메뉴 건너뛰기




Volumn 38, Issue 3, 2000, Pages 271-290

Age-related changes in protein binding of drugs. Implications for therapy

Author keywords

[No Author keywords available]

Indexed keywords

ACEBUTOLOL; ACETAZOLAMIDE; ALBUMIN; ALFENTANIL; ALPRAZOLAM; AMITRIPTYLINE; ANTIDEPRESSANT AGENT; BATANOPRIDE; BENAZEPRIL; CAFFEINE; CANRENONE; CEFONICID; CEFTRIAXONE; CHLORDIAZEPOXIDE; CHLOROQUINE; CHLORPROMAZINE; CLADRIBINE; CLOMETHIAZOLE; DESIPRAMINE; DIAZEPAM; DIFLUNISAL; DIGITOXIN; DIURETIC AGENT; DONEPEZIL; DRUG; HYPNOTIC SEDATIVE AGENT; NEUROLEPTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; PLASMA PROTEIN; UNINDEXED DRUG;

EID: 0034117268     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-200038030-00005     Document Type: Review
Times cited : (180)

References (162)
  • 1
    • 0019952227 scopus 로고
    • Importante of protein binding for the interpretation of serum of plasma drug concentrations
    • May-Jun
    • 1. Greenblatt DJ, Sellers EM, Koch-Weser J. Importante of protein binding for the interpretation of serum of plasma drug concentrations. J Clin Pharmacol 1982 May-Jun; 22 (5-6): 259-63
    • (1982) J Clin Pharmacol , vol.22 , Issue.5-6 , pp. 259-263
    • Greenblatt, D.J.1    Sellers, E.M.2    Koch-Weser, J.3
  • 2
    • 0016289031 scopus 로고
    • Drug levels in the target tissue and effect
    • Jul
    • 2. Ariëns EJ. Drug levels in the target tissue and effect Clin Pharmacol Ther 1974 Jul; 16 (1): 155-75
    • (1974) Clin Pharmacol Ther , vol.16 , Issue.1 , pp. 155-175
    • Ariëns, E.J.1
  • 3
    • 0023910884 scopus 로고
    • Kinetics of drug effects in man
    • 3. Oosterhuis B, van Boxtel CJ. Kinetics of drug effects in man. Ther Drug Monit 1988; 10 (2): 121-32
    • (1988) Ther Drug Monit , vol.10 , Issue.2 , pp. 121-132
    • Oosterhuis, B.1    Van Boxtel, C.J.2
  • 4
    • 0029889951 scopus 로고    scopus 로고
    • Measurement and analysis of unbound drug concentrations
    • Jun
    • 4. Wright JD, Boudinot FD. Ujhelyi MR. Measurement and analysis of unbound drug concentrations. Clin Pharmacokinet 1996 Jun; 30 (6): 445-62
    • (1996) Clin Pharmacokinet , vol.30 , Issue.6 , pp. 445-462
    • Wright, J.D.1    Boudinot, F.D.2    Ujhelyi, M.R.3
  • 5
    • 0015504418 scopus 로고
    • Altered protein binding of diphenylhydantoin in uremic plasma
    • Jan
    • 5. Blum MR, Riegelman S, Becker CE. Altered protein binding of diphenylhydantoin in uremic plasma [letter]. N Engl J Med 1972 Jan; 286 (2): 109
    • (1972) N Engl J Med , vol.286 , Issue.2 , pp. 109
    • Blum, M.R.1    Riegelman, S.2    Becker, C.E.3
  • 6
    • 0014953325 scopus 로고
    • Abnormal pharmacokinetics of phenytoin in a patient with uremia
    • Oct
    • 6. Odar-Cederlof I, Lunde P. Sjogvist F. Abnormal pharmacokinetics of phenytoin in a patient with uremia. Lancet 1970 Oct; 11 (7677): 831-2
    • (1970) Lancet , vol.11 , Issue.7677 , pp. 831-832
    • Odar-Cederlof, I.1    Lunde, P.2    Sjogvist, F.3
  • 7
    • 0019490857 scopus 로고
    • Pharmacokinetic concepts - drug binding, apparent volume of distribution and clearance
    • 7. Gibaldi M, Koup JR. Pharmacokinetic concepts - drug binding, apparent volume of distribution and clearance. Eur J Clin Pharmacol 1981; 20 (4): 299-305
    • (1981) Eur J Clin Pharmacol , vol.20 , Issue.4 , pp. 299-305
    • Gibaldi, M.1    Koup, J.R.2
  • 8
    • 0015691623 scopus 로고
    • Influence of protein binding on the pharmacologic activity of antibiotics
    • Nov
    • 8. Kunin CM, Craig WA, Kornguth M, et al. Influence of protein binding on the pharmacologic activity of antibiotics. Ann N Y Acad Sci 1973 Nov; 226: 214-24
    • (1973) Ann N Y Acad Sci , vol.226 , pp. 214-224
    • Kunin, C.M.1    Craig, W.A.2    Kornguth, M.3
  • 9
    • 0019220256 scopus 로고
    • Disease-induced changes in the plasma binding of basic drugs
    • May-Jun
    • 9. Piafsky KM. Disease-induced changes in the plasma binding of basic drugs. Clin Pharmacokinet 1980 May-Jun; 5 (3): 246-62
    • (1980) Clin Pharmacokinet , vol.5 , Issue.3 , pp. 246-262
    • Piafsky, K.M.1
  • 10
    • 0029125489 scopus 로고
    • Changes in the binding capacity of alpha-1-acid glycoprotein in patients with renal insufficiency
    • Oct
    • 10. Kishino S, Nomura A, Di ZS, et al. Changes in the binding capacity of alpha-1-acid glycoprotein in patients with renal insufficiency. Ther Drug Monit 1995 Oct; 17 (5): 449-53
    • (1995) Ther Drug Monit , vol.17 , Issue.5 , pp. 449-453
    • Kishino, S.1    Nomura, A.2    Di, Z.S.3
  • 11
    • 0023690101 scopus 로고
    • Drug binding of human alpha-1-acid glycoprotein in health and disease
    • March
    • 11. Kremer JMH, Wilting J, Janssen LHM. Drug binding of human alpha-1-acid glycoprotein in health and disease. Pharmacol Rev 1988 March; 40 (1): 1-47
    • (1988) Pharmacol Rev , vol.40 , Issue.1 , pp. 1-47
    • Kremer, J.M.H.1    Wilting, J.2    Janssen, L.H.M.3
  • 12
    • 0027258949 scopus 로고
    • Effect of patient age on tests of acute-phase response
    • Sep
    • 12. Caswell M, Pike LA, Bull BS, et al. Effect of patient age on tests of acute-phase response. Arch Pathol Lab Med 1993 Sep; 117 (9): 906-10
    • (1993) Arch Pathol Lab Med , vol.117 , Issue.9 , pp. 906-910
    • Caswell, M.1    Pike, L.A.2    Bull, B.S.3
  • 13
    • 84941397610 scopus 로고
    • Serum total sialic acid and other acute phase proteins in elderly subjects
    • Oct
    • 13. Crook MA, Treloar A, Haq M, et al. Serum total sialic acid and other acute phase proteins in elderly subjects. Eur J Clin Chem Clin Biochem 1994 Oct; 32 (10): 745-7
    • (1994) Eur J Clin Chem Clin Biochem , vol.32 , Issue.10 , pp. 745-747
    • Crook, M.A.1    Treloar, A.2    Haq, M.3
  • 14
    • 0025344429 scopus 로고
    • Effects of age on the protein binding and disposition of propranolol stereoisomers
    • Apr
    • 14. Lalonde RL, Tenero DM, Burlew BS, et al. Effects of age on the protein binding and disposition of propranolol stereoisomers. Clin Pharmacol Ther 1990 Apr; 47 (4): 447-55
    • (1990) Clin Pharmacol Ther , vol.47 , Issue.4 , pp. 447-455
    • Lalonde, R.L.1    Tenero, D.M.2    Burlew, B.S.3
  • 15
    • 0025319172 scopus 로고
    • The effect of age on serum concentrations of albumin and alpha 1-acid glycoprotein
    • Feb
    • 15. Veering BT, Burm AG, Souverijn JH, et al. The effect of age on serum concentrations of albumin and alpha 1-acid glycoprotein. Br J Clin Pharmacol 1990 Feb; 29 (2): 201-6
    • (1990) Br J Clin Pharmacol , vol.29 , Issue.2 , pp. 201-206
    • Veering, B.T.1    Burm, A.G.2    Souverijn, J.H.3
  • 16
    • 0026991605 scopus 로고
    • Pharmacokinetics of local anesthetics in children
    • 16. Ecoffey C. Pharmacokinetics of local anesthetics in children. Cah Anesthesiol 1992; 40 (7): 533-6
    • (1992) Cah Anesthesiol , vol.40 , Issue.7 , pp. 533-536
    • Ecoffey, C.1
  • 17
    • 0026343091 scopus 로고
    • Changes in alpha 1-acid glycoprotein serum concentrations and glycoforms in the developing human fetus
    • Dec
    • 17. Seta N, Tissot B, Forestier F, et al. Changes in alpha 1-acid glycoprotein serum concentrations and glycoforms in the developing human fetus. Clin Chim Acta 1991 Dec; 203 (2-3): 167-75
    • (1991) Clin Chim Acta , vol.203 , Issue.2-3 , pp. 167-175
    • Seta, N.1    Tissot, B.2    Forestier, F.3
  • 18
    • 0025159041 scopus 로고
    • Protein binding of antiepileptic drugs during pregnancy, labor and puerperium
    • Jan
    • 18. Bardy AH, Hiilesmaa VK, Teramo K, et al. Protein binding of antiepileptic drugs during pregnancy, labor and puerperium. Ther Drug Monit 1990 Jan; 12 (1): 40-6
    • (1990) Ther Drug Monit , vol.12 , Issue.1 , pp. 40-46
    • Bardy, A.H.1    Hiilesmaa, V.K.2    Teramo, K.3
  • 19
    • 0025139714 scopus 로고
    • Plasma protein binding of drugs in pregnancy and in neonates
    • Jan
    • 19. Notarianni LJ. Plasma protein binding of drugs in pregnancy and in neonates. Clin Pharmacokinet 1990 Jan; 18 (1): 20-36
    • (1990) Clin Pharmacokinet , vol.18 , Issue.1 , pp. 20-36
    • Notarianni, L.J.1
  • 20
    • 0027433577 scopus 로고
    • Albumin levels in pregnancy: A hypothesis - decreased levels of albumin are related to increased levels of alpha-fetoprotein
    • Oct
    • 20. Maher JE, Goldenberg RL, Tamura T, et al. Albumin levels in pregnancy: a hypothesis - decreased levels of albumin are related to increased levels of alpha-fetoprotein. Early Hum Dev 1993 Oct; 34 (3): 209-15
    • (1993) Early Hum Dev , vol.34 , Issue.3 , pp. 209-215
    • Maher, J.E.1    Goldenberg, R.L.2    Tamura, T.3
  • 21
    • 0025208385 scopus 로고
    • Effects of age on plasma protein binding of sufentanil
    • Mar
    • 21. Meistelman C, Benhamou D, Barre J, et al. Effects of age on plasma protein binding of sufentanil. Anesthesiology 1990 Mar; 72 (3): 470-3
    • (1990) Anesthesiology , vol.72 , Issue.3 , pp. 470-473
    • Meistelman, C.1    Benhamou, D.2    Barre, J.3
  • 22
    • 0014178991 scopus 로고
    • Albumin metabolism in the nephrotic syndrome in adults
    • Dec
    • 22. Jensen H, Rossing N, Andersen SB, et al. Albumin metabolism in the nephrotic syndrome in adults. Clin Sci 1967 Dec; 33 (3): 445-57
    • (1967) Clin Sci , vol.33 , Issue.3 , pp. 445-457
    • Jensen, H.1    Rossing, N.2    Andersen, S.B.3
  • 23
    • 0027183443 scopus 로고
    • Serum and urinary alpha-1 acid glycoprotein in chronic renal failure
    • 23. Vasson MP, Baguet JC, Arveiller MR, et al. Serum and urinary alpha-1 acid glycoprotein in chronic renal failure. Nephron 1993; 65 (2): 299-303
    • (1993) Nephron , vol.65 , Issue.2 , pp. 299-303
    • Vasson, M.P.1    Baguet, J.C.2    Arveiller, M.R.3
  • 24
    • 0027319333 scopus 로고
    • The pharmacokinetics of remoxipride and metabolites in patients with various degrees of renal function
    • Jun
    • 24. Movin-Osswald G, Boelaert J, Hammarlund-Udenaes M, et al. The pharmacokinetics of remoxipride and metabolites in patients with various degrees of renal function. Br J Clin Pharmacol 1993 Jun; 35 (6): 615-22
    • (1993) Br J Clin Pharmacol , vol.35 , Issue.6 , pp. 615-622
    • Movin-Osswald, G.1    Boelaert, J.2    Hammarlund-Udenaes, M.3
  • 25
    • 0026065378 scopus 로고
    • Serum alpha-1 acid glycoprotein in chronic renal failure and hemodialysis
    • Feb
    • 25. Vasson MP, Paul JL, Coudere R, et al. Serum alpha-1 acid glycoprotein in chronic renal failure and hemodialysis. Int J Artif Organs 1991 Feb; 14 (2): 92-6
    • (1991) Int J Artif Organs , vol.14 , Issue.2 , pp. 92-96
    • Vasson, M.P.1    Paul, J.L.2    Coudere, R.3
  • 27
    • 0021718147 scopus 로고
    • Differential effects of hepatic cirrhosis on the plasma protein binding of drugs
    • 27. Garcia-Morillas M, Gil-Extremera B, Caracuel-Ruiz. Differential effects of hepatic cirrhosis on the plasma protein binding of drugs. Int J Clin Pharmacol Res 1984; 4 (5): 327-33
    • (1984) Int J Clin Pharmacol Res , vol.4 , Issue.5 , pp. 327-333
    • Garcia-Morillas, M.1    Gil-Extremera, B.2
  • 28
    • 0015276180 scopus 로고
    • Plasma protein pattern in cirrhosis of the liver
    • 28. Hallen J, Laurell CB. Plasma protein pattern in cirrhosis of the liver. Scand J Clin Lab Invest Suppl 1972; 124: 97-103
    • (1972) Scand J Clin Lab Invest Suppl , vol.124 , pp. 97-103
    • Hallen, J.1    Laurell, C.B.2
  • 29
    • 0015276385 scopus 로고
    • Sequential changes of the plasma protein pattern in inoculation hepatitis
    • 29. Kindmark CO, Laurell CB. Sequential changes of the plasma protein pattern in inoculation hepatitis. Scand J Clin Lab Invest Suppl 1972; 124: 105-15
    • (1972) Scand J Clin Lab Invest Suppl , vol.124 , pp. 105-115
    • Kindmark, C.O.1    Laurell, C.B.2
  • 30
    • 84943480928 scopus 로고
    • Serum proteins in liver cirrhosis: Effects of shunt surgery
    • Dec
    • 30. Joelsson B, Alwmark A, Gullstrand P, et al. Serum proteins in liver cirrhosis: effects of shunt surgery. J Clin Chem Clin Biochem 1987 Dec; 25 (12): 865-8
    • (1987) J Clin Chem Clin Biochem , vol.25 , Issue.12 , pp. 865-868
    • Joelsson, B.1    Alwmark, A.2    Gullstrand, P.3
  • 31
    • 0024854391 scopus 로고
    • 1-acid glycoprotein in two benign liver diseases: Alcoholic cirrhosis and acute hepatitis
    • 1-acid glycoprotein in two benign liver diseases: alcoholic cirrhosis and acute hepatitis. Clin Chim Acta Dec 1989; 186 (1): 59-66
    • (1989) Clin Chim Acta Dec , vol.186 , Issue.1 , pp. 59-66
    • Biou, D.1    Chanton, P.2    Konan, D.3
  • 32
    • 0027282619 scopus 로고
    • Increase of serum alpha 1-acid glycoprotein despite the decline of liver synthetic function in cirrhotics with hepatocellular carcinoma
    • Jul
    • 32. Falleti E, Pirisi M, Fabris C, et al. Increase of serum alpha 1-acid glycoprotein despite the decline of liver synthetic function in cirrhotics with hepatocellular carcinoma. Eur J Clin Chem Clin Biochem 1993 Jul; 31 (7): 407-11
    • (1993) Eur J Clin Chem Clin Biochem , vol.31 , Issue.7 , pp. 407-411
    • Falleti, E.1    Pirisi, M.2    Fabris, C.3
  • 33
    • 0026538924 scopus 로고
    • Interindividual variability in the concentrations of albumin and alpha-1-acid glycoprotein in patients with renal or liver disease, newborns and healthy subjects: Implications for binding of drugs
    • Apr
    • 33. Viani A, Rizzo G, Carrai M, et al. Interindividual variability in the concentrations of albumin and alpha-1-acid glycoprotein in patients with renal or liver disease, newborns and healthy subjects: implications for binding of drugs. Int J Clin Pharmacol Ther Toxicol 1992 Apr; 30 (4): 128-33
    • (1992) Int J Clin Pharmacol Ther Toxicol , vol.30 , Issue.4 , pp. 128-133
    • Viani, A.1    Rizzo, G.2    Carrai, M.3
  • 35
    • 0022650069 scopus 로고
    • Postburn serum drug binding and serum concentrations
    • Feb
    • 35. Bloedow DC, Hansrough JF, Hardin T, et al. Postburn serum drug binding and serum concentrations. J Clin Pharmacol 1986 Feb; 26 (2): 147-51
    • (1986) J Clin Pharmacol , vol.26 , Issue.2 , pp. 147-151
    • Bloedow, D.C.1    Hansrough, J.F.2    Hardin, T.3
  • 36
    • 0021277857 scopus 로고
    • Plasma protein binding of drugs after severe burn injury
    • Apr
    • 36. Martyn JAJ, Abernethy DR, Greenblatt DJ. Plasma protein binding of drugs after severe burn injury. Clin Pharmacol Ther 1984 Apr; 35 (4): 535-9
    • (1984) Clin Pharmacol Ther , vol.35 , Issue.4 , pp. 535-539
    • Martyn, J.A.J.1    Abernethy, D.R.2    Greenblatt, D.J.3
  • 37
    • 0002922003 scopus 로고
    • Implication of altered plasma protein binding in disease states
    • Benet LZ, Massourd N, Garbetoglio JG, et al., editors. New York: Raven Press
    • 37. Tozer TN. Implication of altered plasma protein binding in disease states. In: Benet LZ, Massourd N, Garbetoglio JG, et al., editors. Pharmacokinetic basis for drug treatment. New York: Raven Press, 1984
    • (1984) Pharmacokinetic Basis for Drug Treatment
    • Tozer, T.N.1
  • 38
    • 0015946877 scopus 로고
    • Plasma protein binding of diphenylhydantoin. Effects of sex hormones, renal, and hepatic disease
    • Mar
    • 38. Hooper WD, Bochner F, Eadie MJ, et al. Plasma protein binding of diphenylhydantoin. Effects of sex hormones, renal, and hepatic disease. Clin Pharmacol Ther 1974 Mar; 15: 276-82
    • (1974) Clin Pharmacol Ther , vol.15 , pp. 276-282
    • Hooper, W.D.1    Bochner, F.2    Eadie, M.J.3
  • 39
    • 0017313254 scopus 로고
    • Decreased drug binding in serum from patients with chronic hepatic disease
    • Mar
    • 39. Wallace S, Brodie MJ. Decreased drug binding in serum from patients with chronic hepatic disease. Eur J Clin Pharmacol 1976 Mar; 9 (5-6): 429-32
    • (1976) Eur J Clin Pharmacol , vol.9 , Issue.5-6 , pp. 429-432
    • Wallace, S.1    Brodie, M.J.2
  • 40
    • 0021707165 scopus 로고
    • Abnormal serum protein binding of acidic drugs in diabetes mellitus
    • 40. Riuz-Cabello F, Erill S. Abnormal serum protein binding of acidic drugs in diabetes mellitus. Clin Pharmacol Ther 1984; 36: 691-5
    • (1984) Clin Pharmacol Ther , vol.36 , pp. 691-695
    • Riuz-Cabello, F.1    Erill, S.2
  • 41
    • 0020036932 scopus 로고
    • Diazepam and lidocaine plasma protein binding in renal disease
    • Mar
    • 41. Grossman SH, Davis D, Kitchell BB, et al. Diazepam and lidocaine plasma protein binding in renal disease. Clin Pharmacol Ther 1982 Mar; 31 (3): 350-7
    • (1982) Clin Pharmacol Ther , vol.31 , Issue.3 , pp. 350-357
    • Grossman, S.H.1    Davis, D.2    Kitchell, B.B.3
  • 42
    • 0017143101 scopus 로고
    • Plasma protein binding of diazepam and tolbutamide in chronic alcoholics
    • Jul
    • 42. Thiessen JJ, Sellers EM, Denbeigh P, et al. Plasma protein binding of diazepam and tolbutamide in chronic alcoholics. J Clin Pharmacol 1976 Jul; 16 (7): 345-51
    • (1976) J Clin Pharmacol , vol.16 , Issue.7 , pp. 345-351
    • Thiessen, J.J.1    Sellers, E.M.2    Denbeigh, P.3
  • 43
    • 0019814099 scopus 로고
    • Altered plasma protein binding of drugs in thyroid disease
    • Jul-Aug
    • 43. Feely J, Stevenson IH, Crooks J. Altered plasma protein binding of drugs in thyroid disease. Clin Pharmacokinet 1981 Jul-Aug; 6 (4): 298-305
    • (1981) Clin Pharmacokinet , vol.6 , Issue.4 , pp. 298-305
    • Feely, J.1    Stevenson, I.H.2    Crooks, J.3
  • 44
    • 0017756159 scopus 로고
    • Evaluation of methods to determine protein binding of drugs
    • Jul
    • 44. Kurz H, Trunk H, Wetrz B. Evaluation of methods to determine protein binding of drugs. Arzneimittel Forschung 1977 Jul; 27 (7): 1373-80
    • (1977) Arzneimittel Forschung , vol.27 , Issue.7 , pp. 1373-1380
    • Kurz, H.1    Trunk, H.2    Wetrz, B.3
  • 45
    • 0000676179 scopus 로고
    • Protein binding
    • Garnett Er, Hirtz. JL, editors. New York: Marcel Dekker
    • 45. Chigell CU. Protein binding. In: Garnett Er, Hirtz. JL, editors. Drug fate and metabolism. Vol 1. New York: Marcel Dekker, 1977: 187-228
    • (1977) Drug Fate and Metabolism , vol.1 , pp. 187-228
    • Chigell, C.U.1
  • 46
    • 0021324934 scopus 로고
    • Ultrafiltration vs. Equilibrium dialysis for determination of free fraction
    • Jan
    • 46. Bowers WF, Fulton S, Thompson J. Ultrafiltration vs. equilibrium dialysis for determination of free fraction. Clin Pharmacokinet 1984 Jan; 9 Suppl. 1: 49-60
    • (1984) Clin Pharmacokinet , vol.9 , Issue.SUPPL. 1 , pp. 49-60
    • Bowers, W.F.1    Fulton, S.2    Thompson, J.3
  • 47
    • 0026457029 scopus 로고
    • Methods of determining plasma and tissue binding of drugs: Pharmacokinetic consequences
    • Dec
    • 47. Pacifici GM, Viana A. Methods of determining plasma and tissue binding of drugs: pharmacokinetic consequences. Clin Pharmacokinet 1992 Dec; 23 (6): 449-68
    • (1992) Clin Pharmacokinet , vol.23 , Issue.6 , pp. 449-468
    • Pacifici, G.M.1    Viana, A.2
  • 48
    • 0028917147 scopus 로고
    • Application of microdialysis to clinical pharmacokinetics in humans
    • Apr
    • 48. Muller M, Scmid R, Georgopoulos A, et al. Application of microdialysis to clinical pharmacokinetics in humans. Clin Pharmacol Ther 1995 Apr; 57 (4): 371-80
    • (1995) Clin Pharmacol Ther , vol.57 , Issue.4 , pp. 371-380
    • Muller, M.1    Scmid, R.2    Georgopoulos, A.3
  • 49
    • 13644281331 scopus 로고
    • Tissue directed pharmacokinetics
    • Sep 12
    • 49. Schentag JJ, Ballow CH. Tissue directed pharmacokinetics. Am J Med 1991 Sep 12; 91 (3A): 5-11
    • (1991) Am J Med , vol.91 , Issue.3 A , pp. 5-11
    • Schentag, J.J.1    Ballow, C.H.2
  • 50
    • 0017736386 scopus 로고
    • Protein binding of antimicrobials: Clinical pharmacokinetic and therapeutic implications
    • Jul-Aug
    • 50. Craig WA, Welling PG. Protein binding of antimicrobials: clinical pharmacokinetic and therapeutic implications. Clin Pharmacokinet 1977 Jul-Aug; 2 (4): 252-68
    • (1977) Clin Pharmacokinet , vol.2 , Issue.4 , pp. 252-268
    • Craig, W.A.1    Welling, P.G.2
  • 51
    • 0017481335 scopus 로고
    • Binding of drugs by albumin and plasma protein
    • Apr
    • 51. Vallner JJ. Binding of drugs by albumin and plasma protein. J Pharm Sci 1977 Apr; 66 (4): 447-63
    • (1977) J Pharm Sci , vol.66 , Issue.4 , pp. 447-463
    • Vallner, J.J.1
  • 52
    • 0017099526 scopus 로고
    • Plasma and tissue protein binding of drugs in pharmacokinetics
    • 52. Jusko WJ, Gretch M. Plasma and tissue protein binding of drugs in pharmacokinetics. Drug Metab Rev 1976; 5 (1): 43-140
    • (1976) Drug Metab Rev , vol.5 , Issue.1 , pp. 43-140
    • Jusko, W.J.1    Gretch, M.2
  • 54
    • 0018402274 scopus 로고
    • Delivery and transport of glucocorticoids to target cells
    • 54. Ballard PL. Delivery and transport of glucocorticoids to target cells. Monogr Endocrinol 1979; 12: 25-48
    • (1979) Monogr Endocrinol , vol.12 , pp. 25-48
    • Ballard, P.L.1
  • 55
    • 0013642728 scopus 로고
    • Lipoprotein binding of drugs
    • Reidenberg MM, Erill S, editors. New York: Praeger Publishers
    • 55. Lemaire M, Urien S, Albengres((intials?)), et al. Lipoprotein binding of drugs. In: Reidenberg MM, Erill S, editors. Drug-protein binding. New York: Praeger Publishers, 1986: 36-45
    • (1986) Drug-protein Binding , pp. 36-45
    • Lemaire, M.1    Urien, S.2    Albengres3
  • 56
    • 0000062283 scopus 로고
    • Influence of protein binding and use of unbound (free) drug concentrations
    • (chapter 5). Evans WE, Schentag JJ, Jusko WJ, editors. Spokene (WA): Applied Therapeutics, Inc
    • 56. MacKichan J. Influence of protein binding and use of unbound (free) drug concentrations (chapter 5). In: Evans WE, Schentag JJ, Jusko WJ, editors. Applied pharmacokinetics: principles of therapeutic drug monitoring. Spokene (WA): Applied Therapeutics, Inc, 1993: 1-48
    • (1993) Applied Pharmacokinetics: Principles of Therapeutic Drug Monitoring , pp. 1-48
    • MacKichan, J.1
  • 57
    • 0021319828 scopus 로고
    • The relative importance of albumin, lipoproteins and orosomucoid for drug serum binding
    • 57. Pike E, Skuterud B, Kierulf P, et al. The relative importance of albumin, lipoproteins and orosomucoid for drug serum binding. Clin Pharmacokinet 1984; 9 Suppl. 1: 84-101
    • (1984) Clin Pharmacokinet , vol.9 , Issue.SUPPL. 1 , pp. 84-101
    • Pike, E.1    Skuterud, B.2    Kierulf, P.3
  • 58
    • 0019538149 scopus 로고
    • Molecular aspects of ligand binding to serum albumin
    • Mar
    • 58. Kragh-Hansen U. Molecular aspects of ligand binding to serum albumin. Pharmacol Rev 1981 Mar; 33 (1): 17-53
    • (1981) Pharmacol Rev , vol.33 , Issue.1 , pp. 17-53
    • Kragh-Hansen, U.1
  • 59
    • 0015936843 scopus 로고
    • Physicochemical aspects of drug-protein interactions: A general perspective
    • Nov
    • 59. Klotz IM, Physicochemical aspects of drug-protein interactions: a general perspective. Ann N Y Acad Sci 1973 Nov 26; 226: 18-35
    • (1973) Ann N Y Acad Sci , vol.26 , Issue.226 , pp. 18-35
    • Klotz, I.M.1
  • 61
    • 0020426218 scopus 로고
    • The classification of drugs on the basis of the drug-binding site on human serum albumin
    • Dec
    • 61. Iwatsuru M, Nishigori H, Maruyama K. The classification of drugs on the basis of the drug-binding site on human serum albumin. Chem Pharm Bull 1982 Dec; 30 (2): 4489-93
    • (1982) Chem Pharm Bull , vol.30 , Issue.2 , pp. 4489-4493
    • Iwatsuru, M.1    Nishigori, H.2    Maruyama, K.3
  • 62
    • 0016801988 scopus 로고
    • The characterization of two specific drug binding sites on human serum albumin
    • Nov
    • 62. Sudlow G, Birkett DJ, Wade DN. The characterization of two specific drug binding sites on human serum albumin. Mol Pharmacol 1975 Nov; 11 (6): 824-32
    • (1975) Mol Pharmacol , vol.11 , Issue.6 , pp. 824-832
    • Sudlow, G.1    Birkett, D.J.2    Wade, D.N.3
  • 66
    • 0022550771 scopus 로고
    • Pharmacokinetic changes in aging
    • May 16
    • 66. Cohen JL. Pharmacokinetic changes in aging. Am J Med 1986 May 16; 80 (5A Suppl.): 31-8
    • (1986) Am J Med , vol.80 , Issue.5 A SUPPL. , pp. 31-38
    • Cohen, J.L.1
  • 67
    • 0024447750 scopus 로고
    • Clinical pharmacokinetic considerations in the elderly: An update
    • Oct
    • 67. Dawling S, Crome P. Clinical pharmacokinetic considerations in the elderly: an update. Clin Pharmacokinet 1989 Oct; 17 (4): 236-63
    • (1989) Clin Pharmacokinet , vol.17 , Issue.4 , pp. 236-263
    • Dawling, S.1    Crome, P.2
  • 68
    • 0018415172 scopus 로고
    • Reduced serum albumin concentration in the elderly: A report from the Boston Collaborative Drug Surveillance Program
    • Jan
    • 68. Greenblatt DJ. Reduced serum albumin concentration in the elderly: a report from the Boston Collaborative Drug Surveillance Program. J Am Geriatr Soc 1979 Jan; 27 (1): 20-2
    • (1979) J Am Geriatr Soc , vol.27 , Issue.1 , pp. 20-22
    • Greenblatt, D.J.1
  • 69
    • 0027008775 scopus 로고
    • Principles of alterations to drug kinetics and dynamics in the elderly
    • Dec
    • 69. Leslie C, Scott PJW, Caird FI. Principles of alterations to drug kinetics and dynamics in the elderly. Med Lab Sci 1992 Dec; 49 (4): 319-25
    • (1992) Med Lab Sci , vol.49 , Issue.4 , pp. 319-325
    • Leslie, C.1    Scott, P.J.W.2    Caird, F.I.3
  • 70
    • 0021362757 scopus 로고
    • Protein binding and drug clearance
    • Jan
    • 70. Rowland M. Protein binding and drug clearance. Clin Pharmacokinet 1984 Jan; 9 Suppl. 1: 10-7
    • (1984) Clin Pharmacokinet , vol.9 , Issue.SUPPL. 1 , pp. 10-17
    • Rowland, M.1
  • 71
    • 0024244939 scopus 로고
    • Effect of a protein change on unbound and total plasma concentrations for drugs of intermediate hepatic extraction
    • Oct
    • 71. Smallwood RH, Mihaly GW, Smallwood RA, et al. Effect of a protein change on unbound and total plasma concentrations for drugs of intermediate hepatic extraction. J Pharmacokinet Biopharm 1988 Oct; 16 (5): 529-42
    • (1988) J Pharmacokinet Biopharm , vol.16 , Issue.5 , pp. 529-542
    • Smallwood, R.H.1    Mihaly, G.W.2    Smallwood, R.A.3
  • 72
    • 0021245919 scopus 로고
    • Hepatic elimination of drugs with concentration-dependent serum protein binding
    • Feb
    • 72. Huang J, Øie S. Hepatic elimination of drugs with concentration-dependent serum protein binding. J Pharmacokinet Biopharm 1984 Feb; 12 (1): 67-81
    • (1984) J Pharmacokinet Biopharm , vol.12 , Issue.1 , pp. 67-81
    • Huang, J.1    Øie, S.2
  • 73
    • 0019779931 scopus 로고
    • Protein binding of drugs in plasma, interstital fluid and tissues: Effect on pharmacokinetics
    • 73. Faed EM. Protein binding of drugs in plasma, interstital fluid and tissues: effect on pharmacokinetics. Eur J Clin Pharmacol 1981; 21 (1): 77-81
    • (1981) Eur J Clin Pharmacol , vol.21 , Issue.1 , pp. 77-81
    • Faed, E.M.1
  • 74
    • 0018774231 scopus 로고
    • Effect of plasma protein and tissue binding on the time course of drug concentration in plasma
    • 74. McNamara PJ, Levy G, Gibaldi M. Effect of plasma protein and tissue binding on the time course of drug concentration in plasma. J Pharmacokinet Biopharm 1979; 7 (2): 195-206
    • (1979) J Pharmacokinet Biopharm , vol.7 , Issue.2 , pp. 195-206
    • McNamara, P.J.1    Levy, G.2    Gibaldi, M.3
  • 75
    • 0020511430 scopus 로고
    • Plasma and tissue binding considerations in drug disposition
    • 75. Wilkinson GR. Plasma and tissue binding considerations in drug disposition. Drug Metab Rev 1983; 14 (3): 427-65
    • (1983) Drug Metab Rev , vol.14 , Issue.3 , pp. 427-465
    • Wilkinson, G.R.1
  • 76
    • 0023129495 scopus 로고
    • Plasma protein binding of drugs in the elderly. Clinical pharmacokinetics in the elderly
    • Jan
    • 76. Wallace SM, Verbeeck RK. Plasma protein binding of drugs in the elderly. Clinical pharmacokinetics in the elderly. Clin Pharmacokinet 1987 Jan; 12 (1): 41-7
    • (1987) Clin Pharmacokinet , vol.12 , Issue.1 , pp. 41-47
    • Wallace, S.M.1    Verbeeck, R.K.2
  • 77
    • 0013850721 scopus 로고
    • Blood levels at the equilibrium state after multiple dosing
    • Sep 18
    • 77. Wagner JG, Northam JI, Alway CD, et al. Blood levels at the equilibrium state after multiple dosing. Nature 1965 Sep 18; 207 (3): 1301-2
    • (1965) Nature , vol.207 , Issue.3 , pp. 1301-1302
    • Wagner, J.G.1    Northam, J.I.2    Alway, C.D.3
  • 78
    • 0000673072 scopus 로고
    • Diphenylhydantoin metabolism, blood levels and toxicity
    • 78. Kutt H, Winters W, Kokenga R. et al. Diphenylhydantoin metabolism, blood levels and toxicity. Arch Neurol 1964; 11: 642-8
    • (1964) Arch Neurol , vol.11 , pp. 642-648
    • Kutt, H.1    Winters, W.2    Kokenga, R.3
  • 79
    • 0026816113 scopus 로고
    • Effect of aging on the pharmacokinetics of acebutolol enantiomers
    • Feb
    • 79. Piquette-Miller M, Foster RT, Kappagoda CT, et al. Effect of aging on the pharmacokinetics of acebutolol enantiomers. J Clin Pharmacol 1992 Feb; 32 (2): 148-56
    • (1992) J Clin Pharmacol , vol.32 , Issue.2 , pp. 148-156
    • Piquette-Miller, M.1    Foster, R.T.2    Kappagoda, C.T.3
  • 80
    • 0022249769 scopus 로고
    • Influence of advanced age on the disposition of acetazolamide
    • Mar
    • 80. Chapron DJ, Sweeney KR, Feig PU, et al. Influence of advanced age on the disposition of acetazolamide. Br J Clin Pharmacol 1985 Mar; 19 (3): 363-71
    • (1985) Br J Clin Pharmacol , vol.19 , Issue.3 , pp. 363-371
    • Chapron, D.J.1    Sweeney, K.R.2    Feig, P.U.3
  • 81
    • 0026481061 scopus 로고
    • Elucidating the relationship between acetazolamide plasma protein binding and renal clearance us ing an albumin infusion
    • Nov
    • 81. Gomolin IH, Chapron DJ. Elucidating the relationship between acetazolamide plasma protein binding and renal clearance us ing an albumin infusion. J Clin Pharmacol 1992 Nov; 32 (11): 1028-32
    • (1992) J Clin Pharmacol , vol.32 , Issue.11 , pp. 1028-1032
    • Gomolin, I.H.1    Chapron, D.J.2
  • 82
    • 0026536819 scopus 로고
    • Pharmacodynam ics of alfentanil: The role of plasma protein binding
    • Jan
    • 82. Lemmens HJM, Burn AGL, Bouill JG, et al. Pharmacodynam ics of alfentanil: the role of plasma protein binding. Anesthesiology 1992 Jan; 76 (1): 65-70
    • (1992) Anesthesiology , vol.76 , Issue.1 , pp. 65-70
    • Lemmens, H.J.M.1    Burn, A.G.L.2    Bouill, J.G.3
  • 84
    • 0020699738 scopus 로고
    • Alprazolam kinetics in the elderly: Relation to antipyrine disposition
    • Mar
    • 84. Greenblatt DJ, Divoll M, Abernethy DR, et al. Alprazolam kinetics in the elderly: relation to antipyrine disposition. Arch Gen Psychiatry 1983 Mar; 40 (3): 287-90
    • (1983) Arch Gen Psychiatry , vol.40 , Issue.3 , pp. 287-290
    • Greenblatt, D.J.1    Divoll, M.2    Abernethy, D.R.3
  • 85
    • 0020596675 scopus 로고
    • Amitriptyline disposition in young and elderly normal men
    • Mar
    • 85. Schulz P, Turner-Tamiyasu K, Smith G, et al. Amitriptyline disposition in young and elderly normal men. Clin Pharmacol Ther 1983 Mar; 33 (3): 360-6
    • (1983) Clin Pharmacol Ther , vol.33 , Issue.3 , pp. 360-366
    • Schulz, P.1    Turner-Tamiyasu, K.2    Smith, G.3
  • 86
    • 0027301806 scopus 로고
    • The disposition and protein binding of batanopride and its metabolites in subjects with renal impairment
    • 86. St Peter JV, Brady ME, Foote EF, et al. The disposition and protein binding of batanopride and its metabolites in subjects with renal impairment. Eur J Clin Pharmacol 1993; 45 (1): 59-63
    • (1993) Eur J Clin Pharmacol , vol.45 , Issue.1 , pp. 59-63
    • St Peter, J.V.1    Brady, M.E.2    Foote, E.F.3
  • 87
    • 0025261679 scopus 로고
    • Pharmacokinetics and pharmacodynamics of the ACE inhibitor benazepril hydrochloride in the elderly
    • 87. Kaiser G, Ackermann R, Durnin CJ, et al. Pharmacokinetics and pharmacodynamics of the ACE inhibitor benazepril hydrochloride in the elderly. Eur J Clin Pharmacol 1990; 38 (4): 379-85
    • (1990) Eur J Clin Pharmacol , vol.38 , Issue.4 , pp. 379-385
    • Kaiser, G.1    Ackermann, R.2    Durnin, C.J.3
  • 88
    • 0027244446 scopus 로고
    • The effects of age on the pharmacokinetics and pharmacodynamics of single oral doses of benazepril and enalapril
    • Sep
    • 88. MacDonald NJ, Sioufi A. Howie CA, et al. The effects of age on the pharmacokinetics and pharmacodynamics of single oral doses of benazepril and enalapril. Br J Clin Pharmacol 1993 Sep; 36 (3): 205-9
    • (1993) Br J Clin Pharmacol , vol.36 , Issue.3 , pp. 205-209
    • MacDonald, N.J.1    Sioufi, A.2    Howie, C.A.3
  • 89
    • 0021738021 scopus 로고
    • Comparison of plasma levels of canrenone and metabolites after base hydrolysis in young and elderly subjects following single and multiple doses of spironolactone
    • 89. Ho PC, Bourne DWA, Triggs EJ, et al. Comparison of plasma levels of canrenone and metabolites after base hydrolysis in young and elderly subjects following single and multiple doses of spironolactone. Eur J Clin Pharmacol 1984; 27: 435-9
    • (1984) Eur J Clin Pharmacol , vol.27 , pp. 435-439
    • Ho, P.C.1    Bourne, D.W.A.2    Triggs, E.J.3
  • 90
    • 0020395919 scopus 로고
    • Protein binding of caffeine in young and elderly males
    • Dec
    • 90. Blanchard J. Protein binding of caffeine in young and elderly males. J Pharm Sci 1982 Dec; 71 (12): 1415-8
    • (1982) J Pharm Sci , vol.71 , Issue.12 , pp. 1415-1418
    • Blanchard, J.1
  • 91
    • 0027169632 scopus 로고
    • Disposition of intramuscular cefonicid in elderly patients
    • Aug
    • 91. Karki SD, Bentley DW, Luzier A, et al. Disposition of intramuscular cefonicid in elderly patients. J Am Geriatr Soc 1993 Aug; 41 (8): 808-10
    • (1993) J Am Geriatr Soc , vol.41 , Issue.8 , pp. 808-810
    • Karki, S.D.1    Bentley, D.W.2    Luzier, A.3
  • 92
    • 0022542096 scopus 로고
    • Effect of saturable serum protein binding on the pharmacokinetics of unbound cefonicid in humans
    • Oct
    • 92. Dudley MN, Shyu WC, Nightingale CH. Effect of saturable serum protein binding on the pharmacokinetics of unbound cefonicid in humans. Antimicrob Agents Chemother 1986 Oct; 30 (4): 565-9
    • (1986) Antimicrob Agents Chemother , vol.30 , Issue.4 , pp. 565-569
    • Dudley, M.N.1    Shyu, W.C.2    Nightingale, C.H.3
  • 94
    • 0017848553 scopus 로고
    • Effect of age and parenchymal liver disease on the disposition and elimination of chlorodiazepoxide
    • Sep
    • 94. Roberts RK, Wilkerson GR, Branch RA, et al. Effect of age and parenchymal liver disease on the disposition and elimination of chlorodiazepoxide. Gastroenterology 1978 Sep; 75 (3): 479-85
    • (1978) Gastroenterology , vol.75 , Issue.3 , pp. 479-485
    • Roberts, R.K.1    Wilkerson, G.R.2    Branch, R.A.3
  • 95
    • 0021200499 scopus 로고
    • Effect of age and sex on the plasma binding of acidic and basic drugs
    • 95. Verbeeck RK, Cardinal JA, Wallace SM. Effect of age and sex on the plasma binding of acidic and basic drugs. Eur J Clin Pharmacol 1984; 27 (1): 91-7
    • (1984) Eur J Clin Pharmacol , vol.27 , Issue.1 , pp. 91-97
    • Verbeeck, R.K.1    Cardinal, J.A.2    Wallace, S.M.3
  • 96
    • 0020693405 scopus 로고
    • Characterization of chloroquine plasma protein binding in man
    • Mar
    • 96. Walker O. Birkett DJ, Alvan G, et al. Characterization of chloroquine plasma protein binding in man. Br J Clin Pharmacol 1983 Mar; 15 (3): 375-7
    • (1983) Br J Clin Pharmacol , vol.15 , Issue.3 , pp. 375-377
    • Walker, O.1    Birkett, D.J.2    Alvan, G.3
  • 97
    • 0027404736 scopus 로고
    • Stereoselective pharmacokinetic properties of chloroquine and de-ethyl chloroquine in humans
    • Mar
    • 97. Augustijns P, Verbeerke N. Stereoselective pharmacokinetic properties of chloroquine and de-ethyl chloroquine in humans. Clin Pharmacokinet 1993 Mar; 24 (3): 259-69
    • (1993) Clin Pharmacokinet , vol.24 , Issue.3 , pp. 259-269
    • Augustijns, P.1    Verbeerke, N.2
  • 98
    • 0027968989 scopus 로고
    • Protein binding of 2-chloro-2′-deoxyadenosine (cladribine) in healthy subjects and in patients with leukaemia
    • 98. Albertioni F, Heronren L. Protein binding of 2-chloro-2′-deoxyadenosine (cladribine) in healthy subjects and in patients with leukaemia. Eur J Clin Pharmacol 1994; 46 (6): 563-4
    • (1994) Eur J Clin Pharmacol , vol.46 , Issue.6 , pp. 563-564
    • Albertioni, F.1    Heronren, L.2
  • 99
    • 0017743032 scopus 로고
    • Plasma levels of chlormethiazole and two metabolites after oral administration to young and aged subjects
    • Oct 14
    • 99. Nation RL. Vine J, Triggs EJ, et al. Plasma levels of chlormethiazole and two metabolites after oral administration to young and aged subjects. Eur J Clin Pharmacol 1977 Oct 14; 12 (2): 137-45
    • (1977) Eur J Clin Pharmacol , vol.12 , Issue.2 , pp. 137-145
    • Nation, R.L.1    Vine, J.2    Triggs, E.J.3
  • 100
    • 0021930697 scopus 로고
    • Imipramine and desipramine disposition in the elderly
    • Jan
    • 100. Abernathy DR, Greenblatt DJ, Shader RI. Imipramine and desipramine disposition in the elderly. J Pharmacol Exp Ther 1985 Jan; 232 (1): 183-8
    • (1985) J Pharmacol Exp Ther , vol.232 , Issue.1 , pp. 183-188
    • Abernathy, D.R.1    Greenblatt, D.J.2    Shader, R.I.3
  • 101
    • 0019483945 scopus 로고
    • Comparative protein binding of diazepam and desmethydiazepam
    • May-Jun
    • 101 Allen MD, Greenblatt DJ. Comparative protein binding of diazepam and desmethydiazepam. J Clin Pharmacol 1981 May-Jun; 21 (5-6): 219-23
    • (1981) J Clin Pharmacol , vol.21 , Issue.5-6 , pp. 219-223
    • Allen, M.D.1    Greenblatt, D.J.2
  • 102
    • 0019812150 scopus 로고
    • Effect of age and sex on disposition of desmethyldiazepam formed from its precursor clorazepate
    • 102. Shader RI, Greenblatt DJ, Cirraulo DA, et al. Effect of age and sex on disposition of desmethyldiazepam formed from its precursor clorazepate. Psychopharmacology 1981; 75 (2): 193-7
    • (1981) Psychopharmacology , vol.75 , Issue.2 , pp. 193-197
    • Shader, R.I.1    Greenblatt, D.J.2    Cirraulo, D.A.3
  • 103
    • 0026544768 scopus 로고
    • The effect of aging on plasma albumin and plasma protein binding of diazepam, salicyclic acid, and digitoxin in healthy subjects and patients with renal impairment
    • Mar
    • 103. Viani A, Rizzo G, Carrai M, et al. The effect of aging on plasma albumin and plasma protein binding of diazepam, salicyclic acid, and digitoxin in healthy subjects and patients with renal impairment. Br J Clin Pharmacol 1992 Mar; 33 (3): 299-304
    • (1992) Br J Clin Pharmacol , vol.33 , Issue.3 , pp. 299-304
    • Viani, A.1    Rizzo, G.2    Carrai, M.3
  • 105
    • 0018870991 scopus 로고
    • Influence of chronic renal failure and hemodialysis on diflunisal plasma protein binding
    • 105. Verbeeck RK, De Schepper PJ. Influence of chronic renal failure and hemodialysis on diflunisal plasma protein binding. Clin Pharmacol Ther 1980; 27: 628-35
    • (1980) Clin Pharmacol Ther , vol.27 , pp. 628-635
    • Verbeeck, R.K.1    De Schepper, P.J.2
  • 106
    • 0022398628 scopus 로고
    • The influence of age and smoking on the elimination of disopyramide
    • Nov
    • 106. Bonde J. Pedersen LE, Bodtker S, et al. The influence of age and smoking on the elimination of disopyramide. Br J Clin Pharmacol 1985 Nov; 20 (5): 453-8
    • (1985) Br J Clin Pharmacol , vol.20 , Issue.5 , pp. 453-458
    • Bonde, J.1    Pedersen, L.E.2    Bodtker, S.3
  • 107
    • 0027141935 scopus 로고
    • Comparsion of the pharmacokinetics of E2020, a new compound for Alzheimer's disease, in healthy young and elderly subjects
    • Nov
    • 107. Ohnishi A, Mihara M, Kamakura H, et al. Comparsion of the pharmacokinetics of E2020, a new compound for Alzheimer's disease, in healthy young and elderly subjects. J Clin Pharmacol 1993 Nov; 33 (11): 1086-91
    • (1993) J Clin Pharmacol , vol.33 , Issue.11 , pp. 1086-1091
    • Ohnishi, A.1    Mihara, M.2    Kamakura, H.3
  • 108
    • 0022578363 scopus 로고
    • Etodalac kinetics in the elderly
    • May
    • 108. Scatina J, Hicks D. Kraml M, et al. Etodalac kinetics in the elderly. Clin Pharmacol Ther 1986 May; 39 (5): 550-3
    • (1986) Clin Pharmacol Ther , vol.39 , Issue.5 , pp. 550-553
    • Scatina, J.1    Hicks, D.2    Kraml, M.3
  • 109
    • 0019509203 scopus 로고
    • Plasma protein binding of etomidate in different age groups and in patients with chronic respiratory insufficiency
    • Apr
    • 109. Carlos R, Calvo R, Erill S. Plasma protein binding of etomidate in different age groups and in patients with chronic respiratory insufficiency. Int J Clin Pharmacol TherToxicol 1981 Apr; 19 (4): 171-4
    • (1981) Int J Clin Pharmacol Thertoxicol , vol.19 , Issue.4 , pp. 171-174
    • Carlos, R.1    Calvo, R.2    Erill, S.3
  • 110
    • 0019624375 scopus 로고
    • Kinetics and clinical effects of flurazepam in young and elderly noninsomniacs
    • Oct
    • 110. Greenblatt DJ, Divoll M, Harmatz JS, et al. Kinetics and clinical effects of flurazepam in young and elderly noninsomniacs. Clin Pharmacol Ther 1981 Oct; 30 (4): 475-86
    • (1981) Clin Pharmacol Ther , vol.30 , Issue.4 , pp. 475-486
    • Greenblatt, D.J.1    Divoll, M.2    Harmatz, J.S.3
  • 111
    • 0020617892 scopus 로고
    • The pharmacokinetics of frusemide are influenced by age
    • Oct
    • 111. Andreasen F, Hansen U, Husted SE, et al. The pharmacokinetics of frusemide are influenced by age. Br J Clin Pharmacol 1983 Oct; 16 (4): 391-7
    • (1983) Br J Clin Pharmacol , vol.16 , Issue.4 , pp. 391-397
    • Andreasen, F.1    Hansen, U.2    Husted, S.E.3
  • 112
    • 0019405460 scopus 로고
    • Total and free serum haloperidol levels in schizophrenic patients and the effect of age, thioridazine and fatty acids on haloperidol serum protein binding in vitro
    • Apr
    • 112. Rowell FJ, Hui SM, Fairburn AF, et al. Total and free serum haloperidol levels in schizophrenic patients and the effect of age, thioridazine and fatty acids on haloperidol serum protein binding in vitro. Br J Clin Pharmacol 1981 Apr: 11 (4): 377-82
    • (1981) Br J Clin Pharmacol , vol.11 , Issue.4 , pp. 377-382
    • Rowell, F.J.1    Hui, S.M.2    Fairburn, A.F.3
  • 113
    • 0028960702 scopus 로고
    • Enantioselective disposition of ibuprofen on elderly persons with and without renal impairment
    • Apr
    • 113. Rudy AC, Knight PM, Brater DC, et al. Enantioselective disposition of ibuprofen on elderly persons with and without renal impairment. J Pharmacol ExpTher 1995 Apr; 273 (1): 88-93
    • (1995) J Pharmacol Expther , vol.273 , Issue.1 , pp. 88-93
    • Rudy, A.C.1    Knight, P.M.2    Brater, D.C.3
  • 114
    • 0022405131 scopus 로고
    • Protein binding and disposition of lignocaine in the elderly
    • 114. Cusack B, O'Malley K, Lavan J, et al. Protein binding and disposition of lignocaine in the elderly. Eur J Clin Pharmacol 1985; 29 (3): 323-9
    • (1985) Eur J Clin Pharmacol , vol.29 , Issue.3 , pp. 323-329
    • Cusack, B.1    O'Malley, K.2    Lavan, J.3
  • 115
    • 0020039508 scopus 로고
    • Effect of age and sex on lorazepam protein binding
    • Feb
    • 115. Divoll M, Greenblatt DJ. Effect of age and sex on lorazepam protein binding. J Pharm Pharmacol 1982 Feb; 34 (2): 122-3
    • (1982) J Pharm Pharmacol , vol.34 , Issue.2 , pp. 122-123
    • Divoll, M.1    Greenblatt, D.J.2
  • 116
    • 0020505226 scopus 로고
    • Pharmacokinetics of the new analgesic, meptazinol after oral and intravenous administration to volunteers
    • 116. Norbury HM, Franklin RA, Graham DF. Pharmacokinetics of the new analgesic, meptazinol after oral and intravenous administration to volunteers. Eur J Clin Pharmacol 1983; 25 (1): 77-80
    • (1983) Eur J Clin Pharmacol , vol.25 , Issue.1 , pp. 77-80
    • Norbury, H.M.1    Franklin, R.A.2    Graham, D.F.3
  • 117
    • 0021214778 scopus 로고
    • Pharmacokinetics of meptazinol after single and multiple oral administration to elderly patients
    • 117. Norbury HM, Franklin RA, Graham DF, et al. Pharmacokinetics of meptazinol after single and multiple oral administration to elderly patients. Eur J Clin Pharmacol 1984; 27: 223-6
    • (1984) Eur J Clin Pharmacol , vol.27 , pp. 223-226
    • Norbury, H.M.1    Franklin, R.A.2    Graham, D.F.3
  • 118
    • 0029940946 scopus 로고    scopus 로고
    • Total and free metholrexate pharmacokinetics in rheumatoid arthritis patients
    • 118. Edno L, Bressolle F, Gomeni R, et al. Total and free metholrexate pharmacokinetics in rheumatoid arthritis patients. Ther Drug Monit 1996; 18: 128-34
    • (1996) Ther Drug Monit , vol.18 , pp. 128-134
    • Edno, L.1    Bressolle, F.2    Gomeni, R.3
  • 119
    • 0022352999 scopus 로고
    • A comparsion of atenolol, metoprolol, oxprenolol and propranolol in elderly hypertensive and young subjects
    • Oct
    • 119. Rigby JW, Scott AK, Hawksworth GM, et al. A comparsion of atenolol, metoprolol, oxprenolol and propranolol in elderly hypertensive and young subjects. Br J Clin Pharmacol 1985 Oct; 20 (4): 327-31
    • (1985) Br J Clin Pharmacol , vol.20 , Issue.4 , pp. 327-331
    • Rigby, J.W.1    Scott, A.K.2    Hawksworth, G.M.3
  • 120
    • 0021192084 scopus 로고
    • Effect of age, gender, and obesity on midazolam kinetics
    • Jul
    • 120. Greenblatt DJ, Abernathy DR, Locniskar A, et al. Effect of age, gender, and obesity on midazolam kinetics. Anesthesiology 1984 Jul; 61 (1): 27-45
    • (1984) Anesthesiology , vol.61 , Issue.1 , pp. 27-45
    • Greenblatt, D.J.1    Abernathy, D.R.2    Locniskar, A.3
  • 121
    • 0028038305 scopus 로고
    • Effect of salicylic acid on the plasma protein binding and the misoprostol acid
    • Jun
    • 121. Cook CS, Schoenhard GL, Karim A. Effect of salicylic acid on the plasma protein binding and the misoprostol acid. J Pharm Sci 1994 Jun; 83 (6): 883-6
    • (1994) J Pharm Sci , vol.83 , Issue.6 , pp. 883-886
    • Cook, C.S.1    Schoenhard, G.L.2    Karim, A.3
  • 123
    • 0030445112 scopus 로고    scopus 로고
    • Age-dependent alteration of the serum-unbound fraction of nicardipine, a calcium-channel blocker, in man
    • Dec
    • 123. Sugioka N, Koyama H, Kawakubo M, et al. Age-dependent alteration of the serum-unbound fraction of nicardipine, a calcium-channel blocker, in man. J Pharm Pharmacol 1996 Dec; 48 (12): 1327-31
    • (1996) J Pharm Pharmacol , vol.48 , Issue.12 , pp. 1327-1331
    • Sugioka, N.1    Koyama, H.2    Kawakubo, M.3
  • 124
    • 0020698528 scopus 로고
    • Effect of age and liver cirrhosis on the pharmacokinetics of nitrazepam
    • Mar
    • 124. Jochemsen R, Van Beusekom Br. Spoelstra P, et al. Effect of age and liver cirrhosis on the pharmacokinetics of nitrazepam. Br J Clin Pharmacol 1983 Mar; 15 (3): 295-302
    • (1983) Br J Clin Pharmacol , vol.15 , Issue.3 , pp. 295-302
    • Jochemsen, R.1    Van Beusekom, B.2    Spoelstra, P.3
  • 125
    • 0022337430 scopus 로고
    • Age, sex and nitrazepam kinetics: Relation to antipyrine disposition
    • Dec
    • 125. Greenblatt DJ, Abernathy DR, Locniskar A, et al. Age, sex and nitrazepam kinetics: relation to antipyrine disposition. Clin Pharmacol Ther 1985 Dec; 38 (6): 697-703
    • (1985) Clin Pharmacol Ther , vol.38 , Issue.6 , pp. 697-703
    • Greenblatt, D.J.1    Abernathy, D.R.2    Locniskar, A.3
  • 127
    • 0030891896 scopus 로고    scopus 로고
    • Oxaprozin and piroxicam, nonsteriodal anti-inflammatory drugs with long half-lives: Effect of protein binding differences on steady state pharmacokinetics
    • Apr
    • 127. Karim A, Noveck R, McMahon G, et al. Oxaprozin and piroxicam, nonsteriodal anti-inflammatory drugs with long half-lives: effect of protein binding differences on steady state pharmacokinetics. J Clin Pharmacol 1997 Apr; 37 (4): 267-78
    • (1997) J Clin Pharmacol , vol.37 , Issue.4 , pp. 267-278
    • Karim, A.1    Noveck, R.2    McMahon, G.3
  • 128
    • 0016428023 scopus 로고
    • Meperidine kinetics in man: Intravenous injection in surgical patients and volunteers
    • Jan
    • 128. Mather LE, Tucker GT, Pflug AE, et al. Meperidine kinetics in man: intravenous injection in surgical patients and volunteers Clin Pharmacol Ther 1975 Jan; 17 (1): 21-30
    • (1975) Clin Pharmacol Ther , vol.17 , Issue.1 , pp. 21-30
    • Mather, L.E.1    Tucker, G.T.2    Pflug, A.E.3
  • 129
    • 0020402126 scopus 로고
    • Pethidine binding to blood cells and plasma proteins in old and young subjects
    • 129. Holmberg L, Odar-Cederlöft I, Nilsson JLG, et al. Pethidine binding to blood cells and plasma proteins in old and young subjects. Eur J Clin Pharmacol 1982; 22 (2): 457-61
    • (1982) Eur J Clin Pharmacol , vol.22 , Issue.2 , pp. 457-461
    • Holmberg, L.1    Odar-Cederlöft, I.2    Nilsson, J.L.G.3
  • 130
    • 0016757377 scopus 로고
    • Plasma protein binding of drugs as a function of age
    • Oct
    • 130. Bender AD, Post A, Meier JP, et al. Plasma protein binding of drugs as a function of age. J Pharm Sci 1975 Oct; 64 (10): 1711-3
    • (1975) J Pharm Sci , vol.64 , Issue.10 , pp. 1711-1713
    • Bender, A.D.1    Post, A.2    Meier, J.P.3
  • 131
    • 0020432969 scopus 로고
    • Plasma protein binding of phenytoin in the aged: In vivo studies
    • Mar
    • 131. Patterson M, Heazelwood R, Smithhurst B, et al. Plasma protein binding of phenytoin in the aged: in vivo studies. Br J Clin Pharmacol 1982 Mar; 13 (3): 423-5
    • (1982) Br J Clin Pharmacol , vol.13 , Issue.3 , pp. 423-425
    • Patterson, M.1    Heazelwood, R.2    Smithhurst, B.3
  • 132
    • 0022389008 scopus 로고
    • Effect of age and sex on piroxicam disposition
    • Jan
    • 132. Richardson CJ, Blocka KLN, Ross SG, et al. Effect of age and sex on piroxicam disposition. Clin Pharmacol Ther 1985 Jan; 37 (1): 13-8
    • (1985) Clin Pharmacol Ther , vol.37 , Issue.1 , pp. 13-18
    • Richardson, C.J.1    Blocka, K.L.N.2    Ross, S.G.3
  • 133
    • 0026658019 scopus 로고
    • Plasma protein binding of catecholamines, prazosin and propranolol in diabetes mellitus
    • 133. Trovik TS, Jaeger R, Jorde R, et al. Plasma protein binding of catecholamines, prazosin and propranolol in diabetes mellitus. Eur J Clin Pharmacol 1992; 43 (3): 265-8
    • (1992) Eur J Clin Pharmacol , vol.43 , Issue.3 , pp. 265-268
    • Trovik, T.S.1    Jaeger, R.2    Jorde, R.3
  • 134
    • 0029875181 scopus 로고    scopus 로고
    • The effect of aging on the pharmacokinetics and pharmacodynamics of prazosin
    • 134. Andros E, Detmar-Hanna D, Suteparuk S, et al. The effect of aging on the pharmacokinetics and pharmacodynamics of prazosin. Eur J Clin Pharmacol 1996; 50: 41-6
    • (1996) Eur J Clin Pharmacol , vol.50 , pp. 41-46
    • Andros, E.1    Detmar-Hanna, D.2    Suteparuk, S.3
  • 135
    • 0025109736 scopus 로고
    • Altered beta-adrenergic sensitivity and protein binding to l-propranolol in the elderly
    • Nov
    • 135. Tenero DM, Bottorff MB, Burlew BS. Altered beta-adrenergic sensitivity and protein binding to l-propranolol in the elderly. J Cardiovasc Pharmacol 1990 Nov; 16 (5) 702-7
    • (1990) J Cardiovasc Pharmacol , vol.16 , Issue.5 , pp. 702-707
    • Tenero, D.M.1    Bottorff, M.B.2    Burlew, B.S.3
  • 136
    • 0026631840 scopus 로고
    • Age and gender influence the stereoselective pharmacokinetics of propranolol
    • Jun
    • 136. Gilmore DA, Gal J, Gerber JG, et al. Age and gender influence the stereoselective pharmacokinetics of propranolol. J Pharmacol Exp Ther 1992 Jun; 261 (3): 1181-6
    • (1992) J Pharmacol Exp Ther , vol.261 , Issue.3 , pp. 1181-1186
    • Gilmore, D.A.1    Gal, J.2    Gerber, J.G.3
  • 137
    • 0021272712 scopus 로고
    • Influence of age on serum protein binding of propranolol
    • 137. Bendayan R, Pieper JA, Stewart RB, et al. Influence of age on serum protein binding of propranolol. Eur J Clin Pharmacol 1984; 26 (2): 251-4
    • (1984) Eur J Clin Pharmacol , vol.26 , Issue.2 , pp. 251-254
    • Bendayan, R.1    Pieper, J.A.2    Stewart, R.B.3
  • 138
    • 0024542846 scopus 로고
    • Stereoselective binding of propranolol in the elderly
    • 138. Colagelo P, Chandler M, Bloiun R, et al. Stereoselective binding of propranolol in the elderly. Br J Clin Pharmacol 1989; 27: 519-22
    • (1989) Br J Clin Pharmacol , vol.27 , pp. 519-522
    • Colagelo, P.1    Chandler, M.2    Bloiun, R.3
  • 139
    • 0019350788 scopus 로고
    • Pharmacokinetics of atenolol and propranolol in young and elderly subjects
    • 139. Barber HE, Hawksworth GM, Petrie JC, et al. Pharmacokinetics of atenolol and propranolol in young and elderly subjects [abstract]. Br J Clin Pharmacol 1981; 11: 118P-9P
    • (1981) Br J Clin Pharmacol , vol.11
    • Barber, H.E.1    Hawksworth, G.M.2    Petrie, J.C.3
  • 140
    • 0018145266 scopus 로고
    • Reduced quinidine clearance in elderly persons
    • Sep
    • 140. Ochs HR, Greenblatt DJ, Woo E, et al. Reduced quinidine clearance in elderly persons. Am J Cardiol 1978 Sep; 42 (3): 481-5
    • (1978) Am J Cardiol , vol.42 , Issue.3 , pp. 481-485
    • Ochs, H.R.1    Greenblatt, D.J.2    Woo, E.3
  • 141
    • 0028879889 scopus 로고
    • Influence of age, renal and liver impairment on the pharmacokinetics of risperidone in man
    • 141. Snoeck E, Van Peer A, Sack M, et al. Influence of age, renal and liver impairment on the pharmacokinetics of risperidone in man. Psychopharmacology 1995; 122: 223-9
    • (1995) Psychopharmacology , vol.122 , pp. 223-229
    • Snoeck, E.1    Van Peer, A.2    Sack, M.3
  • 142
    • 0020517365 scopus 로고
    • Pharmacokinetics of aspirin and salicylate in elderly subjects and in patients with alcoholic liver disease
    • 142. Roberts MS, Rumble RH, Wanwimolruk S, et al. Pharmacokinetics of aspirin and salicylate in elderly subjects and in patients with alcoholic liver disease. Eur J Clin Pharmacol 1983; 25 (2): 253-61
    • (1983) Eur J Clin Pharmacol , vol.25 , Issue.2 , pp. 253-261
    • Roberts, M.S.1    Rumble, R.H.2    Wanwimolruk, S.3
  • 143
    • 0021881994 scopus 로고
    • Salicylate protein binding in serum from young and elderly subjects as measured by diafiltration
    • 143. Lesko LJ, Narang PK, Yeager L, et al. Salicylate protein binding in serum from young and elderly subjects as measured by diafiltration. Eur J Clin Pharmacol 1985; 28 (3): 339-45
    • (1985) Eur J Clin Pharmacol , vol.28 , Issue.3 , pp. 339-345
    • Lesko, L.J.1    Narang, P.K.2    Yeager, L.3
  • 144
    • 0028856208 scopus 로고
    • Protein binding of sotalol enantiomers in young and elderly human and rat serum using ultrafiltration
    • Nov
    • 144. Carr RA, Pasutto FM, Lewanczuk RZ, et al. Protein binding of sotalol enantiomers in young and elderly human and rat serum using ultrafiltration. Biopharm Drug Dispos 1995 Nov; 16 (8): 705-12
    • (1995) Biopharm Drug Dispos , vol.16 , Issue.8 , pp. 705-712
    • Carr, R.A.1    Pasutto, F.M.2    Lewanczuk, R.Z.3
  • 145
    • 0022411345 scopus 로고
    • Pharmacokinetics of the trimethoprim-sulphamethoxazole combination in the elderly
    • Dec
    • 145. Varoquaux O, LaJoie D, Gobart C, et al. Pharmacokinetics of the trimethoprim-sulphamethoxazole combination in the elderly. Br J Clin Pharmacol 1985 Dec; 20 (6): 575-81
    • (1985) Br J Clin Pharmacol , vol.20 , Issue.6 , pp. 575-581
    • Varoquaux, O.1    Lajoie, D.2    Gobart, C.3
  • 146
    • 0029019021 scopus 로고
    • The effects of age and gender on the pharmacokinetics of tenidap sodium in patients with rheumatoid arthritis and osteoarthritis
    • 146. Caldwell JR, Kirby DS, Gardner MJ, et al. The effects of age and gender on the pharmacokinetics of tenidap sodium in patients with rheumatoid arthritis and osteoarthritis. Br J Clin Pharmacol 1995; 39 (I Suppl): 3S-9S
    • (1995) Br J Clin Pharmacol , vol.39 , Issue.1 SUPPL.
    • Caldwell, J.R.1    Kirby, D.S.2    Gardner, M.J.3
  • 147
    • 0024240218 scopus 로고
    • Theophylline pharmacokinetics in normal elderly subjects
    • Nov
    • 147. Shin SG, Juan D, Rammohan M. Theophylline pharmacokinetics in normal elderly subjects. Clin Pharmacol Ther 1988 Nov; 44 (5): 522-30
    • (1988) Clin Pharmacol Ther , vol.44 , Issue.5 , pp. 522-530
    • Shin, S.G.1    Juan, D.2    Rammohan, M.3
  • 148
    • 0019456374 scopus 로고
    • Theophylline pharmacokinetics in advanced age
    • 148. Antal EJ, Kramer PA, Mercik SA, et al. Theophylline pharmacokinetics in advanced age. Br J Clin Pharmcol 1981; 12 (5) 637-45
    • (1981) Br J Clin Pharmcol , vol.12 , Issue.5 , pp. 637-645
    • Antal, E.J.1    Kramer, P.A.2    Mercik, S.A.3
  • 149
    • 0019371512 scopus 로고
    • Theophylline serum protein binding in obstructive airways disease
    • Jun
    • 149. Lesko LJ, Tabor KJ, Johnson BF. Theophylline serum protein binding in obstructive airways disease. Clin Pharmacol Ther 1981 Jun; 29 (6): 776-81
    • (1981) Clin Pharmacol Ther , vol.29 , Issue.6 , pp. 776-781
    • Lesko, L.J.1    Tabor, K.J.2    Johnson, B.F.3
  • 150
    • 0021860913 scopus 로고
    • Binding of tiaprofenic acid to human sera and isolated serum proteins
    • 150. Nilsen OG, Storhaug A, Dale O. Binding of tiaprofenic acid to human sera and isolated serum proteins. Arzneimettel Forschung 1985; 35 (6); 984-7
    • (1985) Arzneimettel Forschung , vol.35 , Issue.6 , pp. 984-987
    • Nilsen, O.G.1    Storhaug, A.2    Dale, O.3
  • 151
    • 0020659138 scopus 로고
    • Reduced clearance of triazolam in old age: Relationot antipyrine oxidizing capacity
    • Mar
    • 151. Greenblatt DJ, Divoll M, Abernathy DR, et al. Reduced clearance of triazolam in old age: relationot antipyrine oxidizing capacity. Br J Clin Pharmacol 1983 Mar; 15 (3): 303-9
    • (1983) Br J Clin Pharmacol , vol.15 , Issue.3 , pp. 303-309
    • Greenblatt, D.J.1    Divoll, M.2    Abernathy, D.R.3
  • 152
    • 0021179555 scopus 로고
    • Pharmacokinetics of valproic acid in the elderly
    • Jun
    • 152. Perucca E, Grimaldi R, Gotti G, et al. Pharmacokinetics of valproic acid in the elderly. Br J Clin Pharmacol 1984 Jun; 17 (6): 665-9
    • (1984) Br J Clin Pharmacol , vol.17 , Issue.6 , pp. 665-669
    • Perucca, E.1    Grimaldi, R.2    Gotti, G.3
  • 153
    • 0021806783 scopus 로고
    • Valproic acid clearance: Unbound fraction and diurnal variation in young and elderly adults
    • Jun
    • 153. Bauer LA, Davis R, Wilensky A, et al. Valproic acid clearance: unbound fraction and diurnal variation in young and elderly adults. Clin Pharmacol Ther 1985 Jun; 37 (6): 697-700
    • (1985) Clin Pharmacol Ther , vol.37 , Issue.6 , pp. 697-700
    • Bauer, L.A.1    Davis, R.2    Wilensky, A.3
  • 154
  • 155
    • 0029875727 scopus 로고    scopus 로고
    • Variability in the plasma protein binding of velnacrine: A potential agent for Alzheimer's disease
    • 155. Wood DM, Ford JM, Roberts CJC. Variability in the plasma protein binding of velnacrine: a potential agent for Alzheimer's disease. Eur J Clin Pharmacol 1996; 50: 115-9
    • (1996) Eur J Clin Pharmacol , vol.50 , pp. 115-119
    • Wood, D.M.1    Ford, J.M.2    Roberts, C.J.C.3
  • 156
    • 0028357260 scopus 로고
    • Aging of women alters S-verapamil pharmacokinetics and pharmacodynamics
    • 156. Schwartz JB, Capili H, Daugherty J. Aging of women alters S-verapamil pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther 1994; 509-17
    • (1994) Clin Pharmacol Ther , pp. 509-517
    • Schwartz, J.B.1    Capili, H.2    Daugherty, J.3
  • 157
  • 158
    • 0028791822 scopus 로고
    • The pharmacokinetics of zileuton in healthy young and elderly volunteers
    • 158. Braeckman RA, Granneman GR, Locke CS, et al. The pharmacokinetics of zileuton in healthy young and elderly volunteers. Clin Pharmacokinet 1995; 29: 42-8
    • (1995) Clin Pharmacokinet , vol.29 , pp. 42-48
    • Braeckman, R.A.1    Granneman, G.R.2    Locke, C.S.3
  • 160
    • 0025792018 scopus 로고
    • Naproxen free plasma concentrations and unbound fractions in patients with osteoarthritis: Relation to age, sex, efficacy and adverse events
    • 160. Hundal Ø, Rugstad HE, Husby G. Naproxen free plasma concentrations and unbound fractions in patients with osteoarthritis: relation to age, sex, efficacy and adverse events. Ther Drug Monit 1991; 13: 478-84
    • (1991) Ther Drug Monit , vol.13 , pp. 478-484
    • Hundal, Ø.1    Rugstad, H.E.2    Husby, G.3
  • 161
    • 0025837021 scopus 로고
    • Age-and dose-dependent naproxen disposition in Fischer 334 rats
    • 161. Satterwhite JH, Boudinot FD. Age-and dose-dependent naproxen disposition in Fischer 334 rats. J Gerontol 1991; 46 (6): B222-7
    • (1991) J Gerontol , vol.46 , Issue.6
    • Satterwhite, J.H.1    Boudinot, F.D.2
  • 162
    • 0029149378 scopus 로고
    • Effects of age on the pharmacodynamics of naproxen in the rat
    • 162. Satterwhite JH, Boudinot FD. Effects of age on the pharmacodynamics of naproxen in the rat. Exp Gerontol 1995; 30 (5): 505-15
    • (1995) Exp Gerontol , vol.30 , Issue.5 , pp. 505-515
    • Satterwhite, J.H.1    Boudinot, F.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.