5-Substituted imidazole-4-acetic acid analogues: Synthesis, modeling, and pharmacological characterization of a series of novel γ-aminobutyric acidC receptor agonists

Journal of Medicinal Chemistry

Volumn 50, Issue 17, 2007, Pages 4147-4161

  Madsen, Christian ^a   Jensen, Anders A ^a   Liljefors, Tommy ^a   Kristiansen, Uffe ^a   Nielsen, Birgitte ^a   Hansen, Camilla P ^a   Larsen, Mogens ^b   Ebert, Bjarke ^b   Bang Andersen, Benny ^b   Krogsgaard Larsen, Povl ^a   Frølund, Bente ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

(1,2,5,6 TETRAHYDROPYRIDIN 4 YL)METHYLPHOSPHINIC ACID; 2 AMINOMETHYLCYCLOPROPANECARBOXYLIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID C RECEPTOR; 4 AMINOBUTYRIC ACID C RECEPTOR STIMULATING AGENT; 4 AMINOCROTONIC ACID; 4 IMIDAZOLEACETIC ACID; 4(5) (CARBOXYMETHYL) 5(4) (4 FLUOROPHENYL)IMIDAZOLE; 4(5) (CARBOXYMETHYL) 5(4) METHYLIMIDAZOLE; 4(5) (CARBOXYMETHYL) 5(4) PHENYLIMIDAZOLE; ARECAIDINE; CARBOXYLIC ACID DERIVATIVE; CYCLOPROPANE DERIVATIVE; GABOXADOL; MUSCIMOL; PARTIAL AGONIST; PHOSPHINIC ACID DERIVATIVE; SERINE; THREONINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; DRUG BINDING SITE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; LIGAND BINDING; MEMBRANE POTENTIAL; MOLECULAR MODEL; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BRAIN; CELL LINE; GABA AGONISTS; HUMANS; IMIDAZOLES; LIGANDS; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RADIOLIGAND ASSAY; RATS; RECEPTORS, GABA; RECEPTORS, GABA-A; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34548125301     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070447j     Document Type: Article

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