DNA polyplexes based on degradable oligoethylenimine-derivatives: Combination with EGF receptor targeting and endosomal release functions

Journal of Controlled Release

Volumn 116, Issue 2 SPEC. ISS., 2006, Pages 115-122

  Kloeckner, Julia ^a   Boeckle, Sabine ^a   Persson, Daniel ^a   Roedl, Wolfgang ^a   Ogris, Manfred ^a   Berg, Kristian ^b   Wagner, Ernst ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Endosomal release; Epidermal growth factor; Melittin; Nonviral vectors; Oligoethylenimine; Photochemical internalization; Polyplex

Indexed keywords

CELLS; DEGRADATION; DERIVATIVES; EPIDEMIOLOGY; MOLECULAR STRUCTURE; PHOTOCHEMICAL REACTIONS;

ENDOSOMAL RELEASE; EPIDERMAL GROWTH FACTOR; MELITTIN; NONVIRAL VECTORS; OLIGOETHYLENIMINE; PHOTOCHEMICAL INTERNALIZATION; POLYPLEX;

DNA;

CYTEINYLGLYCYLISOLEUCYLGLYCYLALANYLVALYLLEUCYLLYSYLVALYLLEUCYL THREONYLTHREONYLGLYCYLLEUCYLPROLYLALANYLLEUCYLISOLEUCYLTRYPTOPHANYL ISOLEUCYLLYSYLARGINYLLYSYLARGINYLGLUTAMYLGLUTAMIC ACID; CYTEINYLISOLEUCYLGLYCYLALANYLVALYLLEUCYLLYSYLVALYLLEUCYLTHREONYL THREONYLGLYCYLLEUCYLPROLYLALANYLLEUCYLISOLEUCYLTRYPTOPHANYLISOLEUCYL LYSYLARGINYLLYSYLARGINYLGLUTAMYLGLUTAMINYLGLUTAMINE; DNA DIRECTED DNA POLYMERASE; DRUG CARRIER; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTER DERIVATIVE; GLYCYLISOLEUCYLGLYCYLALANYLVALYLLEUCYLLYSYLVALYLLEUCYLTHREONYL THREONYLGLYCYLLEUCYLPROLYLALANYLLEUCYLISOLEUCYLTRYPTOPHANYLISOLEUCYL LYSYLARGINYLLYSYLARGINYLGLUTAMYLGLUTAMYLCYSTEINE; LIGAND; LUCIFERASE; LUMITRANS; MACROGOL; MELITTIN; NMA 3; OLIGOETHYLENIMINE 1,6 HEXANEDIOL DIACRYLATE CONJUGATE; PHOTOSENSITIZING AGENT; PLASMID DNA; POLYETHYLENEIMINE; POLYMER; TETRAKIS(4 SULFOPHENYL)PORPHINE;

ANIMAL CELL; ARTICLE; BIODEGRADABILITY; CANCER CELL; COMPARATIVE STUDY; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG PURIFICATION; DRUG RECEPTOR BINDING; DRUG RELEASE; DRUG SYNTHESIS; DRUG TARGETING; ENDOSOME; GENE OVEREXPRESSION; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; OBSERVATION; PHOTOCHEMICAL EFFICIENCY; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; REPORTER GENE;

EID: 33750976822     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2006.07.002     Document Type: Article

References (36)

1. De Smedt S.C., Demeester J., and Hennink W.E. Cationic polymer based gene delivery systems. Pharm. Res. 17 (2000) 113-126
2. Brown M.D., Schatzlein A.G., and Uchegbu I.F. Gene delivery with synthetic (non viral) carriers. Int. J. Pharm. 229 (2001) 1-21
3. Wagner E. Strategies to improve DNA polyplexes for in vivo gene transfer: will "artificial viruses" be the answer?. Pharm. Res. 21 (2004) 8-14
4. Kursa M., Walker G.F., Roessler V., Ogris M., Roedl W., Kircheis R., and Wagner E. Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer. Bioconjug. Chem. 14 (2003) 222-231
5. Wolschek M.F., Thallinger C., Kursa M., Rossler V., Allen M., Lichtenberger C., Kircheis R., Lucas T., Willheim M., Reinisch W., Gangl A., Wagner E., and Jansen B. Specific systemic nonviral gene delivery to human hepatocellular carcinoma xenografts in SCID mice. Hepatology 36 (2002) 1106-1114
6. Ogris M., Walker G., Blessing T., Kircheis R., Wolschek M., and Wagner E. Tumor-targeted gene therapy: strategies for the preparation of ligand-polyethylene glycol-polyethylenimine/DNA complexes. J. Control. Release 91 (2003) 173-181
7. Sonawane N.D., Szoka Jr. F.C., and Verkman A.S. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J. Biol. Chem. 278 (2003) 44826-44831
8. Cotten M., Langle-Rouault F., Kirlappos H., Wagner E., Mechtler K., Zenke M., Beug H., and Birnstiel M.L. Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels. Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 4033-4037
9. Plank C., Oberhauser B., Mechtler K., Koch C., and Wagner E. The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems. J. Biol. Chem. 269 (1994) 12918-12924
10. Zauner W., Blaas D., Kuechler E., and Wagner E. Rhinovirus-mediated endosomal release of transfection complexes. J. Virol. 69 (1995) 1085-1092
11. Haensler J., and Szoka Jr. F.C. Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjug. Chem. 4 (1993) 372-379
12. Gottschalk S., Sparrow J.T., Hauer J., Mims M.P., Leland F.E., Woo S.L., and Smith L.C. A novel DNA-peptide complex for efficient gene transfer and expression in mammalian cells. Gene Ther. 3 (1996) 48-57
13. Kichler A., Leborgne C., Marz J., Danos O., and Bechinger B. Histidine-rich amphipathic peptide antibiotics promote efficient delivery of DNA into mammalian cells. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 1564-1568
14. Ogris M., Carlisle R.C., Bettinger T., and Seymour L.W. Melittin enables efficient vesicular escape and enhanced nuclear access of nonviral gene delivery vectors. J. Biol. Chem. 276 (2001) 47550-47555
15. Boeckle S., Wagner E., and Ogris M. C- versus N-terminally linked melittin-polyethylenimine conjugates: the site of linkage strongly influences activity of DNA polyplexes. J. Gene Med. 7 (2005) 1335-1347
16. Boeckle S., Fahrmeir J., Rodl W., Ogris M., and Wagner E. Melittin analogs with high lytic activity at endosomal pH enhance transfection with purified targeted PEI polyplexes. J. Control. Release 112 (2006) 240-248
17. Berg K., Selbo P.K., Prasmickaite L., Tjelle T.E., Sandvig K., Moan J., Gaudernack G., Fodstad O., Kjolsrud S., Anholt H., Rodal G.H., Rodal S.K., and Hogset A. Photochemical internalization: a novel technology for delivery of macromolecules into cytosol. Cancer Res. 59 (1999) 1180-1183
18. Engesaeter B.O., Bonsted A., Berg K., Hogset A., Engebraten O., Fodstad O., Curiel D.T., and Maelandsmo G.M. PCI-enhanced adenoviral transduction employs the known uptake mechanism of adenoviral particles. Cancer Gene Ther. 12 (2005) 439-448
19. Hogset A., Prasmickaite L., Tjelle T.E., and Berg K. Photochemical transfection: a new technology for light-induced, site-directed gene delivery. Hum. Gene Ther. 11 (2000) 869-880
20. Prasmickaite L., Hogset A., Tjelle T.E., Olsen V.M., and Berg K. Role of endosomes in gene transfection mediated by photochemical internalisation (PCI). J. Gene Med. 2 (2000) 477-488
21. Prasmickaite L., Hogset A., and Berg K. Evaluation of different photosensitizers for use in photochemical gene transfection. Photochem. Photobiol. 73 (2001) 388-395
22. Hogset A., Prasmickaite L., Engesaeter B.O., Hellum M., Selbo P.K., Olsen V.M., Maelandsmo G.M., and Berg K. Light directed gene transfer by photochemical internalisation. Curr. Gene Ther. 3 (2003) 89-112
23. Kloeckner J., Prasmickaite L., Hogset A., Berg K., and Wagner E. Photochemically enhanced gene delivery of EGF receptor-targeted DNA polyplexes. J. Drug Target. 12 (2004) 205-213
24. Zou S.M., Erbacher P., Remy J.S., and Behr J.P. Systemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouse. J. Gene Med. 2 (2000) 128-134
25. Chollet P., Favrot M.C., Hurbin A., and Coll J.L. Side-effects of a systemic injection of linear polyethylenimine-DNA complexes. J. Gene Med. 4 (2002) 84-91
26. Gosselin M.A., Guo W., and Lee R.J. Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine. Bioconjug. Chem. 12 (2001) 989-994
27. Forrest M.L., Koerber J.T., and Pack D.W. A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery. Bioconjug. Chem. 14 (2003) 934-940
28. Thomas M., Ge Q., Lu J.J., Chen J., and Klibanov A.M. Cross-linked small polyethylenimines: while still nontoxic, deliver DNA efficiently to mammalian cells in vitro and in vivo. Pharm. Res. 22 (2005) 373-380
29. Kim Y.H., Park J.H., Lee M., Kim Y.H., Park T.G., and Kim S.W. Polyethylenimine with acid-labile linkages as a biodegradable gene carrier. J. Control. Release 103 (2005) 209-219
30. Anderson D.G., Akinc A., Hossain N., and Langer R. Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters). Molec. Ther. 11 (2005) 426-434
31. Zhong Z., Song Y., Engbersen J.F., Lok M.C., Hennink W.E., and Feijen J. A versatile family of degradable non-viral gene carriers based on hyperbranched poly(ester amines). J. Control. Release 109 (2005) 317-329
32. J. Kloeckner, E. Wagner, M. Ogris, Degradable gene carriers based on oligomerized polyamines, Eur. J. Pharm. Sci. (in press).
33. J. Kloeckner, S. Bruzzano, M. Ogris, E. Wagner, Gene carriers based on hexanediol diacrylate-linked oligoethylenimine: effect of chemical structure of polymer on biological properties, Bioconjug. Chem. (in press).
34. Brissault B., Kichler A., Guis C., Leborgne C., Danos O., and Cheradame H. Synthesis of linear polyethylenimine derivatives for DNA transfection. Bioconjug. Chem. 14 (2003) 581-587
35. Plank C., Zatloukal K., Cotten M., Mechtler K., and Wagner E. Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand. Bioconjug. Chem. 3 (1992) 533-539
36. Snyder S.L., and Sobocinski P.Z. An improved 2,4,6-trinitrobenzenesulfonic acid method for the determination of amines. Anal. Biochem. 64 (1975) 284-288