Nucleotide binding, ATP hydrolysis, and mutation of the catalytic carboxylates of human P-glycoprotein cause distinct conformational changes in the transmembrane segments

Biochemistry

Volumn 46, Issue 32, 2007, Pages 9328-9336

  Loo, Tip W ^a   Bartlett, M Claire ^a   Clarke, David M ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; BINDING SITES; CARBOXYLATION; CATALYST ACTIVITY; CONFORMATIONS; HYDROLYSIS; NUCLEOTIDES;

MUTATION; NUCLEOTIDE BINDING DOMAIN (NBD);

GLYCOPROTEINS;

ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; CARBOXYLIC ACID; CYSTEINE; GLUTAMIC ACID; GLUTAMINE; GLYCOPROTEIN P; LEUCINE; NUCLEOTIDE; PHENYLALANINE; VALINE;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CELL STRAIN HEK293; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDROLYSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN CROSS LINKING; PROTEIN DOMAIN; REACTION ANALYSIS; SEQUENCE ANALYSIS;

ADENOSINE TRIPHOSPHATE; AMINO ACID SUBSTITUTION; CARBOXYLIC ACIDS; CATALYSIS; CELL LINE; CROSS-LINKING REAGENTS; CYSTEINE; DISULFIDES; ENERGY METABOLISM; EXTRACELLULAR SPACE; HUMANS; HYDROLYSIS; MEMBRANE PROTEINS; MUTATION; NUCLEOTIDES; P-GLYCOPROTEIN; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; VINBLASTINE;

EID: 34547911075     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700837y     Document Type: Article

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