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Metabonomics: Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
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Metabonomics: A platform for studying drug toxicity and gene function
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Proton NMR spectra of urine as indicators of renal damage. Mercury-induced nephrotoxicity in rats
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High-resolution proton magnetic resonance spectroscopy of biological fluids
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Chemometric models for toxicity classification based on NMR spectra of biofluids
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Holmes, E., Nicholls, A. W., Lindon, J. C., Connor, S. C., Connelly, J. C., Haselden, J. N., Damment, S. J. P., Spraul, M., Neidig, P., and Nicholson, J. K. (2000) Chemometric models for toxicity classification based on NMR spectra of biofluids. Chem. Res. Toxicol. 13, 471-478.
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Metabonomic investigations into hydrazine toxicity in the rat: Induction of 2-amino acidipic acid
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Nicholls, A. W., Holmes, E., Lindon, J. C., Farrant, R. D., Haselden, J. N., Damment, S. J. P., and Nicholson, J. K. (2001) Metabonomic investigations into hydrazine toxicity in the rat: induction of 2-amino acidipic acid. Chem. Res. Toxicol. 14, 975-987.
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Creatinuria as an early indicator of cadmium induced testicular damage
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Gray, J. A., Nicholson, J. K., and Timbrell, J. A. (1986) Creatinuria as an early indicator of cadmium induced testicular damage. Hum. Toxicol. 5, 402-403.
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Studies on the relationship between testicular toxicity and urinary and plasma creatine concentration
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Gray, J. A., Nicholson, J. K., Creasy, D. M., and Timbrell, J. A. (1990) Studies on the relationship between testicular toxicity and urinary and plasma creatine concentration. Arch. Toxicol. 64, 443-450.
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A metabonomic approach to the investigation of drug-induced phospholipidosis: A NMR spectroscopy and pattern recognition study
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Nicholls, A. W., Nicholson, J. K., Haselden, J. N., and Waterfield, C. J. (2000) A metabonomic approach to the investigation of drug-induced phospholipidosis: a NMR spectroscopy and pattern recognition study. Biomarkers 5, 410-423.
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Application of pattern recognition methods to the analysis and classification of toxicological data derived from proton nuclear magnetic resonance spectroscopy of urine
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Gartland, K. P., Beddell, C. R., Lindon, J. C., and Nicholson, J. K. (1991) Application of pattern recognition methods to the analysis and classification of toxicological data derived from proton nuclear magnetic resonance spectroscopy of urine. Mol. Pharmacol. 39, 629-642.
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1H NMR spectroscopy of urine combined with pattern-recognition
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1H NMR spectroscopy of urine combined with pattern-recognition. NMR Biomed. 11, 235-244.
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Pattern recognition methods and applications in biomedical magnetic resonance
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The identification of novel biomarkers of renal toxicity using automatic data reduction techniques and PCA of proton NMR spectra of urine
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Holmes, E., Nicholson, J. K, Nicholls, A. W., Lindon, J. C., Connor, S. C., Polley, S., and Connelly, J. (1998) The identification of novel biomarkers of renal toxicity using automatic data reduction techniques and PCA of proton NMR spectra of urine. Chemom. Intell. Lab. Syst. 44, 245-255.
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An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: Application to the C57BL10J and Alpk: ApfCD mouse
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Gavaghan, C. L., Holmes, E., Lenz, E., Wilson, I. D., and Nicholson, J. K. (2000) An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk: ApfCD mouse. FEBS Lett. 484, 169-174.
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Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins
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Beckwith-Hall, B. M., Nicholson, J. K., Nicholls, A. W., Foxall, P. J. D., Lindon, J. C., Connor, S. C., Abdi, M., Connelly, J., and Holmes, E. (1998) Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins. Chem. Res. Toxicol. 11, 260-272.
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0035881952
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Investigations into biochemical changes due to diurnal variation and estrus cycle in female rats using high-resolution (1)H NMR spectroscopy of urine and pattern recognition
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Bollard, M. E., Holmes, E., Lindon, J. C., Mitchell, S. C., Branstetter, D., Zhang, W., and Nicholson J. K. (2001) Investigations into biochemical changes due to diurnal variation and estrus cycle in female rats using high-resolution (1)H NMR spectroscopy of urine and pattern recognition. Anal. Biochem. 295, 194-202.
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The thin line between gut commensal and pathogen
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Effect of diet of the urinary excretion of hippuric acid and other dietary-derived aromatics in rat. A complex interaction between diet, gut microflora and substrate specificity
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Gut flora and the origin of some urinary aromatic phenolic compounds
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NMR spectroscopy of biofluids
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1H NMR spectra of normal urines: Reference ranges of major metabolites
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1H NMR spectra of normal urines: Reference ranges of major metabolites. Clin. Chem. Acta 265, 85-97.
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Pattern recognition classification of the site of nephrotoxicity based on metabolic data derived from proton nuclear magnetic resonance spectra of urine
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Metabolism and excretion of methylamines in rats
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1H NMR spectroscopic and histopathological studies on propyleneimine-induced renal papillary necrosis in the rat and the multimammate desert mouse (Mastomys natalensis)
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1H NMR spectroscopic and histopathological studies on propyleneimine-induced renal papillary necrosis in the rat and the multimammate desert mouse (Mastomys natalensis). Comp. Biochem. Physiol., Part C: Pharmacol. Toxicol. Endocrinol. 116, 125-134.
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