-
1
-
-
0002210727
-
A syndrome produced by diverse nocuous agents
-
Selye H. A syndrome produced by diverse nocuous agents. Nature 138 (1936) 230-231
-
(1936)
Nature
, vol.138
, pp. 230-231
-
-
Selye, H.1
-
2
-
-
32644479922
-
Cellular redox state and insulin sensitivity: potential role of lipoic acid
-
Zierath J.R., and Wallberg-Henriksen H. (Eds), Taylor and Francis
-
Rudich A., and Bashan N. Cellular redox state and insulin sensitivity: potential role of lipoic acid. In: Zierath J.R., and Wallberg-Henriksen H. (Eds). Muscle Metabolism (2002), Taylor and Francis 329-348
-
(2002)
Muscle Metabolism
, pp. 329-348
-
-
Rudich, A.1
Bashan, N.2
-
3
-
-
33645745733
-
Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with Type 2 diabetes
-
Monnier L., et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with Type 2 diabetes. J. Am. Med. Assoc. 295 (2006) 1681-1687
-
(2006)
J. Am. Med. Assoc.
, vol.295
, pp. 1681-1687
-
-
Monnier, L.1
-
4
-
-
85030434746
-
Increased oxidative stress in obesity and its impact on metabolic syndrome
-
Furukawa S., et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Invest. 114 (2004) 1752-1761
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 1752-1761
-
-
Furukawa, S.1
-
5
-
-
12144273607
-
PKC-δ-dependent activation of oxidative stress in adipocytes of obese and insulin-resistant mice: role for NADPH oxidase
-
Talior I., et al. PKC-δ-dependent activation of oxidative stress in adipocytes of obese and insulin-resistant mice: role for NADPH oxidase. Am. J. Physiol. Endocrinol. Metab. 288 (2005) E405-E411
-
(2005)
Am. J. Physiol. Endocrinol. Metab.
, vol.288
-
-
Talior, I.1
-
6
-
-
20344373410
-
Overexpression of glucose-6-phosphate dehydrogenase is associated with lipid dysregulation and insulin resistance in obesity
-
Park J., et al. Overexpression of glucose-6-phosphate dehydrogenase is associated with lipid dysregulation and insulin resistance in obesity. Mol. Cell. Biol. 25 (2005) 5146-5157
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 5146-5157
-
-
Park, J.1
-
7
-
-
33744950569
-
Adipose tissue proadipogenic redox changes in obesity
-
Galinier A., et al. Adipose tissue proadipogenic redox changes in obesity. J. Biol. Chem. 281 (2006) 12682-12687
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 12682-12687
-
-
Galinier, A.1
-
8
-
-
34247361278
-
Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal
-
Grimsrud P.A., et al. Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal. Mol. Cell. Proteomics 6 (2007) 624-637
-
(2007)
Mol. Cell. Proteomics
, vol.6
, pp. 624-637
-
-
Grimsrud, P.A.1
-
9
-
-
33748314535
-
Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity
-
Cancello R., et al. Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity. Diabetes 55 (2006) 1554-1561
-
(2006)
Diabetes
, vol.55
, pp. 1554-1561
-
-
Cancello, R.1
-
10
-
-
34347249246
-
Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the co-morbidities of obesity
-
Harman-Boehm I., et al. Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the co-morbidities of obesity. J. Clin. Endocrinol. Metab. 92 (2007) 2240-2247
-
(2007)
J. Clin. Endocrinol. Metab.
, vol.92
, pp. 2240-2247
-
-
Harman-Boehm, I.1
-
11
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
Weisberg S.P., et al. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112 (2003) 1796-1808
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
-
12
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
Xu H., et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112 (2003) 1821-1830
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1821-1830
-
-
Xu, H.1
-
13
-
-
33846026712
-
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
-
Lumeng C.N., et al. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest. 117 (2007) 175-184
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 175-184
-
-
Lumeng, C.N.1
-
14
-
-
31644443192
-
Ceramides in insulin resistance and lipotoxicity
-
Summers S.A. Ceramides in insulin resistance and lipotoxicity. Prog. Lipid Res. 45 (2006) 42-72
-
(2006)
Prog. Lipid Res.
, vol.45
, pp. 42-72
-
-
Summers, S.A.1
-
16
-
-
2042540707
-
Activation of the hexosamine signaling pathway in adipose tissue results in decreased serum adiponectin and skeletal muscle insulin resistance
-
Hazel M., et al. Activation of the hexosamine signaling pathway in adipose tissue results in decreased serum adiponectin and skeletal muscle insulin resistance. Endocrinology 145 (2004) 2118-2128
-
(2004)
Endocrinology
, vol.145
, pp. 2118-2128
-
-
Hazel, M.1
-
17
-
-
6344261703
-
Role of hexosamines in insulin resistance and nutrient sensing in human adipose and muscle tissue
-
Pouwels M.J., et al. Role of hexosamines in insulin resistance and nutrient sensing in human adipose and muscle tissue. J. Clin. Endocrinol. Metab. 89 (2004) 5132-5137
-
(2004)
J. Clin. Endocrinol. Metab.
, vol.89
, pp. 5132-5137
-
-
Pouwels, M.J.1
-
18
-
-
20044363264
-
The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species
-
Lin Y., et al. The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. J. Biol. Chem. 280 (2005) 4617-4626
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 4617-4626
-
-
Lin, Y.1
-
19
-
-
33750590489
-
Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk
-
Samad F., et al. Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk. Diabetes 55 (2006) 2579-2587
-
(2006)
Diabetes
, vol.55
, pp. 2579-2587
-
-
Samad, F.1
-
20
-
-
0142164965
-
Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes
-
Chavez J.A., and Summers S.A. Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. Arch. Biochem. Biophys. 419 (2003) 101-109
-
(2003)
Arch. Biochem. Biophys.
, vol.419
, pp. 101-109
-
-
Chavez, J.A.1
Summers, S.A.2
-
21
-
-
2442539128
-
No in vitro effects of fatty acids on glucose uptake, lipolysis or insulin signaling in rat adipocytes
-
Lundgren M., and Eriksson J.W. No in vitro effects of fatty acids on glucose uptake, lipolysis or insulin signaling in rat adipocytes. Horm. Metab. Res. 36 (2004) 203-209
-
(2004)
Horm. Metab. Res.
, vol.36
, pp. 203-209
-
-
Lundgren, M.1
Eriksson, J.W.2
-
22
-
-
27444445460
-
JNK and tumor necrosis factor-α mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes
-
Nguyen M.T., et al. JNK and tumor necrosis factor-α mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J. Biol. Chem. 280 (2005) 35361-35371
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 35361-35371
-
-
Nguyen, M.T.1
-
23
-
-
26244448904
-
A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor α
-
Suganami T., et al. A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor α. Arterioscler. Thromb. Vasc. Biol. 25 (2005) 2062-2068
-
(2005)
Arterioscler. Thromb. Vasc. Biol.
, vol.25
, pp. 2062-2068
-
-
Suganami, T.1
-
24
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
Shi H., et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest. 116 (2006) 3015-3025
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 3015-3025
-
-
Shi, H.1
-
25
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and Type 2 diabetes
-
Ozcan U., et al. Endoplasmic reticulum stress links obesity, insulin action, and Type 2 diabetes. Science 306 (2004) 457-461
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
-
26
-
-
34047119110
-
Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation
-
Hosogai N., et al. Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 56 (2007) 901-911
-
(2007)
Diabetes
, vol.56
, pp. 901-911
-
-
Hosogai, N.1
-
27
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil G.S. Inflammation and metabolic disorders. Nature 444 (2006) 860-867
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
28
-
-
27444437321
-
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
-
Cinti S., et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J. Lipid Res. 46 (2005) 2347-2355
-
(2005)
J. Lipid Res.
, vol.46
, pp. 2347-2355
-
-
Cinti, S.1
-
29
-
-
0031831765
-
Qualitative regional differences in adipose tissue growth and cellularity in male Wistar rats fed ad libitum
-
DiGirolamo M., et al. Qualitative regional differences in adipose tissue growth and cellularity in male Wistar rats fed ad libitum. Am. J. Physiol. 274 (1998) R1460-R1467
-
(1998)
Am. J. Physiol.
, vol.274
-
-
DiGirolamo, M.1
-
30
-
-
33846323706
-
Role of the Toll-like receptor 4/NF-κB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages
-
Suganami T., et al. Role of the Toll-like receptor 4/NF-κB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler. Thromb. Vasc. Biol. 27 (2007) 84-91
-
(2007)
Arterioscler. Thromb. Vasc. Biol.
, vol.27
, pp. 84-91
-
-
Suganami, T.1
-
31
-
-
34047175336
-
Uncoupling protein 2 controls adiponectin gene expression in adipose tissue through the modulation of reactive oxygen species production
-
Chevillotte E., et al. Uncoupling protein 2 controls adiponectin gene expression in adipose tissue through the modulation of reactive oxygen species production. Diabetes 56 (2007) 1042-1050
-
(2007)
Diabetes
, vol.56
, pp. 1042-1050
-
-
Chevillotte, E.1
-
32
-
-
14944340746
-
Oxidative stress and antioxidant treatment in diabetes
-
Scott J.A., and King G.L. Oxidative stress and antioxidant treatment in diabetes. Ann. N. Y. Acad. Sci. 1031 (2004) 204-213
-
(2004)
Ann. N. Y. Acad. Sci.
, vol.1031
, pp. 204-213
-
-
Scott, J.A.1
King, G.L.2
-
33
-
-
28244488706
-
Inflammation-activated protein kinases as targets for drug development
-
Karin M. Inflammation-activated protein kinases as targets for drug development. Proc. Am. Thorac. Soc. 2 (2005) 386-390
-
(2005)
Proc. Am. Thorac. Soc.
, vol.2
, pp. 386-390
-
-
Karin, M.1
-
34
-
-
33846569938
-
Targeting mammalian target of rapamycin (mTOR) for health and diseases
-
Tsang C.K., et al. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Discov. Today 12 (2007) 112-124
-
(2007)
Drug Discov. Today
, vol.12
, pp. 112-124
-
-
Tsang, C.K.1
-
37
-
-
0037341276
-
Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression
-
Carlson C.J., et al. Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression. Diabetes 52 (2003) 634-641
-
(2003)
Diabetes
, vol.52
, pp. 634-641
-
-
Carlson, C.J.1
-
38
-
-
33846603289
-
Pathophysiological roles of ASK1-MAP kinase signaling pathways
-
Nagai H., et al. Pathophysiological roles of ASK1-MAP kinase signaling pathways. J. Biochem. Mol. Biol. 40 (2007) 1-6
-
(2007)
J. Biochem. Mol. Biol.
, vol.40
, pp. 1-6
-
-
Nagai, H.1
-
39
-
-
33144463713
-
An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARγ, adipogenesis, and insulin-responsive hexose transport
-
Tang X., et al. An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARγ, adipogenesis, and insulin-responsive hexose transport. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 2087-2092
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 2087-2092
-
-
Tang, X.1
-
40
-
-
33244481462
-
Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance
-
Zick Y. Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance. Sci. STKE 2005 (2005) pe4
-
(2005)
Sci. STKE
, vol.2005
-
-
Zick, Y.1
-
41
-
-
0037339991
-
Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes
-
Fujishiro M., et al. Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes. Mol. Endocrinol. 17 (2003) 487-497
-
(2003)
Mol. Endocrinol.
, vol.17
, pp. 487-497
-
-
Fujishiro, M.1
-
42
-
-
20444458773
-
Pharmacological inhibition of p38 MAP kinase results in improved glucose uptake in insulin-resistant 3T3-L1 adipocytes
-
Carlson C.J., and Rondinone C.M. Pharmacological inhibition of p38 MAP kinase results in improved glucose uptake in insulin-resistant 3T3-L1 adipocytes. Metabolism 54 (2005) 895-901
-
(2005)
Metabolism
, vol.54
, pp. 895-901
-
-
Carlson, C.J.1
Rondinone, C.M.2
-
43
-
-
3442895916
-
Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes
-
Gao Z., et al. Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes. Mol. Endocrinol. 18 (2004) 2024-2034
-
(2004)
Mol. Endocrinol.
, vol.18
, pp. 2024-2034
-
-
Gao, Z.1
-
44
-
-
0034463918
-
A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1
-
Haruta T., et al. A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol. Endocrinol. 14 (2000) 783-794
-
(2000)
Mol. Endocrinol.
, vol.14
, pp. 783-794
-
-
Haruta, T.1
-
45
-
-
0035979775
-
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ
-
Yuan M., et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ. Science 293 (2001) 1673-1677
-
(2001)
Science
, vol.293
, pp. 1673-1677
-
-
Yuan, M.1
-
46
-
-
5644301067
-
Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing TNF-α induction of p38 and p42/p44 mitogen-activated protein kinases
-
Hernandez R., et al. Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing TNF-α induction of p38 and p42/p44 mitogen-activated protein kinases. Diabetologia 47 (2004) 1615-1624
-
(2004)
Diabetologia
, vol.47
, pp. 1615-1624
-
-
Hernandez, R.1
-
47
-
-
11144344885
-
c-Jun N-terminal kinase is involved in the suppression of adiponectin expression by TNF-α in 3T3-L1 adipocytes
-
Kim K.Y., et al. c-Jun N-terminal kinase is involved in the suppression of adiponectin expression by TNF-α in 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun. 327 (2005) 460-467
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.327
, pp. 460-467
-
-
Kim, K.Y.1
-
48
-
-
11144356766
-
Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance
-
Rohl M., et al. Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance. J. Clin. Invest. 113 (2004) 474-481
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 474-481
-
-
Rohl, M.1
-
49
-
-
0034903710
-
Prevention of fat-induced insulin resistance by salicylate
-
Kim J.K., et al. Prevention of fat-induced insulin resistance by salicylate. J. Clin. Invest. 108 (2001) 437-446
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 437-446
-
-
Kim, J.K.1
-
50
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of Type 2 diabetes
-
Ozcan U., et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of Type 2 diabetes. Science 313 (2006) 1137-1140
-
(2006)
Science
, vol.313
, pp. 1137-1140
-
-
Ozcan, U.1
-
51
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J., et al. A central role for JNK in obesity and insulin resistance. Nature 420 (2002) 333-336
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
-
52
-
-
4043073652
-
An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue
-
Jaeschke A., et al. An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Genes Dev. 18 (2004) 1976-1980
-
(2004)
Genes Dev.
, vol.18
, pp. 1976-1980
-
-
Jaeschke, A.1
-
53
-
-
20044364733
-
Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion
-
Prada P.O., et al. Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion. Endocrinology 146 (2005) 1576-1587
-
(2005)
Endocrinology
, vol.146
, pp. 1576-1587
-
-
Prada, P.O.1
-
54
-
-
0942268725
-
Rosiglitazone, an agonist of peroxisome-proliferator-activated receptor gamma (PPARγ), decreases inhibitory serine phosphorylation of IRS1 in vitro and in vivo
-
Jiang G., et al. Rosiglitazone, an agonist of peroxisome-proliferator-activated receptor gamma (PPARγ), decreases inhibitory serine phosphorylation of IRS1 in vitro and in vivo. Biochem. J. 377 (2004) 339-346
-
(2004)
Biochem. J.
, vol.377
, pp. 339-346
-
-
Jiang, G.1
-
55
-
-
4544220704
-
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
-
Um S.H., et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431 (2004) 200-205
-
(2004)
Nature
, vol.431
, pp. 200-205
-
-
Um, S.H.1
-
56
-
-
33846806078
-
Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2
-
Le Bacquer O., et al. Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. J. Clin. Invest. 117 (2007) 387-396
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 387-396
-
-
Le Bacquer, O.1
-
57
-
-
33846841155
-
A link between protein translation and body weight
-
Rui L. A link between protein translation and body weight. J. Clin. Invest. 117 (2007) 310-313
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 310-313
-
-
Rui, L.1
-
58
-
-
34250863505
-
MAP kinases, IKK and insulin signaling in human omental versus subcutaneous adipose tissue in obesity
-
Bashan N., et al. MAP kinases, IKK and insulin signaling in human omental versus subcutaneous adipose tissue in obesity. Endocrinology 148 (2007) 2955-2962
-
(2007)
Endocrinology
, vol.148
, pp. 2955-2962
-
-
Bashan, N.1
-
59
-
-
14244269217
-
Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-κB and IκB kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro
-
Lappas M., et al. Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-κB and IκB kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro. Endocrinology 146 (2005) 1491-1497
-
(2005)
Endocrinology
, vol.146
, pp. 1491-1497
-
-
Lappas, M.1
-
60
-
-
27544487938
-
JNK: bridging the insulin signaling and inflammatory pathway
-
Liu G., and Rondinone C.M. JNK: bridging the insulin signaling and inflammatory pathway. Curr. Opin. Investig. Drugs 6 (2005) 979-987
-
(2005)
Curr. Opin. Investig. Drugs
, vol.6
, pp. 979-987
-
-
Liu, G.1
Rondinone, C.M.2
-
61
-
-
7044230885
-
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide
-
Kaneto H., et al. Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide. Nat. Med. 10 (2004) 1128-1132
-
(2004)
Nat. Med.
, vol.10
, pp. 1128-1132
-
-
Kaneto, H.1
-
62
-
-
0037474274
-
c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade
-
Lee Y.H., et al. c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J. Biol. Chem. 278 (2003) 2896-2902
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 2896-2902
-
-
Lee, Y.H.1
-
63
-
-
0036796875
-
Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of Type 2 diabetes
-
Evans J.L., et al. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of Type 2 diabetes. Endocr. Rev. 23 (2002) 599-622
-
(2002)
Endocr. Rev.
, vol.23
, pp. 599-622
-
-
Evans, J.L.1
-
64
-
-
33748781446
-
Role of MAPKs in development and differentiation: lessons from knockout mice
-
Aouadi M., et al. Role of MAPKs in development and differentiation: lessons from knockout mice. Biochimie 88 (2006) 1091-1098
-
(2006)
Biochimie
, vol.88
, pp. 1091-1098
-
-
Aouadi, M.1
-
65
-
-
33845873659
-
Interleukin-1β-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression
-
Jager J., et al. Interleukin-1β-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology 148 (2007) 241-251
-
(2007)
Endocrinology
, vol.148
, pp. 241-251
-
-
Jager, J.1
-
66
-
-
19944433322
-
The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis
-
Bost F., et al. The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis. Diabetes 54 (2005) 402-411
-
(2005)
Diabetes
, vol.54
, pp. 402-411
-
-
Bost, F.1
-
67
-
-
0033773334
-
Tumor necrosis factor α-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes
-
Engelman J.A., et al. Tumor necrosis factor α-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes. Mol. Endocrinol. 14 (2000) 1557-1569
-
(2000)
Mol. Endocrinol.
, vol.14
, pp. 1557-1569
-
-
Engelman, J.A.1
-
68
-
-
0042591261
-
Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases
-
Gao Z., et al. Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases. J. Biol. Chem. 278 (2003) 24944-24950
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 24944-24950
-
-
Gao, Z.1
-
69
-
-
1542616960
-
Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation
-
Carlson C.J., et al. Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation. Biochem. Biophys. Res. Commun. 316 (2004) 533-539
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.316
, pp. 533-539
-
-
Carlson, C.J.1
-
70
-
-
33644886769
-
Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation
-
Tzatsos A., and Kandror K.V. Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol. Cell. Biol. 26 (2006) 63-76
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 63-76
-
-
Tzatsos, A.1
Kandror, K.V.2
-
71
-
-
14244252683
-
Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes
-
Tremblay F., et al. Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes. Endocrinology 146 (2005) 1328-1337
-
(2005)
Endocrinology
, vol.146
, pp. 1328-1337
-
-
Tremblay, F.1
-
72
-
-
8544244084
-
PKC-theta knockout mice are protected from fat-induced insulin resistance
-
Kim J.K., et al. PKC-theta knockout mice are protected from fat-induced insulin resistance. J. Clin. Invest. 114 (2004) 823-827
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 823-827
-
-
Kim, J.K.1
|