메뉴 건너뛰기




Volumn 3, Issue 7, 2007, Pages 402-407

DNA damage repair is unaffected by mimicked heterozygous levels of BRCA2 in HT-29 cells

Author keywords

BRCA2; DNA damage repair; Heterozygosity; RNAi

Indexed keywords

BRCA2 PROTEIN; MITOMYCIN C; PROTEIN P27; PROTEIN P53; RAD51 PROTEIN;

EID: 35148825472     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.3.402     Document Type: Article
Times cited : (5)

References (24)
  • 1
    • 0006713602 scopus 로고
    • Identification of the breast cancer susceptibility gene BRCA2
    • Wooster R, Bignell G, Lancaster J et al. Identification of the breast cancer susceptibility gene BRCA2. Nature 1995, 378(6559):789-792.
    • (1995) Nature , vol.378 , Issue.6559 , pp. 789-792
    • Wooster, R.1    Bignell, G.2    Lancaster, J.3
  • 2
    • 0035098503 scopus 로고    scopus 로고
    • Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer
    • Risch HA, McLaughlin JR, Cole DE et al. Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer. Am J Hum Genet 2001, 68(3):700-710.
    • (2001) Am J Hum Genet , vol.68 , Issue.3 , pp. 700-710
    • Risch, H.A.1    McLaughlin, J.R.2    Cole, D.E.3
  • 3
    • 0029680501 scopus 로고    scopus 로고
    • A common mutation in BRCA2 that predisposes to a variety of cancers is found in both Jewish Ashkenazi and non-Jewish individuals
    • Berman DB, Costalas J, Schultz DC et al. A common mutation in BRCA2 that predisposes to a variety of cancers is found in both Jewish Ashkenazi and non-Jewish individuals. Cancer Res 1996, 56(15):3409-3414.
    • (1996) Cancer Res , vol.56 , Issue.15 , pp. 3409-3414
    • Berman, D.B.1    Costalas, J.2    Schultz, D.C.3
  • 4
    • 0029007696 scopus 로고
    • Consistent loss of the wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-13
    • Collins N, McManus R, Wooster R et al. Consistent loss of the wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-13. Oncogene 1995, 10(8):1673-1675.
    • (1995) Oncogene , vol.10 , Issue.8 , pp. 1673-1675
    • Collins, N.1    McManus, R.2    Wooster, R.3
  • 5
    • 13344269668 scopus 로고    scopus 로고
    • The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds
    • Tavtigian SV, Simard J, Rommens J et al. The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds. Nat Genet 1996, 12(3):333-337.
    • (1996) Nat Genet , vol.12 , Issue.3 , pp. 333-337
    • Tavtigian, S.V.1    Simard, J.2    Rommens, J.3
  • 6
    • 0030933762 scopus 로고    scopus 로고
    • Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
    • Sharan SK, Morimatsu M, Albrecht U et al. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature 1997, 386(6627):804-810.
    • (1997) Nature , vol.386 , Issue.6627 , pp. 804-810
    • Sharan, S.K.1    Morimatsu, M.2    Albrecht, U.3
  • 7
    • 0032574733 scopus 로고    scopus 로고
    • The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment
    • Chen PL, Chen CF, Chen Y et al. The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. Proc Natl Acad Sci USA 1998, 95(9):5287-5292.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.9 , pp. 5287-5292
    • Chen, P.L.1    Chen, C.F.2    Chen, Y.3
  • 8
    • 0031990269 scopus 로고    scopus 로고
    • Involvement of Brca2 in DNA repair
    • Patel KJ, Yu VP, Lee H et al. Involvement of Brca2 in DNA repair. Mol Cell 1998, 1(3):347-357.
    • (1998) Mol Cell , vol.1 , Issue.3 , pp. 347-357
    • Patel, K.J.1    Yu, V.P.2    Lee, H.3
  • 9
    • 0034213735 scopus 로고    scopus 로고
    • Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation
    • Yu VP, Koehler M, Steinlein C et al. Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation. Genes Dev 2000, 14(11):1400-1406.
    • (2000) Genes Dev , vol.14 , Issue.11 , pp. 1400-1406
    • Yu, V.P.1    Koehler, M.2    Steinlein, C.3
  • 10
    • 33749639069 scopus 로고    scopus 로고
    • Cellular characterization of cells from the Fanconi anemia complementation group, FA-D1/BRCA2
    • Godthelp BC, van Buul PP, Jaspers NG et al. Cellular characterization of cells from the Fanconi anemia complementation group, FA-D1/BRCA2. Mutat Res 2006, 601(1-2):191-201.
    • (2006) Mutat Res , vol.601 , Issue.1-2 , pp. 191-201
    • Godthelp, B.C.1    van Buul, P.P.2    Jaspers, N.G.3
  • 11
    • 0033533731 scopus 로고    scopus 로고
    • Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification
    • Tutt A, Gabriel A, Bertwistle D et al. Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification. Curr Biol 1999, 9(19):1107-1110.
    • (1999) Curr Biol , vol.9 , Issue.19 , pp. 1107-1110
    • Tutt, A.1    Gabriel, A.2    Bertwistle, D.3
  • 12
    • 0035099044 scopus 로고    scopus 로고
    • BRCA2 is required for homology-directed repair of chromosomal breaks
    • Moynahan ME, Pierce AJ, Jasin M. BRCA2 is required for homology-directed repair of chromosomal breaks. Mol Cell 2001, 7(2):263-272.
    • (2001) Mol Cell , vol.7 , Issue.2 , pp. 263-272
    • Moynahan, M.E.1    Pierce, A.J.2    Jasin, M.3
  • 13
    • 0035801472 scopus 로고    scopus 로고
    • Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences
    • Tutt A, Bertwistle D, Valentine J et al. Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences. Embo J 2001, 20(17):4704-4716.
    • (2001) Embo J , vol.20 , Issue.17 , pp. 4704-4716
    • Tutt, A.1    Bertwistle, D.2    Valentine, J.3
  • 14
    • 0035105999 scopus 로고    scopus 로고
    • Role of BRCA2 in control of the RAD51 recombination and DNA repair protein
    • Davies AA, Masson JY, McIlwraith MJ et al. Role of BRCA2 in control of the RAD51 recombination and DNA repair protein. Mol Cell 2001, 7(2):273-282.
    • (2001) Mol Cell , vol.7 , Issue.2 , pp. 273-282
    • Davies, A.A.1    Masson, J.Y.2    McIlwraith, M.J.3
  • 15
    • 0015043748 scopus 로고
    • Mutation and cancer: Statistical study of retinoblastoma
    • Knudson AGJr. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A 1971, 68(4):820-823.
    • (1971) Proc Natl Acad Sci U S A , vol.68 , Issue.4 , pp. 820-823
    • AGJr, K.1
  • 16
    • 0142154273 scopus 로고    scopus 로고
    • Phenotypic effects of heterozygosity for a BRCA2 mutation
    • Warren M, Lord CJ, Masabanda J et al. Phenotypic effects of heterozygosity for a BRCA2 mutation. Hum Mol Genet 2003, 12(20):2645-2656.
    • (2003) Hum Mol Genet , vol.12 , Issue.20 , pp. 2645-2656
    • Warren, M.1    Lord, C.J.2    Masabanda, J.3
  • 17
    • 2542473262 scopus 로고    scopus 로고
    • Increased rates of spontaneous sister chromatid exchange in lymphocytes of BRCA2+/- carriers of familial breast cancer clusters
    • Kim MK, Zitzmann S, Westermann F et al. Increased rates of spontaneous sister chromatid exchange in lymphocytes of BRCA2+/- carriers of familial breast cancer clusters. Cancer Lett 2004, 210(1):85-94.
    • (2004) Cancer Lett , vol.210 , Issue.1 , pp. 85-94
    • Kim, M.K.1    Zitzmann, S.2    Westermann, F.3
  • 18
    • 33749249540 scopus 로고    scopus 로고
    • Lower level of BRCA2 protein in heterozygous mutation carriers is correlated with an increase in DNA double strand breaks and an impaired DSB repair
    • Arnold K, Kim MK, Frerk K et al. Lower level of BRCA2 protein in heterozygous mutation carriers is correlated with an increase in DNA double strand breaks and an impaired DSB repair. Cancer Lett 2006, 243(1):90-100.
    • (2006) Cancer Lett , vol.243 , Issue.1 , pp. 90-100
    • Arnold, K.1    Kim, M.K.2    Frerk, K.3
  • 19
    • 0036726313 scopus 로고    scopus 로고
    • Stable suppression of tumorigenicity by virus-mediated RNA interference
    • Brummelkamp TR, Bernards R, Agami R. Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell 2002, 2(3):243-247.
    • (2002) Cancer Cell , vol.2 , Issue.3 , pp. 243-247
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 20
    • 4344717012 scopus 로고    scopus 로고
    • BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage
    • Schoenfeld AR, Apgar S, Dolios G et al. BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage. Mol Cell Biol 2004, 24(17):7444-7455.
    • (2004) Mol Cell Biol , vol.24 , Issue.17 , pp. 7444-7455
    • Schoenfeld, A.R.1    Apgar, S.2    Dolios, G.3
  • 21
    • 0029955714 scopus 로고    scopus 로고
    • The pCL vector system: Rapid production of helper-free, high-titer, recombinant retroviruses
    • Naviaux RK, Costanzi E, Haas M et al. The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses. J Virol 1996, 70(8):5701-5705.
    • (1996) J Virol , vol.70 , Issue.8 , pp. 5701-5705
    • Naviaux, R.K.1    Costanzi, E.2    Haas, M.3
  • 22
    • 0033179235 scopus 로고    scopus 로고
    • BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo
    • Yuan SS, Lee SY, Chen G et al. BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo. Cancer Res 1999, 59(15):3547-3551.
    • (1999) Cancer Res , vol.59 , Issue.15 , pp. 3547-3551
    • Yuan, S.S.1    Lee, S.Y.2    Chen, G.3
  • 23
    • 0030659153 scopus 로고    scopus 로고
    • Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
    • Connor F, Bertwistle D, Mee PJ et al. Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation. Nat Genet 1997, 17(4):423-430.
    • (1997) Nat Genet , vol.17 , Issue.4 , pp. 423-430
    • Connor, F.1    Bertwistle, D.2    Mee, P.J.3
  • 24
    • 0035734285 scopus 로고    scopus 로고
    • Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer
    • Jonkers J, Meuwissen R, van der Gulden H et al. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet 2001, 29(4):418-425.
    • (2001) Nat Genet , vol.29 , Issue.4 , pp. 418-425
    • Jonkers, J.1    Meuwissen, R.2    van der Gulden, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.