Application of metabonomics in a comparative profiling study reveals N-acetylfelinine excretion as a biomarker for inhibition of the farnesyl pathway by bisphosphonates

Chemical Research in Toxicology

Volumn 20, Issue 9, 2007, Pages 1291-1299

  Dieterle, Frank ^a   Schlotterbeck, Götz ^a   Binder, Martin ^a   Ross, Alfred ^a   Suter, Laura ^a   Senn, Hans ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; BISPHOSPHONIC ACID DERIVATIVE; CREATININE; GERANYLTRANSFERASE; GLUCOSE; IBANDRONIC ACID; N ACETYLFELININE; UNCLASSIFIED DRUG; ZOLEDRONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CREATININE URINE LEVEL; DRUG SAFETY; ENZYME INHIBITION; FELIDAE; GLUCOSE URINE LEVEL; HISTOPATHOLOGY; KIDNEY PARENCHYMA; LIVER TOXICITY; MALE; METABOLIC REGULATION; METABOLOMICS; NEPHROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT; SPRAGUE DAWLEY RAT; URINALYSIS; URINARY EXCRETION;

ANIMALS; BIOLOGICAL MARKERS; CREATINE; CYSTEINE; DIPHOSPHONATES; GERANYLTRANSTRANSFERASE; GLUCOSE; IMIDAZOLES; MOLECULAR STRUCTURE; PRENYLATION; RATS; SIGNAL TRANSDUCTION; TAURINE;

FELIDAE; RATTUS;

EID: 35148830526     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx700151t     Document Type: Article

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