An Arginine Involved in GABA Binding and Unbinding but Not Gating of the GABAA Receptor

Journal of Neuroscience

Volumn 24, Issue 11, 2004, Pages 2733-2741

  Wagner, David A ^a,b   Czajkowski, Cynthia ^a   Jones, Mathew V ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b Marquette University   (United States)

Author keywords

Agonist; Antagonist; HEK293 cells; Kinetics; Mutation; Sin gle channel

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ARGININE; CYSTEINE; LIGAND;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; CHANNEL GATING; CONTROLLED STUDY; EMBRYO; HORMONE BINDING; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; KINETICS; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR INTRINSIC ACTIVITY; SYNAPSE;

AMINO ACID SUBSTITUTION; ANIMALS; ARGININE; BINDING, COMPETITIVE; CELL LINE; GAMMA-AMINOBUTYRIC ACID; HUMANS; ION CHANNEL GATING; KIDNEY; LIGANDS; MUTAGENESIS, SITE-DIRECTED; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; RATS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 1642282626     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4316-03.2004     Document Type: Article

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