Age-dependent changes in β-adrenoceptor function in human detrusors and possible mechanisms

Chinese Medical Journal

Volumn 116, Issue 10, 2003, Pages 1511-1514

  Li, Gang ^a   Li, Kai ^a   Li, Zhenhua ^a   Wang, Ping ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

adrenergic receptors; Bladder smooth muscle; Detrusors

Indexed keywords

4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BUCLADESINE; CYCLIC AMP; FORSKOLIN; ISOPRENALINE; POTASSIUM CHLORIDE;

ADRENERGIC ACTIVITY; ADULT; AGED; AGING; ARTICLE; BINDING ASSAY; BINDING SITE; BLADDER COMPLIANCE; CELL ASSAY; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; DETRUSOR MUSCLE; DISSOCIATION CONSTANT; DRUG RESPONSE; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN TISSUE; MALE; MUSCLE CONTRACTILITY; MUSCLE RELAXATION; PROTEIN FUNCTION; RECEPTOR DENSITY; STATISTICAL SIGNIFICANCE;

ADRENERGIC BETA-AGONISTS; AGE FACTORS; AGED; AGING; FEMALE; HUMANS; MALE; MIDDLE AGED; MUSCLE CONTRACTION; MUSCLE, SMOOTH; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC, BETA; URINARY BLADDER;

EID: 0345328601     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Madersbacher S, Pycha A, Schatzl G, et al. The aging lower urinary tract: a comparative urodynamic study of men and women. Urology 1998;51:206-212.
2. 3-adrenoceptor in human and rat detrusor muscle. J Urol 1999;161:680-685.
3. 3-adrenoceptor in the human detrusor muscle. Br J Pharmacol 1999;126:819-825.
4. Diokno AC, Brown MB, Goldstein N, et al. Epidemiology of bladder emptying symptoms in elderly men. J Urol 1992;148: 1817-1821.
5. Hall IP. Second messengers, ion channels and pharmacology of airway smooth muscle. Eur Respir J 2000;15:1120-1127.
6. Lefkowitz RJ. G protein-coupled receptors III. New roles for receptor kinases and β-arrestins in receptor signaling and desensitization. J Biol Chem 1998;273:18677-18680.
7. Nishimoto T, Latifpour J, Wheeler MA, et al. Age-dependent alternations in β-adrenergic responsiveness of rat detrusor smooth muscle. J Urol 1995;153:1701-1706.
8. 3 muscurinic receptors in overactive bladder. Urology 2000;55: 47-49.
9. Wheeler MA, Pontari M, Nishimoto T, et al. Changes in lipid composition and isoproterenol- and ethanol-stimulated adenylate cyclase activity in aging Fischer rat bladders. J Pharmacol Exp Ther 1990;254:277-284.