Novel 1-hydroxyazole bioisosteres of glutamic acid. Synthesis, protolytic properties, and pharmacology

Journal of Medicinal Chemistry

Volumn 45, Issue 1, 2002, Pages 19-31

  Stensbol T B ^a   Uhlmann, P ^a   Morel, S ^a   Eriksen, B L ^a   Felding, J ^a   Kromann, H ^a   Hermit, M B ^a   Greenwood, J R ^a   Brauner Osborne H ^a   Madsen, U ^a   Junager, F ^b   Krogsgaard Larsen, P ^a   Begtrup, M ^a   Vedso P ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

1 HYDROXYAZOLE DERIVATIVE; 1 HYDROXYPYRAZOLE DERIVATIVE; 1,2,3 HYDROXYTRIAZOLE DERIVATIVE; 2 AMINO 3 (1 HYDROXY 1,2,3 TRIAZOL 5 YL)PROPIONIC ACID; 2 AMINO 3 (1 HYDROXY 4 METHYL 1,2,3 TRIAZOL 5 YL)PROPIONIC ACID; 2 AMINO 3 (1 HYDROXY 4 METHYL 5 PYRAZOLYL)PROPIONIC ACID; 2 AMINO 3 (1 HYDROXY 5 PYRAZOLYL)PROPIONIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; AMPA RECEPTOR AGONIST; GLUTAMIC ACID DERIVATIVE; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; NONHUMAN; PKA; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; AZOLES; BRAIN; CARRIER PROTEINS; CHO CELLS; COS CELLS; CRICETINAE; ELECTROPHYSIOLOGY; GLUTAMIC ACID; GLUTAMINE; MALE; MODELS, MOLECULAR; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTOSOMES;

EID: 0037011909     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010303j     Document Type: Article

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