Stimulation of [3H]GABA and β-[3H]alanine release from rat brain slices by cis-4-aminocrotonic acid

Journal of Neurochemistry

Volumn 68, Issue 2, 1997, Pages 786-794

  Chebib, Mary ^a   Johnston, Graham A R ^a  

^a University of Sydney   (Australia)

Author keywords

cis 4 Aminocrotonic acid; CNS; GABA transporters; Nipecotic acid; Release; Alanine

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOCROTONIC ACID; ALANINE; 4-AMINOCROTONIC ACID; ASPARTIC ACID; BIOLOGICAL MARKER; CARRIER PROTEIN; CROTONIC ACID DERIVATIVE; DIAGNOSTIC AGENT; GABAERGIC RECEPTOR AFFECTING AGENT; GLUTAMINE; NIPECOTIC ACID DERIVATIVE; POTASSIUM CHLORIDE; SK&F 89976 A; SK&F 89976-A; TAURINE; TRITIUM;

AMINO ACID TRANSPORT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; MOLECULAR CLONING; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN LOCALIZATION; RAT; SPINAL CORD; ANIMAL; CEREBELLUM; DOSE RESPONSE; DRUG EFFECT; MALE; METABOLISM; ORGAN CULTURE TECHNIQUE; RETINA; SPRAGUE DAWLEY RAT; TRANSPORT AT THE CELLULAR LEVEL;

ALANINE; ANIMALS; ASPARTIC ACID; BIOLOGICAL MARKERS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CEREBELLUM; CEREBRAL CORTEX; CROTONIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; GABA AGENTS; GAMMA-AMINOBUTYRIC ACID; GLUTAMINE; MALE; NIPECOTIC ACIDS; ORGAN CULTURE TECHNIQUES; POTASSIUM CHLORIDE; RATS; RATS, SPRAGUE-DAWLEY; RETINA; SPINAL CORD; TAURINE; TRITIUM;

EID: 0030614597     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.68020786.x     Document Type: Article

References (52)

1. Balcar V. J., Mark J., Borg J., and Mandel P. (1979) High-affinity uptake of gamma-aminobutyric acid in cultured glial and neuronal cells. Neurochem. Res. 4, 339-354.
2. Biedermann B., Eberhardt W., and Reichelt W. (1994) GABA uptake into isolated retinal Müller glial cells of the guinea-pig detected electrophysiologically. Neuroreport 5, 438-440.
3. Borden L. A., Smith K. E., Hartig P. R., Branchek T. A., and Weinshank R. L. (1992) Molecular heterogeneity of the γ-ammobutyric acid (GABA) transport system. J. Biol. Chem. 267, 21098-21104.
4. Borden L. A., Dhar T. G. M., Smith K. E., Weinshank R. L., Branchek T. A., and Gluchowski C. (1994) Tiagabine, SK&F 89976-A, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur. J. Pharmacol. 269, 219-224.
5. Borden L. A., Smith K. E., Gustafson E. L., Branchek T. A., and Weinshank R. L. (1995a) Cloning and expression of a betaine/ GABA transporter from human brain. J. Neurochem. 64, 977-984.
6. Borden L. A., Smith K. E., Vaysse P. J., Gustafson E. L., Weinshank R. L., and Branchek T. A. (1995b) Re-evaluation of GABA transport in neuronal and glial cell cultures: correlation of pharmacology and mRNA localization. Receptors Channels 3, 129-146.
7. Brechtel C. E., Hu L., and King S. C. (1996) Substrate specificity of the Escherichia coli 4-aminobutyrate carrier encoded by gapP: uptake and counterflow of structurally diverse molecules. Am. Soc. Biochem. Mol. Biol. 271, 783-788.
8. Breckenridge R. J., Nicholson S. H., Nicol A. J., Suckling C. J., Leigh B., and Iversen L. (1981) Inhibition of neuronal GABA uptake and glial β-alanine uptake by synthetic GABA analogues. Biochem. Pharmacol. 30, 3045-3049.
9. 1 receptors by glycine and β-alanine. Neuroreport 6, 1118-1120.
10. 50) of an enzymatic reaction. Biochem. Pharmacol. 22, 3099-3108.
11. Clark J. A. and Amara S. G. (1994) Stable expression of a neuronal γ-aminobutyric acid transporter, GAT-3, in mammalian cells demonstrates unique pharmacological properties and ion dependence. Mol. Pharmacol. 46, 550-557.
12. Clark J. A., Deutch A. Y., Gallipoli P. Z., and Amara S. G. (1992) Functional expression and CNS distribution of a β-alanine-sensitive neuronal GABA transporter. Neuron 9, 337-348.
13. Cummins C. J., Glover R. A., and Sellinger O. Z. (1982) β-Alanine uptake is not a marker for brain astroglia in culture. Brain Res. 239, 299-302.
14. 1 cDNA: a novel GABA subunit highly expressed in the retina. Proc. Natl. Acad. Sci. USA 88, 2673-2677.
15. 1 to human chromosome 6q14-q21 and the mouse chromosome 4. Genomics 12, 801.
16. Davies L. P. and Johnston G. A. R. (1976) Uptake and release of D-and L-aspartate by brain slices. J. Neurochem. 26, 1007-1015.
17. Drew C. A., Johnston G. A. R., and Weatherby R. P. (1984) Bicuculline-insensitive GABA receptors: studies on the binding of (-)-baclofen to rat cerebellar membranes. Neurosci. Lett. 52, 317-321.
18. l- channels in rat retinal bipolar cells. Nature 361, 159-162.
19. Guastella J., Nelson N., Nelson H., Czyzyk L., Keynan S., Miedal M. C., Davidson N., Lester H., and Kanner B. (1990) Cloning and expression of a rat brain GABA transporter. Science 249, 1303-1306.
20. B sites in rat brain. Nature 290, 149-152.
21. Iversen L. L. and Johnston G. A (1971) GABA uptake in rat central nervous system: comparison of uptake in slices and homogenates and the effects of some inhibitors. J. Neurochem. 18, 1939-1950.
22. Iversen L. L. and Kelly J. S. (1975) Uptake and metabolism of γ-aminobutyric acid by neurons and glial cells. Biochem. Pharmacol. 24, 933-938.
23. 3H]GABA by slices of rat cerebral cortex. J. Neurochem. 15, 1141-1149.
24. Johnston G. A. R. (1977) Effects of calcium on the potassium-stimulated release of radioactive β-alanine and γ-aminobutyric acid from slices of rat cerebral cortex and spinal cord. Brain Res. 121, 179-181.
25. Johnston G. A. R. (1986) Multiplicity of GABA receptors, in Receptor Biochemistry and Methodology, Vol. 5: Benzodiazepine/ GABA Receptors Chloride Channels (Olsen R. W. and Venter J. C., eds), pp. 57-71. Alan R. Liss, New York.
26. C-receptors. Prog. Brain Res. 100, 61-65.
27. Johnston G. A. R. and Stephanson A. L. (1976) Inhibitors of the glial uptake of β-alanine in rat brain slices. Brain Res. 102, 374-378.
28. Johnston G. A. R., Curtis D. R., Beart P. M., Game C. J. A., McCulloch R. M., and Twitchin B. (1975) cis-and trans-4-aminocrotonic acid as GABA analogues of restricted conformation. J. Neurochem. 24, 157-160.
29. Johnston G. A. R., Krogsgaard-Larsen P., Stephanson A. L., and Twitchin B. (1976a) Inhibition of the uptake of GABA and related amino acids in rat brain slices of the optical isomers of nipecotic acid. J. Neurochem. 26, 1029-1032.
30. Johnston G. A. R., Stephanson A. L., and Twitchin B. (1976b) Uptake and release of nipecotic acid by rat brain slices. J. Neurochem. 26, 83-87.
31. Kaczmarek L. K. and Davison A. L. (1972) Uptake and release of taurine from rat brain slices. J. Neurochem. 19, 2355-2362.
32. Kusama T., Spivak C. E., Whiting P., Dawson V. L., Schaeffer J. C., and Uhl G. R. (1993a) Pharmacology of GABA ρ1 and GABA α/β receptors expressed in Xenopus oocytes and COS cells. Br. J. Pharmacol 109, 200-206.
33. 1. Eur. J. Pharmacol. Mol. Pharmacol. 245, 83-84.
34. Larsson O. M., Hertz L., and Schousboe A. (1980) GABA uptake in astrocytes in primary cultures: coupling with two sodium ions. J. Neurosci. Res. 5, 469-477.
35. Larsson O. M., Johnston G. A. R., and Schousboe A. (1983) Differences in uptake kinetics of cis-3-aminocyclohexane carboxylic acid into neurons and astrocytes in primary cultures. Brain Res. 260, 279-285.
36. Larsson O. M., Griffiths R., Allen I. C., and Schousboe A. (1986) Mutual inhibition kinetic analysis of γ-aminobutyric acid, taurine, and β-alanine high-affinity transport into neurons and astrocytes: evidence for similarity between the taurine and β-alanine carriers in both cell types. J. Neurochem. 47, 426-432.
37. 3H]GABA. Dev. Brain Res. 10, 227-241.
38. Liu Q.-R., Lopez-Corcuera B., Mandiyan S., Nelson H., and Nelson N. (1993) Molecular characterisation of four pharmacologically distinct γ-aminobutyric acid (GABA) transporters in mouse brain. J. Biol Chem. 268, 2106-2112.
39. Lopez-Corcuera B., Liu Q.-R., Mandiyan S., Nelson H., and Nelson N. (1992) Expression of a mouse brain cDNA encoding a novel γ-aminobutyric acid (GABA) transporter. J. Biol. Chem. 267, 17491-17493.
40. Lukasiewicz P. D. and Werblin F. S. (1994) A novel GABA receptor modulates synaptic transmission from bipolar to ganglion and amacrine cells in the tiger salamander retina. J. Neurosci. 14, 1213-1223.
41. Martin D. L. and Shain W. (1979) High affinity transport of taurine and β-alanine and low affinity transport of γ-aminobutyric acid by a single transport system in cultured glioma cells. J. Biol. Chem. 254, 7076-7084.
42. Polenzani L., Woodward R. M., and Miledi R. (1991) Expression of mammalian γ-aminobutyric acid receptors with distinct pharmacology in Xenopus oocytes. J. Pharmacol. Exp. Ther. 41, 683-687.
43. Qian H. and Dowling J. E. (1993) Novel GABA responses from rod-driven retinal horizontal cells. Nature 361, 162-164.
44. Saransaari P. and Oja S. S. (1993) Uptake and release of β-alanine in cerebellar granule cells in primary culture: regulation of release by glutamatergic and GABAergic receptors. Neuroscience 53, 475-481.
45. 3H]GABA uptake into the satellite glial cells of rat sensory ganglia. Brain Res. 66, 289-300.
46. 3H]β-alanine by glia: association with the glial uptake systems for GABA. Brain Res. 86, 243-257.
47. 1 receptor RNA induces bicuculline-, barbiturate-, and benzodiazepine-insensitive γ-aminobutyric acid responses in Xenopus oocytes. Mol. Pharmacol. 41, 683-687.
48. Smith K. E., Borden L. A., Wang C. H., Hartig P. R., Branchek T. A., and Weinshank R. L. (1992) Cloning and expression of a high affinity taurine transporter from rat brain. Mol. Pharmacol. 42, 563-569.
49. 2) cloned from human retina forms bicuculline-insensitive homooligomeric receptors in Xenopus oocytes. J. Neurosci. 14, 6524-6531.
50. B receptor agonists and antagonists. Mol. Pharmacol. 43, 609-625.
51. --dependent betaine transporter that is regulated by hypertonicity. J. Biol. Chem. 267, 649-652.
52. Yunger L. M., Fowler P. J., Zarevics P., and Setler P. E. (1984) Novel inhibitors of y-aminobutyric acid (GABA) uptake: anti-convulsant actions in rats and mice. J. Pharmacol. Exp. Ther. 228, 109-115.