Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABAC receptor antagonists

Neurochemistry International

Volumn 42, Issue 7, 2003, Pages 561-565

  Krehan, Dorte ^a   Frølund, Bente ^a   Krogsgaard Larsen, Povl ^a   Kehler, Jan ^b   Johnston, Graham A R ^c   Chebib, Mary ^d  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b H LUNDBECK A S   (Denmark)

^c University of Sydney   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Bioisosteres; Electrophysiology; GABAC antagonists; GABAC receptors; Homomeric receptors; Isonipecotic acid isosteres; Xenopus oocytes

Indexed keywords

(1,2,5,6 TETRAHYDROPYRIDIN 4 YL)METHYLPHOSPHINIC ACID; 3 PIPERIDEINE DERIVATIVE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID C RECEPTOR; 4 AMINOBUTYRIC ACID C RECEPTOR BLOCKING AGENT; AMINO ACID DERIVATIVE; PHOSPHINIC ACID DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; PIPERIDIN 4 YLPHOSPHINIC ACID; PIPERIDIN 4 YLPHOSPHONIC ACID; PIPERIDIN 4 YLSELENINIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; DERIVATIZATION; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; HUMAN; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; XENOPUS;

ANIMALS; CARBOXYLIC ACIDS; FEMALE; GABA ANTAGONISTS; HUMANS; ISONIPECOTIC ACIDS; OOCYTES; ORGANOSELENIUM COMPOUNDS; PHOSPHINIC ACIDS; PHOSPHONIC ACIDS; PROTEIN ISOFORMS; RECEPTORS, GABA; XENOPUS LAEVIS;

NEUROLAENA LOBATA;

EID: 12244294479     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(02)00162-6     Document Type: Article

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