-
1
-
-
34748909264
-
Biochemical aspects of aging
-
Gornall AG, ed, 2nd ed. Philadelphia: Lippincott Raven Press;
-
Liew CC. Biochemical aspects of aging. In: Gornall AG, ed. Applied Biochemistry of Clinical Disorders. 2nd ed. Philadelphia: Lippincott Raven Press; 1986:558-565.
-
(1986)
Applied Biochemistry of Clinical Disorders
, pp. 558-565
-
-
Liew, C.C.1
-
2
-
-
0028877125
-
Aging: A biological perspective
-
Rattan SI. Aging: a biological perspective. Mol Aspects Med. 1995;16:439-508.
-
(1995)
Mol Aspects Med
, vol.16
, pp. 439-508
-
-
Rattan, S.I.1
-
3
-
-
0030670635
-
Aging: A subject that must be at top of world agendas
-
Greengross S, Murphy E, Quam L, et al. Aging: a subject that must be at top of world agendas. BMJ. 1997;315:1029-1030.
-
(1997)
BMJ
, vol.315
, pp. 1029-1030
-
-
Greengross, S.1
Murphy, E.2
Quam, L.3
-
4
-
-
0028197618
-
Pharmacokinetic studies in elderly people: Are they necessary?
-
Crome P, Flanagan RJ. Pharmacokinetic studies in elderly people: are they necessary? Clin Pharmacokinet. 1994;26:243-247.
-
(1994)
Clin Pharmacokinet
, vol.26
, pp. 243-247
-
-
Crome, P.1
Flanagan, R.J.2
-
5
-
-
26044482960
-
Protein oxidation and degradation during postmitotic senescence
-
Grune T, Merker K, Jung T, et al. Protein oxidation and degradation during postmitotic senescence. Free Radic Biol Med. 2005;39:1208-1215.
-
(2005)
Free Radic Biol Med
, vol.39
, pp. 1208-1215
-
-
Grune, T.1
Merker, K.2
Jung, T.3
-
6
-
-
0029116061
-
Oxidative damage to mitochondrial-DNA and its relationship to aging
-
Richter C. Oxidative damage to mitochondrial-DNA and its relationship to aging. Int J Biochem Cell B. 1995;27:647-653.
-
(1995)
Int J Biochem Cell B
, vol.27
, pp. 647-653
-
-
Richter, C.1
-
7
-
-
0037093677
-
Molecular exploration of age-related NFκB/IKK downregulation by calorie restriction in rat kidney
-
Kim H-J, Chung H-Y. Molecular exploration of age-related NFκB/IKK downregulation by calorie restriction in rat kidney. Free Rad Biol Med. 2002;32:991-1005.
-
(2002)
Free Rad Biol Med
, vol.32
, pp. 991-1005
-
-
Kim, H.-J.1
Chung, H.-Y.2
-
8
-
-
0036666093
-
Calorie restriction modulates redox-sensitive AP-1 during the aging process
-
Kim HJ, Jung KJ, Seo AY, et al. Calorie restriction modulates redox-sensitive AP-1 during the aging process. J Am Aging Assoc. 2002;25:123-130.
-
(2002)
J Am Aging Assoc
, vol.25
, pp. 123-130
-
-
Kim, H.J.1
Jung, K.J.2
Seo, A.Y.3
-
9
-
-
0035092972
-
Lipofuscin accumulation in proliferating fibroblasts in vitro: An indicator of oxidative stress
-
Sitte N, Merker K, Grune T, et al. Lipofuscin accumulation in proliferating fibroblasts in vitro: an indicator of oxidative stress. Exp Gerontol. 2001;36:475-486.
-
(2001)
Exp Gerontol
, vol.36
, pp. 475-486
-
-
Sitte, N.1
Merker, K.2
Grune, T.3
-
10
-
-
0027461419
-
Pulmonary pentane excretion increases with age in healthy subjects
-
Zarling EJ, Mobarhan S, Bowan P. Pulmonary pentane excretion increases with age in healthy subjects. Mech Aging Dev. 1993;67:141-147.
-
(1993)
Mech Aging Dev
, vol.67
, pp. 141-147
-
-
Zarling, E.J.1
Mobarhan, S.2
Bowan, P.3
-
11
-
-
0033929763
-
-
Higami Y, Shimokawa I. Apoptosis in the aging process. Cell Tissue Res. 2002;301:125-132.
-
Higami Y, Shimokawa I. Apoptosis in the aging process. Cell Tissue Res. 2002;301:125-132.
-
-
-
-
12
-
-
0030738721
-
Apoptosis in dopaminergic neurons of the human substantia nigra during normal aging
-
Anglade P, Vyas S, Hirsch EC, et al. Apoptosis in dopaminergic neurons of the human substantia nigra during normal aging. Histol Histopathol. 1997;12:603-610.
-
(1997)
Histol Histopathol
, vol.12
, pp. 603-610
-
-
Anglade, P.1
Vyas, S.2
Hirsch, E.C.3
-
13
-
-
2642572647
-
Aging, biology, and geriatric clinical pharmacology
-
McLean AJ, Le Couteur DG. Aging, biology, and geriatric clinical pharmacology. Pharmacol Rev. 2004;56:163-184.
-
(2004)
Pharmacol Rev
, vol.56
, pp. 163-184
-
-
McLean, A.J.1
Le Couteur, D.G.2
-
14
-
-
0031854072
-
Pharmacokinetic and pharmacodynamic changes in the elderly: Clinical implications
-
Hammerlein A, Derendorf H, Lowenthal DT. Pharmacokinetic and pharmacodynamic changes in the elderly: clinical implications. Clin Pharmacokinet. 1998;35:49-64.
-
(1998)
Clin Pharmacokinet
, vol.35
, pp. 49-64
-
-
Hammerlein, A.1
Derendorf, H.2
Lowenthal, D.T.3
-
15
-
-
0031944801
-
Clinical pharmacology in an aging population
-
Abrams WB, Beers MH. Clinical pharmacology in an aging population. Clin Pharmacol Ther. 1998;63:281-284.
-
(1998)
Clin Pharmacol Ther
, vol.63
, pp. 281-284
-
-
Abrams, W.B.1
Beers, M.H.2
-
16
-
-
33645763956
-
Drug dosage in the elderly: Dermatological drugs
-
Flammiger A, Maibach H. Drug dosage in the elderly: dermatological drugs. Drugs Aging. 2006;23:203-215.
-
(2006)
Drugs Aging
, vol.23
, pp. 203-215
-
-
Flammiger, A.1
Maibach, H.2
-
18
-
-
10644252493
-
Effect of aging on the pharmacokinetics of gastrointestinal drugs
-
eds, Basel: Interdiscipl Top Gerontol, Karger;
-
Klotz U. Effect of aging on the pharmacokinetics of gastrointestinal drugs. In: Pilotto A, Malfertheiner P, Holt PR, eds. Aging and the Gastrointestinal Tract. Vol. 32. Basel: Interdiscipl Top Gerontol, Karger; 2003:28-39.
-
(2003)
Aging and the Gastrointestinal Tract
, vol.32
, pp. 28-39
-
-
Klotz, U.1
-
19
-
-
0031727173
-
Drug dosage in the elderly. Is it rational?
-
Turnheim K. Drug dosage in the elderly. Is it rational? Drugs Aging. 1998;13:357-379.
-
(1998)
Drugs Aging
, vol.13
, pp. 357-379
-
-
Turnheim, K.1
-
20
-
-
0342547065
-
The effects of diet, aging, and disease-states on presystemic elimination and oral drug bioavailability in humans
-
Wilkinson GR. The effects of diet, aging, and disease-states on presystemic elimination and oral drug bioavailability in humans. Adv Drug Deliv Rev. 1997;27:129-159.
-
(1997)
Adv Drug Deliv Rev
, vol.27
, pp. 129-159
-
-
Wilkinson, G.R.1
-
21
-
-
2442543344
-
P-glycoprotein function in the elderly
-
Brenner SS, Klotz U. P-glycoprotein function in the elderly. Eur J Clin Pharmacol. 2004;60:97-102.
-
(2004)
Eur J Clin Pharmacol
, vol.60
, pp. 97-102
-
-
Brenner, S.S.1
Klotz, U.2
-
22
-
-
33744936006
-
Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[(11)C]verapamil and positron emission tomography
-
Toornvliet R, van Berckel BN, Luurtsema G, et al. Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[(11)C]verapamil and positron emission tomography. Clin Pharmacol Ther. 2006;79:540-548.
-
(2006)
Clin Pharmacol Ther
, vol.79
, pp. 540-548
-
-
Toornvliet, R.1
van Berckel, B.N.2
Luurtsema, G.3
-
23
-
-
0016430689
-
The effect of age and liver disease on the disposition and elimination of diazepam in adult man
-
Klotz U, Avant GR, Hoyumpa A, et al. The effect of age and liver disease on the disposition and elimination of diazepam in adult man. J Clin Invest. 1975;55:347-59.
-
(1975)
J Clin Invest
, vol.55
, pp. 347-359
-
-
Klotz, U.1
Avant, G.R.2
Hoyumpa, A.3
-
24
-
-
0035695389
-
Liver function and phase I drug metabolism in the elderly
-
Schmucker DL. Liver function and phase I drug metabolism in the elderly. Drugs Aging. 2001;18:837-851.
-
(2001)
Drugs Aging
, vol.18
, pp. 837-851
-
-
Schmucker, D.L.1
-
25
-
-
0034117268
-
Age-related changes in protein binding of drugs: Implications for therapy
-
Grandison MK, Boudinot FD. Age-related changes in protein binding of drugs: implications for therapy. Clin Pharmacokinet. 2000;38:271-290.
-
(2000)
Clin Pharmacokinet
, vol.38
, pp. 271-290
-
-
Grandison, M.K.1
Boudinot, F.D.2
-
26
-
-
0036218554
-
Changes in plasma protein binding have little clinical relevance
-
Benet LZ, Hoener BA. Changes in plasma protein binding have little clinical relevance. Clin Pharmacol Ther. 2002;71:115-21.
-
(2002)
Clin Pharmacol Ther
, vol.71
, pp. 115-121
-
-
Benet, L.Z.1
Hoener, B.A.2
-
27
-
-
0022644116
-
Hepatic drug metabolism in the elderly
-
Kitani K. Hepatic drug metabolism in the elderly. Hepatology. 1986;6:316-319.
-
(1986)
Hepatology
, vol.6
, pp. 316-319
-
-
Kitani, K.1
-
28
-
-
0030982413
-
Clinical pharmacokinetic considerations in the elderly: An update
-
Kinirons MT, Crome P. Clinical pharmacokinetic considerations in the elderly: an update. Clin Pharmacokinet. 1997;33:302-312.
-
(1997)
Clin Pharmacokinet
, vol.33
, pp. 302-312
-
-
Kinirons, M.T.1
Crome, P.2
-
29
-
-
0031898907
-
The aging liver. Drug clearance and oxygen diffusion hypothesis
-
LeCouteur DG, McLean AJ. The aging liver. Drug clearance and oxygen diffusion hypothesis. Clin Pharmacokinet. 1998;34:359-373.
-
(1998)
Clin Pharmacokinet
, vol.34
, pp. 359-373
-
-
LeCouteur, D.G.1
McLean, A.J.2
-
30
-
-
0042707810
-
When drug therapy gets old: Pharmacokinetics and pharmacodynamics in the elderly
-
Turnheim K. When drug therapy gets old: pharmacokinetics and pharmacodynamics in the elderly. Exp Gerontol. 2003;38:843-853.
-
(2003)
Exp Gerontol
, vol.38
, pp. 843-853
-
-
Turnheim, K.1
-
31
-
-
21044454600
-
Drug metabolism and ageing
-
Wynne H. Drug metabolism and ageing. J Br Menopause Soc. 2005;11:51-56.
-
(2005)
J Br Menopause Soc
, vol.11
, pp. 51-56
-
-
Wynne, H.1
-
32
-
-
0028237729
-
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
-
Shimada T, Yamazaki H, Mimura M, et al. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther. 1994;270:414-423.
-
(1994)
J Pharmacol Exp Ther
, vol.270
, pp. 414-423
-
-
Shimada, T.1
Yamazaki, H.2
Mimura, M.3
-
33
-
-
4444278991
-
The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes
-
Parkinson A, Mudra DR, Johnson C, et al. The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes. Toxicol Appl Pharmacol. 2004;199:193-209.
-
(2004)
Toxicol Appl Pharmacol
, vol.199
, pp. 193-209
-
-
Parkinson, A.1
Mudra, D.R.2
Johnson, C.3
-
34
-
-
0021025435
-
Age differences in effects on blood pressure, flicker fusion frequency, salivation and pharmacokinetics of single oral doses of dothiepin and amitriptyline
-
Ogura C, Kishimoto A, Mizukawa R, et al. Age differences in effects on blood pressure, flicker fusion frequency, salivation and pharmacokinetics of single oral doses of dothiepin and amitriptyline. Eur J Clin Pharmacol. 1983;25:811-814.
-
(1983)
Eur J Clin Pharmacol
, vol.25
, pp. 811-814
-
-
Ogura, C.1
Kishimoto, A.2
Mizukawa, R.3
-
35
-
-
0021592110
-
Absorption and disposition of ibuprofen in the elderly
-
Greenblatt DJ, Abernethy DR, Matlis R, et al. Absorption and disposition of ibuprofen in the elderly. Arthritis Rheum. 1984;27:1066-1069.
-
(1984)
Arthritis Rheum
, vol.27
, pp. 1066-1069
-
-
Greenblatt, D.J.1
Abernethy, D.R.2
Matlis, R.3
-
36
-
-
0023024813
-
The effect of age on theophylline clearance in normal subjects
-
Randolph WC, Seaman JJ, Dickson B, et al. The effect of age on theophylline clearance in normal subjects. Br J Clin Pharmacol. 1986;22:603-605.
-
(1986)
Br J Clin Pharmacol
, vol.22
, pp. 603-605
-
-
Randolph, W.C.1
Seaman, J.J.2
Dickson, B.3
-
39
-
-
0029128788
-
Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver
-
George J, Byth K, Farrell GC. Age but not gender selectively affects expression of individual cytochrome P450 proteins in human liver. Biochem Pharmacol. 1995;50:727-730.
-
(1995)
Biochem Pharmacol
, vol.50
, pp. 727-730
-
-
George, J.1
Byth, K.2
Farrell, G.C.3
-
40
-
-
0031783832
-
In vivo age-related changes in hepatic drug-oxidizing capacity in humans
-
Tanaka E. In vivo age-related changes in hepatic drug-oxidizing capacity in humans. J Clin Pharm Ther. 1998;23:247-255.
-
(1998)
J Clin Pharm Ther
, vol.23
, pp. 247-255
-
-
Tanaka, E.1
-
41
-
-
0035513910
-
Variability of cytochrome P450 1A2 activity over time in young and elderly healthy volunteers
-
Simon T, Becquemont L, Hamon B, et al. Variability of cytochrome P450 1A2 activity over time in young and elderly healthy volunteers. Br J Clin Pharmacol. 2001;52:601-604.
-
(2001)
Br J Clin Pharmacol
, vol.52
, pp. 601-604
-
-
Simon, T.1
Becquemont, L.2
Hamon, B.3
-
42
-
-
0038153195
-
Serum carbamazepine concentrations in elderly patients: A case-matched pharmacokinetic evaluation based on therapeutic drug monitoring data
-
Battino D, Croci D, Rossini A, et al. Serum carbamazepine concentrations in elderly patients: a case-matched pharmacokinetic evaluation based on therapeutic drug monitoring data. Epilepsia. 2003;44:923-929.
-
(2003)
Epilepsia
, vol.44
, pp. 923-929
-
-
Battino, D.1
Croci, D.2
Rossini, A.3
-
43
-
-
10044230234
-
Bioequivalence revisited: Influence of age and sex on CYP enzymes
-
Bebia Z, Buch SC, Wilson JW, et al. Bioequivalence revisited: influence of age and sex on CYP enzymes. Clin Pharmacol Ther. 2004;76:618-627.
-
(2004)
Clin Pharmacol Ther
, vol.76
, pp. 618-627
-
-
Bebia, Z.1
Buch, S.C.2
Wilson, J.W.3
-
44
-
-
0042833213
-
-
Gorski JC, Vannaprasaht S, Hamman MA, et al. The effect of age, sex, and rifampin administration on intestinal and hepatic cytochrome P450 3A activity. Clin Pharmacol Ther. 2003;74:275-87; erratum, 2004;75:249.
-
Gorski JC, Vannaprasaht S, Hamman MA, et al. The effect of age, sex, and rifampin administration on intestinal and hepatic cytochrome P450 3A activity. Clin Pharmacol Ther. 2003;74:275-87; erratum, 2004;75:249.
-
-
-
-
45
-
-
13844251076
-
Influence of age and gender on risperidone plasma concentration
-
Aichhorn W, Weiss U, Marksteiner J, et al. Influence of age and gender on risperidone plasma concentration. J Psychopharmacol. 2005;19:395-401.
-
(2005)
J Psychopharmacol
, vol.19
, pp. 395-401
-
-
Aichhorn, W.1
Weiss, U.2
Marksteiner, J.3
-
46
-
-
26944440101
-
The effect of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokinetics
-
Ishizawa Y, Yasui-Furukori N, Takahata T, et al. The effect of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokinetics. Clin Pharmacokinet. 2005;44:1179-1189.
-
(2005)
Clin Pharmacokinet
, vol.44
, pp. 1179-1189
-
-
Ishizawa, Y.1
Yasui-Furukori, N.2
Takahata, T.3
-
47
-
-
0025765079
-
Clinical pharmacokinetics in patients with liver disease
-
McLean AJ, Morgan DJ. Clinical pharmacokinetics in patients with liver disease. Clin Pharmacokinet. 1991;21:42-69.
-
(1991)
Clin Pharmacokinet
, vol.21
, pp. 42-69
-
-
McLean, A.J.1
Morgan, D.J.2
-
48
-
-
0025245869
-
The association of age and frailty with paracetamol conjugation in man
-
Wynne HA, Cope LH, Herd B, et al. The association of age and frailty with paracetamol conjugation in man. Age Ageing. 1990;19:419-424.
-
(1990)
Age Ageing
, vol.19
, pp. 419-424
-
-
Wynne, H.A.1
Cope, L.H.2
Herd, B.3
-
49
-
-
9144246190
-
Drug development and use in the elderly: Search for the right dose and dosing regimen (Parts I and II)
-
Shah RR. Drug development and use in the elderly: search for the right dose and dosing regimen (Parts I and II). Br J Clin Pharmacol. 2004;58:452-469.
-
(2004)
Br J Clin Pharmacol
, vol.58
, pp. 452-469
-
-
Shah, R.R.1
-
50
-
-
0032756477
-
Association between a CYP3A4 genetic variant and clinical presentation in African-American prostate cancer patients
-
Paris OL, Kupelian PA, Hall JM, et al. Association between a CYP3A4 genetic variant and clinical presentation in African-American prostate cancer patients. Cancer Epidemiol Biomarkers Prev. 1999;8:901-905.
-
(1999)
Cancer Epidemiol Biomarkers Prev
, vol.8
, pp. 901-905
-
-
Paris, O.L.1
Kupelian, P.A.2
Hall, J.M.3
-
51
-
-
30744458841
-
Impact of a genetic variant in CYP3A4 on risk and clinical presentation of prostate cancer among white and African-American men
-
Bangsi D, Zhou J, Sun Y, et al. Impact of a genetic variant in CYP3A4 on risk and clinical presentation of prostate cancer among white and African-American men. Urol Oncol. 2006;24:21-27.
-
(2006)
Urol Oncol
, vol.24
, pp. 21-27
-
-
Bangsi, D.1
Zhou, J.2
Sun, Y.3
-
52
-
-
0037402520
-
Effects of age and the CYP2D6*10 allele on the plasma haloperidol concentration/dose ratio
-
Ohara K, Tanabu S, Ishibashi K, et al. Effects of age and the CYP2D6*10 allele on the plasma haloperidol concentration/dose ratio. Prog Neuropsychopharmacol Biol Psychiatry. 2003;27:347-350.
-
(2003)
Prog Neuropsychopharmacol Biol Psychiatry
, vol.27
, pp. 347-350
-
-
Ohara, K.1
Tanabu, S.2
Ishibashi, K.3
-
53
-
-
0037226087
-
Influence of age and cytochrome P450 2C9 genotype on the steady-state disposition of diclofenac and celecoxib
-
Brenner SS, Herrlinger C, Dilger K, et al. Influence of age and cytochrome P450 2C9 genotype on the steady-state disposition of diclofenac and celecoxib. Clin Pharmacokinet. 2003;42:283-292.
-
(2003)
Clin Pharmacokinet
, vol.42
, pp. 283-292
-
-
Brenner, S.S.1
Herrlinger, C.2
Dilger, K.3
-
54
-
-
0344994575
-
Age-dependent changes of the kidneys: Pharmacological implications
-
Muhlberg W, Platt D. Age-dependent changes of the kidneys: pharmacological implications. Gerontology. 1999;45:243-253.
-
(1999)
Gerontology
, vol.45
, pp. 243-253
-
-
Muhlberg, W.1
Platt, D.2
-
55
-
-
0030947798
-
Use of aminoglycosides in Elderly patients. Pharmacokinetic and clinical considerations
-
Morike K, Schwab M, Klotz U. Use of aminoglycosides in Elderly patients. Pharmacokinetic and clinical considerations. Drugs Aging. 1997;10:259-277.
-
(1997)
Drugs Aging
, vol.10
, pp. 259-277
-
-
Morike, K.1
Schwab, M.2
Klotz, U.3
-
56
-
-
0030994748
-
Wide variation in single, daily-dose aminoglycoside pharmacokinetics in patients with burn injuries
-
Hoey LL, Tschida SJ, Rotschafer JC, et al. Wide variation in single, daily-dose aminoglycoside pharmacokinetics in patients with burn injuries. J Burn Care Rehabil. 1997;18:116-124.
-
(1997)
J Burn Care Rehabil
, vol.18
, pp. 116-124
-
-
Hoey, L.L.1
Tschida, S.J.2
Rotschafer, J.C.3
-
57
-
-
0025099781
-
Accuracy of pharmacokinetic dose determination of gentamicin in geriatric patients
-
Lackner TE, Birge S. Accuracy of pharmacokinetic dose determination of gentamicin in geriatric patients. DICP. 1990;24:29-32.
-
(1990)
DICP
, vol.24
, pp. 29-32
-
-
Lackner, T.E.1
Birge, S.2
-
58
-
-
0028060142
-
Correlation between nephrotoxicity and pharmacokinetic parameters of gentamicin
-
el-Sayed YM. Correlation between nephrotoxicity and pharmacokinetic parameters of gentamicin. J Clin Pharm Ther. 1994;19:267-271.
-
(1994)
J Clin Pharm Ther
, vol.19
, pp. 267-271
-
-
el-Sayed, Y.M.1
-
59
-
-
0031828430
-
Population analysis of once-daily dosing of gentamicin in patients with neutropenia
-
Peterson AK, Duffull SB. Population analysis of once-daily dosing of gentamicin in patients with neutropenia. Aust N Z J Med. 1998;28:311-315.
-
(1998)
Aust N Z J Med
, vol.28
, pp. 311-315
-
-
Peterson, A.K.1
Duffull, S.B.2
-
60
-
-
0028341368
-
Selection of optimal prophylactic aminoglycoside dosage in cancer patients: Population pharmacokinetic approaches
-
Ordovas JP, Ronchera CL, Poveda JL, et al. Selection of optimal prophylactic aminoglycoside dosage in cancer patients: population pharmacokinetic approaches. J Clin Pharm Ther. 1994;19:47-56.
-
(1994)
J Clin Pharm Ther
, vol.19
, pp. 47-56
-
-
Ordovas, J.P.1
Ronchera, C.L.2
Poveda, J.L.3
-
61
-
-
84944368488
-
Wide interpatient variations in gentamicin dose requirements for geriatric patients
-
Zaske DE, Irvine P, Strand LM, et al. Wide interpatient variations in gentamicin dose requirements for geriatric patients. JAMA. 1982;248:3122-3126.
-
(1982)
JAMA
, vol.248
, pp. 3122-3126
-
-
Zaske, D.E.1
Irvine, P.2
Strand, L.M.3
-
62
-
-
0344994575
-
Age-dependent changes of the kidneys: Pharmacological implications
-
Muhlberg W, Platt D. Age-dependent changes of the kidneys: pharmacological implications. Gerontology. 1999;45:243-253.
-
(1999)
Gerontology
, vol.45
, pp. 243-253
-
-
Muhlberg, W.1
Platt, D.2
-
63
-
-
0025140774
-
Altered pharmacodynamics in the elderly
-
Feely J, Coakley D. Altered pharmacodynamics in the elderly. Clin Geriatr Med. 1990;6:269-283.
-
(1990)
Clin Geriatr Med
, vol.6
, pp. 269-283
-
-
Feely, J.1
Coakley, D.2
-
64
-
-
2642567691
-
Cholinergic activity and amyloid precursor protein processing in aging and Alzheimer's disease
-
Zhang X. Cholinergic activity and amyloid precursor protein processing in aging and Alzheimer's disease. Curr Drug Targets CNS Neurol Disord. 2004;3:137-152.
-
(2004)
Curr Drug Targets CNS Neurol Disord
, vol.3
, pp. 137-152
-
-
Zhang, X.1
-
65
-
-
0842305081
-
Age-related changes of muscarinic cholinergic receptor subtypes in the striatum of Fisher 344 rats
-
Tayebati SK, Di Tullio MA, et al. Age-related changes of muscarinic cholinergic receptor subtypes in the striatum of Fisher 344 rats. Exp Gerontol. 2004;39:217-223.
-
(2004)
Exp Gerontol
, vol.39
, pp. 217-223
-
-
Tayebati, S.K.1
Di Tullio, M.A.2
-
66
-
-
24944467463
-
Muscarinic receptor agonists and antagonists in the treatment of Alzheimer's disease
-
Clader JW, Wang Y. Muscarinic receptor agonists and antagonists in the treatment of Alzheimer's disease. Curr Pharm Des. 2005;11:3353-3361.
-
(2005)
Curr Pharm Des
, vol.11
, pp. 3353-3361
-
-
Clader, J.W.1
Wang, Y.2
-
67
-
-
4644286385
-
Autonomic receptor systems in the failing and aging human heart: Similarities and differences
-
Brodde OE, Leineweber K. Autonomic receptor systems in the failing and aging human heart: similarities and differences. Eur J Pharmacol. 2004;500:167-176.
-
(2004)
Eur J Pharmacol
, vol.500
, pp. 167-176
-
-
Brodde, O.E.1
Leineweber, K.2
-
68
-
-
0035957246
-
Acetylcholine release in human heart atrium: Influence of muscarinic autoreceptors, diabetes and age
-
Oberhauser V, Schwertfeger E, Rutz T, et al. Acetylcholine release in human heart atrium: influence of muscarinic autoreceptors, diabetes and age. Circulation. 2001;103:1638-1643.
-
(2001)
Circulation
, vol.103
, pp. 1638-1643
-
-
Oberhauser, V.1
Schwertfeger, E.2
Rutz, T.3
-
69
-
-
0037426440
-
Baroreflex buffering is reduced with age in healthy men
-
Jones PP, Christou DD, Jordan J, et al. Baroreflex buffering is reduced with age in healthy men. Circulation. 2003;107:1770-1774.
-
(2003)
Circulation
, vol.107
, pp. 1770-1774
-
-
Jones, P.P.1
Christou, D.D.2
Jordan, J.3
-
70
-
-
27644446977
-
Reduced alpha adrenergic mediated contraction of renal preglomerular blood vessels as a function of gender and aging
-
Passmore JC, Joshua IG, Rowell PP, et al. Reduced alpha adrenergic mediated contraction of renal preglomerular blood vessels as a function of gender and aging. J Cell Biochem. 2005;96:672-681.
-
(2005)
J Cell Biochem
, vol.96
, pp. 672-681
-
-
Passmore, J.C.1
Joshua, I.G.2
Rowell, P.P.3
-
71
-
-
0029875181
-
The effect of aging on the pharmacokinetics and pharmacodynamics of prazosin
-
Andros E, Detmar-Hanna D, Suteparuk S, et al. The effect of aging on the pharmacokinetics and pharmacodynamics of prazosin. Eur J Clin Pharmacol. 1996;50:41-46.
-
(1996)
Eur J Clin Pharmacol
, vol.50
, pp. 41-46
-
-
Andros, E.1
Detmar-Hanna, D.2
Suteparuk, S.3
-
72
-
-
0031426844
-
-
Ferrara N, Davia K, Abete P, et al. Alterations in β-adrenoceptor mechanisms in the aging heart. Relationship with heart failure, aging. Clin Exp Res. 1997;9:391-403.
-
Ferrara N, Davia K, Abete P, et al. Alterations in β-adrenoceptor mechanisms in the aging heart. Relationship with heart failure, aging. Clin Exp Res. 1997;9:391-403.
-
-
-
-
73
-
-
0031933301
-
Alterations in myocardial signal transduction due to aging and chronic dynamic exercise
-
Roth DA, White CD, Podolin DA, et al. Alterations in myocardial signal transduction due to aging and chronic dynamic exercise. J Appl Physiol. 1998;84:177-184.
-
(1998)
J Appl Physiol
, vol.84
, pp. 177-184
-
-
Roth, D.A.1
White, C.D.2
Podolin, D.A.3
-
74
-
-
34748873627
-
Age-related changes in pharmacokinetics and pharmacodynamics: Basic principles and practical applications
-
Mangoni AA, Jackson SHD. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol. 2003;56:254-260.
-
(2003)
Br J Clin Pharmacol
, vol.56
, pp. 254-260
-
-
Mangoni, A.A.1
Jackson, S.H.D.2
-
75
-
-
0032983692
-
Functional and molecular or biological evidence for a possible β3-adrenoceptor in the human detrusor muscle
-
Igawa Y, Yamazaki Y, Takeda H, et al. Functional and molecular or biological evidence for a possible β3-adrenoceptor in the human detrusor muscle. Br J Pharmacol. 1999;126:819-825.
-
(1999)
Br J Pharmacol
, vol.126
, pp. 819-825
-
-
Igawa, Y.1
Yamazaki, Y.2
Takeda, H.3
-
76
-
-
0032005455
-
The aging lower urinary tract: A comparative urodynamic study of men and women
-
Madersbacher S, Pycha A, Schatzl G, et al. The aging lower urinary tract: a comparative urodynamic study of men and women. Urology. 1998;51:206-212.
-
(1998)
Urology
, vol.51
, pp. 206-212
-
-
Madersbacher, S.1
Pycha, A.2
Schatzl, G.3
-
77
-
-
0345328601
-
Age-dependent changes in β-adrenoceptor function in human detrusors and possible mechanisms
-
Li G, Li K, Li Z, et al. Age-dependent changes in β-adrenoceptor function in human detrusors and possible mechanisms. Chin Med J (Engl). 2003;116:1511-1514.
-
(2003)
Chin Med J (Engl)
, vol.116
, pp. 1511-1514
-
-
Li, G.1
Li, K.2
Li, Z.3
-
78
-
-
0035064736
-
Regulations of opioid dependence by opioid receptor types
-
Narita M, Funada M, Suzuki T. Regulations of opioid dependence by opioid receptor types. Pharmacol Ther. 2001;89:1-15.
-
(2001)
Pharmacol Ther
, vol.89
, pp. 1-15
-
-
Narita, M.1
Funada, M.2
Suzuki, T.3
-
79
-
-
0034941982
-
Age-related differences in sensitivity to the antinociceptive effects of opioids in male rats: Influence of nociceptive intensity and intrinsic efficacy at the mu receptor
-
Smith MA, Gray JD. Age-related differences in sensitivity to the antinociceptive effects of opioids in male rats: influence of nociceptive intensity and intrinsic efficacy at the mu receptor. Psychopharmacology. 2001;156:445-453.
-
(2001)
Psychopharmacology
, vol.156
, pp. 445-453
-
-
Smith, M.A.1
Gray, J.D.2
-
80
-
-
0031944188
-
Serotonin in aging, late-life depression, and Alzheimer's disease: The emerging role of functional imaging
-
Meltzer CC, Smith G, DeKosky ST, et al. Serotonin in aging, late-life depression, and Alzheimer's disease: the emerging role of functional imaging. Neuropsychopharmacology. 1998;18:407-430.
-
(1998)
Neuropsychopharmacology
, vol.18
, pp. 407-430
-
-
Meltzer, C.C.1
Smith, G.2
DeKosky, S.T.3
-
81
-
-
31144459194
-
Age-related emotionality is associated with cortical delta-opioid receptor dysfunction-dependent astrogliosis
-
Narita M, Kuzumaki N, Narita M, et al. Age-related emotionality is associated with cortical delta-opioid receptor dysfunction-dependent astrogliosis. Neuroscience. 2006;137:1359-1367.
-
(2006)
Neuroscience
, vol.137
, pp. 1359-1367
-
-
Narita, M.1
Kuzumaki, N.2
Narita, M.3
-
82
-
-
16744364787
-
Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses
-
Filliol D, Ghozland S, Chluba J, et al. Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses. Nat Genet. 2000;25:195-200.
-
(2000)
Nat Genet
, vol.25
, pp. 195-200
-
-
Filliol, D.1
Ghozland, S.2
Chluba, J.3
-
83
-
-
0031797635
-
Effect of age on pharmacokinetics and pharmacodynamics in man
-
Klotz U. Effect of age on pharmacokinetics and pharmacodynamics in man. Int J Clin Pharmacol Ther. 1998;36:581-585.
-
(1998)
Int J Clin Pharmacol Ther
, vol.36
, pp. 581-585
-
-
Klotz, U.1
-
84
-
-
0030957930
-
Alprazolam in young and elderly men: Sensitivity and tolerance to psychomotor, sedative, and memory effects
-
Bertz RJ, Kroboth PD, Kroboth FJ, et al. Alprazolam in young and elderly men: sensitivity and tolerance to psychomotor, sedative, and memory effects. J Pharmacol Exp Ther. 1997;281:1317-1329.
-
(1997)
J Pharmacol Exp Ther
, vol.281
, pp. 1317-1329
-
-
Bertz, R.J.1
Kroboth, P.D.2
Kroboth, F.J.3
-
85
-
-
0031863607
-
Pharmacokinetics and the pharmacodynamic action of midazolam in young and elderly patients under tooth extraction
-
Platten HP, Schweizer E, Dilger K, et al. Pharmacokinetics and the pharmacodynamic action of midazolam in young and elderly patients under tooth extraction. Clin Pharmacol Ther. 1998;63:552-560.
-
(1998)
Clin Pharmacol Ther
, vol.63
, pp. 552-560
-
-
Platten, H.P.1
Schweizer, E.2
Dilger, K.3
-
86
-
-
0141646512
-
Congestive heart failure and the elderly
-
Boxer R, Yang SX, Hager WD. Congestive heart failure and the elderly. Conn Med. 2003;67:497-503.
-
(2003)
Conn Med
, vol.67
, pp. 497-503
-
-
Boxer, R.1
Yang, S.X.2
Hager, W.D.3
-
88
-
-
0034661284
-
Update on digoxin therapy in congestive heart failure
-
Haji SA, Movahed A. Update on digoxin therapy in congestive heart failure. Am Fam Phys. 2000;62:409-416.
-
(2000)
Am Fam Phys
, vol.62
, pp. 409-416
-
-
Haji, S.A.1
Movahed, A.2
-
89
-
-
0033647312
-
Differential pharmacokinetics of digoxin in elderly patients
-
Hanratty CG, McGlinchey P, Johnston GD, et al. Differential pharmacokinetics of digoxin in elderly patients. Drugs Aging. 2000;17:353-362.
-
(2000)
Drugs Aging
, vol.17
, pp. 353-362
-
-
Hanratty, C.G.1
McGlinchey, P.2
Johnston, G.D.3
-
90
-
-
0034112553
-
Effect of aging on the incidence of digoxin toxicity
-
Miura T, Kojima R, Sugiura Y, et al. Effect of aging on the incidence of digoxin toxicity. Ann Pharmacother. 2000;34:427-432.
-
(2000)
Ann Pharmacother
, vol.34
, pp. 427-432
-
-
Miura, T.1
Kojima, R.2
Sugiura, Y.3
-
91
-
-
0042820135
-
The cardiovascular system in the aging patient
-
Moore A, Mangoni AA, Lyons D, et al. The cardiovascular system in the aging patient. Br J Clin Pharmacol. 2003;56:254-260.
-
(2003)
Br J Clin Pharmacol
, vol.56
, pp. 254-260
-
-
Moore, A.1
Mangoni, A.A.2
Lyons, D.3
-
92
-
-
11944274532
-
The influence of age and sex on the clearance of cytochrome P450 3A substrates
-
Cotreau MM, von Moltke LL, Greenblatt DJ. The influence of age and sex on the clearance of cytochrome P450 3A substrates. Clin Pharmacokinet. 2005;44:33-60.
-
(2005)
Clin Pharmacokinet
, vol.44
, pp. 33-60
-
-
Cotreau, M.M.1
von Moltke, L.L.2
Greenblatt, D.J.3
-
93
-
-
0022486728
-
Verapamil pharmacodynamics and disposition in young and elderly hypertensive patients altered electrocardiographic and hypotensive responses
-
Abernethy DR, Schwartz JB, Todd EL, et al. Verapamil pharmacodynamics and disposition in young and elderly hypertensive patients altered electrocardiographic and hypotensive responses. Ann Intern Med. 1986;105:329-336.
-
(1986)
Ann Intern Med
, vol.105
, pp. 329-336
-
-
Abernethy, D.R.1
Schwartz, J.B.2
Todd, E.L.3
-
94
-
-
0027440330
-
Stereo-selective verapamil disposition and dynamics in aging during racemic verapamil administration
-
Abernethy DR, Wainer IW, Longstreth JA, et al. Stereo-selective verapamil disposition and dynamics in aging during racemic verapamil administration. J Pharmacol Exp Ther. 1993;266:904-911.
-
(1993)
J Pharmacol Exp Ther
, vol.266
, pp. 904-911
-
-
Abernethy, D.R.1
Wainer, I.W.2
Longstreth, J.A.3
-
95
-
-
0034536649
-
Increased S-verapamil plasma concentration in rheumatic arthritis without increased cardiac effect
-
Mayo P, Skeith K, Russell AS, et al. Increased S-verapamil plasma concentration in rheumatic arthritis without increased cardiac effect. Br J Clin Pharmacol. 2000;50:605-613.
-
(2000)
Br J Clin Pharmacol
, vol.50
, pp. 605-613
-
-
Mayo, P.1
Skeith, K.2
Russell, A.S.3
-
96
-
-
0032922430
-
-
2+ current by IL-1β in rat ventricular myocytes. Am J Physiol. 1999;276:H141-H148.
-
2+ current by IL-1β in rat ventricular myocytes. Am J Physiol. 1999;276:H141-H148.
-
-
-
-
97
-
-
34447638865
-
Drug disease interactions: Role of inflammatory mediators in disease and variability in drug response
-
Kulmatycki KM, Jamali F. Drug disease interactions: role of inflammatory mediators in disease and variability in drug response. J Pharm Pharm Sci. 2005;8:602-625.
-
(2005)
J Pharm Pharm Sci
, vol.8
, pp. 602-625
-
-
Kulmatycki, K.M.1
Jamali, F.2
-
98
-
-
3042696617
-
Trials of newer approaches to anticoagulation in atrial fibrillation
-
Cooper HA. Trials of newer approaches to anticoagulation in atrial fibrillation. J Interv Card Electrophysiol. 2004;10(Suppl 1):27-31.
-
(2004)
J Interv Card Electrophysiol
, vol.10
, Issue.SUPPL. 1
, pp. 27-31
-
-
Cooper, H.A.1
-
99
-
-
0036152297
-
Increased sensitivity to warfarin in elderly Hispanics
-
Casner PR, Sandoval E. Increased sensitivity to warfarin in elderly Hispanics. J Clin Pharmacol. 2002;42:145-150.
-
(2002)
J Clin Pharmacol
, vol.42
, pp. 145-150
-
-
Casner, P.R.1
Sandoval, E.2
-
100
-
-
30944458205
-
Current issues in the initial phase of warfarin therapy
-
Squizzato A, Steidl L, Ageno W. Current issues in the initial phase of warfarin therapy. Recent Prog Med. 2005;96:612-615.
-
(2005)
Recent Prog Med
, vol.96
, pp. 612-615
-
-
Squizzato, A.1
Steidl, L.2
Ageno, W.3
-
101
-
-
1842475297
-
Cytochrome P450 2C9 polymorphisms (CYP2C9) and warfarin maintenance dose in elderly patients
-
Siguret V, Gouin I, Golmard JL, et al. Cytochrome P450 2C9 polymorphisms (CYP2C9) and warfarin maintenance dose in elderly patients. Rev Med Interne. 2004;25:271-274.
-
(2004)
Rev Med Interne
, vol.25
, pp. 271-274
-
-
Siguret, V.1
Gouin, I.2
Golmard, J.L.3
-
103
-
-
14644446029
-
Opioid use in the elderly
-
Wilder-Smith OH. Opioid use in the elderly. Eur J Pain. 2005;9:137-140.
-
(2005)
Eur J Pain
, vol.9
, pp. 137-140
-
-
Wilder-Smith, O.H.1
-
104
-
-
19044400678
-
Age-dependent opioid escalation in chronic pain patients
-
Buntin-Mushock C, Phillip L, Moriyama K, et al. Age-dependent opioid escalation in chronic pain patients. Anesth Analg. 2005;100:1740-1745.
-
(2005)
Anesth Analg
, vol.100
, pp. 1740-1745
-
-
Buntin-Mushock, C.1
Phillip, L.2
Moriyama, K.3
-
105
-
-
19044385128
-
Age-dependent morphine tolerance development in the rat
-
Wang Y, Mitchell J, Moriyama K, et al. Age-dependent morphine tolerance development in the rat. Anesth Analg. 2005;100:1733-1739.
-
(2005)
Anesth Analg
, vol.100
, pp. 1733-1739
-
-
Wang, Y.1
Mitchell, J.2
Moriyama, K.3
-
106
-
-
0345303864
-
Psychosis in elderly patients: Classification and pharmacotherapy
-
Mintzer J, Targum SD. Psychosis in elderly patients: classification and pharmacotherapy. Psychiatry Neurol. 2003;16:199-206.
-
(2003)
Psychiatry Neurol
, vol.16
, pp. 199-206
-
-
Mintzer, J.1
Targum, S.D.2
-
107
-
-
34748846125
-
Understanding and managing psychosis in late life
-
Available at, accessed July 12
-
Jeste DV, Twamley EW. Understanding and managing psychosis in late life. Psychiatric Times. 2003; XX. Available at www.psychiatrictimes.com (accessed July 12, 2006).
-
(2006)
Psychiatric Times. 2003
-
-
Jeste, D.V.1
Twamley, E.W.2
-
108
-
-
16544367774
-
Pharmacology of antipsychotics in the elderly: A focus on atypicals
-
Finkel S. Pharmacology of antipsychotics in the elderly: a focus on atypicals. J Am Geriatr Soc. 2004;52:S258-S265.
-
(2004)
J Am Geriatr Soc
, vol.52
-
-
Finkel, S.1
-
109
-
-
27544473086
-
Antipsychotics for behavioural and psychological problems in elderly people with dementia: A systematic review of adverse events
-
van Iersel MB, Zuidema SU, Koopmans RT, et al. Antipsychotics for behavioural and psychological problems in elderly people with dementia: a systematic review of adverse events. Drugs Aging. 2005;22:845-858.
-
(2005)
Drugs Aging
, vol.22
, pp. 845-858
-
-
van Iersel, M.B.1
Zuidema, S.U.2
Koopmans, R.T.3
-
110
-
-
0442279024
-
Advances in pharmacotherapy of psychotic disorders in the elderly
-
Kirkwood CK, Givone DM. Advances in pharmacotherapy of psychotic disorders in the elderly. Consult Pharm. 2003;18:539-550.
-
(2003)
Consult Pharm
, vol.18
, pp. 539-550
-
-
Kirkwood, C.K.1
Givone, D.M.2
-
111
-
-
24644512210
-
Atypical antipsychotics in the real world: A naturalistic comparative outcome study
-
Taylor M, Turner M, Watt L, et al. Atypical antipsychotics in the real world: a naturalistic comparative outcome study. Scott Med J. 2005;50:102-106.
-
(2005)
Scott Med J
, vol.50
, pp. 102-106
-
-
Taylor, M.1
Turner, M.2
Watt, L.3
-
112
-
-
0037328229
-
A randomized placebo-controlled trial of risperidone for the treatment of aggression, agitation, and psychosis of dementia
-
Brodaty H, Ames D, Snowdon J, et al. A randomized placebo-controlled trial of risperidone for the treatment of aggression, agitation, and psychosis of dementia. J Clin Psychiatry. 2003;64:134-143.
-
(2003)
J Clin Psychiatry
, vol.64
, pp. 134-143
-
-
Brodaty, H.1
Ames, D.2
Snowdon, J.3
-
113
-
-
13844251076
-
Influence of age and gender on risperidone plasma concentrations
-
Aichhorn W, Weiss U, Marksteiner J, et al. Influence of age and gender on risperidone plasma concentrations. J Psychopharmacol. 2005;19:395-401.
-
(2005)
J Psychopharmacol
, vol.19
, pp. 395-401
-
-
Aichhorn, W.1
Weiss, U.2
Marksteiner, J.3
-
116
-
-
0345731432
-
Inappropriate medication use among frail elderly inpatients
-
Hanlon JT, Artz MB, Pieper CF, et al. Inappropriate medication use among frail elderly inpatients. Ann Pharmacother. 2004;38:9-14.
-
(2004)
Ann Pharmacother
, vol.38
, pp. 9-14
-
-
Hanlon, J.T.1
Artz, M.B.2
Pieper, C.F.3
-
117
-
-
0033434058
-
Undertreatment of hyperlipidemia in the secondary prevention of coronary artery disease
-
Majumdar SR, Gurwitz JH, Soumerai SB. Undertreatment of hyperlipidemia in the secondary prevention of coronary artery disease. J General Intern Med. 1999;14:711-717.
-
(1999)
J General Intern Med
, vol.14
, pp. 711-717
-
-
Majumdar, S.R.1
Gurwitz, J.H.2
Soumerai, S.B.3
-
118
-
-
0037145887
-
Intermountain Heart Collaborative Study. Statin therapy is associated with reduced mortality across all age groups of individuals with significant coronary disease, including very elderly patients
-
Allen Maycock CA, Muhlestein JB, Horne BD, et al. Intermountain Heart Collaborative Study. Statin therapy is associated with reduced mortality across all age groups of individuals with significant coronary disease, including very elderly patients. J Am Coll Cardiol. 2002;40:1777-1785.
-
(2002)
J Am Coll Cardiol
, vol.40
, pp. 1777-1785
-
-
Allen Maycock, C.A.1
Muhlestein, J.B.2
Horne, B.D.3
|