Synthesis of imidazole phosphinic acids as I4AA analogues

Tetrahedron Letters

Volumn 47, Issue 8, 2006, Pages 1253-1255

  Orain, David ^a   Mattes, Henri ^a  

^a Novartis Institute for BioMedical Research Basel   (Switzerland)

Author keywords

GABA; Imidazole; Phosphinic acid; TPMPA

Indexed keywords

1,2,5,6-TETRAHYDROPYRIDIN-4-YLMETHYLPHOSPHINIC ACID; 4 AMINOBUTYRIC ACID C RECEPTOR; ARECAIDINE; IMIDAZOLE PHOSPHINIC ACID 14AA; IMIDAZOLE PHOSPHINIC ACID DERIVATIVE; PHOSPHINIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BROMINATION; DEOXYGENATION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; EYE DISEASE; POLYMERIZATION;

EID: 30944449006     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.12.086     Document Type: Article

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11. 2O): δ 8.34 (d, J = 1.0 Hz, 1H), 7.12 (d, J = 1.5 Hz, 1H), 2.94 (d, J = 14.6 Hz, 2H), 1.41 (m, 4H), 1.27 (m, 2H), 0.79 (t, J = 7.1 Hz, 3H).
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14. 2O): δ 7.50 (s, 1H), 6.82 (br s, 1H), 3.92 (m, 2H), 2.66 (m, 2H), 1.97 (m, 2H), 1.62 (m, 2H), 1.36 (m, 4H), 1.21 (t, J = 7.1 Hz, 3H), 0.86 (t, J = 7.0 Hz, 3H).