Age-dependent changes of the kidneys: Pharmacological implications

Gerontology

Volumn 45, Issue 5, 1999, Pages 243-253

  Muhlberg W ^a   Platt, D ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Aging; Drugs; Kidneys; Nephrotoxicity

Indexed keywords

ANTIBIOTIC AGENT; CREATININE; DIURETIC AGENT; GLUCOSE; NONSTEROID ANTIINFLAMMATORY AGENT; SODIUM; VASOPRESSIN;

ACUTE KIDNEY FAILURE; ACUTE KIDNEY TUBULE NECROSIS; ATHEROSCLEROSIS; CREATININE CLEARANCE; DIABETES MELLITUS; ECHOGRAPHY; GERIATRIC PATIENT; GLOMERULUS FILTRATION RATE; HUMAN; HYPERTENSION; INFLAMMATORY CELL; INTERSTITIAL NEPHRITIS; INTIMA; KIDNEY BLOOD FLOW; KIDNEY FUNCTION; KIDNEY MASS; KIDNEY TUBULE FUNCTION; NEPHROTOXICITY; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; STROMA; VITAMIN D METABOLISM;

AGING; HUMANS; KIDNEY; PHARMACOKINETICS;

EID: 0344994575     PISSN: 0304324X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000022097     Document Type: Review

References (84)

1. Cantu TG, Ellerbeck EF, Yun SW, Castine SD, Kornhauser DM: Drug prescribing for patients with changing real function. Am J Hosp Pharm 1992;12:2944-2948.
2. Tauchi H, Tsuboi K, Okutomi J: Age changes in the human kidney of the different races. Gerontologia 1971;17:87-97.
3. Takeda T, Imada A, Horiuchi A, Kimura M, Mackura S, Hashimoto S: Age-related changes in morphological studies in rat and human kidney. Nippon Jinzo Gakkai Shi 1996;38:555-562.
4. Griffiths GJ, Robinson KB, Cartwright GO, McLachlan MS: Loss of renal tissue in the elderly. Br J Radiol 1976;49:111-117.
5. Porush JG, Faubert PF: Renal Disease in the Aged. Boston, Little, Brown, 1991.
6. Kappel B, Olsen S: Cortical interstitial tissue and sclerosed glomeruli in the normal human kidney related to age and sex: A quantitative study. Virchows Arch [A] 1980;387:271-277.
7. Kaplan C, Pasternack B, Shah H, Gallo G: Age-related incidence of sclerotic glomeruli in human kidneys. Am J Pathol 1975;80:227-234.
8. Nyengaard JR, Bendtsen TF: Glomerular number and size in relation to age, kidney weight and body surface in normal man. Anat Rec 1992;232:194-201.
9. Lubran MM: Renal function in the elderly. Ann Clin Lab Sci 1995;25:122-133.
10. 99mTc-DTPA and inulin. Kidney Int 1992;42:174-178.
11. Thomas SE, Anderson S, Gordon KL, Oyama TT, Shankland SJ, Johnson RJ: Tubuloinlerstitial disease in aging: Evidence for underlying peritubular capillary damage, a potential role for renal ischemia. J Am Soc Nephrol 1998;9: 231-242.
12. Darmady EM, Offer J, Woodhouse MA: The parameters of the aging kidney. J Pathol 1973; 109:195-207.
13. Dontas AS, Merketos SG, Papanayioutou P: The mechanisms of renal tubular defects in old age. Postgrad Med J 1972;48:295-303.
14. Langeveld JP, Veerkamp JH, Duyf CM, Monnens LH: Chemical characterization of glomerular and tubular basement membrane of men of different ages. Kidney Int 1981;20:104-114.
15. Karttunen T, Risteli J, Autio-Harmainen H, Risteli L: Effect of age and diabetes on type IV collagen and laminin in human kidney cortex. Kidney Int 1986;30:586-591.
16. Martin GM, Ogburn CE, Colgin LM, Gown AM, Edland SD, Monnal RJ Jr: Somatic mutations are frequent and increase with age in human kidney epithelial cells. Hum Mol Genet 1996;5:215-221.
17. Brenner B, Meyer TW, Hostetter TH: Dietary protein intake and the progressive nature of kidney disease: The role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation and intrinsic renal disease. N Engl J Med 1982;307:652-659.
18. Kasiske BL: Relationship between vascular discase and associated changes in the human kidney. Kidney Int 1987;31:1153-1159.
19. Pedrini MT, Levey AS, Lau J, Chalmers TC, Wang PH: The effect of dietary protein restriction on the progression of diabetic and nondiabetic renal diseases: A meta-analysis. Ann Int Med 1996;124:627-632.
20. Bauer JH, Reams GP, Wu Z: The aging hypertensive kidney: Pathophysiology and therapeutic options. Am J Med 1991;90(suppl):21-27.
21. Hollenberg NK, Adams DF. Solomon HS. Rashid A. Abrams HL. Merrill JP: Senescence and the renal vasculature in normal man. Circ Res 1974;34:309-316.
22. McLachlan MS, Guthrie JC, Anderson CK, Fulker MJ: Vascular and glomerular changes in the aging kidney. J Pathol 1977;121:65-78.
23. Ricci A: The renal dopaminergic system in ageing. J Auton Pharmacol 1990;10(suppl):19-24.
24. Baylis C, Schmidt R: The aging glomerulus. Semin Nephrol 1996;16:265-276.
25. Davies DF, Shock NW: Age changes in glomerular filtration rate: Effective renal plasma flow and tubular excretory capacity in adult males. J Clin Invest 1950;29:496-507.
26. Lindeman RD, Tobin J, Shock NW: Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc 1985;33:278-285.
27. Rowe JW, Andres R, Tobin JD, Norris AH, Shock NW: The effect of age on creatinine clearance in men: A cross-sectional and longitudinal study. J Gerontol 1976;31:155-163.
28. Lindeman RD: Overview: Renal physiology and pathophysiology of aging. Am J Kidney Dis 1990;16:275-282.
29. Cockcroft DW, Gault MH: Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31-41.
30. Corman B, Barrault MB, Klingler C, Houot AM, Michel JB, Della Bruna R, Pinet F, Soubrier F: Renin gene expression in the aging kidney: Effect of sodium restriction. Mech Ageing Dev 1995;84:1-13.
31. Mimran A, Ribstein J, Jover B: Aging and sodium homeostasis. Kidney Int 1992;37(suppl): 107-113.
32. Kaysen GA, Myers BD: The aging kidney. Clin Geriatr Med 1985;1:207-222.
33. Ledingham JG, Crowe MJ, Forsling ML, Phillips PA, Rolls BJ: Effects of aging on vasopressin secretion, water excretion, and thirst in man. Kidney Int 1987;27(suppl):90-92.
34. Morimoto S, Ogihara T: Physiological and pathological aging and electrolyte metabolism. Nippon Ronen Igakkai Zasshi 1991;28:325-330.
35. Luft FC, Fineberg NS, Weinberger MH: The influence of age on renal function and renin and aldosterone responses to sodium-volume expansion and contraction in normotensive and mildly hypertensive humans. Am J Hypertens 1992;5:520-528.
36. Schück O, Nádvornikova H, Teplan V: Acidification capacity of the kidneys and aging. Physiol Bohemoslov 1989;38:117-125.
37. Sorribas V, Lötscher M, Lofting J, Biber J, Kaissling B, Murer H, Levi M: Cellular mechanisms of the age-related decrease in renal phosphate reabsorption. Kidney Int 1996;50:855-863.
38. Chapuy MC, Durr F, Chapuy P: Age-related changes in parathyroid hormone and 25-hydroxycholecalciferol levels. J Gerontol 1983; 38:19-22.
39. Marcus R, Masdirg P, Young G: Age-related changes in parathyroid hormone and parathyroid hormone action in normal humans. J Clin Endocrinol Metab 1984;58:223-230.
40. Massry SG, Faddy GZ, Zhou XJ, Chandrasoma P, Cheng L, Filburn CR: Impaired insulin secretion of aging: Role of renal failure and hyperparathyroidism. Kidney Int 1991;40: 662-667.
41. Greenblatt DJ: Reduced serum albumin concentration in the elderly: A report from The Boston Collaborative Drug Surveillance Program. J Am Geriatr Soc 1979;27:20-22.
42. Meyer BR: Renal function in aging. J Am Geriatr Soc 1989;37:791-800.
43. Brown WW, Davis BB, Spry LA, Wongsurawat N. Malone JD, Domoto DT: Aging and the kidney. Arch Intern Med 1986;146:1790-1796.
44. Niederstadt C, Steinhoff J: The kidneys in aging. Z Gerontol Geriatr 1997;30:200-207.
45. Oh VM: Multiple medication: Problems of the elderly patient. Int Dent J 1991;41:348-358.
46. Pacifici GM, Viani A, Taddeucci-Brunelli G, Rizzo G, Carrai M, Schulz HU: Effects of development, aging, and renal and hepatic insufficiency as well as hemodialysis on the plasma concentrations of albumin and alpha-1-acid glycoprotein: Implications for binding of drugs. Ther Drug Monit 1986;8:259-263.
47. Pacifici GM, Viani A, Franchi M, Gervasi PG, Longo V, Di Simplicio P, Temellini A, Romiti P, Santerini S, Vannucci L: Profile of drug-metabolizing enzymes in the cortex and medully of the human kidney. Pharmacology 1989; 39:299-308.
48. Pelletier J, Desrosiers RR, Bjeliveau R: Age-related changes in carboxyl methylation of proteins in the kidney. Mech Ageing Dev 1996;86: 115-135.
49. Ujhelyi MR, Bottorff MB, Schur M, Roll K, Zhang H, Stewart J, Markel ML: Aging effects on the organic base transporter and stereoselective renal clearance. Clin Pharmacol Ther 1997;62:117-128.
50. Perez Gutthann S, Garcia Rodriguez LA, Raiford DS, Duque Oliart A, Ris Romeu J: Nonsteroidal anti-inflammatory drugs and the risk of hospitalization for acute renal failure. Arch Intern Med 1996;156:2433-2439.
51. Stillman MT: Interaction and selection of therapeutic agents in the elderly: NSAIDs and the ageing kidney. Scand J Rheumatol 1989; 82(suppl):33-38.
52. Weinblatt ML: Nonsteroidal, anti-inflammatory drug toxicity: Increased risk in the elderly. Scand J Rheumatol 1991;91(suppl):9-17.
53. Willmore LJ: The effect of age on pharmacokinetics of antiepileptic drugs. Epilepsia 1995; 36(suppl 5):14-21.
54. Wollam GL, Tarazi RC, Bravo EL, Dustan HP: Diuretic potency of combined hydrochlorothiazide and furosemide therapy in patients with azotemia. Am J Med 1982;72:929-938.
55. Blackshear JL, Davidman M, Stillman T: Identification of risk for renal insufficiency from nonsteroidal anti-inflammatory drugs. Arch Intern Med 1983;143:1130-1134.
56. Fradet G, Legac X, Charlois T, Ponge T, Cottin S: latrogenic drug-induced diseases, requiring hospitalization, in patients over 65 years of age: 1-year retrospective study in an internal medicine department. Rev Méd Interne 1996;17: 456-460.
57. McCarthy JT, Torres VE, Romero JC, Wochos DN, Velosa JA: Acute intrinsic renal failure induced by indomethacin: Role of prostaglandin synthetase inhibition. Mayo Clin Proc 1982;57:289-296.
58. Horton R, Zipser R, Fichman M: Prostaglandins, renal function and vascular regulation. Med Clin North Am 1981;64:891-914.
59. Packer M, Lee WH, Medina N, Yushak M, Kessler PD: Functional renal insufficiency during long-term therapy with captopril and enalapril in severe chronic heart failure. Ann Intern Med 1987;106:346-354.
60. Mörike K, Schwab M, Klotz U: Use of aminoglycosides in elderly patients: Pharmacokinetic and clinical considerations. Drugs Aging 1997; 10:259-277.
61. Smith CR, Baughman KL, Edwards CQ, Rogers JF, Lietman PS: Controlled comparison of amikacin and gentamicin. N Engl J Med 1977; 296:349-353.
62. Smith CR, Lipsky JJ, Laskin OL, Hellmann DB, Mellits ED, Longstreth J, Lietman PS: Double-blind comparison of the nephrotoxicity and auditory toxicity of gentamicin and tobramycin. N Engl J Med 1980;30:1106-1109.
63. Carlin PC, Idelson BA, Casano AA, Alexander EA, McCabe WR: Nephrotoxicity associated with cephalothin administration. Arch Intern Med 1975;135:797-801.
64. Miller RP, Bates JH: Amphotericin B toxicity: A follow-up report of 5 × 3 patients. Ann Intern Med 1969;71:1089-1095.
65. Mandai AK, Baig M, Koutoubi Z: Management of acute renal failure in the elderly: Treatment options. Drugs Aging 1996;9:226-250.
66. de Mulder PH: Drug treatment of cancer in elderly patients. Tidschr Gerontol Geriatr 1990;21:173-176.
67. Kimmick GG, Fleming R, Muss HB, Balducci L: Cancer chemotherapy in older ions for treatment. Drugs Aging 1992;2:423-431.
68. Tett SE, Triggs EJ: Use of methotrexate in older patients: A risk-benefit assessment. Drugs Aging 1996;9:458-471.
69. Belmin J: Antihypertensive agents in elderly patients. Rev Prat 1990;40:1379-1380.
70. Andreucci VE, Russo D, Cianciaruso B, Andreucci M: Some sodium, potassium and water changes in the elderly and their treatment. Nephrol Dial Transplant 1996;11(suppl):9-17.
71. Grenfell A: Acute renal failure in diabetics. Intensive Care Med 1986;12:6-12.
72. Lynn KL, Bailey RR, Swainson CP: Renal failure with potassium-sparing diuretics. NZ Med J 1985;98:629-633.
73. Mühlberg W: Untersuchungen zur Pharmakokinetik und Toxikologie multimorbider geriatrischer Patienten. Habilitationsschrift Erlangen-Nürnberg, 1997.
74. Mühlberg W, Platt D, Neubig E: Pharmacokinetics and pharmacodynamics of furosemide in geriatric patients. Arch Gerontol Geriatr 1986;5:249-261.
75. McLigeyo SO: Calculation of creatinine clearance from plasma creatinine. East Afr Med J 1993;70:3-5.
76. Shoji T, Hayashi T, Kitamura E, Okada N, Nakanishi I, Tsubakihara Y: Predictability of creatinine clearance from scrum creatinine in chronic glomerulonephritis. Nippon Jinzo Gakkai Shi 1993;35:287-292.
77. Gates GF: Creatinine clearance estimation from serum crcatinine values: An analysis of three mathematical modes of glomerular filtration. Am J Kidney Dis 1985;5:199-205.
78. Hull JH, Hak LJ, Kock GG, Wargin WA, Chi S, Mattocks AM: Influence of range of renal function and liver disease on predictability of creatinine clearance. Clin Pharmacol Ther 1981;29:516-521.
79. Jellife RW: Creatinine clearance: Bedside estimate. Ann Intern Med 1973;79:604-605.
80. Mawer EG, Knowles BR, Lucas SB, Stirland RM, Tooth JA: Computer assisted prescribing of kanamycin for patients with renal insufficiency. Lancet 1972;1:12-15.
81. Sampson MD, Drury PL: Accurate estimation of glomerular filtration rate in diabetic nephropathy from age, body weight, and serum creatinine. Diabetes Care 1992;15:609-612.
82. Ajayi AA: Estimation of creatinine clearance from scrum creatinine: Utility of the Cockcroft and Gault equation in Nigerian patients. Eur J Clin Pharmacol 1991;40:429-431.
83. Gross JL, Silveiro SP, de Azevedo MJ, Pecis M, Friedman R: Estimated creatinine clearance is not an accurate index of glomerular filtration rate in normoalbuminuric diabetic patients. Diabetes Care 1993;16:407-408.
84. Mandhani A, Sanjeevan KV, Charuasia D, Bhandari M: Renal and prostatic disorders in the elderly. Indian J Med Res 1997;106:286-294.