ICOS-B7RP-I costimulation in acute and chronic allograft rejection
    • Özkaynak E, Gao W, Shemmeri N et al. Importance of ICOS-B7RP-I costimulation in acute and chronic allograft rejection. Nat Immunol 2001; 2: 591-596.
    • (2001) Nat Immunol , vol.2 , pp. 591-596
    • Özkaynak, E.1    Gao, W.2    Shemmeri, N.3
  • 30
    • 0035959983 scopus 로고    scopus 로고
    • Coadministration of either cyclosporine or steroids with humanized monoclonal antibodies against CD80 and CD86 successfully prolong allograft survival after life supporting renal transplantation in cynomolgus monkeys
    • Hausen B, Klupp J, Christinas U et al. Coadministration of either cyclosporine or steroids with humanized monoclonal antibodies against CD80 and CD86 successfully prolong allograft survival after life supporting renal transplantation in cynomolgus monkeys. Transplantation 2001; 72: 1128-1137.
    • (2001) Transplantation , vol.72 , pp. 1128-1137
    • Hausen, B.1    Klupp, J.2    Christinas, U.3
  • 31
    • 0035114479 scopus 로고    scopus 로고
    • Immunosuppressive strategies for prevention of transplant rejection
    • Dumont FJ. Immunosuppressive strategies for prevention of transplant rejection. Expert Opin Ther Patents 2001; 11: 377-404.
    • (2001) Expert Opin Ther Patents , vol.11 , pp. 377-404
    • Dumont, F.J.1
  • 32
    • 0031054442 scopus 로고    scopus 로고
    • Peripheral expression of JAK3 is required to maintain T lymphocyte function
    • Thomis CD, Berg JL. Peripheral expression of JAK3 is required to maintain T lymphocyte function. J Exp Med 1997; 185: 197-206.
    • (1997) J Exp Med , vol.185 , pp. 197-206
    • Thomis, C.D.1    Berg, J.L.2
  • 33
    • 0027403374 scopus 로고
    • Interieukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans
    • Noguchi MH, Yi HM, Rosenblatt AH et al. Interieukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans. Cell 1993; 73: 147-157.
    • (1993) Cell , vol.73 , pp. 147-157
    • Noguchi, M.H.1    Yi, H.M.2    Rosenblatt, A.H.3
  • 34
    • 0031976727 scopus 로고    scopus 로고
    • Malononitrilamides: A new strategy of immunosuppression for allo- and xenotransplantation
    • Schorlemmer H, Bartlett R, Kurrle R. Malononitrilamides: a new strategy of immunosuppression for allo- and xenotransplantation. Transplant Proc 1998; 30: 884-890.
    • (1998) Transplant Proc , vol.30 , pp. 884-890
    • Schorlemmer, H.1    Bartlett, R.2    Kurrle, R.3
  • 35
    • 0035884709 scopus 로고    scopus 로고
    • FTY720: Altered lymphocyte traffic results in allograft protection (review)
    • Brinkmann V, Pincshewer D, Feng L, Chen S. FTY720: altered lymphocyte traffic results in allograft protection (review), Transplantation 2001; 72: 764-769.
    • (2001) Transplantation , vol.72 , pp. 764-769
    • Brinkmann, V.1    Pincshewer, D.2    Feng, L.3    Chen, S.4
  • 36
    • 0037066466 scopus 로고    scopus 로고
    • Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
    • Mandala S, Hajdu R, Bergstrom J et al. Alteration of lymphocyte trafficking by sphingosine-1 -phosphate receptor agonists. Science 2002; 296: 346-349.
    • (2002) Science , vol.296 , pp. 346-349
    • Mandala, S.1    Hajdu, R.2    Bergstrom, J.3
  • 37
    • 0000905835 scopus 로고    scopus 로고
    • Identification of EDG-6 as a target of FTY720, a novel transplantation drug
    • Chen S, Garcia GE, Liao R, Brinkmann V, Feng L. Identification of EDG-6 as a target of FTY720, a novel transplantation drug. Am J Transplant 2001; 1 (Suppl.): 456.
    • (2001) Am J Transplant , vol.1 , Issue.SUPPL. , pp. 456
    • Chen, S.1    Garcia, G.E.2    Liao, R.3    Brinkmann, V.4    Feng, L.5
  • 38
    • 0036205659 scopus 로고    scopus 로고
    • First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients
    • Budde K, Schmouder RL, Brunkhorst R et al. First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients. J Am Soc Nephrol 2002; 13: 1073-1083.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1073-1083
    • Budde, K.1    Schmouder, R.L.2    Brunkhorst, R.3
  • 39
    • 0001418395 scopus 로고    scopus 로고
    • Systemic exposure and preliminary efficacy of FTY720 in de novo renal transplant recipients
    • Skerjanec A, Hsu CH, Pellet P, Chodoff L, Schmoouder R, Sablinski T. Systemic exposure and preliminary efficacy of FTY720 in de novo renal transplant recipients (abstract #964). Am J Transplant 2002; 2 (Suppl. 3): 380.
    • (2002) Am J Transplant , vol.2 , Issue.SUPPL. 3 , pp. 380
    • Skerjanec, A.1    Hsu, C.H.2    Pellet, P.3    Chodoff, L.4    Schmoouder, R.5    Sablinski, T.6
  • 40
    • 0001418396 scopus 로고    scopus 로고
    • FTY720, RAD and corticosteroids for the prevention of graft loss and acute rejection in renal allograft recipients at increased risk of delayed graft function
    • Lorber M, Tedeso-Silva H, Felipe CR et al. FTY720, RAD and corticosteroids for the prevention of graft loss and acute rejection in renal allograft recipients at increased risk of delayed graft function (abstract #962). Am J Transplant 2002; 2 (Suppl. 3): 380.
    • (2002) Am J Transplant , vol.2 , Issue.SUPPL. 3 , pp. 380
    • Lorber, M.1    Tedeso-Silva, H.2    Felipe, C.R.3
  • 41
    • 0033868651 scopus 로고    scopus 로고
    • The chemokine/chemokine-receptor family: Potential and progress for therapeutic intervention
    • Cascieri MA, Springer MS. The chemokine/chemokine-receptor family: potential and progress for therapeutic intervention, Curr Opin Chem Biol 2000; 4: 420-427.
    • (2000) Curr Opin Chem Biol , vol.4 , pp. 420-427
    • Cascieri, M.A.1    Springer, M.S.2
  • 43
    • 0032710882 scopus 로고    scopus 로고
    • T cell infiltration into class II MHC-disparate allografts and acute rejection is dependent on the IFN-gamma-induced chemokine mig
    • Koga S, Auerbach MB, Engeman TM, Novick AC, Toma H, Fairchild RL. T cell infiltration into class II MHC-disparate allografts and acute rejection is dependent on the IFN-gamma-induced chemokine mig. J Immunol 1999; 163: 4878-4885.
    • (1999) J Immunol , vol.163 , pp. 4878-4885
    • Koga, S.1    Auerbach, M.B.2    Engeman, T.M.3    Novick, A.C.4    Toma, H.5    Fairchild, R.L.6
  • 44
    • 0035886302 scopus 로고    scopus 로고
    • Beneficial effects of targeting CCR5 in allograft recipients
    • Gao W, Faia KL, Csizmadia V et al. Beneficial effects of targeting CCR5 in allograft recipients. Transplantation 2001; 72: 1199-1205.
    • (2001) Transplantation , vol.72 , pp. 1199-1205
    • Gao, W.1    Faia, K.L.2    Csizmadia, V.3
  • 46
    • 0035886033 scopus 로고    scopus 로고
    • Chemokines and allograft rejection: Narrowing the list of suspects
    • Nelson PJ, Krensky A. Chemokines and allograft rejection: narrowing the list of suspects. Transplantation 2001; 72: 1195-1197.
    • (2001) Transplantation , vol.72 , pp. 1195-1197
    • Nelson, P.J.1    Krensky, A.2


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