Partial GABAA Receptor Agonists. Synthesis and in Vitro Pharmacology of a Series of Nonannulated Analogs of 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol

Journal of Medicinal Chemistry

Volumn 38, Issue 17, 1995, Pages 3287-3296

  Frølund, Bente ^a   Kristiansen, Uffe ^a   Brehm, Lotte ^a   Hansen, Annette B ^a   Krogsgaard Larsen, Povl ^a   Falch, Erik ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4,5,6,7-TETRAHYDROISOXAZOLO(5,4-C)PYRIDIN-3-OL; GABOXADOL; ISOXAZOLE DERIVATIVE; RECEPTORS, GABA A; 3 (4 PIPERIDYL) 3 ISOXAZOLOL; 3 HYDROXY 5 (4 PIPERIDYL)ISOXAZOLE; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; 5 (1,2,3,6 TETRAHYDRO 4 PYRIDYL) 3 ISOTHIAZOLOL; ACRYLIC ACID; ARECAIDINE; ISONIPECOTIC ACID; MUSCIMOL; PARTIAL AGONIST; PROPIONIC ACID; THIOMUSCIMOL; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BRAIN CORTEX; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; MOUSE; NERVE CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY; RAT; RAT STRAIN; 4 AMINOBUTYRIC ACID UPTAKE; ANIMAL CELL; ANIMAL TISSUE; BLOOD BRAIN BARRIER; BRAIN CELL; BRAIN SYNAPTOSOME; CONTROLLED STUDY; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; EMBRYO; NONHUMAN; PATCH CLAMP; RECEPTOR AFFINITY; SYNAPTIC MEMBRANE;

ANIMAL; CELLS, CULTURED; CEREBRAL CORTEX; ISOXAZOLES; MAGNETIC RESONANCE SPECTROSCOPY; MICE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SUPPORT, NON-U.S. GOV'T;

EID: 0029150501     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00017a014     Document Type: Article

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