Electrophoretic purification of tumor-targeted polyethylenimine-based polyplexes reduces toxic side effects in vivo

Journal of Controlled Release

Volumn 122, Issue 3, 2007, Pages 236-245

  Fahrmeir, Julia ^a   Gunther, Michael ^a   Tietze, Nicole ^a   Wagner, Ernst ^a   Ogris, Manfred ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Biocompatibility; Electrophoresis; Non viral gene delivery; Polyplex purification; Tumor targeting

Indexed keywords

NON-VIRAL GENE DELIVERY; POLYETHYLENIMINE (PEI); POLYPLEX PURIFICATION; TUMOR TARGETING;

BIOCOMPATIBILITY; ELECTROPHORESIS; GENE EXPRESSION; GENE TRANSFER; SIZE EXCLUSION CHROMATOGRAPHY; TOXICITY; TUMORS;

ORGANIC POLYMERS;

DNA; DNA PHOSPHATE; NITROGEN; PHOSPHATE; POLYETHYLENEIMINE; POLYMER; POLYPLEX; TRANSFERRIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER MODEL; CONTROLLED STUDY; DEATH; ELECTROPHORESIS; GEL PERMEATION CHROMATOGRAPHY; GENE EXPRESSION; GENE TRANSFER; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PURIFICATION; TOXICITY TESTING; TUMOR;

ANIMALS; BODY WEIGHT; CELL LINE, TUMOR; DNA; DRUG CARRIERS; ELECTROPHORESIS; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; LUCIFERASES; MICE; NEOPLASM TRANSPLANTATION; NEOPLASMS; PARTICLE SIZE; POLYETHYLENEIMINE; TOXICITY TESTS; TRANSFECTION; ULTRAFILTRATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 34548653510     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2007.05.013     Document Type: Article

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