Opioid use in the elderly

European Journal of Pain

Volumn 9, Issue 2 SPEC. ISS., 2005, Pages 137-140

  Wilder Smith, Oliver H G ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Old age; Opioids; Pharmacodynamics; Pharmacokinetics; Prescribing

Indexed keywords

DIHYDROCODEINE; FENTANYL; MORPHINE; MORPHINE 3 GLUCURONIDE; MORPHINE 6 GLUCURONIDE; NEUROTRANSMITTER; OPIATE; PEPTIDE; PETHIDINE;

AGING; ANALGESIA; BINDING AFFINITY; BODY COMPOSITION; COMORBIDITY; DRUG EFFICACY; HUMAN; LIVER FUNCTION; MEDICAL INFORMATION; MEDICAL RESEARCH; NOCICEPTION; NONHUMAN; PAIN; PHYSICIAN; POLYPHARMACY; POSTOPERATIVE CARE; PRESCRIPTION; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SIDE EFFECT; TITRIMETRY; URINARY EXCRETION;

EID: 14644446029     PISSN: 10903801     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpain.2004.07.011     Document Type: Article

References (25)

1. F. Aubrun, D. Bunge, O. Langeron, G. Saillant, P. Coriat, and B. Riou Postoperative morphine consumption in the elderly patient Anesthesiology 99 2003 160 165
2. K.N. Davies, C.M. Castleden, A. McBurney, and C. Jagger The effect of ageing on the pharmacokinetics of dihydrocodeine Eur. J. Clin. Pharmacol. 37 1989 375 379
3. F.M. Gloth 3rd Pain management in older adults: prevention and treatment J. Am. Geriatr. Soc. 49 2001 188 199
4. M.T. Holdsworth, W.B. Forman, T.A. Killilea, K.M. Nystrom, R. Paul, and S.C. Brand Transdermal fentanyl disposition in elderly subjects Gerontology 40 1994 32 37
5. A.K. Islam, M.L. Cooper, and R.J. Bodnar Interactions among aging, gender, and gonadectomy effects upon morphine antinociception in rats Physiol. Behav. 54 1993 45 53
6. Jage J. Opioid tolerance and dependence - do they matter? Eur J Pain [in press]
7. D. Jourdan, S. Boghossian, A. Alloui, C. Veyrat-Durebex, M.A. Coudore, and A. Eschalier Age-related changes in nociception and effect of morphine in the Lou rat Eur. J. Pain 4 2000 291 300
8. D. Jourdan, G. Pickering, F. Marchand, J.M. Gaulier, J. Alliot, and A. Eschalier Impact of ageing on the antinociceptive effect of reference analgesics in the Lou/c rat Br. J. Pharmacol. 137 2002 813 820
9. E. Kramer, and R.J. Bodnar Age-related decrements in morphine analgesia: a parametric analysis Neurobiol. Aging 7 1986 185 191
10. Kress, HG, Kraft B. Opioid medication and driving ability. Eur J Pain in press, doi: 10.1016/j.ejpain.2004.05.010
11. H.J. Lemmens, A.G. Burm, P.J. Hennis, M.P. Gladines, and J.G. Bovill Influence of age on the pharmacokinetics of alfentanil. Gender dependence Clin. Pharmacokinet. 19 1990 416 422
12. G. Loick, L. Radbruch, R. Sabatowski, M. Siessegger, S. Grond, and K.A. Lehmann Morphine dose and side effects: a comparison of older and younger patients with tumor pain Dtsch. Med. Wochenschr. 125 2000 1216 1221
13. P.E. Macintyre, and D.A. Jarvis Age is the best predictor of postoperative morphine requirements Pain 64 1996 357 364
14. R.S. Matteo, A.E. Schwartz, E. Ornstein, W.L. Young, and W.J. Chang Pharmacokinetics of sufentanil in the elderly surgical patient Can. J. Anaesth. 37 1990 852 856
15. R.B. Messing, B.J. Vasquez, V.R. Spiehler, J.L. Martinez Jr., R.A. Jensen, and H. Rigter 3H-Dihydromorphine binding in brain regions of young and aged rats Life Sci. 26 1980 921 927
16. A. Nicak, and A. Kohut Development of tolerance to morphine and pethidine in rats in dependence on age Act. Nerv. Super (Praha) 20 1978 231 235
17. G. Pickering, D. Jourdan, A. Eschalier, and C. Dubray Impact of age, gender and cognitive functioning on pain perception Gerontology 48 2002 112 118
18. P.A. Rochon, and J.H. Gurwitz Drug therapy Lancet 346 1995 32 36
19. J.W. Sear, C.W. Hand, and R.A. Moore Studies on morphine disposition: plasma concentrations of morphine and its metabolites in anesthetized middle-aged and elderly surgical patients J. Clin. Anesth. 1 1989 164 169
20. M.A. Singleton, J.I. Rosen, and D.M. Fisher Pharmacokinetics of fentanyl in the elderly Br. J. Anaesth. 60 1988 619 622
21. M.A. Smith, and J.D. Gray Age-related differences in sensitivity to the antinociceptive effects of opioids in male rats. Influence of nociceptive intensity and intrinsic efficacy at the μ receptor Psychopharmacology (Berl.) 156 2001 445 453
22. E. Ueno, D.D. Liu, I.K. Ho, and B. Hoskins Opiate receptor characteristics in brains from young, mature and aged mice Neurobiol. Aging 9 1988 279 283
23. J.T. Van Crugten, A.A. Somogyi, R.L. Nation, and G. Reynolds The effect of old age on the disposition and antinociceptive response of morphine and morphine-6 beta-glucuronide in the rat Pain 71 1997 199 205
24. A. Vigano, E. Bruera, and M.E. Suarez-Almazor Age, pain intensity, and opioid dose in patients with advanced cancer Cancer 83 1998 1244 1250
25. A. Woodhouse, and L.E. Mather The influence of age upon opioid analgesic use in the patient-controlled analgesia (PCA) environment Anaesthesia 52 1997 949 955