Effect of aging on the incidence of digoxin toxicity

Annals of Pharmacotherapy

Volumn 34, Issue 4, 2000, Pages 427-432

  Miura, Takanori ^a   Kojima, Ryoji ^b   Sugiura, Youji ^a   Mizutani, Masaru ^a   Takatsu, Fumimaro ^a   Suzuki, Yoshio ^b  

^a Kosei Hospital   (Japan)

^b MEIJO UNIVERSITY   (Japan)

Author keywords

Aging; Digoxin; Serum digoxin concentration; Toxicity

Indexed keywords

ANTIARRHYTHMIC AGENT; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; NITRATE;

ADULT; AGED; AGING; ARTICLE; DIGITALIS INTOXICATION; DISEASE PREDISPOSITION; DRUG BLOOD LEVEL; FEMALE; HEART ATRIUM FIBRILLATION; HEART FAILURE; HUMAN; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SYMPTOMATOLOGY;

AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; CARDIOTONIC AGENTS; DIGOXIN; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; RISK FACTORS;

EID: 0034112553     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.19103     Document Type: Article

References (36)

1. Lee DC-S, Johnson RA, Bingham JB. Heart failure in outpatients: a randomized trial of digoxin versus placebo. N Engl J Med 1982;306:699-705.
2. Uretsky BF, Young JB, Shanhidi FE. Randomized study assessing the effect of digoxin withdrawal in patients with mild to moderate chronic congestive heart failure: results of the PROVED trial. J Am Coll Cardiol 1993;22:955-62.
3. The Digitalis Investigation Group. The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med 1997;336:525-33.
4. Kelly RA, Smith TW. Digoxin in heart failure: implications of recent trials. J Am Coll Cardiol 1993;22(suppl):107A-12A.
5. Packer M, Gheorghiade M, Young JB. Withdrawal of digoxin from patients with chronic heart failure treated with angiotensin-converting-enzyme inhibitors: RADIANCE study. N Engl J Med 1993;329:1-7.
6. Marcus FI. Pharmacokinetic interactions between digoxin and other drugs. J Am Coll Cardiol 1985;5(suppl A):82A-90A.
7. Rodin S, Johnson BF. Pharmacokinetic interactions with digoxin. Clin Pharmacokinet 1988;15:227-44.
8. Henry IB, San A. The influence of quinidine and other agents on digitalis glycosides. Am Heart J 1982;104:289-302.
9. Hager WD, Fenster PE, Mayersohn M, Perrier D, Graves P, Marcus FI. Digoxin-quinidine interaction. N Engl J Med 1979;300:1238-41.
10. Hager WD, Mayersohn M, Perrier D, Graves PE. Digoxin bioavailability during quinidine administration. Clin Pharmacol Ther 1981;30:594-8.
11. Herman OK, Elieser K. Verapamil and digoxin: their respective effects on atrial fibrillation and their interaction. Am J Cardiol 1982;50:894-902.
12. Herman OK, Roberto L, Eliahu W, Elio DS, Carlos L, Juan G, et al. The influence of verapamil on serum digoxin concentration. Circulation 1982;65:998-1003.
13. Nolan PE Jr, Marcus FI, Erstad BL, Hoyer GL, Furman C, Kirsten EB. Effects of coadministration of propafenone on the pharmacokinetics of digoxin in healthy volunteer subjects. J Clin Pharmacol 1989;29:46-52.
14. Lambert C, Lamontagne D, Hottlet H, Du Souich P. Amiodarone-digoxin interaction in rats. Drug Metab Dispos 1989;17:704-8.
15. Robinson K, Johnston A, Walker S, Mulrow JP, Mckenna WJ, Holt DW. The digoxin-amiodarone interaction. Cardiovasc Drugs Ther 1989; 3:25-8.
16. Fenster PE, White NW Jr. Hanson CD. Pharmacokinetic evaluation of the digoxin-amiodarone interaction. J Am Coll Cardiol 1985;5:108-12.
17. Lindenbaum J, Rund DG, Butler VP Jr, Tse-Eng D, Saha JR. Interaction of digoxin by the gut flora: reversal by antibiotic therapy. N Engl J Med 1981;305:789-94.
18. Norregaard-Hansen K, Klitgaard NA, Pedersen KE. The significance of the enterohepatic circulation on the metabolism of digoxin in patients with the ability of intestinal conversion of the drug. Acta Med Scand 1986;220:89-92.
19. Koren G. Interaction between digoxin and commonly coadministered drugs in children. Pediatrics 1985;75:1032-7.
20. Brown DD, Schmid J, Long RA, Hull JH. A steady-state evaluation of the effects of propantheline bromide and cholestyramine on the bioavailability of digoxin when administered as tablets or capsules. J Clin Pharmacol 1985;25:360-4.
21. Johnson BF, Bustrack JA, Urbach DR, Hull JH, Marwaha R. Effect of metoclopramide on digoxin absorption from tablets and capsules. Clin Pharmacol Ther 1984;36:724-30.
22. Kirch W, Janisch HD, Santos SR, Duhrsen U, Dylewicz P, Ohnhaus EE. Effect of cisapride and metoclopramide on digoxin bioavailability. Eur J Drug Metab Pharmacokinet 1986;11:249-50.
23. Mahdyoon H, Battilana G, Rosman H, Goldstein S, Gheorghiade M. The evolving pattern of digoxin intoxication: observations at a large urban hospital from 1980-1988. Am Heart J 1990;120:1189-94.
24. Smith TW. Digitalis toxicity: epidemiology and clinical use of serum concentration measurements. Am J Med 1975;58:470-6.
25. Kelly RA, Smith TW. Recognition and management of digitalis toxicity. Am J Cardiol 1992;69:108G-19G.
26. Ryohei H, Katsumi M. Estimation of population pharmacokinetic parameters in the Japanese. I. Digoxin. Jpn J Ther Drug Monitor 1994;11: 7-17.
27. Kanai I, Kanai M. Creatinine clearance test. In: Kanai I, Kanai M, eds. Kanai's manual of clinical laboratory medicine. Tokyo: Kinbara Press, 1998:1472-5.
28. Williamson KM, Thrasher KA, Fulton KB, LaPointe NM, Duhham GD, Cooper AA. Digoxin toxicity: an evaluation in current clinical practice. Arch Intern Med 1998;158:2444-9.
29. Smith TW, Haber E. Digoxin intoxication: the relationship of clinical presentation to serum digoxin concentration. J Clin Invest 1970;49:2377-86.
30. Beller GA, Smith TW, Abelmann WH, Haber E, Hood WB. Digitalis intoxication: a prospective clinical study with serum level correlation. N Engl J Med 1971;284:989-97.
31. Duhme DW, Greenblatt DJ, Koch WJ. Reduction of digoxin toxicity associated with measurement of serum levels. Ann Intern Med 1974;80: 516-9.
32. Evered DC, Chapman C. Plasma digoxin concentrations and digoxin toxicity in hospital patients. Br Heart J 1971;33:540-6.
33. Katano Y, Temma K, Kennedy RH. Enhanced ouabain sensitivity of the heart and myocardial sodium pump in aged rats. Eur J Pharmacol 1984; 105:95-103.
34. Katano Y, Kennedy RH, Stemmer PM, Temma K, Akira T. Aging and digitalis sensitivity of cardiac muscle in rats. Eur J Pharmacol 1985;113: 167-78.
35. Kennedy RH, Seifen E. Aging: ouabain-sensitive Rb+ uptake rate and responsiveness to digoxin in rat left atrial muscle. J Pharmacol Exp Ther 1989;248:104-10.
36. Khatter JC, Navaratnam S, Agbanyo M. Mechanisms of reduced digitalis tolerance with advancing age in the guinea pig. Biochem Pharmacol 1990;40:997-1003.